Photosensitivity and gene abnormality in circadian rhythm sleep disorders
| Project/Area Number |
16614005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
OKAWA Masako Shiga University of Medical Science, Department of Psychiatry, Professor, 医学部, 教授 (80160430)
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Hirohiko Shiga University of Medical Science, Department of Psychiatry, Assistant Professor, 医学部, 講師 (30293830)
OZEKI Yuji Shiga University of Medical Science, Department of Psychiatry, research associate, 医学部, 助手 (90303768)
KONISHI Mizuho Shiga University of Medical Science, Department of Psychiatry, Research Assistant, 医学部, 教務職員 (90378448)
定松 美幸 滋賀医科大学, 医学部, 講師 (90252387)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Photosensitivity / Gene / Biological rhythm / Temperature / Melatonin / 概日リズム睡眠障害 / 生体時計 / 高照度光 / 深部体温 / 眠気 / 時計遺伝子 |
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| Research Abstract |
Objectives of the study were to investigate the efficacy of hospitalization treatment with giving light therapy and social cues and to clarify their psychological characteristics using Picture-Frustration Study (P-F Study). The participants were 30 patients with circadian rhythm sleep disorders (18 delayed sleep phase syndrome ; DSPS patients, 5 non-24 hour sleep wake syndrome, 7 irregular sleep-wake rhythm) with school refusal during adolescence consisting of 20 boys and 10 girls (mean age±SD=16.0±1.4,range = 13-18) staying our ward during the period of between April 2004 and December 2005.
Over 90% of patients with school refusal improved their sleep-wake rhythm just after hospitalization, over 50% of them continued to improve their sleep-wake rhythm after discharge and were able to attend school after that. Significances between groups of improvement (I) and un-improvement (UI) in sleep wake rhythms were observed in the age of hospitalization, and the age of onset. I group showed higher ages of hospitalization and onset than UI group. The psychological characteristics for DSPS patients with school refusal, especially in patients who were not able to improve sleep-wake rhythm and school refusal after discharge were low aggression, low expression of their dissatisfaction, high suppression of their emotion, low social interest and high self-reproof. Patients who did not show improvement their sleep-wake rhythm through hospitalization have some psychological problems such as those mentioned above. Therefore, they may need to take psychological intervention such as the self-assertion training. Hospitalization and light therapy is useful for the treatment of circadian rhythm sleep disorders. The gene morphism study for patients have been undertaking in our laboratory.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Cerebral white matter blood flow is constant during human non-rapid eye movement sleep : a positron emission tomographic study2005
Author(s)
Hiroki M, Uema T, Kajimura N, Ogawa K, Nishikawa M, Kato M, Watanabe T, Nakajima T, Takano H, Imabayashi E, Ohnishi T, Takayama Y, Matsuda H, Uchiyama M, Okawa M, Takahashi K, Fukuyama H
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Journal Title
J Appl Physiol 98
Pages: 1846-1854
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Cerebral white matter blood flow is constant during human non-rapid eye movement sleep : a positron emission tomographic study2005
Author(s)
Hiroki M, Uema T, Kajimura N, Ogawa K, Nishikawa M, Kato M, Watanabe T, Nakajima T, Takano H, Imabayashi E, Ohnishi T, Takayama Y, Matsuda H, Uchiyama M, Okawa M, Takahashi K, Fukuyama H
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Journal Title
J Appl Physiol 98(5)
Pages: 1846-1854
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Deactivation by benzodiazepine of the basal forebrain and amygdala in normal humans during sleep : A placebo-controlled [^<15>O〕H_2O pet study2004
Author(s)
Kajimura N, Nishikawa M, Uchiyama M, Kato M, Watanabe T, Nakajima T, Honi T, Nakabayashi T, Sekimoto M, Ogawa K, Takano H, Imabayashi E, Hiroki M, Onishi T, Uema T, Takayama Y, Matsuda H, Okawa M, Takahashi K
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Journal Title
Am J Psychiatry 161(4)
Pages: 748-751
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Deactivation by benzodiazepine of the basal forebrain and amygdala in normal humans during sleep : A placebo-controlled [^<15>O]H2O pet study.2004
Author(s)
Kajimura N, Nishikawa M, Uchiyama M, Kato M, Watanabe T, Nakajima T, Hori T, Nakabayashi T, Sekimoto M, Ogawa K, Takano H, Imabayashi E, Hiroki M, Onishi T, Uema T, Takayama Y, Matsuda H, Okawa M, Takahashi K
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Journal Title
Am J Psychiatry 161(4)
Pages: 748-751
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Deactivation by benzodiazepine of the basal forebrain and amygdala in normal humans during sleep : A placebo-controlled [^<15>O]H2O pet study2004
Author(s)
Kajimura N, Nishikawa M, Uchiyama M, Kato M, Watanabe T, Nakajima T, Hori T, Nakabayashi T, Sekimoto M, Ogawa K, Takano H, Imabayashi E, Hiroki M, Onishi T, Uema T, Takayama Y, Matsuda H, Okawa M, Takahashi K
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Journal Title
Am J Pshchiatry 161(4)
Pages: 748-751
Related Report
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