Research on the expression and function of cytokine in the human endometrium during implantation period

• Project/Area Number: 16591672
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Oita University
• Principal Investigator: NASU Kaei Oita University, Faculty of Medicine, Assistant Professor (30274757)
• Co-Investigator(Kenkyū-buntansha): TAKAI Noriyuki Oita Univerkty, Faculty of Medicine, Instructor (50295185) ; KAWANO Yasushi Oita University, Faculty of Medicine, Assistant Professor (40274758) ; 宮川 勇生 大分大学, 医学部, 教授 (70040607)
• Project Period (FY): 2004 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥4,050,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000); Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: Endometrium / Cytokine / chemokine / Tissue remodeling / Endometriosis / Leukocyte trafficking / Menstrual cycle / Inflammation / Contractility / 3-dimensional collagen gel culture / Rho / α-smooth muscle actin / Contratilily / Cell proliferation / Wound repair / Motility / Scarring / Tissue remodelling / Transforming growth factor-β / Platelet-derived growth factor / Contratility / サイトカインネットワーク / ケモカイン / 着床

Research Abstract

The aim of our research project is to investigate the expression of chemokines in the human endometrium and their possible implications in the endometrium during the human reproductive processes. Our study a was conducted to identify the roles of chemokines in normal and pathological situations during the menstrual cycle and implantation. A number of chemokines mediate leukocyte traffic through their specific receptors in the human endometrium Although four subfamilies of chemokines have been described to date, CC-, CXC-, and CX_3C-chemokines are reported to be involved in endometrial leukocyte trafficking and function and are also involved in other phenomena. Chemokines play relevant roles in many physiologic and pathologic endometrial events, such as menstruation, decidualization, implantation, and the maintenance of early pregnancy. Knowledge about these roles of may provide insight into the mechanism underlying the recruitment and function of inflammatory cells during the human reproductive processes.

Research Products

• [Journal Article] Tumor necrosis factor-α regulates vascular endothelial growth factor secretion byhuman oviductal epithelial cells and stromal fibroblasts (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Kawano Y, Narahara H.
  • Journal Title: Fertil Steril 87 Pages: 220-222
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Application ofthe nuclear factor-κB inhibitor,BAY11-7085,for the treatment of endometriosis:an in vitro study (2007)
  • Author(s): Nasu K, Nishida M, Ueda T, Yuge A, Takai N, Narahara H.
  • Journal Title: Am J Physiol Endocrinol Metab 293
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interleukin-13 stimulates the secretion ofvasculaz endothelial growth factor and solublefins-like tyrosine kinase-1 by human oviductal epithelial cells (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawano Y, Yoshimatsu J, Narahara H.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol 133 Pages: 208-212
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Collagen contractility is enhanced in human endometriotic stromal cells:a possible mechanism involved in the pathogenesis of endometriosis-associated fibrosis (2007)
  • Author(s): Yhge A, Nasu K, Matsumoto H, Nishiida M, Narahara H.
  • Journal Title: Hum Reprod 22 Pages: 938-944
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human oviductal epithelial cells express Toll-like receptor3 and repond to double-stranded RNA:Fallopian tube-specific mucoal immunity against viral infection (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Narahara H.
  • Journal Title: Hum Reprod 22 Pages: 356-361
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The role of apoptotic dysfunction in the pathogenesis of endometriosis (2007)
  • Author(s): Nasu K, Nishida M, Yuge A, Takai N, Narahara H.
  • Journal Title: Curr Women's Health Rev 3 Pages: 113-122
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Site-Specific innate immune system in the female genital tract (2007)
  • Author(s): Nasu K, Itoh H, Nishida M, Yuge A, Narahara H.
