| Project/Area Number |
16591317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | National University Corporation Tottori University. |
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Principal Investigator |
KONDO Akira Tottori University, University Hospital, Research Associate, 医学部附属病院, 助手 (90304211)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJITANI Shunichi Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30188544)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2004: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | gastric cancer / sentinel lymphnode / micrometastasis |
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| Research Abstract |
The aim of our study is to determine the adequacy the sentinel node concept to gastric cancer. Intraoperative lymphatic mapping was attempted in 34 patients using a combination of indocyanine green and radioisotope injected into the gastric submucosa adjacent to the tumor. Standard radical gastrectomy with lymphadenectomy was performed in all patients and the resected nodes were evaluated by routine histopathological examination. The rate of sentinel node detection was 94.1% (32/34). Among totally 87 of detected sentinel nodes, 24 nodes were detected by only dye, 50 nodes were detected by only radioisotope and 23 nodes were detected by both procedures. Six sentinel nodes were located beyond the perigastric area. A patient with muscular layer invasive cancer had metastasis in a green-dyed node without radioactivity in the perigastric area. Two advanced cancer patients had lymphnode metastases but cancer cells were not detected in the sentinel nodes. Combination of dye and radioisotope seems to be important for successful detection of sentinel nodes. Micrometastasis were not detected in the sentinel lymph nodes by immunostain finging and magnetic cell sorting. Our results indicate the complexity of lymphatic streams within and from the stomach. Although sentinel node navigation surgery is a promising technique, large-scale studies are needed to establish the sentinel node concept in gastric cancer.
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