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Molecular biological study for short sleeper (Identification of the short sleeper gene)

Research Project

Project/Area Number 16614010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 睡眠学
Research InstitutionAshikaga Institute of Technology

Principal Investigator

KOBAYASHI Toshinori  Ashikaga Institute of Technology, Department of Technology, Professor, 工学部, 教授 (70133642)

Co-Investigator(Kenkyū-buntansha) SHINOZAWA Takao  Waseda University, Department of Technology, Professor, 大学院・理工学研究科, 教授 (30025449)
Project Period (FY) 2004 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2006: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2004: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordsshort sleeper / daytime activity / short sleeper gene / human sleep / long sleeper / sleep length / actigram / REM sleep / 睡眠 / 遺伝子 / 人間 / 性格遺伝子 / ビジランス / 行動 / 性格 / 活動量 / 休止活動リズム / 時計遺伝子
Research Abstract

We estimated the relationship between human average sleep length and his daytime activity by the mathematical model in 2004. It was found that a human sleep length closely related to the activity level during daytime. Subjective Sleep Wakefulness Rhythm (SWR) and Rest Activity Cycle (RAC) were continuously recorded for two weeks for 15 university students by both the sleep log and the achigram in 2005. It was found that the activity level during day time for the short sleeper (SS) group, whose average sleep length was less than 6 hrs, was higher than the long sleeper (LS) group with their sleep length of more than 9 hrs. The 8 middle age businessmen with a considerable shorter sleep length were selected for the polisomnography (PSG) study, and their sleep were recorded for 3 consecutive nights in 2006. It was found that a REM episode was not continuously appeared in the SS group, whose sleep length was about 5 hrs and half, and that the discontinuity of REM sleep reflected their stressful days. There was not significant difference in personality estimated by YG personality test between the shorter and the long sleeper groups. However, we have a strong impression that the personality of SS group was characterized by both mentally aggressive and physically hyper active in compared with LL group.
It can be considered from these three years investigation that the behaviors of SS group is characterized by hyper activity level during day time in compared with LS group. So, it is possible that the personality gene with hyper activity during day time is the most important candidate as the short sleeper gene. It is no time to identify the gene related to short sleeper, because it took much time to identify the characteristics of SS-group for three years.

Report

(4 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • Research Products

    (10 results)

All 2006 2005 2004

All Journal Article (10 results)

  • [Journal Article] 睡眠リズムと子どもの発達2006

    • Author(s)
      小林敏孝
    • Journal Title

      子供の健康科学 7(1)

      Pages: 26-33

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 睡眠の分子生物学研究 (モデルによるショートスリーパの考察)2005

    • Author(s)
      山本理恵, 小林敏孝, 篠沢隆雄
    • Journal Title

      足利工業大学研究報告 39号

      Pages: 113-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular biological study for short sleeper (Mathematical model simulation for short sleeper)2005

    • Author(s)
      Rie Yamamoto, Toshinori Kobayashi, Takao Shinozawa
    • Journal Title

      Ashikaga Institute of Technology Research Report No.39

      Pages: 113-118

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mental sweat and personality2005

    • Author(s)
      Toshinori Kobayashi
    • Journal Title

      The psychophysiology meeting in Lille, France (Oral presentation)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 睡眠の分子生物学的研究(モデルによるショートスリーパの考察)2005

    • Author(s)
      山本理恵, 小林敏孝, 篠沢隆雄
    • Journal Title

      足利工業大学 研究紀要 39号

      Pages: 93-98

    • NAID

      110004616854

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 睡眠リズムと子供の健康2005

    • Author(s)
      小林敏孝
    • Journal Title

      子どもの健康科学 17巻(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 睡眠の分子生物学的研究(モデルによるショートスリーパの考察)2005

    • Author(s)
      山本理恵, 小林敏孝, 篠沢隆雄
    • Journal Title

      足利工業大学 研究集録 39

      Pages: 113-118

    • NAID

      110004616854

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 精神性発汗と性格傾向の関係2004

    • Author(s)
      冨田真一, 萬代 宰, 小林敏孝
    • Journal Title

      足利工業大学研究報告 38号

      Pages: 93-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The relationship between mental sweat and personality.2004

    • Author(s)
      Tomita Shinichi, Mandai Osamu, Toshinori Kobayashi
    • Journal Title

      Ashikaga Institute of Technology Research Report No.38

      Pages: 93-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 精神性発汗と性格傾向の関係(人間の情動能力の評価法の開発)2004

    • Author(s)
      富田真一, 萬代宰, 小林敏孝, 他
    • Journal Title

      足利工業大学 研究集録 38

      Pages: 79-82

    • Related Report
      2004 Annual Research Report

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Published: 2004-04-01   Modified: 2016-04-21  

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