The establishment of novel multimodal treatment through the hepatoma specific siginaling pathway for the intractable and advanced hepatocellular carcinoma
| Project/Area Number |
16591314
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NAGANO Hiroaki Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (10294050)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Atushi Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (00362731)
MARUBASHI Shigeru Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (20362725)
|
|---|
| Project Period (FY) |
2004 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | hepatocellular carcinoma / intractable and advanced cancer / portal venous thrombus / Gene Expression Profiling / IFN-α / chemotherapy / IFN-receptor / angiogenesis / IFN併用化学療法 / TRAIL / TRAIL受容体 / NK細胞 / Fas / Fas-L |
|---|
| Research Abstract |
1)The mechanism of the antitumor effect through the IFN-IFNAR signaling
The anti-tumor effect of IFN/5-FU combined therapy was significantly correlated with the strength of IFNAR expression, in the HCC cells in-vitro. This was also proved in the experiment of the IFNAR gene transfection model. In this mechanism, the upragulation of the p-STATS and Bcl-xl expression were most significantly correlated with anti-tumor effect, among the several signal transductional factors.
2)Anti tumor effect through TRAIL/TRAIL receptor and Fas/FasL
Among peripheral blood cells, NK cells were found to exert the cytotoxic effects on human hepatoma cells. In addition, the involvement of CTL system in the anti tumor effect was examined and confirmed in terms of the relationship of apoptosis in this study.
3)The Gene Expression Profiling
Using the clinical samples treated by IFN-α and 5-FU, the gene expression profiling would be suggested to be useful for the prediction of the treatment efficacy at the over 85%.
|
Report
(3 results)
Research Products
(74 results)
-
-
-
-
-
-
-
[Journal Article] Angiogenesis in cholangiocellular carcinoma : Expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospodin-1 and clinicopathological significance.2006
Author(s)
Tang D, Nagano H, Yamamoto H, Wada H, Nakamura M, Kondo M, Ota H, Yoshioka S, Kato H, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Wakasa K. Monden M.
-
Journal Title
Oncology Reports 15
Pages: 525-532
Related Report
-
[Journal Article] TGF-beta1-induced cell growth arrest and partial differentiation is related to suppression of Id1 in some human hepatoma cells.2006
Author(s)
Damdinsuren B, Nagano H, Kondo M, Natsag J, Hanada H, Nakamura M.Wada H, Kato H, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Monden M.
-
Journal Title
Oncology Reports 15(2)
Pages: 401-408
Related Report
-
[Journal Article] Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma : A new approach to identify novel tumor markers.2006
Author(s)
Kurokawa Y, Honma K, Takemasa I, Nakamori S, Kita-Matsuo H, Motoori M, Nagano H, Dono K, Ochiya T, Monden M, Kato K.
-
Journal Title
Int J Oncol 28(2)
Pages: 383-391
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Combination of interferon alpha and 5-fluorouracil induces apoptosis through interferon alpha/beta receptor in human hepatocellular carcinoma cells.2005
Author(s)
Kondo M, Nagano H, Wada H, Damdinsuren B, Yamamoto H, Hiraoka N, Eguchi H, Miyamoto A, Yamamoto T, Ota H, Nakamura M, Marubashi S, Dono K, Umeshita K, Nakamori S, Sakon M, Monden M.
-
Journal Title
Clinical Cancer Research 11
Pages: 1277-1286
Related Report
-
[Journal Article] Expression of ID proteins in human hepatocellular carcinoma : Relevance to tumor dedifferentiation.2005
Author(s)
Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, Marubashi S, Miyamoto A, Umeshita K, Dono K, Nakamori S, Wakasa K, Sakon M, Monden M.
-
Journal Title
Int J Oncol 26
Pages: 319-327
Related Report
-
[Journal Article] Association between tumor recurrence after surgery in patients with hepatocellular carcinoma and measurement of alpha-fetoprotein mRNA in peripheral blood but not bone marrow2005
Author(s)
Morimoto O, Nagano H, Miyamoto A, Fujiwara Y, Kendo M, Yamamoto T, Ota H, Nakamura M, Wada H, Damdinsuren B, Marubashi S, Dono K, Umeshita K, Nakamori S, Sakon M, Monden M.
-
Journal Title
Surgery Today 35(12)
Pages: 1033-1041
Related Report
-
[Journal Article] Treatment of hepatocellular carcinoma with major portal vein thrombosis by combination of subcutaneous interferon-α and rintra-arterial 5-fluorouracil. Role of expression of type 1 inteiferon receptor2005
Author(s)
Ota H, Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Nakamura M, Damdinsuren B, Wada H, Marubashi, Miyamoto A, Dono K, Umeshita K, Nakamori S, Wakasa K, Monden M
-
Journal Title
Br J Cancer 93(5)
Pages: 557-564
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma : Importance of angiopoietin-2 and hypoxia-induced factor-1 □
Author(s)
Wada H, Nagano H, Yamamoto H, Yang Y, Kondo M, Ota H, Nakamura M, Yoshioka S, Kato H, Damdinsuren B.Tang D, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Nakamori S, Sakon M, Dono K, Wakasa K, Monden M.
-
Journal Title
Liver International (in press)
Related Report
-
[Journal Article] Hepatic resection followed by IFN-α and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch.
Author(s)
Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Ota H, Nakamura M, Wada H, Bazarragcha D, Marubashi S, Miyamoto A, Takeda Y, Keizo Dono, Umeshita K, Nakamori S, Monden M
-
Journal Title
Hepatogastroenterology (in press)
Related Report
-
[Journal Article] Clinical and Pathological Features of Allen's type C of Resected Combined Hepatocellular and Cholangiocarcinoma. A Comparative Study with Hepatocellular Carcinoma and Cholangiocellular Carcinoma
Author(s)
Tang D, Nagano H, Nakamura M, Kondo M, Ota H, Wada H, Yoshioka S, Kato H, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K, Monden M
-
Journal Title
J Gastrointest Surg (in press)
Related Report
-
[Journal Article] Overexpression of MT3-MMP in hepatocellular carcinoma correlates with capsular invasion.
Author(s)
Arai I, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Sugita Y, Ota H, Yoshioka S, Nakamura M, Wada H, Damdinsuren B, Kato H, Marubashi S, Miyamoto A, Takeda Y, Dono K, Umeshita K, Nakamori S, Wakasa K, Sakon M, Monden M.
-
Journal Title
Hepatogastroenterology (in press)
Related Report
-
[Journal Article] Expression of type I Interferon Receptor as a Predictive Marker in Clinical Response of Interferon-α Treatment for Gastrointestinal Cancers
Author(s)
Ota H, Nagano H, Doki Y, Sekimoto M, Kondo M, Wada H, Nakamura M, Noda T, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Dono K, Umeshita K, Nakamori S, Wakasa K, Monden M
-
Journal Title
Oncology Reports (in press)
Related Report
-