  • Journal Title: Curr Res Immunol 1 Pages: 171-191
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of contractility of cultured human endomerial stromal cells by tumor necrosis factor-α (2007)
  • Author(s): Yuge A, Nasu K, Tsusue H, Ikegami E, Nishida M, Matsumoto H, Narahara H.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol (Epub ahead of print)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-a regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts (2007)
  • Author(s): Nasu, K, Itoh, H, Yuge, A, Nishida, M, Kawano, Y, Narahara, H
  • Journal Title: Fertil Steril 87 Pages: 220-222
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of the nuclear factor-KB inhibitor, BAY 11-7085, for the treatment of endometriosis : an in vitro study (2007)
  • Author(s): Nasu, K, Nishida, M, Ueda, T, Yuge, A, Takai, N, Narahara, H
  • Journal Title: Am J Physiol Endocrinol Metab 293 Pages: 16-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-13 stimulates the secretion of vascular endothelial growth facto, and soluble fins-like tyrosine kinase-1 by human oviductal epithelial cells (2007)
  • Author(s): Nasu, K, Itoh, H, Yuge, A, Kawano, Y, Yoshimatsu, J, Narahara, H
  • Journal Title: Eur J Obstet Gynecol Reprod Biol 133 Pages: 208-212
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Collagen contractility is enhanced in human endometriotic stromal cells : a possible mechanism involved in the pathogenesis of endometriosis-associated fibrosis (2007)
  • Author(s): Yuge, A, Nasu, K, Matsumoto, H, Nishida, M, Narahara, H
  • Journal Title: Hum Reprod 22 Pages: 938-944
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA : Fallopian tube-specific mucosal immunity against viral infection (2007)
  • Author(s): Nasu, K, Itoh, H, Yuge, A, Nishida, M, Narahara, H
  • Journal Title: Hum Reprod 22 Pages: 356-361
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of apoptotic dysfunction in the pathogenesis of endometriosis (2007)
  • Author(s): Nasu, K, Nishida, M, Yuge, A, Takai, N, Narahara, H
  • Journal Title: Curr Women's Health Rev 3 Pages: 113-122
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Site-Specific innate immune system in the female genital tract (2007)
  • Author(s): Nasu, K, Itoh, H, Nishida, M, Yuge, A, Narahara, H
  • Journal Title: Curr Res Immunol 1 Pages: 171-191
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of contractility of cultured human endometrial stromal cells by tumor necrosis factor-a. (2007)
  • Author(s): Yuge, A, Nasu, K, Tsusue, H, Ikegami, E, Nishida, M, Matsumoto, H, Narahara, H
  • Journal Title: Eur J Obstet Gynecol Reprod Biol(Epub ahead of print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of the nuclear factor-κB inhibitor, BAY 11-7085, for the treatment of endometriosis: an in vitro study (2007)
  • Author(s): Nasu K, Nishida M, Ueda T, Yuge A, Takai N, Narahara H.
  • Journal Title: Am J Physiol Endocrinol Metab 293
  • Peer Reviewed
• [Journal Article] Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Narahara H.
  • Journal Title: Hum Reprod 22 Pages: 356-361
  • Peer Reviewed
• [Journal Article] Collagen contractility is enhamed in human endometriotic stromal cells: a possible mechanism involved in the pathogenesis of endometriosis-associated fibrosis (2007)
  • Author(s): Yuge A, Nasu K, Matsumoto H, Nishida M, Narahara H.
  • Journal Title: Hum Reprod 22 Pages: 938-944
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-α regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Kawano Y, Narahara H.
  • Journal Title: Fertil Steril 87 Pages: 220-222
  • Peer Reviewed
• [Journal Article] Interleukin-13 stimulates the secretion of vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 by human oviductal epithelial cells (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawano Y, Yoshimatsu J, Narahara H.
  • Journal Title: Eur J Obstet Gynecol Reprod Biol 133 Pages: 208-212
  • Peer Reviewed
• [Journal Article] 子宮内膜症に対する治療薬としての選択的nuclear factor-κB阻害剤BAY11-7085の有用性 (2007)
  • Author(s): 奈須家栄, 西田正和, 弓削彰利, 高井教行, 楢原久司.
  • Journal Title: エンドメトリオーシス研究会会誌 28 Pages: 41-43
• [Journal Article] 子宮内膜症の瘢痕形成のmechanismに関するin vitroでの検討 (2007)
  • Author(s): 弓削彰利, 奈須家栄, 西田正和, 松本治伸, 楢原久司.
