| Project/Area Number |
16591239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Research Institute for Brain and Blood Vessels -Akita |
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Principal Investigator |
MIURA Shuichi Research Institute for Brain and Blood Vessels -Akita, Department of radiology and nuclear medicine, Director, 放射線医学研究部, 研究部長 (10370256)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOSEGAWA Eku Research Institute for Brain and Blood Vessels -Akita, Department of radiology and nuclear medicine, Senior Scientist, 放射線医学研究部, 主任研究員 (30370258)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | PET / receptor / NMPB / muscarinic / cholinergic / Binding / Alzheimer / アルツハイマー |
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| Research Abstract |
Quantification of human brain muscarinic cholinergic receptors was investigated with the use of N-[^<11>C]methyl-3-piperidyl benzilate ([^<11>C]3NMPB) and positron emission tomography (PET). The regional distribution pattern of [^<11>C] 3NMPB was the highest in the striatum ; intermediate in the occipital, temporal and frontal cortices, cingulate gyrus, and thalamus ; lower in the pons ; and lowest in the cerebellum. The binding potential (BP) of [^<11>C] 3NMPB in the brain region was obtained with the use of compartmental models including regional least-squares curve-fitting analyses employing both arterial plasma tracer time-course and radioactivity time-course in the cerebellum as an input function into the brain and uptake ratio of the brain region to cerebellum. The BP estimates obtained with the use of these procedures in all brain regions correlated well with muscarinic receptor densities in the human brain as reported in vitro. Our results indicate the potential for accurate determinations of muscarinic receptor binding in the living human brain with the use of [^<11>C]3NMPB and PET. The mean BP estimates obtained in six patients with Alzheimer disease were lower in all brain regions than in six normal volunteers. However, there was no significant difference between the BP estimates for any brain region in the patients and normal volunteers. This result suggested that muscarinic receptors were kept still in the brain of patient with Alzheimer disease.
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