| Project/Area Number |
16592023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
AKIMOTO Yoshiaki Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (10147720)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Makiko (IKEDA Makiko) Nihon University, School of Dentistry at Matsudo, Research Assistant(Full-Time), 松戸歯学部, 助手 (00267113)
MATSUMOTO Hiroko Nihon University, School of Dentistry at Matsudo, Lecturer(Full-Time), 松戸歯学部, 講師 (50221594)
FUJII Akira Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70102564)
YAMAMOTO Hirotsugu Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (00102591)
HIRAYAMA Teruyasu Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (10189871)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | methicillin-resistant staphylococci / methicillin-resistant Staphylococcus aureus / methicillin-resistant Staphylococcus epidermidis / odontogenic infection / incidence of isolation / antimicrobial susceptibility / subcutanus abscess |
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| Research Abstract |
There were 611 cases of odontogenic infections in the course of the 3 years (April 2004-December 2006), in which staphylococci were isolated from 22 cases involving 16 cases of Staphylococcus aureus and 6 cases of Staphylococcus epidermidis. Concerning methicillin-resistant strain, there were one case of methicillin-resistant Staphylococcus aureus (MRSA) and two cases of methicillin-resistant Staphylococcus epidermidis (MRCoNS). The case ratios of MRSA/all odontogenic infections and MRCoNS/all odontogenic infections were 0.002 and 0.003, respectively. The frequency of both MRSA and MRCoNS were low (less than 1%). Although there were 19 cases of odontogenic infections caused by deciduous tooth infection, MRSA and MRCoNS were not isolated.
Most or all of MRSA and MRCoNS were sensitive to minocycline, arbekacin, rifampicin and vancomycin, but not sensitive to ampicillin, sulbenicillin, cefaclor, cefpiramide, flomoxef and tobramycin. Rifampicin showed the lowest MICs (< 0.1 mcg/ml). The sensitive drugs of MRSA were similar to those of MRCoNS.
In conclusion, the frequency of isolation of MRSA or MrCoNS was low. However, MRSA or MrCoNS was constantly isolated during 3 years, close attention should be paid to MRSA or MRCoNS infection in odontogenic infection.
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