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Regulation of Wnt signaling pathway by galectin-3 in hepato-biliary-pancreatic cancer : Special reference to mutation of galectin-3

Research Project

Project/Area Number 16591291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionGunma University

Principal Investigator

SHIMURA Tatsuo  Gunma University, Faculty of Medicine, Assistant Professor (00282393)

Co-Investigator(Kenkyū-buntansha) TSUTSUMI Souichi  Gunma University, Graduate school of Medicine, Assistant Professor (30323356)
ASAO Takayuki  Gunma University, Graduate school of Medicine, Associate Professor (40212469)
KUWANO Hiroyuki  Gunma University, Graduate school of Medicine, Professor (90186560)
Project Period (FY) 2004 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,750,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsgalectin-3 / Wnt / Hepato-Biliary-Pancreatic cancer / gastrointestinal malignancy / 遺伝子変異
Research Abstract

Galectin-3 (gal-3), a pleiotrophic protein, is an important regulator of tumor metastasis, which like beta-catenin shuttles between the nucleus and the cytosol in a phosphorylation-dependent manner. We report herein that beta-catenin stimulation of cyclin D1 and c-myc expression is gal-3 dependent. Gal-3 binds to beta-catenin/Tcf complex, colocalizes with beta-catenin in the nucleus, and induces the transcriptional activity of Tcf-4 as determined by the TOP/FOPFLASH reporter system. We have identified the beta-catenin gal-3-binding sequences, which are in the NH2 and COOH termini of the proteins encompassing amino acid residues 1 to 131 and 143 to 250, respectively. These data indicate that gal-3 is a novel binding partner for beta-catenin involved in the regulation of Wnt/beta-catenin signaling pathway.
Analysis of the human gal-3 sequence reveled a structural similarity to beta-catenin as it also contains the consensus sequence (S92XXXS96) for glycogen synthase kinase-3beta (GSK-3beta … More ) phosphorylation and can serve as its substrate. In addition, Axin, a regulator protein of Wnt that complexes with beta-catenin, also binds gal-3 using the same sequence motif identified here by a deletion mutant analysis. The data presented here give credence to the suggestion that gal-3 is a key regulator in the Wnt/beta-catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin.
Gal-3 and Ki-67 expressions were assessed by immunohistochemistry in 115 patients with gastric cancer. PCR-single strand conformation polymorphism (SSCP)-sequence analysis and the levels of gal-3 mRNA were also examined. The present study demonstrated that gal-3 expression was correlated with nodal status, lymphatic inivasion, pathological stage and histological parameters. On the other hand, gal-3 expression did not correlate with the expression of Ki-67. Reduced expression of gal-3 was significantly associated with a poor prognosis and multivariate analysis showed that gal-3 expression was an independent prognostic factor. On PCR-SSCP-sequence analysis, 2 single nucleotide polymorphisms (SNPs) were detected in the gal-3 gene, but none showed mutations. Reduced gal-3 expression was associated with lymph node metastasis, advanced stage and tumor differentiation in gastric cancer. Gal-3 expression could be a useful prognostic factor in gastric cancer.
Immunohistochemical assessment of galectin-3, beta-catenin and Ki-67 expression was performed on samples from 108 patients with colorectal cancer. The expression of galectin-3 was classified at the tumor surface and the invasive front, and its relationship with clinicopathological factors was considered from a statistical viewpoint. There was significant liver metastasis when the expression of galectin-3 was lower at the invasive front of a tumor compared to its surface (p = 0.04). There were also significant correlations between beta-catenin expression at the tumor surface and liver metastasis and tumor stage (p=0.03, p=0.04 respectively). The reduction of galectin-3 expression in tumor invasion, metastasis and proliferation in patients with colorectal cancer is suggested. Less

Report

(5 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (90 results)

All 2007 2006 2005 2004

All Journal Article (74 results) (of which Peer Reviewed: 27 results) Presentation (16 results)

  • [Journal Article] Efficacy of transplanting cryo-preserved and encapsulated xenogeneic fetal liverfragment as an auxiliary liver support in 90%-hepatectomized rats.2007

