Pathophysiological analysis of sleep-disordered breathing using mouse model of the disease
| Project/Area Number |
16614007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
睡眠学
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| Research Institution | Kyoto University |
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Principal Investigator |
KADOTANI Hiroshi Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (90362516)
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| Project Period (FY) |
2004 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Sleep / Sleep Apnea Syndrome / Sleep-disordered Breathing / Metabolic Syndrome / Brain Machine Interface / 睡眠障害 / 高血圧 / マウス / 概日リズム |
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| Research Abstract |
Hypoxia and hypercapnia may cause arousal from sleep and sleep fragmentation in human obstructive sleep apnea syndrome. Recently, several reports presented chronic repetitive ambient hypoxia as a rodent model of sleep-disordered breathing. However, with such a model, it is not possible to elucidate the relative roles of hypercapnia as well as hypoxia on sleep and vigilance. Thus, we made a mouse model of sleep-induced hypercapnia and/or hypoxia to assess this question.
With our model, we disrupted mouse from sleep for a week. As a result, not only sleep rebound, but also hypertension and hyperglycemia were induced in the mouse. This model may be very useful to elucidate interaction between sleep-disordered breathing and metabolic syndrome.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Acceptance and short-term tolerance of nasal continuous positive airway pressure therapy in elderly patients with obstructive sleep apnea.2004
Author(s)
Harada, M, Taniguchi, M, Ohi, M, Nakai, N, Okura, M, Wakamura, T, Tamura, M, Kadotani, H, Chin,K
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Journal Title
Sleep and Biological Rhythms 2・1
Pages: 53-56
Description
「研究成果報告書概要(和文)」より
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