  • Journal Title: エンドメトリオーシス研究会会誌 28 Pages: 101-103
• [Journal Article] Platelet-derived growth factorによるヒト子宮内膜のtissue remodelingの調節 (2007)
  • Author(s): 奈須家栄, 松本治伸, 弓削彰利, 楢原久司.
  • Journal Title: 産婦実際 56 Pages: 1259-1264
• [Journal Article] 子宮内膜症に伴う疼痛と薬物療法 (2007)
  • Author(s): 奈須家栄, 楢原久司.
  • Journal Title: 産婦治療 95 Pages: 382-387
• [Journal Article] Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA : Fallopian tube-specific mucosal immunity against viral infection (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Narahara H
  • Journal Title: Hum Reprod 22(2) Pages: 356-361
• [Journal Article] Tumor necrosis factor-α regulates vascular endothelial growth factor secretion by human oveductal epithelial cell and stromal fibroblasts (2007)
  • Author(s): Nasu K, Itoh H, Yuge A, Nishida M, Kawano Y, Narahara H
  • Journal Title: Fertil Steril 87(1) Pages: 220-222
• [Journal Article] Regulation of proliferation,motility,and contractivity of cultured human endometrial stromal cells by transforming growth factor-β isoforms (2006)
  • Author(s): Nasu K, Nishida M, Masumoto H, Bing S, Inoue C, Kawano Y, Miyakawa L.
  • Journal Title: Fertil Steril 84Suppl2 Pages: 1114-1123
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] β-hydroxyisovaleryshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic tromal cells:a preliminary in vitro study (2006)
  • Author(s): Nishida M, Nasu K, Ueda T, Yuge A, Takai N, Narahara H.
  • Journal Title: Hum Reprod 21 Pages: 2850-2856
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hypoxia regulaes vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Itoh H, Nasu K, Matsumoto H, Kawano Y, Yoshimatsu J, Narahara H.
  • Journal Title: Fertil Steril 85Suppl1 Pages: 1097-1102
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human oviductal stromal fibroblasts,but not oviductal epithelial cells,express Toll-like receptor4:the site-specific mucosal immunity of the human fallopian tube against bacterial infection (2006)
  • Author(s): Itoh H, Nasu K, Nishida M, Matsumoto H, Yuge A, Narahara H.
  • Journal Title: Am J Reprod Immunol 56 Pages: 91-101
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-I regulates vascular endothelial growth factor secretion byhuman oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawano Y, Narahara H.
  • Journal Title: J Soc Gynecol Investig 13 Pages: 368-371
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interleukin-1β regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawno Y, Yoshimatsu J, Nazahaza H.
  • Journal Title: Gynecol Endocrinol 22 Pages: 495-500
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] β-hydroxyisovalerylshikonin induces apoptosis and GO/G1 cell-cycle arrest of endometriotic stromal cells : a preliminary in vitro study (2006)
  • Author(s): Nishida, M, Nasu, K, Ueda, T, Yuge, A, Takai, N, Narahara, H
  • Journal Title: Hum Reprod 21 Pages: 2850-2856
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hypoxia regulates vascular endothelial growth factor and soluble fins-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Itoh, H Nasu, K, Matsumoto, H, Kawano, Y, Yoshimatsu, J, Narahara, H
  • Journal Title: Fertil Steril 85 Suppl 1 Pages: 1097-1102
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4 : the site-specific mucosal immunity of the human fallopian tube against bacterial infection (2006)
  • Author(s): Itoh, H, Nasu, K, Nishida, M, Matsumoto, H, Yuge, A, Narahara, H
  • Journal Title: Am J Reprod Immunol 56 Pages: 91-101
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Insulin-like growth factor-I regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu, K, Itoh, H, Yuge, A, Kawano, Y, Narahara, H
  • Journal Title: J Soc Gynecol Investig 13 Pages: 368-371
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-113 regulates vascular endothelial growth factor and soluble fins-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu, K, Itoh, H, Yuge, A, Kawano, Y, Yoshimatsu, J, Narahara, H
  • Journal Title: Gynecol Endocrinol 22 Pages: 495-500