    • Author(s)
      Shimura T, Kuwano H, Suzuki H, Kanoh K, Takebe K, Hagihara M, Asao T
    • Journal Title

      Hepatogastroenterology. 54(73)

      Pages: 206-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Fascin expression is correlated with tumor progression of extrahepatic bile duct cancer.2007

    • Author(s)
      Okada K, Shimura T, Asakawa K, Hashimoto S, Mochida Y, Suehiro T
    • Journal Title

      Hepatogastroenterology. 54(73)

      Pages: 17-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Galectin-3 expression in colorectal cancer: relation to invasion and metastasis2007

    • Author(s)
      Tsuboi K, Shimura T, Masuda N, Ide M, Tsutsumi S, Yamaguchi S, Asao T
    • Journal Title

      Anticancer Res 27(4B)

      Pages: 2289-96

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Trans-ileocecal portal vein embolization as a preoperative treatment for right trisegmentectomy with caudate lobectomy.2007

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Kuwano H.
    • Journal Title

      J Surg Oncol. Epub ahead of print

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Primary liver cancers with nonalcoholic steatohepatitis.2007

    • Author(s)
      Hashizume H, Sato K, Takagi H, Hirokawa T, Kojima A, Sohara N
    • Journal Title

      Eur J Gastroenterol Hepatol. 19(10)

      Pages: 827-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preoperative endoscopic pancreatic stenting for prophylaxis of pancreatic duct disruption during extirpation of a pancreatic head tumor.2007

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Mochida Y, Okada K, Araki K, Kuwano H
    • Journal Title

      Am J Surg 194(4)

      Pages: 553-5

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy of transplanting cryo-preserved and encapsulated xenogeneic fetal liver fragment as an auxiliary liver support in 90%-hepatectomized rats2007

    • Author(s)
      Shimura T, Kuwano H, Suzuki H, Kanoh K, Takebe K, Hagihara M, Asao T
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 206-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Fascin expression is correlated with tumor progression of extrahepatic bile duct cancer2007

    • Author(s)
      Okada K, Shimura T, Asakawa K, Hashimoto S, Mochida Y, Suehiro T, Kuwano H.
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 17-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Galectin-3 expression in colorectal cancer: relation to invasion and metastasis2007

    • Author(s)
      Tsuboi K, Shimura T, Masuda N, Ide M, Tsutsumi S, Yamaguchi S, Asao T, Kuwano H
    • Journal Title

      Anticancer Res 27(4B)

      Pages: 2289-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Trans-ileocecal portal vein embolization as a preoperative treatment for right trisegmentectomy with caudate lobectomy2007

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Kuwano H.
    • Journal Title

      J Surg Oncol

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Primary liver cancers with nonalcoholic steatohepatitis2007

    • Author(s)
      Hashizume H, Sato K, Takagi H, Hirokawa T, Kojima A, Sohara N, Kakizaki S, Mochida Y, Shimura T, Sunose Y, Ohwada S, Mori M.
    • Journal Title

      Eur J Gastroenterol Hepatol 19(10)

      Pages: 827-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preoperative endoscopic pancreatic stenting for prophylaxis of pancreatic duct disruption during extirpation of a pancreatic head tumor2007

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Mochida Y, Okada K, Araki K, Kuwano H.
    • Journal Title

      Am J Surg 194(4)

      Pages: 553-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Galectin-3 expression in colorectal cancer: relation to invasion and mrtastasis2007

    • Author(s)
      Tsuboi K, Shimura T, Masuda N, Ide M, Tsutsumi S, yamaguchi S, Asao T, Kuwano H.
    • Journal Title

      Anticacer Res 27(4B)

      Pages: 289-2296

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative endoscopic pancreatic stenting for prohylaxis of pancreatic duct disruption during extirpation of a pancreatic head tumor2007

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Moshida Y, Okada K, Araki K, Kuwano H.
    • Journal Title

      Am J surg 194(4)

      Pages: 553-555

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental results and warly clinical experience with an easy method for intracoprocal knot tying using a novel laparoscopic needleholder2007

