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Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.

Research Project

Project/Area Number 16592006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHIDA Hideo  The University of Tokushima, Graduate School, Institute of Health Bioscience, Associate Professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (30116131)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Masato  The University of Tokushima, Graduate School, Institute of Health Bioscience, Assistant Professor, 大学院・ヘルスバイオサイエンス研究部, 助手 (10243718)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsCancer Immunotherapy / dendritic cell / OK-432 / TS-1 / Toll-loke receptor / lipoteichoic acid-related molecule OK-PSA / clinical trial / 細胞免疫療法 / OK-432 / Toll-like receptor 4 (TLR4)
Research Abstract

Dendritic cells (DCs) are professional antigen-presenting cells. Adequately matured DCs can stimulate T cells to induce tumor-specific cytotoxic T lymphocytes (CTLs). A streptococcal anticancer immunotherapeutic agent OK-432 can strongly mature DCs. In tumor-bearing mouse model, radiation therapy (RT) or oral administration of anticancer drug TS-1 followed by an intratumoral injection of syngeneic bone-marrow-derived DCs and of OK-432 resulted in inducing CTLs and in inhibiting tumor growth. The therapy did not elicit any significant effects in tumor-bearing mice in which Toll-like receptor (TLR) 4 is mutated. We have already succeeded in isolating an active component of OK-432 (lipoteichoic acid-related molecule OK-PSA). OK-PSA matured DCs far better, than original OK-432 in vitro, and OK-PSA-treated DCs stimulated allogeneic T cells to produce IFN-γ, and to induce allo-antigen specific CTLs. In in vivo model, TS-1+DCs+OK-PSA therapy exhibited anticancer effect stronger than the therapy using TS-1, DCs and OK-432. Based on these basic data, we have started an early stage clinical trial, "the therapy with an intratumoral administration of DCs in combination with TS-1 and OK-432", in oral cancer patients in which the standard therapies were not effective. Of 5 cases, complete remission (CR) was observed in one case, partial remission (PR) in 3 cases, and stable desease (SD) in one case. No significant toxicity over grade 3 was observed. It was strongly suggested that an intratumoral administration in combination with TS-1 and OK-432 is safety and effective in oral cancer patients.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (110 results)

All 2006 2005 2004

All Journal Article (105 results) Book (5 results)

  • [Journal Article] OK-432を併用した口腔癌に対する樹状細胞療法2006

    • Author(s)
      岡本正人
    • Journal Title

      BIO Clinica 20・2

      Pages: 53-58

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling2006

    • Author(s)
      Masato Okamoto
    • Journal Title

      J Immunother 29・1

      Pages: 78-86

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of OK-432-derived DNA : One of the active constituents of OK-432, a streptococcal immunotherapeutic agent2006

    • Author(s)
      Tetsuya Oshimawa
    • Journal Title

      J Immunother (in press)(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inovolvement of nitric oxide in anti-tumor effects of OK-432, a streptococcal anti-tumor immunotherapeutic agent2006

    • Author(s)
      Tetsuya Oshimawa
    • Journal Title

      Int Immunopharmacol (in press)(in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Dendritic cell-therapy in combination with OK-432 in oral cancer.2006

    • Author(s)
      Masato Okamoto
    • Journal Title

      BIO Clinica 20(2)

      Pages: 53-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling.2006

    • Author(s)
      Masato Okamoto
    • Journal Title

      J Immunother 29(1)

      Pages: 78-86

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Involvement of nitric oxide in anti-tumor effects of OK-432, a streptococcal anti-tumor immunotherapeutic agent.2006

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      Int Immunopharmacol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of OK-432-derived DNA : One of the active constituents of OK-432, a streptococcal immunotherapeutic agent.2006

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      J Immunother (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of OK-432-derived DNA : One of the active constituents of OK-432, a streptococcal immunotherapeutic agent2006

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      J mmunother in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of nitric oxide in anti-tumor effects of OK-432, a streptococcal anti-tumor immunotherapeutic agent2006

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      Int Immunopharmacol in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mechanism of anti-cancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and Toll-like receptor 4 signaling2006

    • Author(s)
      Masato Okamoto
    • Journal Title

      J mmunother 29・1

      Pages: 78-86

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 特集[樹状細胞ワクチン]OK-432を併用した口腔癌に対する樹状細胞療法2006

    • Author(s)
      岡本正人
    • Journal Title

      BIO Clinica 20・2

      Pages: 53-58

    • Related Report
      2005 Annual Research Report
  • [Journal Article] OK-432(ピシバニール)の樹状細胞に対する作用2005