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hypoxia regulates VEGF vascular endothelial growth factor and soluble fins-like-tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Itoh H, Nasu K, Matsumoto H, Kawano Y, Yoshimatsu J, Narahara H
  • Journal Title: Fertil Steril 85 Suppl. 1 Pages: 1097-1102
• [Journal Article] Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express Toll-like receptor 4 : the site-specific mucosal immunity of the human fallopian tube against bacterial infection (2006)
  • Author(s): Itoh H, Nasu K, Nishida M, Matsumoto H, Yuge A, Narahara H
  • Journal Title: Am J Report Immunol 56(2) Pages: 91-101
• [Journal Article] Insulin-like growth factor-I regulates vascular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawano Y, Narahara H
  • Journal Title: J Soc Gynecol Investig 21(11) Pages: 2850-2586
• [Journal Article] Interleukin-1β regulates vacular endothelial growth factor secretion by human oviductal epithelial cells and stromal fibroblasts (2006)
  • Author(s): Nasu K, Itoh H, Yuge A, Kawano Y, Yoshimatsu J, Narahara H
  • Journal Title: Gynecol Endocrinol 22(9) Pages: 495-500
• [Journal Article] Bufalin induces apoptosis and G0/G1 cell cycle arrest of endometriotic stromal cells : a promising therapeutic agent for the treatment of endometriosis (2006)
  • Author(s): Nasu K, Nishida M, Ueda T, et al.
  • Journal Title: Molecular Human Reproduction (in press)
• [Journal Article] Hypoxia regulates VEGF vascular endothelial growth factor and soluble fms-like-tyrosine kinase-1 secretion by human oviductal epithelial cells and... (2006)
  • Author(s): Itoh H, Nasu K, Matsumoto H, et al.
  • Journal Title: Fertility and Sterility 84・4(in press)
• [Journal Article] Endometriotic cells are resistant to interferon-γ-induced cell growth inhibition and apoptosis:a possible mechanism involved in the pathogenesis of endometriosis (2005)
  • Author(s): Nishida M, Nasu K, Ueda T, Fukuda J, Takai N, Miyakawa I.
  • Journal Title: Mol Hum Reprod 11 Pages: 29-34
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Regulation of proliferation,motility,and contractility of human endometrial cells by platelet-derived growth factor (2005)
  • Author(s): Matsumoto H, Nasu K, Nishida M, Ito H, Bing S, Miyakawa I.
  • Journal Title: J Chin Endocrinal Metab 90 Pages: 3560-3567
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells:a promising agent for the treatment of endometriosis (2005)
  • Author(s): Nasu K, Nishida M, Ueda T, Takai N, Bing S, Narahara H, Miyakawa I.
  • Journal Title: Mol Hum Reprod 11 Pages: 817-823
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Endometriotic cells are resistant to interferon-y-induced cell growth inhibition and apoptosis : a possible mechanism involved in the pathogenesis of endometriosis (2005)
  • Author(s): Nishida, M, Nasu, K, Ueda, T, Fukuda, J, Takai, N, Miyakawa, I
  • Journal Title: Mol Hum Reprod 11 Pages: 29-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of proliferation, motility, and contractility of human endometrial stromal cells by platelet-derived growth factor (2005)
  • Author(s): Matsumoto, H, Nasu, K, Nishida, M, Ito, H, Bing, S, Miyakawa, I
  • Journal Title: J Clin Endocrinol Metab 90 Pages: 3560-3567
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of proliferation, motility, and contractivity of cultured human endometrial stromal cells by transforming growth factor-13 isoforms (2005)
  • Author(s): Nasu, K, Nishida, M, Matsumoto, H, Bing, S, Inoue, C, Kawano, Y, Miyakawa, I
  • Journal Title: Fertil Steril 84 Suppl 2 Pages: 1114-1123
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bufalin induces apoptosis and the GO/G1 cell cycle arrest of endometriotic stromal cells : a promising agent for the treatment of endometriosis (2005)
  • Author(s): Nasu, K, Nishida, M, Ueda, T, Takai, N, Bing, S, Narahara, H, Miyakawa, I
  • Journal Title: Mol Hum Reprod 11 Pages: 817-823
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulation of proliferation, motility, and contractivity of human endometrial stromal cells by transforming growth factor-β isoforms (2005)
  • Author(s): Nasu K, Nishida M, Matsumoto H, et al.
