| Project/Area Number |
16591752
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIKADO Takashi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (50243233)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKA Shunji Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (60260387)
OTORI Yasumasa Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (40303953)
HOSOHATA Jun Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (20324759)
MIYOSHI Tomomitsu Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (70314309)
前田 直之 大阪大学, 医学系研究科, 寄付講座教授 (00273623)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Neuroprotection / Transcorneal Electrical Stimulation / Retinitis Pigmentosa / Ischemic Optic Neuropathy / Normal tension glaucoma / Visual Field / Erectroretinogram / Phosphene / 電気刺激 / IGF-1 / 視神経管骨折 / 緑内障 |
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| Research Abstract |
(1)Neuroprotection of photoreceptors by trancorneal electrical stimulation in RCS rats
In the previous study, we confirmed nth effectiveness of Tanscorneal electrical stimulation (Tc ES) was effective to increase the survival rate of retinal ganglion cells (RGCs) in axotomized rat. In this study we examined the Effect of TcES on the survival rate of photoreceptors in royal college of surgeon's rat (RCS rat). TcES was applied once a week for 4 times from 3 week after birth. Electrortinography (ERG) showed significant large amplitude of scotopic threshold response (STR) in the treated group compared with the control group. Histological study showed the thickness of outer nuclear layer was significantly larger in the treated group compared with the control group. These data showed the effectiveness of TcES for the protection of photoreceptors.
(2)Clinical study of TcES in patients of optic neuropathy.
Based on the animal study, we investigated the effectiveness of TcES in patients with optic neuropathy. IRB was obtained from the committee of Osaka University Medical School. Thirteen eyes with anterior ischemic optic neuropathy, 7 eyes with traumatic optic neuropathy (TON) and 8 eyes with optic atrophy (OA) were enrolled in the study. After TcES, 4 eyes (31%) with AION, 2 eyes (29%) with TON and 2 eyes (25%) of OA showed an improvement of visual acuity equal or greater than 0.3 log MAR unit. We also investigated the threshold current to evoke pupillary reflex (TCPR), the threshold current to evoke central phosphene (TCCP) or peripheral phosphene (TCPP), visual acuity (VA), the area of visual field of Goldmann perimetry V/4 (AVF). The TCCP correlated with TCPR and VA. TCPP correlated with AVF. The improvement of VA after TcES correlated with the improvement of TCCP. These data suggested that the function of the central retina was reflected by TCCP and that of peripheral retina was reflected by TCPP. TCPR is an objective parameter to represent the total retinal function.
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