    • Author(s)
      両馬良樹
    • Journal Title

      細胞 37・7

      Pages: 279-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Oral squamous cell carcinoma cells induce osteoclast differentiatio by suppression of osteopretegerin expression in osteoblasts2005

    • Author(s)
      Takayuki Tada
    • Journal Title

      Int J Cancer 116・2

      Pages: 253-262

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition by bisphosphonate (YM529) of bone invasion in a mouse model of oral squamous cell carcinoma2005

    • Author(s)
      Nianhui Cui
    • Journal Title

      Clin Cancer Res 11・7

      Pages: 2713-2719

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response : Immune cell migration and nitric oxide production2005

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      Int J Cancer 116・4

      Pages: 571-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] 口腔扁平上皮癌細胞に対するセファランチンによる放射線感受性増強作用2005

    • Author(s)
      玉谷哲也
    • Journal Title

      口科誌 54・2

      Pages: 230-236

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemical constituents from fruits and seeds of Myrica rubra (Myricaceae)2005

    • Author(s)
      Ai Suga
    • Journal Title

      Natural Med 59・2

      Pages: 70-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cyclobutane dimers from the Colombian medicinal plant Acyrocline bogotensis2005

    • Author(s)
      Takaaki Sagawa
    • Journal Title

      J Nad Prod 68・4

      Pages: 502-505

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト頭頸部癌細胞株におけるToll-like receptor 2、4および9の発現と各リガンドに対する反応性2005

    • Author(s)
      田野智之
    • Journal Title

      口科誌 54・3

      Pages: 344-352

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium2005

    • Author(s)
      Naonobu Tanaka
    • Journal Title

      Organic Lett 7・14

      Pages: 2997-2999

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 放射線、5-FUおよびOK-432 : IL-10、TGF-βの抑制効果2005

    • Author(s)
      岡本正人
    • Journal Title

      癌と化学療法 32・11

      Pages: 1556-1558

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト頭頸部癌細胞におけるOK-432活性成分によるToll-like receptor(TLR)4を介したp53非依存的アポトーシスの誘導2005

    • Author(s)
      田野智之
    • Journal Title

      癌と化学療法 32・11

      Pages: 1562-1564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] OK-432由来DNAの抗腫瘍活性2005

    • Author(s)
      押川哲也
    • Journal Title

      癌と化学療法 3211

      Pages: 1559-1562

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation2005

    • Author(s)
      Koji Harada
    • Journal Title

      Anticancer Res 25・3c

      Pages: 2471-2475

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Basic investigation on the development of molecular targeting therapy against cyclin-dependent kinase inhibitor p27Kip1 in head and neck cancer cells2005

    • Author(s)
      Supriatno
    • Journal Title

      Int J Oncol 27・3

      Pages: 627-635

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosis in oral cancer cells2005

    • Author(s)
      Koji Harada
    • Journal Title

      Oral Oncol 41・6

      Pages: 623-630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High antitumor activity using intratumoral injection of plasmid DNA with mutant-type p27Kip1 gene following in vivo electroporation2005

    • Author(s)
      Koji Harada
    • Journal Title

      Oncol Rep 13・2

      Pages: 201-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effects of OK-432 (Picibanil) on dendritic cells.2005

    • Author(s)
      Yoshiki Ryoma
    • Journal Title

      The Cell 37(7)

      Pages: 279-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biyouyanagin A, an anti-HIV agent from Hypericum chinense L. var. salicifolium.2005

    • Author(s)
      Naonobu Tanaka
    • Journal Title

      Organic Letters 7(14)

      Pages: 2997-2999

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Radiation, 5-FU and OK-432 : Inhibitory effect of IL-10 and TGF-β.2005

    • Author(s)
      Masato Okamoto
    • Journal Title

      Jpn J Cancer Chemother 31(11)

      Pages: 1556-1558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Induction of apoptosis in human head and neck cancer cell lines by an active component of OK-432 through p53-independent pathway via Toll-like receptor (TLR) 4 signaling.2005

    • Author(s)
      Tomiyuki Tano
    • Journal Title

      Jpn J Cancer Chemother 31(11)

      Pages: 1562-1564

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor immunity induced by OK-432-derived DNA.2005

    • Author(s)
      Tetsuya Oshimawa
    • Journal Title

      IJpn J Cancer Chemother 31(11)