    • Author(s)
      Asao T, Yamaguchi S, tsutsumi S, Moshiki E, kuwano H.
    • Journal Title

      Surg Endose 21(9)

      Pages: 1553-1556

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fascin expression is correlated with tumor progression of extrahepatic bile duct cancer.2007

    • Author(s)
      Okada K
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 17-21

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Efficacy of transplanting cryo-preserved and encapsulated xenogeneic fetal liver fragment as an auxiliary liver support in 90%-hepatectomized rats.2007

    • Author(s)
      Shimura T
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 206-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immunohistochemical expression of 14-3-3 sigma protein in intraductal-papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.2006

    • Author(s)
      Okada T, Masuda N, Fukai Y, Shimura T, Nishida Y, Hosouchi Y
    • Journal Title

      Anticancer Res. 26(4B)

      Pages: 3105-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor:a case report'2006

    • Author(s)
      Nakajima Y, Takagi H, Sohara N, Sato K, Kakizaki S, Nomoto K, Suzuki H
    • Journal Title

      World J Gastroenterol. 12(11)

      Pages: 1805-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reduced galectin-3 expression is an indicator of unfavorable prognosis in gastric cancer.2006

    • Author(s)
      Okada K, Shimura T, Suehiro T, Mochiki E, Kuwano H.
    • Journal Title

      Anticancer Res. 26(2B)

      Pages: 1369-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Laparoscopy-assisted distal pancreatectomy with mobilization of the distal pancreas and the spleen outside the abdominal cavity.2006

    • Author(s)
      Shimura T, Suehiro T, Mochida Y, Hashimoto S, Okada K, Asao T
    • Journal Title

      Surg Laparosc Endosc Percutan Tech 16(6)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The soluble form of human leukocyte antigen class Iantigen causes apoptosis on hepatocellular carcinoma cell lines.2006

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Asao T, Kuwano H
    • Journal Title

      Oncol Rep 16(6)

      Pages: 1375-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mutinous tumor and invasive ductal carcinoma of the pancreas2006

    • Author(s)
      Okada T, Masuda N, Fukai Y, Shimura T, Nishida Y, Hosouchi Y, Kashiwabara K, Nakajima T, Kuwano H.
    • Journal Title

      Anticancer Res 26(4B)

      Pages: 3105-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor: a case report2006

    • Author(s)
      Nakajima Y, Takagi H, Sohara N, Sato K, Kakizaki S, Nomoto K, Suzuki H, Suehiro T, Shimura T, Asao T, Kuwano H, Mori M, Nishikura K
    • Journal Title

      World J Gastroenterol 12(11)

      Pages: 1805-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reduced galectin-3 expression is an indicator of unfavorable prognosis in gastric cancer2006

    • Author(s)
      Okada K, Shimura T, Suehiro T, Mochiki E, Kuwano H.
    • Journal Title

      Anticancer Res 26(2B)

      Pages: 1369-76

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Laparoscopy-assisted distal pancreatectomy with mobilization of the distal pancreas and the spleen outside the abdominal cavity2006

    • Author(s)
      Shimura T, Suehiro T, Mochida Y, Hashimoto S, Okada K, Asao T, Kuwano H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech 16(6)

      Pages: 387-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines2006

    • Author(s)
      Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Asao T, Kuwano H.
    • Journal Title

      Oncol Rep 16(6)

      Pages: 1375-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Laparoscopy-assisted distal pancreatectomy with mobilization of the distal pancreas and the spleen outside the abdominal cavity.2006

    • Author(s)
      Shimura T
    • Journal Title

      Surg Laparosc Endosc Percutan Tech 16(6)

      Pages: 387-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines.2006

    • Author(s)
      Shimura T
    • Journal Title

      Oncology Reports 16(6)

      Pages: 1375-80

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immunohistochemical expression of 14-3-3 sigma protein in intraductal papillary-mucinous tumor and invasive ductal carcinoma of the pancreas.2006

    • Author(s)
      Okada T
    • Journal Title

      Anticancer Research 26(4B)

