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目標に向かう空間ナビゲーションのための視床下部ー海馬回路の機能解明

Research Project

Project/Area Number16F16386
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research
Host Researcher McHugh Thomas  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50553731)
Foreign Research Fellow CHEN SHUO  国立研究開発法人理化学研究所, 脳科学総合研究センター, 外国人特別研究員
Project Period (FY) 2016-10-07 – 2018-03-31
Project Status Granted(Fiscal Year 2017)
Budget Amount *help
¥2,300,000 (Direct Cost : ¥2,300,000)
Fiscal Year 2017 : ¥1,100,000 (Direct Cost : ¥1,100,000)
Fiscal Year 2016 : ¥1,200,000 (Direct Cost : ¥1,200,000)
Keywordshypothalamus / hippocampus / DG / spatial working memory
Outline of Annual Research Achievements

Optogenetic stimulation of SuM terminals in the DG does not impair social behavior, however we have found that inhibition of these projections leads to profound deficits in spatial working memory, while stimulation of the terminals impaired context habituation. In vivo recordings of hippocampal physiology during T-maze behavior combined with optogenetics suggests that silencing of this input impairs trajectory-specific firing rate modulation of CA1 pyramidal cells in a manner that correlates with an increase in error trials. These data establish the SuM inputs as a novel modulator of hippocampal spatial memory and we are currently conducting analyses to link the behavioral and single unit phenotypes to alterations in hippocampal oscillations and dynamic information routing in the circuit.

Current Status of Research Progress
Current Status of Research Progress

1 :  Research has progressed more than it was originally planned.

Reason

The project has developed several interesting lines of inquiry. The main focus on the role of the SuM/Dg circuit in spatial working memory has lead to clear behavioral and physiological phenotypes. In related work we have begun to examine the SuM projections to the medial septum and have striking and differential data showing that optogenetic stimulation of these fibers induces high speed movement and triggers a strong increase in the theta oscillation. these unexpected data will lead to a parallel series of experiments.

Strategy for Future Research Activity

We are currently focused on adding more In vivo recordings of hippocampal physiology during manipulation of the SuM fibres in both the DG and medial septum. The effort this fiscal year will be to complete data collection and begin detailed analyses.

Report

(1results)
  • 2016 Annual Research Report

Research Products

(1results)

All 2016

All Presentation

  • [Presentation] Go Social or Spatial: Divergent Information Routing by a Hypothalamo-hippocampal Circuit2016

    • Author(s)
      Shuo Chen, Yanqiu Tao, Marie Wintzer, Denis Polygalov, Arthur Huang, Roman Boehringer, Jingyi Chen, Thomas McHugh
    • Organizer
      Optogenetic Approaches to Understanding Neural Circuits & Behavior Gordon Research Conference
    • Place of Presentation
      Maine, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report

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Published : 2016-10-11   Modified : 2018-01-16  

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