      Pages: 1559-1561

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemical constituents from fruits and seeds of Myrica rubra (Myricaceae).2005

    • Author(s)
      Ai Suga A
    • Journal Title

      Natural Medicines 59(2)

      Pages: 70-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cyclobutane dimers from the Colombian medicinal plant Acyrocline bogotensis.2005

    • Author(s)
      Takaaki Sagawa
    • Journal Title

      J Nat Prod 68(4)

      Pages: 502-505

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Toll-like receptor 2, 4 and 9 in human head and neck cancer cell lines and their responsiveness against each ligand.2005

    • Author(s)
      Tomoyuki Tano
    • Journal Title

      J Jpn Stomatol Soc 54(3)

      Pages: 344-352

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response : Immune cell migration and nitric oxide production.2005

    • Author(s)
      Tetsuya Oshikawa
    • Journal Title

      Int J Cancer 116(4)

      Pages: 571-578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Effect of YM529 on a model of mandiblar invasion by oral squamous cell carcinoma in mice.2005

    • Author(s)
      Nianhui Cui
    • Journal Title

      Clin Cancer Res 11(7)

      Pages: 2713-2719

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteopretegerin expression in osteoblasts.2005

    • Author(s)
      Takayuki Tada
    • Journal Title

      Int J Cancer 116(2)

      Pages: 253-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhanced radiosensitization by cepharanthin in human oral squamous carcinoma cells-Inhibition of NF-κB as a molecular target-2005

    • Journal Title

      J Jpn Stomatol Soc 54(2)

      Pages: 230-236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.2005

    • Author(s)
      Koji Harada
    • Journal Title

      Anticancer Res 25(3c)

      Pages: 2471-2475

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Basic investigation on the development of molecular targeting therapy against cyclin-dependent kinase inhibitor p27Kip1 in head and neck cancer cells.2005

    • Author(s)
      Supriatno
    • Journal Title

      Int J Oncol 27(3)

      Pages: 627-635

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosi in oral cancer cells.2005

    • Author(s)
      Koji Harada
    • Journal Title

      Oral Oncol 41(6)

      Pages: 623-630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] High antitumor activity using intratumoral injection of plasmid DNA with mutant-type p27Kip1 gene following in vivo electroporation.2005

    • Author(s)
      Koji Harada
    • Journal Title

      Oncol Rep 13(2)

      Pages: 201-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteopretegerin expression in osteoblasts2005

    • Author(s)
      Takeyuki Tada
    • Journal Title

      Int J Cancer 116・2

      Pages: 253-262

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of YM529 on a model of mandiblar invasion by oral squamous cell carcinoma in mice2005

    • Author(s)
      Nianhui Cui
    • Journal Title

      Clin Cancer Res 11・7

      Pages: 2713-2719

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Biyouyanagin A, an anti-HIV agent from Hypericum chinense L.var.salicifolium2005

    • Author(s)
      Naonobu Tanaka
    • Journal Title

      Organic Letters 7・14

      Pages: 2997-2999

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 口腔扁平上皮癌細胞に対するセファランチンによる放射線感受性増強作用2005

    • Author(s)
      玉谷哲也
    • Journal Title

      日本口腔科学会雑誌 54・2

      Pages: 230-236

    • Related Report
      2005 Annual Research Report
  • [Journal Article] High expression of S-phase kinase-associated protein 2(Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation2005

    • Author(s)
      Koji Harada
    • Journal Title

      Anticancer Res 25・3c

      Pages: 2471-2475

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Down-regulation of S-phase kinase associated protein 2(Skp2) induces apoptosis in oral cancer cells2005

    • Author(s)
      Koji Harada
    • Journal Title

      Oral Oncol 41・6

      Pages: 623-630

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヒト頭頸部癌細胞株におけるToll-like receptor 2、4および9の発現と各リガンドに対する反応性2005

    • Author(s)
      田野智之
    • Journal Title

      日本口腔科学会雑誌 54・3

      Pages: 344-352

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cyclobutane dimers from the Colombian medicinal plant Acyroclin bogotensis2005

    • Author(s)
      Takaaki Sagawa
    • Journal Title

      J Nat Prod 68・4

      Pages: 502-505

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Chemical constituents from fruits and seeds of Myrica rubra (Myricaceae).2005

    • Author(s)
      Ai Suga
    • Journal Title

      Natural Medicines 59・2

      Pages: 70-75

    • Related Report
      2005 Annual Research Report
  • [Journal Article] OK-432由来DNAの抗腫瘍活性2005