      Pages: 3105-10

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reduced galectin-3 expression is an indicator of unfavorable prognosis in gastric cancer.2006

    • Author(s)
      Okada K
    • Journal Title

      Anticancer Research 26(2B)

      Pages: 1369-76

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Loss of KAI1 expression in gastric cancer2005

    • Author(s)
      Tsutsumi S, Shimura T, Morinaga N, Mochiki E, Asao T, Kuwano H
    • Journal Title

      Hepatogastroenterology. 52(61)281-4

      Pages: 281-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor C(VEGF-C)expression in pT2 gastric cancer.2005

    • Author(s)
      Tsutsumi S, Kuwano H, Shimura T, Morinaga N, Mochiki E, Asao T
    • Journal Title

      Hepatogastroenterology 52(62)

      Pages: 629-32

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Implication of galectin-3 in Wnt signaling.2005

    • Author(s)
      Shimura T, Takenaka Y, Fukumori T, Tsutsumi S, Okada K, Hogan V
    • Journal Title

      Cancer Res 65(9)

      Pages: 3535-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of intraportal infusion to improve small for size graft injury in living donor adult liver transplantation.2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y
    • Journal Title

      Transpl Int. 18(8)

      Pages: 923-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ets-1 expression in gastric cancer.2005

    • Author(s)
      Tsutsumi S, Kuwano H, Nagashima N, Shimura T, Mochiki E, Asao T
    • Journal Title

      Hepatogastroenterology. 52(62)

      Pages: 654-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impact of graft hepatic vein inferior vena cava reconstruction with graft venoplasty and inferior vena cava cavoplasty in living donor adult liver transplantation using a left lobe graft.2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T
    • Journal Title

      Transplantation. 80(7)

      Pages: 964-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] In situ dye injection bile leakage test of the graft in living donor liver transplantation.2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T
    • Journal Title

      Transplantation 80(10)

      Pages: 1398-401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of HLA compatibility and lymphocyte cross-matching on acute cellular rejection following living donor adult liver transplantation2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T
    • Journal Title

      Liver Int 25(6)

      Pages: 1182-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prevention of hepatitis B virus infection from hepatitis B core antibody-positive donor graft using hepatitis B immune globulin and lamivudine in living donor liver transplantation.2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T
    • Journal Title

      Liver Int 25(6)

      Pages: 1169-74

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Loss of KAI1 expression in gastric cancer2005

    • Author(s)
      Tsutsumi S, Shimura T, Morinaga N, Mochiki E, Asao T, Kuwano H
    • Journal Title

      Hepatogastroenterology 52(61)

      Pages: 281-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vascular endothelial growth factor C (VEGF-C) expression in pT2 gastric cancer2005

    • Author(s)
      Tsutsumi S, Kuwano H, Shimura T, Morinaga N, Mochiki E, Asao T
    • Journal Title

      Hepatogastroenterology 52(62)

      Pages: 629-32

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Implication of galectin-3 in Wnt signaling2005

    • Author(s)
      Shimura T, Takenaka Y, Fukumori T, Tsutsumi S, Okada K, Hogan V, Kikuchi A, Kuwano H, Raz A
    • Journal Title

      Cancer Res 65(9)

      Pages: 3535-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of intraportal infusion to improve small for size graft injury in living donor adult liver transplantation2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Hashimoto S, Maehara Y, Kuwano H
    • Journal Title

      Transpl Int 18(8)

      Pages: 923-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ets-1 expression in gastric cancer2005

    • Author(s)
      Tsutsumi S, Kuwano H, Nagashima N, Shimura T, Mochiki E, Asao T
    • Journal Title

      Hepatogastroenterology 52(62)

      Pages: 654-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Impact of graft hepatic vein inferior vena cava reconstruction with graft venoplasty and inferior vena cava cavoplasty in living donor adult liver transplantation using a left lobe graft2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Maehara Y, Kuwano H.
    • Journal Title

      Transplantation 80(7)

      Pages: 964-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] In situ dye injection bile leakage test of the graft in living donor liver transplantation2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Maehara Y, Kuwano H.
    • Journal Title