  • Journal Title: Fertility and Sterility 82・Suppl 2 Pages: 1114-1123
• [Journal Article] Expression and regulation of thrombospondin-1 by human endometrial stromal cells (2005)
  • Author(s): Kawano Y, Nakamura S, Nasu K, et al.
  • Journal Title: Fertility and Sterility 83・4 Pages: 1056-1059
• [Journal Article] Regulation of proliferation, motility, and contractivity of human endometrial stromal cells by platelet-derived growth factor (2005)
  • Author(s): Matsumoto H, Nasu K, Nishida M, et al.
  • Journal Title: Journal of Clinical Endocrinology & Metabolism 90・6 Pages: 3560-3567
• [Journal Article] Endometriotic cells are resistant to interferon- γ -induced cell growth inhibition and apoptosis a mechanism involved in the pathogenesis of … (2005)
  • Author(s): Masakazu Nishida, Kaei Nasu, Tami Ueda, Junichiro Fukuda, et al.
  • Journal Title: Molecular Human Reproduction 11・1 Pages: 29-34
• [Journal Article] Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemoldnes in endometriotic stromal cells:a possible mechanism for the altered immunological funcions in endometriosis (2004)
  • Author(s): Nisluda M, Nasu K, Fukuda J, Kawano Y, Narahara H, Miyakawa I.
  • Journal Title: J Clin Endocrinol Metab 89 Pages: 5094-5100
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells : a possible mechanism for the altered immunological functions in endometriosis (2004)
  • Author(s): Nishida, M, Nasu, K, Fukuda, J, Kawano, Y, Narahara, H, Miyakawa, I
  • Journal Title: J Clin Endocrinol Metab 89 Pages: 5094-5100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cultured human endometrial epithelial cells produce thymus and activation-regulated chemokine with stimulation of interleukin-4 and … (2004)
  • Author(s): Kaei Nasu, Bing Sun, Masakazu Nishida, Junichiro Fukuda, et al.
  • Journal Title: Fertility and Sterility 82・Suppl 3 Pages: 1014-1018
• [Journal Article] Hypoxya simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial … (2004)
  • Author(s): Kaei Nasu, Masakazu Nishida, Junichiro Fukuda, Yasushi Kawano, et al.
  • Journal Title: Fertility and Sterility 82・3 Pages: 756-759
• [Journal Article] Differential effects of interferon-α and - β on the secretion of vascular endothelial growth factor by eutopic and ectopic endometrial stromal cells (2004)
  • Author(s): Junichiro Fukuda, Yasushi Kawano, Kaei Nasu, Masakazu Nishida, et al.
  • Journal Title: Fertility and Sterility 82・3 Pages: 749-751
• [Journal Article] Synergistic effects of interleukin (IL)-1 α and ceramide analogue on the production of IL-6,IL-8 and macrophage colony-stimulating factor by … (2004)
  • Author(s): Yasushi Kawano, Junichiro Fukuda, Kaei Nasu, Harunobu Matsumoto, et al.
  • Journal Title: Fertility and Sterility 82・Suppl 3 Pages: 1043-1047
• [Journal Article] Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells : a … (2004)
  • Author(s): Masakazu Nishida, Kaei Nasu, Junichiro Fukuda, Yasushi Kawano, et al.
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism 89・10 Pages: 5094-5100
• [Presentation] 選択的nuclear factor-κB阻害剤BAY 11-7085による子宮内膜症の薬物療法 (2007)
  • Author(s): 奈須家栄, 西田正和, 弓削彰利, 高井教行, 楢原久司.