    • Author(s)
      押川哲也
    • Journal Title

      癌と化学療法 31・11

      Pages: 1559-1561

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ヒト頭頸部癌細胞におけるOK-432活性成分によるToll-like receptor(TLR)4を介したp53非依存的アポトーシスの誘導2005

    • Author(s)
      田野智之
    • Journal Title

      癌と化学療法 31・11

      Pages: 1562-1564

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 放射線、5-FUおよびOK-432:IL-10、TGF-βの抑制効果2005

    • Author(s)
      岡本正人
    • Journal Title

      癌と化学療法 31・11

      Pages: 1556-1558

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Basic investigation on the development of molecular targeting therapy against cyclin-dependent kinase inhibitor p27Kipl in head and neck cancer cells2005

    • Author(s)
      Supriatno
    • Journal Title

      Int J Oncol 27・3

      Pages: 627-635

    • Related Report
      2005 Annual Research Report
  • [Journal Article] High antitumor activity using intratumoral injection of plasmid DNA with mutant-type p27Kipl gene following in vivo electroporation2005

    • Author(s)
      Koil Harada
    • Journal Title

      Oncol Rep 13・2

      Pages: 201-206

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Toll-like receptor-targeting immunotherapy for oral cancer2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Oral Science Int 1・1

      Pages: 1-15

    • NAID

      10020401757

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biological effect of OK-432 (Picibanil) and possible application to dendritic cell therapy2004

    • Author(s)
      Yoshiki Ryoma
    • Journal Title

      Anticancer Res 24・5C

      Pages: 3295-3302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptorとOK-432(ピシバニール)の樹状細胞成熟化作用-OK-432を用いた癌免疫療法の展望2004

    • Author(s)
      両馬良樹
    • Journal Title

      BIO Clinica 19・12

      Pages: 46-49

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TS-1およびOK-432併用樹状細胞腫瘍内投与療法の基礎的検討2004

    • Author(s)
      岡本正人
    • Journal Title

      口科誌 53・1

      Pages: 14-21

    • NAID

      10014260917

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 口腔扁平上皮癌細胞におけるセファランチンのNF-kB活性抑制と放射線感受性増強作用2004

    • Author(s)
      玉谷哲也
    • Journal Title

      口腔組織培養学会誌 13・1

      Pages: 33-34

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト唾液線細胞における筋特異的転写因子MyoDの発現2004

    • Author(s)
      板東高志
    • Journal Title

      口腔組織培養学会誌 13・1

      Pages: 7-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ヒト唾液線導管細胞におけるアクアポリン5の発現誘導2004

    • Author(s)
      茂木勝美
    • Journal Title

      口腔組織培養学会誌 13・1

      Pages: 9-10

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 4 mediates anti-tumor host response induced by fifty-five kDa protein isolated from Aeginetia indica L,a parasitic plant2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Clin Diag Lab Immunol 11・3

      Pages: 483-495

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The clinicopathological significance of the expression of CXCR protein in oral squamous cell carcinoma2004

    • Author(s)
      Ammar Almofti
    • Journal Title

      Int J Oncol 25・1

      Pages: 65-71

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432, a streptococcal preparation2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Cancer Res 64・15

      Pages: 5461-5470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 担癌マウスにおけるTS-1およびOK-432併用樹状細胞腫瘍内投与療法の抗腫瘍効果2004

    • Author(s)
      岡本正人
    • Journal Title

      癌と化学療法 31・11

      Pages: 1562-1564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] OK-432の免疫活性化機構の解析 : 貧食、活性成分の遊出とTLR4シグナルの活性化2004

    • Author(s)
      田野智之
    • Journal Title

      癌と化学療法 31・11

      Pages: 1767-1769

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] TLR4欠損マウスにおけるTLR4発現樹状細胞およびOK-432活性成分腫瘍内投与の抗腫瘍効果2004

    • Author(s)
      押川哲也
    • Journal Title

      癌と化学療法 31・11

      Pages: 1770-1772

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent(S-1)and radiation2004

    • Author(s)
      Koji Harada
    • Journal Title

      Int J Oncol 25・4

      Pages: 905-911

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells2004

    • Author(s)
      Koji Harada
    • Journal Title

      In Vivo 18・4

      Pages: 449-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Combined effects of the oral fluoropyrimidine anticancer agent, S-1 and radiation on human oral cancer cells2004