      Transplantation 80(10)

      Pages: 1398-401

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Influence of HLA compatibility and lymphocyte cross-matching on acute cellular rejection following living donor adult liver transplantation2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Maehara Y, Kuwano H
    • Journal Title

      Liver Int 25(6)

      Pages: 1182-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prevention of hepatitis B virus infection from hepatitis B core antibody-positive donor graft using hepatitis B immune globulin and lamivudine in living donor liver transplantation2005

    • Author(s)
      Suehiro T, Shimada M, Kishikawa K, Shimura T, Soejima Y, Yoshizumi T, Hashimoto K, Mochida Y, Maehara Y, Kuwano H
    • Journal Title

      Liver Int 25(6)

      Pages: 1169-74

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Implication of galectin-3 in Wnt signaling2005

    • Author(s)
      Tatsuo Shimura
    • Journal Title

      Cancer Research 65・9

      Pages: 3535-3537

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mucosa-associated lymphoid tissue lymphoma of the extrahepatic bile duct2005

    • Author(s)
      Tatsuo Shimura
    • Journal Title

      Hepato-Gastroenterology 52・62

      Pages: 360-362

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ets-1 expression in gastric cancer2005

    • Author(s)
      Souichi Tsutsumi
    • Journal Title

      Hepato-Gastroenterology 52・62

      Pages: 654-656

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vascular endothelial growth factor C(VEGF-C)expression in pT2 gastric cancer2005

    • Author(s)
      Souichi Tsutsumi
    • Journal Title

      Hepato-Gastroenterology 52・62

      Pages: 629-632

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Loss of KAI1 expression in gastric cancer2005

    • Author(s)
      Souichi Tsutsumi
    • Journal Title

      Hepato-Gastroenterology 52・61

      Pages: 281-284

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Videoscopic thyroidectomy with fine needle-type apparatuses : an approach that does not leave a scar on the neck or anterior chest.2005

    • Author(s)
      Takayuki Asao
    • Journal Title

      Surgical laparoscopy, endoscopy & Percutaneous techniques 15・6

      Pages: 339-344

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Infuluence of HLA compatibility and lymphocyte cross-matching on acute cellular rejection following living donor adult liver transplantation2005

    • Author(s)
      Taketoshi Suehiro
    • Journal Title

      Liver International 25・6

      Pages: 1182-1188

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prevention of hepatitis B virus infection from hepatitis B core antibody-positive donor graft using hepatitis B immune globulin and lamivudine in living donor liver transplantation2005

    • Author(s)
      Taketoshi Suehiro
    • Journal Title

      Liver Internationl 25・6

      Pages: 1169-1174

    • Related Report
      2005 Annual Research Report
  • [Journal Article] In situ dye injection bile leakage test of the graft in living donor liver transplantation2005

    • Author(s)
      Taketoshi Suehiro
    • Journal Title

      Transplantation 80・10

      Pages: 1398-1401

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of intraportal infusion to improve small for size graft injury in living donor adult liver transplantation2005

    • Author(s)
      Taketoshi Suehiro
    • Journal Title

      Transplant Internationl 18・8

      Pages: 923-928

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Impact of graft hepatic vein inferior vena cava reconstruction with graft venoplasty and inferior vena cava cavoplasty in living donor adult liver transplantation using a left lobe graft2005

    • Author(s)
      Taketoshi Suehiro
    • Journal Title

      Transplantation 15・80

      Pages: 964-968

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Implication of galectin-3 in Wnt signaling2005

    • Author(s)
      Tatsuo Shimura
    • Journal Title

      Cancer Research (in press)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Genetic alterations in esophageal cancer.2005

    • Author(s)
      Hiroyuki Kuwano
    • Journal Title

      Surgery Today 35

      Pages: 7-18

    • NAID

      10014259758

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cell density modulates the metastatic aggressiveness of amouse colon cancer cell line, colon 26.2004

    • Author(s)
      Kuwano H, Miyazaki T, Tsutsumi S, Hirayama I, Shimura T, Mochiki E
    • Journal Title

