| Project/Area Number |
16592068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KATAOKA Masatoshi The University of Tokushima, Institute for Geneome Research, Associate Professor, ゲノム機能研究センター, 助教授 (20224438)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Toshihiko The University of Tokushima, Institute of Health Bioscience, Professor, 大学院・ヘルスバイオサイエンス研究部, 教授 (10127847)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | drug-induced gingival overgrowth / calcium channel blocker / SNPs / gene polymorphism / gingival fibroblast / 歯周疾患 |
|---|
| Research Abstract |
α2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the α2 integrin gene is associated with high/low a2 integrin expression. The aim of this study was to test the hypothesis that expression of α2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the control (odds ratio, 3.61; 95% confidence interval, 2.14-6.10,P<0.05). The present findings suggest that the α2 807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.
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