    • Author(s)
      Koji Harada
    • Journal Title

      Oral Oncol 40・7

      Pages: 713-719

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of antitumor activity of mutant type p27Kip1 gene in an oral cancer cell line2004

    • Author(s)
      Supriatno
    • Journal Title

      Oral Oncol 40・7

      Pages: 679-687

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of an intratumoral administration of dendritic cells in combination with TS-1, an oral fluoropyrimidine anti-cancer drug, and OK-432, a streptococcal immunopotentiator : Involvement of Toll-like receptor 42004

    • Author(s)
      Sharif Uddin Ahmed
    • Journal Title

      J Immunother 27・6

      Pages: 432-441

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Frequent Down-regulation of 14-3-3 σ protein and Hypermethylation of 14-3-3 σ gene in Salivary Gland Adenoid Cystic Carcinoma2004

    • Author(s)
      Daisuke Uchida
    • Journal Title

      Br J Cancer 91・7

      Pages: 1131-1138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamour cell carcinoma2004

    • Author(s)
      Daisuke Uchida
    • Journal Title

      Lab Invest 84・12

      Pages: 1538-1546

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis2004

    • Author(s)
      Hiroyuki Nakagawa
    • Journal Title

      J Nat Prod 67・11

      Pages: 1919-1924

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor-targeting immunotherapy for oral cancer.2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Oral Science Int 1(1)

      Pages: 1-15

    • NAID

      10020401757

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptors and maturation of dendritic cells with OK-432 (Picibanil)-A view of cancer immunotherapy with OK-432.2004

    • Author(s)
      Yoshiki Ryoma
    • Journal Title

      BIO Clinica 19(12)

      Pages: 46-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biological effect of OK-432 (Picibanil) and possible application to dendritic cell therapy.2004

    • Author(s)
      Yoshiki Ryoma
    • Journal Title

      Anticancer Res 24(5C)

      Pages: 3295-3302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Inhibition of NF-κB activity and enhancement of radiation sensitivity by Cepharanthine in oral squamous cell crcinoma cells.2004

    • Author(s)
      Tetsuya Tamatani
    • Journal Title

      Jpn J Tissue Cult Dent Res 13(1)

      Pages: 33-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of muscle-specific transcription factor MyoD in himan salivary duct cells.2004

    • Author(s)
      Takashi Bando
    • Journal Title

      Jpn J Tissue Cult Dent Res 13(1)

      Pages: 7-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Induction of aquaporin 5 expression in human salivary duct cells.2004

    • Author(s)
      Katsumi Motegi
    • Journal Title

      Jpn J Tissue Cult Dent Res 13(1)

      Pages: 9-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma.2004

    • Author(s)
      Ammar Almofti
    • Journal Title

      Int J Oncol 25(1)

      Pages: 65-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation.2004

    • Author(s)
      Koji Harada
    • Journal Title

      Int J Oncol 25(4)

      Pages: 905-911

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Overexpression of iNOS gene suppresses the tumorigenicity and metastasis of oral cancer cells.2004

    • Author(s)
      Koji Harada
    • Journal Title

      In Vivo. 18(4)

      Pages: 449-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Combined effects of the oral fluoropyrimidine anticancer agent, S-1 and radiation on human oral cancer cells.2004

    • Author(s)
      Koji Harada
    • Journal Title

      Oral Oncol 40(7)

      Pages: 713-719

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of antitumor activity of mutant type p27Kip1 gene in an oral cancer cell line.2004

    • Author(s)
      Supriatno
    • Journal Title

      Oral Oncol 40(7)

      Pages: 679-687

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Frequent Down-regulation of 14-3-3 s protein and Hypermethylation of 14-3-3 s gene in Salivary Gland Adenoid Cystic Carcinoma.2004

    • Author(s)
      Daisuke Uchida
    • Journal Title

      Br J Cancer 91

      Pages: 1131-1138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma.2004

    • Author(s)
      Daisuke Uchida
    • Journal Title

      Lab Invest 84(12)

      Pages: 1538-1546

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Intratumoral administration of dendritic cells in combination with TS-1, an oral fluoropyrimidine anti-cancer drug, and OK-432, a streptococcal agent.2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      J Jpn Stomatol Soc 53(1)

      Pages: 14-21

    • NAID

      10014260917

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis.2004

    • Author(s)
      Hiroyuki Nakagawa
    • Journal Title

      J Nat Prod 67(11)

