Pursuit of Substances in Dynamic Ecological Systems

• Project/Area Number: 16GS0206
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: Keio University (2008); Nagoya University (2004-2007)
• Principal Investigator: UEMURA Daisuke Keio University, 理工学部, 教授 (00022731)
• Co-Investigator(Kenkyū-buntansha): ARIMOTO Hirokazu 東北大学, 大学院・生命科学研究科, 教授 (60262789) ; YOSHIDA Kumi 名古屋大学, 大学院・情報科学研究科, 准教授 (90210690) ; KITA Masaki 筑波大学, 大学院・数理物質科学研究科, 講師 (30335012) ; OHNO Osamu 名古屋大学, 大学院・理学研究科, 助教 (20436992)
• Project Period (FY): 2004 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥533,650,000 (Direct Cost: ¥410,500,000、Indirect Cost: ¥123,150,000); Fiscal Year 2008: ¥91,520,000 (Direct Cost: ¥70,400,000、Indirect Cost: ¥21,120,000); Fiscal Year 2007: ¥109,590,000 (Direct Cost: ¥84,300,000、Indirect Cost: ¥25,290,000); Fiscal Year 2006: ¥109,850,000 (Direct Cost: ¥84,500,000、Indirect Cost: ¥25,350,000); Fiscal Year 2005: ¥114,660,000 (Direct Cost: ¥88,200,000、Indirect Cost: ¥26,460,000); Fiscal Year 2004: ¥108,030,000 (Direct Cost: ¥83,100,000、Indirect Cost: ¥24,930,000)
• Keywords: 生態系ダイナミズム / 物質探索 / 生物活性評価 / 抗腫瘍性 / 脂肪蓄積阻害 / 天然物化学 / 生物浩性 / 共生現象鍵物質 / 化学生態学 / 巨大炭素鎖化合物 / 渦鞭毛藻 / 生物活性 / 脂肪蓄積阻害物質 / 炎症惹起物質 / 抗腫瘍性物質 / 骨粗鬆症治療薬 / 麻酔性物質 / 生物分子科学 / タンパク毒

Research Abstract

自然界での生物現象から真摯に学び、特異な生態系でくり広げられる生物現象を「生態系ダイナミズム」という視点で着目し、現象に関与する切れ味の良い有用天然有機分子の探索を試みた。また、新規化合物の単離・構造決定のみで満足することなく、化合物の展開利用までを視野に入れた姿勢で化学合成と生物学的意義の解明を目指した研究に取り組み、複数の重要化合物の発見及びその機能解明を達成した。本研究により、サンゴ幼生誘引物質や哺乳類毒の解明等これまで未解明であった現象に関与する物質を解明するとともに、関連科学分野への波及性を発揮する新規天然有機化合物の発見を導くことができ、生物分子科学の新領域を創成した。

