| Project/Area Number |
16591762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka City University |
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Principal Investigator |
SHIRAKI Kunihiko Osaka City University, Graduate School of Medicine, PROFESSOR, 大学院医学研究科, 教授 (40162771)
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| Co-Investigator(Kenkyū-buntansha) |
KOHNO Takeya Osaka City University, Graduate School of Medicine, ASSOCIATE PROFESSOR, 大学院医学研究科, 助教授 (40215190)
ATAKA Shinsuke Osaka City University, Uraduate School of Medicine, Lecturer, 大学院医学研究科, 講師 (40381983)
永田 智 大阪市立大学, 大学院・医学研究科, 助手 (80381995)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Laser Speckle / Fundus / Blood Flow Measurement / Sodium Iodate / Choriocapillaries / Choroidal Circulation |
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| Research Abstract |
A laser speckle flowgraphy has been used to examine blood flow at an optic nervehead. When retinal major vessels are excluded from a measuring area, SBR values are well correlated with tissue blood flow at the optic nerve head. When the laser speckle flowgraphy is used for a fundus blood flow measurement, the SBR values show total blood flow of a retina and a choroid at the examining area. Thus, when a fundus lesion is limited to a choroid without any influence on a retina, the SBR values would show blood flow changes at the choroidal lesion. However, it is unclear that the laser speckle flowgraphy can reflect the microcirculatlon changes of the choroid.
In the series of this study, scattered photocoagulation was done in the fundi of pigmented rabbits, and SBR values were measured at the photocoagulated lesions and at the spared areas between photocoagulated lesions. Furthermore, sodium iodate was given in different pigmented rabbits to damage retinal pigment epithelium. At the lesions of the damaged retinal pigment epithelium, secondary degeneration and atrophy of choriocapillaries occurred. The SBR values were obtained similarly at these lesions.
At the photocoagulated lesions, the SBR values remained extremely low during the six months of the experiment period, and the spared areas between photocoagulated lesions showed decrease of the SBR values, namely reduced blood folws, three months and six months after the photocoagulation. At lesions of the damaged retinal pigment epithelium of the sodium iodate-administered rabbits, the SBR values decreased to 71% of the original SBR values before the sodiumiodate administration at three months and to 58% at six months. A gradual decrease of the SBR values was seen.
These studies showed that a laser speckle flowgraphy could detect blood flow changes of choroidal microcirculation.
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