      Pages: 1919-1924

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of Toll-like receptor 4 on dendritic cells is significant for anti-cancer effect of dendritic cell-based imnmunotherapy in combination with an active component of OK-432, a streptococcal preparation.2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Cancer Res 64(15)

      Pages: 5461-5470

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Toll-like receptor 4 mediates anti-tumor host response induced by fifty-five kDa protein isolated from Aeginetia indica L, a parasitic plant.2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Clin Diagn Lab Immun 11(3)

      Pages: 483-495

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of an intratumoral administration of dendritic cells in combination with TS-1, an oral fluoropyrimidine anti-cancer drug, and OK-432, a streptococcal immunopotentiator. Involvement of Toll-like receptor 4.2004

    • Author(s)
      Sharif Uddin Ahmed
    • Journal Title

      J Immunother 27(6)

      Pages: 432-441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-tumor effect of intratumoral administration of dendritic cells in combination with TS-1 and OK-432.2004

    • Author(s)
      Masato Okamoto
    • Journal Title

      Jpn J Cancer Chemother 31(11)

      Pages: 1627-1630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Analysis of the immuno-activation mechanism of OK-432 : Phagocytosis, release of active components and TLR4 signaling.2004

    • Author(s)
      Tomiyuki Tano
    • Journal Title

      Jpn J Cancer Chemother 31(11)

      Pages: 1767-1769

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Anti-cancer effect of an intratumoral injection of dendritic cells expressing TLR4 in combination with an active component of OK-432 in TLR4-deficient mice.2004

    • Author(s)
      Tetsuya Oshimawa
    • Journal Title

      Jpn J Cancer Chemother 31(11)

      Pages: 1770-1772

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Acquisition of lymph node, but not distant metastatic potentials, by the overexpression of CXCR4 in human oral squamous cell carcinoma2004

    • Author(s)
      Daisuke Uchida
    • Journal Title

      Lab Invest 84・12

      Pages: 1538-1546

    • Related Report
      2004 Annual Research Report
  • [Journal Article] TS-1およびOK-432併用樹状細胞腫瘍内投与療法の基礎的検討2004

    • Author(s)
      岡本正人
    • Journal Title

      日本口腔科学会雑誌 53・1

      Pages: 14-21

    • NAID

      10014260917

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 口腔扁平上皮癌細胞におけるセファランチンのNF-kB活性抑制と放射線感受性増強作用2004

    • Author(s)
      玉谷哲也
    • Journal Title

      口腔組織培養学会雑誌 13・1

      Pages: 33-34

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Toll-like receptor 4 mediates anti-tumor host response induced by fifty-five kDa protein isolated from Aeginetia indica L, a parasitic plant2004

    • Author(s)
      Ammar Almofti
    • Journal Title

      Int J Oncol 25・1

      Pages: 65-71

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ヒト唾液腺細胞における筋特異的転写因子MyoDの発現2004

    • Author(s)
      坂東高志
    • Journal Title

      口腔組織培養学会雑誌 13・1

      Pages: 7-8

    • Related Report
      2004 Annual Research Report
  • [Book] Streptococcal preparation,OK-432-based immunotherapy for head and neccancer : Possible stimulation of dendritic cells via Toll-Like Receptor42005

    • Author(s)
      Masato Okamoto
    • Total Pages
      255
    • Publisher
      Global Research Network
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Streptococcal preparation, OK-432-based immunotherapy for head and neck cancer : Possible stimulation of dendritic cells via Toll-Like Receptor 4. (R.M.Mohan(ed.) (Res Adv in Cancer, Vol 5)2005

    • Author(s)
      Masato Okamoto
    • Publisher
      Global Research Network, Kerala, India
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Streptococcal preparation, OK-432-based immunotherapy for head and neck cancer : Possible stimulation of dendritic cells via Toll-Like Receptor 42005

    • Author(s)
      Masato Okamoto
    • Total Pages
      255
    • Publisher
      Global Research Network
    • Related Report
      2005 Annual Research Report
  • [Book] 分子作用メカニズムに立脚した今後のOK-432の臨床適応基準と治療戦略2004

    • Author(s)
      岡本正人
    • Total Pages
      87
    • Publisher
      進行印刷株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Criteria of clinical use of OK-432 and its treatment strategy based on the molecular mechanism. (Jpn Res Soc Surg Cancer Imunol(ed.))(Criteria of clinical use of BRMs beaed on the ecidence)2004

    • Author(s)
      Masato Okamoto
    • Publisher
      Shinkoh Press
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary

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Published: 2004-04-01   Modified: 2016-04-21  

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