The relationship of prostaglandin D synthesis and pathogenesis of rheumatoid arthritis.
| Project/Area Number |
16591485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | SHIGA UNIVERSITY OF MEDICAL SCIENCE |
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Principal Investigator |
EGUCHI Yutaka Shiga University of Medical Science, Professor, 医学部, 教授 (00263054)
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| Co-Investigator(Kenkyū-buntansha) |
URADE Yoshihiro Osaka Bioscience Institute, Director, 第2研究部, 研究部長 (10201360)
EGUCHI Naomi Osaka Bioscience Institute, Associate Director, 第2研究部, 研究副部長 (10250086)
KAWASAKI Taku Shiga University of Medical Science, Assistant, 医学部, 助手 (50359775)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | IgM-RF / Osteoarthritis / Immune histochemistry / Synovia / Prostaglandin |
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| Research Abstract |
We firstly demonstrated that serum levels of L-PGDS was increased in patients with rheumatoid arthritis(RA) compared with osteoarthritis(OA) patients and normal control subject. Whereas, knee synovial levels of L-PGDS was significantly increased in RA patients than OA patients. Further, the synovial L-PGDS levels was significantly correlated with titer of IgM-RF. Therefore, the serum level of L-PGDS may be useful for the diagnosis of RA and the marker of the therapeutic target.
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Report
(3 results)
Research Products
(3 results)
