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Objective measurement of patch test reactions due to dental metal compounds by measuring the erythema index and quantity of corneous moisture

Research Project

Project/Area Number 16592021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

TAKAHASHI Shinichi  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, PROFESSOR, 歯学部, 教授 (90197145)

Co-Investigator(Kenkyū-buntansha) KAWASHIMA Junko  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, LECTURER, 歯学部, 講師 (00208357)
MORIMOTO Mitsuaki  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, LECTURER, 歯学部, 講師 (90174458)
YAMANE Genyuki  TOKYO DENTAL COLLEGE, DEPARTMENT OF DENTISTRY, PROFESSOR, 歯学部, 教授 (80096510)
Project Period (FY) 2004 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsdental metal allergy / patch test / eryhtema index / quantity of corneous moisture
Research Abstract

Using the mice delayed hypersensitivity to dinitrochlorobenzene model, we compared the ear swelling rate with erythema index (E.I. ; measured with MEXAMETER MX18【○!R】) and quantity of corneous moisture (Q.G.M. ; measured with CORNEOMETER CM825【○!R】). The ear swelling rate showed a highly significant positive correlation with E.I. but not with Q.C.M. Therefore, E.I was employed for the objective assessment of patch test reactions.
To establish the optimal method for this assessment, we measured the effects of measurement intervals and tape application on E.I. during the patch test reactions in normal volunteers. At the site of metal compound and tape application, E.I. was significantly higher within 30 min after tape removal than after >40 min. E.I. was significantly higher on the 2nd,3rd, and 7th day post-patch test than before the patch test. We concluded that to eliminate the effects of tape application on E.I. most effectively, the standard deviation value (S.D.V) of E.I. at the test site should be preferred over E.I. at the control sites (sites of adjacent tape application and the adjacent normal skin).
We measured the S.D.V. of E.I. in patients with metal allergy (n=10), in those with an irritant reaction (n=10), and in the control group (n=10) on the 2nd,3rd, and 7th day post-patch test. The S.D.V. of E.I. was significantly higher in patients with metal allergy than in the control group on all days examined. S.D.V. was higher in patients with irritant reactions than in the control group on the 2nd and 3rd day, but not on the 7th day. Only on the 7th day, patients with metal allergy had a higher S.V.D. than those with an irritant reaction. These results suggested that patch test reactions can be objectively assessed with MEXAMETER by employing consecutive measurements.

Report

(3 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • Research Products

    (13 results)

All 2005 2004

All Journal Article (13 results)

  • [Journal Article] Structual, enzymatic and molecular studies in a series of nonbullous congenital ichthyosiform erythroderma patients2005

    • Author(s)
      Junko Kawashima, Shinichi Takahashi et al.
    • Journal Title

      Clinical and Experimental Dermatology 30・4

      Pages: 429-431

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] メグザメーターによるパッチテストの定量的判定の試み(第2報)2005

    • Author(s)
      高田篤史, 森本光明, 山根源之, 高橋愼一他
    • Journal Title

      第35回日本皮膚アレルギー学会総会、第30回日本接触皮膚炎会合同学術大会 プログラム・抄録集

      Pages: 164-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 歯科金属アレルギーにおける皮膚貼付試験判定の改善2005

    • Author(s)
      高田篤史, 森本光明, 山根源之, 高橋愼一他
    • Journal Title

      日本口腔科学会雑誌 54・5

      Pages: 528-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Structual, enzymatic and molecular studies in a series of nonbullous congenital ichthyosiform erythroderma patients2005

    • Author(s)
      Junko Kawashima, Shinichi Takahashi et al.
    • Journal Title

      Clinical and Experimental Dermatology 30(4)

      Pages: 429-431

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 亜鉛によるアレルギー性口内炎の診断におけるリンパ球幼若化試験の有用性について2005

    • Author(s)
      岡村泰人, 森本光明, 山根源之, 高橋愼一 他
    • Journal Title

      日本口腔粘膜学会雑誌 11・1

      Pages: 25-29

    • NAID

      10019240630

    • Related Report
      2005 Annual Research Report
  • [Journal Article] メグザメーターによるバッチテストの定量的判定の試み(第2報)2005

    • Author(s)
      高田篤史, 森本光明, 山根源之, 高橋愼一 他
    • Journal Title

      第35回日本皮膚アレルギー学会総会、第30回日本接触皮膚炎学会合同学術大会 プログラム・抄録集

      Pages: 164-164

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 歯科金属アレルギーにおける皮膚貼付試験判定の改善2005

    • Author(s)
      高田篤史, 森本光明, 山根源之, 高橋愼一 他
    • Journal Title

      日本口腔科学会雑誌 54・5

      Pages: 528-528

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pyodermatitis-pyostomatitis vegetans2005

    • Author(s)
      高橋愼一, 川島淳子, 森本光明, 山根源之 他
    • Journal Title

      皮膚病診療 27・増

      Pages: 27-30

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 歯性病巣感染と皮膚疾患2004

    • Author(s)
      高橋愼一, 森本光明, 山根源之
    • Journal Title

      東京都歯科医師会雑誌 52

      Pages: 213-220

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 亜鉛によるアレルギー性口内炎の診断におけるリンパ球幼若化試験の有用性について2004

    • Author(s)
      河合毅師, 森本光明, 山根源之, 高橋愼一他
    • Journal Title

      日本口腔粘膜学会雑誌 10

      Pages: 79-79

    • NAID

      10019240630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Quantitative Evaluation of Eyelid Elasticity Using Cutometer SEM575 and its Clinical Application in Assessing the Efficacy of Tacrolimus Ointment Treatment in Eyelid Atopic Dermatitis2004

    • Author(s)
      Tetsuya Kawakita, Shinichi Takahashi, et al.
    • Journal Title

      Cornea 23

      Pages: 468-471

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] 再発性多発性軟骨炎の1例2004

    • Author(s)
      川島淳子, 高橋愼一
    • Journal Title

      日本臨床皮膚科医学会雑誌 80

      Pages: 131-131

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 皮膚科における扁平苔癬の診断と治療2004

    • Author(s)
      高橋愼一
    • Journal Title

      日本口腔粘膜学会雑誌 10

      Pages: 58-58

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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