  • Organizer: 第22回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 日本大学会館
  • Year and Date: 2007-12-01
• [Presentation] 子宮内膜におけるproteinase-activated receptor-2を介したケモカインの産生調節 (2007)
  • Author(s): 河野康志, 古川雄一, 濱崎智恵子, 奈須家栄, 楢原久司.
  • Organizer: 第22回日本生殖免疫学会総会・学術集会
  • Place of Presentation: 日本大学会館
  • Year and Date: 2007-12-01
• [Presentation] Transforming growth factor-βは子宮内膜間質細胞の増殖、運動性を抑制し、contractilityを増強する (2007)
  • Author(s): 奈須家栄, 松本治伸, 弓削彰利, 西田正和, 楢原久司.
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2007-10-25
• [Presentation] ヒト卵管細胞における低酸素下でのVEGFとsFlt-1産生 (2007)
  • Author(s): 伊東裕子, 奈須家栄, 楢原久司.
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2007-10-25
• [Presentation] 子宮内膜におけるprotease-activated receptorを介したchemokineの産生作用 (2007)
  • Author(s): 河野康志, 古川雄一, 濱崎智恵子, 福田淳一郎, 奈須家栄, 楢原久司.
  • Organizer: 第52回日本生殖医学会総会・学術講演会
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2007-10-25
• [Presentation] 卵管細胞のvascular endothelial growth factorおよびsoluble fms-like tyrosine kinase-1の分泌はinterleukin-1βによって調節される (2007)
  • Author(s): 奈須家栄, 伊東裕子, 弓削彰利, 河野康志, 楢原久司.
  • Organizer: 第25回日本受精着床学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-08-30
• [Presentation] ヒト卵管細胞におけるVEGFとsF1t-1の産生に対する低酸素の作用 (2007)
  • Author(s): 伊東裕子, 奈須家栄, 楢原久司.
  • Organizer: 第25回日本受精着床学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-08-30
• [Presentation] 子宮内膜のtissue remodelingに及ぼすTNF-αの影響 (2007)
  • Author(s): 弓削彰利, 奈須家栄, 松本治伸, 西田正和, 河野康志, 楢原久司.
  • Organizer: 第25回日本受精着床学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-08-30
• [Presentation] 子宮内膜におけるthrombinによるケモカイン産生調節について (2007)
  • Author(s): 古川雄一, 河野康志, 松本治伸, 弓削彰利, 奈須家栄, 楢原久司.
  • Organizer: 第25回日本受精着床学会総会・学術講演会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-08-30
• [Presentation] Application of the nuclear factor-κB inhibitor, BAY 11-7085, for the treatment of endometriosis (2007)
  • Author(s): Nasu K, Nishida M, Yuge A, Takai N, Narahara H.
  • Organizer: 23rdAnnual Meeting of the European Society for Human Reproduction & Embryology
  • Place of Presentation: Lyon Convention Centre
  • Year and Date: 2007-07-03
• [Presentation] Insulin-like growth factor による卵管細胞のvascular endothelial growth factor産生調節 (2007)
  • Author(s): 奈須家栄, 伊東裕子, 弓削彰利, 河野康志, 楢原久司.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] ヒト卵管上皮細胞におけるウイルス感染に対するToll-like receptor (TLR)3の発現と免疫機構 (2007)
  • Author(s): 伊東裕子, 奈須家栄, 楢原久司.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] Bufalinによる子宮内膜症細胞のG0/G1 arrestおよびapoptosisの誘導 (2007)
  • Author(s): 井上智恵子, 奈須家栄, 西田正和, 高井教行, 楢原久司.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] β-Hydroxyisovalerylshikonin(紫根)により引き起こされる子宮内膜症細胞のアポトーシスの検討-子宮内膜症治療薬としての可能性- (2007)
  • Author(s): 西田正和, 奈須家栄, 高井教行, 井上智恵子, 楢原久司.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] The signal transduction system of thrombin on secretion of vascular endothelial growth factor in human endometrial stromal cells (2007)
  • Author(s): Kawano Y, Furukawa Y, Fukuda J, Matsumoto H, Nasu K, Narahara H.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] The effect of epiregulin on secretion of vascular endothelial growth factor in human endometrium (2007)
  • Author(s): Furukawa Y, Kawano Y, Matsumoto H, Yuge A, Nasu K, Narahara H.