      Oncology. 67(5-6)

      Pages: 441-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line.2004

    • Author(s)
      Kuwano H, Miyazaki T, Tsutsumi S, Fukuchi M, Nomoto K, Shimura T
    • Journal Title

      Dig Dis Sci. 49(11-12)

      Pages: 1912-2

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Autocrine motility factor signaling enhances pancreatic cancer metastasis2004

    • Author(s)
      Tsutsumi S, Yanagawa T, Shimura T, Kuwano H, Raz A
    • Journal Title

      Clin Cancer Res 15;10(22)

      Pages: 7775-84

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Galectin-3, a novel binding partner of beta-catenin.2004

    • Author(s)
      T. Shimura, Y. Takenaka, S. Tsutsumi, V. Hogan, A. Kikuchi, A. Raz
    • Journal Title

      Cancer Res 64

      Pages: 6363-6367

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cell density modulates the metastatic aggressiveness of a mouse colon cancer cell line, colon 262004

    • Author(s)
      Kuwano H, Miyazaki T, Tsutsumi S, Hirayama I, Shimura T, Mochiki E, Nomoto K, Fukuchi M, Kato H, Asao T.
    • Journal Title

      Oncology 67(5-6)

      Pages: 441-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line2004

    • Author(s)
      Kuwano H, Miyazaki T, Tsutsumi S, Fukuchi M, Nomoto K, Shimura T, Mochiki E, Kato H, Asao T, Toh Y
    • Journal Title

      Dig Dis Sci 49(11-12)

      Pages: 1912-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Autocrme motility factor signaling enhances pancreatic cancer metastasis2004

    • Author(s)
      Tsutsumi S, Yanagawa T, Shimura T, Kuwano H, Raz A.
    • Journal Title

      Clin Cancer Res 10(22)

      Pages: 7775-84

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Galectin-3, a novel binding partner of beta-catenin2004

    • Author(s)
      T. Shimura, Y. Takenaka, S. Tsutsumi, V. Hogan, A. Kikuchi, A. Raz
    • Journal Title

      Cancer Res 64

      Pages: 6363-6367

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Galectin-3, a novel binding partner of β-catenin2004

    • Author(s)
      Tatsuo Shimura
    • Journal Title

      Cancer Research 64

      Pages: 6363-6367

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Autocrine motility factor signaling enhances pancreatic cancer2004

    • Author(s)
      Souichi Tsutsumi
    • Journal Title

      Clinical Cancer Research 10

      Pages: 7775-7784

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cell density modulates the metastatic aggressiveness of a mouse colon cancer cell line, colon 26.2004

    • Author(s)
      Hiroyuki Kuwano
    • Journal Title

      Oncology 67

      Pages: 441-449

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Malignant transformation of the mouse anorectal epithelium induced by an inoculated human cancer cell line.2004

    • Author(s)
      Hiroyuki Kuwano
    • Journal Title

      Digestive Disease and Science 49

      Pages: 1912-1921

    • Related Report
      2004 Annual Research Report
  • [Presentation] シンポジウム2「消化管腫瘍の分子診断と標的治療-」大膓癌における分子標的としてのgalectin-3の意義2006

    • Author(s)
      志村龍男、浅尾高行、桑野博行
    • Organizer
      DDW
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Impact of Galectin-3 in colorectal cancer treatment2006

    • Author(s)
      Shimura T, Asao T, Kuwano H.
    • Organizer
      DDW2006
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Implication of Galectin-3 in Wnt Signaling Pathway2006

    • Author(s)
      Shimura. T, Tsutsumi S, Suehiro T, Suzuki H, Raz A, Kuwano H
    • Organizer
      11th International Congress of the Metastasis Research Society
    • Place of Presentation
      Tokushima
    • Year and Date
      2006-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Implication of Galetin-3 in Wnt Signaling Pathway2006

    • Author(s)
      Shimura T, Tsutsumi S, Suehiro T, Suzuki H, Raz A, Kuwano H
    • Organizer
      11th International Congress of the Metastasis Research Society
    • Place of Presentation
      Tokushima
    • Year and Date
      2006-09-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] galectin-3-expression in gastric cancer2005

