| Project/Area Number |
16592092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
FUKUHARA Masayo Kyushu Dental College, Department of Dentistry, Research trainee, 歯学部, 特別研修員 (90360057)
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| Co-Investigator(Kenkyū-buntansha) |
ANSAI Toshihiri Kyushu Dental College, Department of Dentistry, Assistant professor, 歯学部, 助教授 (80244789)
TAKATA Yutaka Kyushu Dental College, Department of Dentistry, Professor, 歯学部, 教授 (40163208)
AKIFUSA Sumio Kyushu Dental College, Department of Dentistry, Research trainee, 歯学部, 特別研修員 (40295861)
SONOKI Kazuo Kyushu Dental College, Department of Dentistry, Assistant professor, 歯学部, 助手 (50316155)
TAKEHARA Tadamichi Kyushu Dental College, Department of Dentistry, Professor, 歯学部, 教授 (00038879)
脇坂 正則 九州歯科大学, 歯学部, 助教授 (60274437)
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| Project Period (FY) |
2004 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | elderly / chewing ability / cognitive impairment / mini-mental state examination / pulse wave velocity / arterial stiffness / 糖尿病 / HbA_<1C> / c-reactive protein / 炎症反応 / 住民 / 咀噛能力 |
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| Research Abstract |
Background and Purpose: Cognitive function is impaired in elderly subjects. We did dental and medical examination in 85-years-old subjects in Fukuoka, Japan and studied the relationship between chewing ability and cognitive function. The role of arterial stiffness on cognitive function was also determined.
Methods and Results: This study was designed to explore the relationship between the systemic and dental health conditions of very elderly subjects. Chewing ability was expressed as a number of the selected foods which a subject could chew. Cognitive function and arterial stiffness were assessed by the mini-mental state examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. Two-hundred and seven 85 years-old residents participated the survey and 205 (88 men and 117 women) completed the dental and physical examination, and MMSE. MMSE score was 23.8 ±0.3 (mean ± SE, full score 30) and the number of foods chewed was 10.7 ± 0.3 (full score 15). T
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here was a tendency towards positive correlation between the MMSE score and the number of foods chewed (coefficient of correlation 0.12, p=0.08). When we divided the subjects into 4 groups according to the chewing ability (the number of foods chewed 0-4, 5-9, 10-14, 15), the MMSE score of each group was 22.7 ± 1.3, 23.6 ± 0.7, 23.9 ± 0.5, 24.4 ± 0.5. We also studied the cross-sectional association of the MMSE score and PWV in 203 subjects (87 men and 116 women). Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score 【greater than or equal】24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group compared to the normal MMSE group (25.0 ± 0.8 vs. 22.9 ± 0.5 m/sec, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score.
Conclusions: Oral care to keep chewing ability might prevent cognitive impairment. Cognitive function could be predicted by arterial stiffness as assessed by the PWV in very old subjects. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age. Less
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