  • Organizer: 第59回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2007-04-16
• [Presentation] Application of the nuclear factor-κB inhibitor,BAY 11-7085,for the treatment of endometriosis (2007)
  • Author(s): Nasu K, Nishida M, Yuge A, TakaiN, Narahara H.
  • Organizer: 23rd Annual Meeting ofthe European Society for HumanReproduction&Embryology
  • Place of Presentation: Lyon Convention Centre
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Application of the nuclear factor-KB inhibitor, BAY 11-7085, for the treatment of endometriosis (2007)
  • Author(s): Nasu, K, Nishida, M, Yuge, A, Takai, N, Narahara, H
  • Organizer: 23rd Annual Meeting of the European Society for Human Reproduction & Embryology
  • Place of Presentation: Lyon, France
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Site-specific mucosal immunity of upper female genital tract (2006)
  • Author(s): Nasu K.
  • Organizer: The 3rd Stage Suface Barrier Immunology Study Group 3rd Meeting
  • Place of Presentation: Miyazaki Phoenix Hotel
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Site-specific mucosal immunity of upper female genital tract (2006)
  • Author(s): Nasu, K
  • Organizer: The 3rd Stage Surface Barrier Immunology Study Group 3rd Meeting
  • Place of Presentation: Miyazaki, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Endometriotic cells are resistant to interferon-γ-induced cell growth inhibition and apoptosis (2005)
  • Author(s): Nasu K, Nishida M, Yuge A, Narahara H, Takai N.
  • Organizer: The XIXth Asian and Oceanic Congress of Obstetrics&Gynecology
  • Place of Presentation: COEX Convent ion&Exhibition Center
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Endometriotic cells are resistant to interferon-y-induced cell growth inhibition and apoptosis (2005)
  • Author(s): Nasu, K, Nishida, M, Yuge, A, Takai, N, Narahara, H
  • Organizer: The XIXth Asian and Oceanic Congress of Obstetrics & Gynecology
  • Place of Presentation: Seoul, Korea
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor by cultured human endometrial stromal cells (2004)
  • Author(s): Nasu K, Nisluda M, Fukuda J, Sun B, Kawano Y, Miyakawa I.
  • Organizer: 37th Annual Meeting 37th Annual Meeting of theSociety for Study of Reproduction
  • Place of Presentation: Vancouver
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cultured human endometrial epithelial cells produce thymus and activation-regulatedchemokine upon stimulation with hlterleukin-4 and interleukin-13 (2004)
  • Author(s): Nasu K, Sun B, Nishida M, Fukuda J, Narahara H, Miyakawa I.
  • Organizer: IX International Congress of Reproductive Immunology
  • Place of Presentation: 山のホテル
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor by cultured human endometrial stromal cells (2004)
  • Author(s): Nasu, K, Nishida, M, Fukuda, J, Sun, B, Kawano, Y,-Miyakawa, I
  • Organizer: 37th Annual Meeting 37th Annual Meeting of the Society for Study of Reproduction
  • Place of Presentation: Vancouver, BC, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cultured human endometrial epithelial cells produce thymus and activation-regulated chemokine upon stimulation with interleukin-4 and interleukin-13 (2004)
  • Author(s): Nasu, K, Sun, B, Nishida, M, Fukuda, J, Narahara, H, Miyakawa, I
  • Organizer: IX International Congress of Reproductive Immunology
  • Place of Presentation: Hakone, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] Progress in Chemokine Research (2007)
  • Author(s): Nasu K, Nishida M, Yuge A, Narahara H.
  • Publisher: Nova Science Publishers Inc.