    • Author(s)
      Okada K, Shimura T, Okamura K, Okada T, Hashimoto S, Mochida Y, et. al.
    • Organizer
      The 67th Annual Congress of Japanese Analysis of Surgical Association
    • Place of Presentation
      Tokyo
    • Year and Date
      2005-11-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of Galectin-3 in IPMN and pancreatic cancer2005

    • Author(s)
      Okada K, Shimura T, Okada T, Hashimoto S, Mochida Y, Suehiro T, et. al.
    • Organizer
      The 17th Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Place of Presentation
      Yokohama
    • Year and Date
      2005-06-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression and DNA analysis of galectin-3 in Gastric cancer2005

    • Author(s)
      Okada K, Shimura T, Hashimoto S, Mochida Y, Suehiro T, Mochiki E, et. al.
    • Organizer
      The 105th Annual Congress of Japan Surgical Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-05-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胃癌におけるGalectin-3発現とその遺伝子解析2005

    • Author(s)
      岡田幸士、志村龍男、橋本信次、持田 泰、末廣剛敏、持木彫人、浅尾高行、桑野博行
    • Organizer
      第105回 日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 通常型膵癌と膵管内乳頭粘液性腫瘍におけるGalectin-3発現2005

    • Author(s)
      岡田幸士、志村龍男、岡田寿之、橋本信次、持田 泰、末廣剛敏、浅尾高行、桑野博行
    • Organizer
      第17回日本肝胆膵外科関連会議
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胃癌におけるGalectin-3発現の検討2005

    • Author(s)
      岡田幸士、志村龍男、岡邨香織、岡田寿之、橋本信次、持田 泰、末廣剛敏、浅尾高行、桑野博行
    • Organizer
      第67回 日本臨床外科学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wnt pathway and galectin-32004

    • Author(s)
      Shimura T, Okada K, Hashimoto S, Kanoh K, Tsutsumi S, Suzuki H, et. al.
    • Organizer
      The 59 Annual Meeting of the Japanese Relationship between Society of the gastroenterological Society
    • Place of Presentation
      Kagoshima
    • Year and Date
      2004-07-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between Wnt pathway and Galectin-3 in the mechanism of anoikis inhibition2004

    • Author(s)
      Shimura T, Okada K, Hashimoto S, Kanoh K, Tsutsumi S, Suzuki H, et. al.
    • Organizer
      The 104th Annual Congress of Japan Surgical Society
    • Place of Presentation
      Osaka
    • Year and Date
      2004-04-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of galectin-3 in colorectal cancer and its hepatic metastases2004

    • Author(s)
      Tsuboi K, Shimura T, Masuda N, Ide M, Tsutsumi S, Yamaguchi S, et. al.
    • Organizer
      The 104th Annual Congress of Japan Surgical Society
    • Place of Presentation
      Osaka
    • Year and Date
      2004-04-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] サージカルフォーラム「一般:癌転移・浸潤」 転移のファーストステップである癌細胞の基底膜からの脱着メカニズムと治療戦略:anoikis抑制のメカニズムにおけるWntpathwayとgalectin-3の関連2004

    • Author(s)
      志村龍男、岡田幸士、橋本信次、狩野賢一、堤 荘一、鈴木秀樹、加藤広行、浅尾高行、桑野博行
    • Organizer
      第104回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸癌におけるgalectin-3発現と肝転移の検討2004

    • Author(s)
      坪井香保里、志村龍男、増田典弘、井出宗則、堤 荘一、山口 悟、浅尾高行、桑野博行
    • Organizer
      第104回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wnt pathwayとgalectin-3:消化器癌補助療法への展望2004

    • Author(s)
      志村龍男、岡田幸士、橋本信次、狩野賢一、堤 荘一、鈴木秀樹、加藤広行、浅尾高行、桑野博行
    • Organizer
      第59回日本消化器外科学会定期学術総会
    • Place of Presentation
      鹿児島
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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