Research Products

• [Journal Article] Recent aspects of chemical ecology : Natural toxins, coral communities, and symbiotic relationships (2009)
  • Author(s): D. Uemura, M. Kita, H. Arimoto, M. Kitamura
  • Journal Title: Pure Appl. Chem. 81(in press) Pages: 1093-1111
  • Peer Reviewed
• [Journal Article] Synthesis and structural determination of the C33-C42 fragment of symbiodinolide (2009)
  • Author(s): H. Takamura, et al.
  • Journal Title: Tetrahedron Lett. 50 Pages: 863-866
  • Peer Reviewed
• [Journal Article] A Transannular Diels-Alder Strategy to the Construction of the CDE Ring System of Nakiterpiosin (2009)
  • Author(s): H. Takamura, et al.
  • Journal Title: Heterocycles 77 Pages: 351-364
  • Peer Reviewed
• [Journal Article] Biologically Active Marine Natural Products (2009)
  • Author(s): K. Nakamura, et al.
  • Journal Title: Heterocycles 78 Pages: 1-17
  • Peer Reviewed
• [Journal Article] Design, synthesis, and biological evaluation of biotin-labeled (-)-ternatin a potent fat-accumulation inhibitor aeainst 3T3-L1 adioocytes (2009)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters 19 Pages: 92-95
  • Peer Reviewed
• [Journal Article] Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor aaainst 3T3-L1 adipocytes (2009)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: Bioorg. Med. Chem. Lett. 19 Pages: 867-869
  • Peer Reviewed
• [Journal Article] Application of FITC-labeled Ternatin on Its Cellular Localization in 3T3-L1 Murine Preadipocytes (2009)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: Chemistry Letters 38 Pages: 150-151
  • Peer Reviewed
• [Journal Article] 天然物化学の現状と今後の課題 (2009)
  • Author(s): 上村大輔
  • Journal Title: 化学と工業 62-2 Pages: 133-137
• [Journal Article] 表紙の顔 下村脩 (生物化学者) (2009)
  • Author(s): 上村大輔
  • Journal Title: 学術の動向 3月号 Pages: 3-3
• [Journal Article] 2008年ノーベル化学賞 下村脩博士を祝って (2009)
  • Author(s): 上村大輔
  • Journal Title: 学術の動向 3月号 Pages: 8-10
  • NAID: 130002049620
• [Journal Article] ケミカルバイオロジーの研究動向 (2009)
  • Author(s): 上村大輔
  • Journal Title: 学術の動向 2009年3月号 Pages: 11-14
  • NAID: 130002049599
• [Journal Article] Recent aspects of chemical ecology -Natural toxins, coral communities, and symbiotic relationships- (2009)
  • Author(s): D. Uemura, et al.
  • Journal Title: Pure Appl. Chem. 81 Pages: 1093-1111
  • Peer Reviewed
• [Journal Article] First total synthesis and biological evaluation of the cyclic heptapeptide rhizonin A (2009)
  • Author(s): H. Nakatsuka, et al.
  • Journal Title: Tetrahedron Lett. 50 Pages: 186-188
  • Peer Reviewed
• [Journal Article] Importance of the backbone conformation of (-)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes (2009)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: Org. Biomol. Chem. 7 Pages: 777-784
  • Peer Reviewed
• [Journal Article] 強力な生物活性物質の新世界 (2009)
  • Author(s): 上村大輔
  • Journal Title: 化学のブレークスルー【有機化学編】革新論文から見たこの10年の進歩と未来、化学同人編集部編 Pages: 33-38
• [Journal Article] 哺乳類の持つ毒の科学-トガリネズミ、カモノハシ毒の謎に迫る- (2009)
  • Author(s): 北将樹
  • Journal Title: ビオフィリア 5 Pages: 29-33
  • Peer Reviewed
• [Journal Article] 有機化学のブレークスルー-この10年の進歩を振り返り、その未来を語る (2009)
  • Author(s): 上村大輔
  • Journal Title: 化学 64 Pages: 12-17
• [Journal Article] (-)-Complanine, an Inflammatory Substance of Marine Fireworm: a Synthetic Study (2009)
  • Author(s): K. Nakamura, et al.
  • Journal Title: Beilstein J. Org. Chem. 5
  • Peer Reviewed
• [Journal Article] Chemical Studies on Different Color Development in Blue- and Red-Colored Sepal Cells of Hydrangea macrophylla (2009)
  • Author(s): D. Ito, et al.
  • Journal Title: Biosci. Biotech. Biochem. (印刷中)
  • Peer Reviewed
• [Journal Article] Identification and characterization of flavonoids as sialyltransferase inhibitors (2009)
  • Author(s): I. P. J. K. Hidari, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. (印刷中)
  • Peer Reviewed
• [Journal Article] Blue flower color development by anthocyanins: from chemical structure to cell physiology (2009)
  • Author(s): K. Yoshida, et al.
  • Journal Title: Nat. Prod. Rep. (印刷中)
  • Peer Reviewed
• [Journal Article] A Vacuolar iron transporter in tulip, TgVit1, is responsible for blue coloration in petal cells through Iron accumulation (2009)
  • Author(s): K. Momonoi, et al.
  • Journal Title: Plant J. (印刷中)
  • Peer Reviewed
• [Journal Article] (-)-Ternatin inhibits adipogenesis and lipid metabolism in 3T3-L1 cells (2009)
  • Author(s): M. Ito, et al.
  • Journal Title: Peptides (印刷中)
  • Peer Reviewed
• [Journal Article] Symbiospirols: Novel Long Carbon-chain Compounds Isolated from Symbiotic Marine Dinoflagellate Symbiodinium sp. (2009)
  • Author(s): Y. Tsunematsu, et al.
  • Journal Title: Org. Lett. (印刷中)
  • Peer Reviewed
• [Journal Article] Whole Structure-Activity Relationships of the Fat-Accumulation Inhibitor (-)-ternatin : Recognition of the Importance of Each Amino Acid Residue (2008)
  • Author(s): K. Shimokawa, Y. Iwase, R. Miwa, K. Yamada, D. Uemura
  • Journal Title: J. Med. Chem. 51 Pages: 5912-5914
  • Peer Reviewed
• [Journal Article] Biological activity, structural features, and synthetic studies of (-)-ternatin, a potent fat-accumulation inhibitor of 3T3-L1 adipocytes (2008)
  • Author(s): K. Shimokawa, I. Mashima, A. Asai, T. Ohno, K. Yamada, M. Kita, D. Uemura
  • Journal Title: Chem. Asian J. 3 Pages: 348-3446
  • Peer Reviewed
• [Journal Article] Synthesis and inhibitory effect on fat accumulation of (-)-ternatin derivatives modified in the β-OH-D-Leu7 moiety (2008)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: Org. Biomol. Chem. 6 Pages: 58-60
  • Peer Reviewed
• [Journal Article] Complanine, an inflammation-inducing substance isolated fromthe marine fireworm Eurythoe complanata (2008)
  • Author(s): K. Nakamura, et al.
  • Journal Title: Organic & Biomolecular Chemistry 6 Pages: 2058-2060
  • Peer Reviewed
• [Journal Article] Structure-Activity Relationship of Okadaic Acid, a Potent Proteinphosphatases PP1 and PP2A Inhibitor: 24-epi-Okadaic Acid and a 18-Membered Lactone Analog (2008)
  • Author(s): M. Kita, et al.
  • Journal Title: Heterocycles 76 Pages: 1033-1042
  • NAID: 40016323209
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Benzyl Benzoate and Its Derivatives on Angiotensin II-Induced Hypertension (2008)
  • Author(s): O. Ohno, et al.
  • Journal Title: Bioorganic & Medicinal Chemistry 16 Pages: 7843-7852
  • Peer Reviewed
• [Journal Article] 海洋生物毒 (2008)
  • Author(s): 中村和彦, ほか
  • Journal Title: 天然物化学-海洋生物編-、山村庄亮・長谷川宏司・木越英夫編著、アイピーシー出版 Pages: 126-144
  • Peer Reviewed
• [Journal Article] Stereocontrolled synthesis of the C79-C96 fragment of symbiodinolide (2008)
  • Author(s): H. Takamura, et al.
  • Journal Title: Tetrahedron Lett. 49 Pages: 4626-4629
  • Peer Reviewed
• [Journal Article] Whole Structure-Activity Relationships of the Fat-Accumulation Inhibitor (-)-ternatin: Recognition of the Importance of Each Amino Acid Residue (2008)
  • Author(s): K. Shimokawa, et al.
  • Journal Title: J. Med. Chem. 51 Pages: 5912-5914
  • Peer Reviewed
• [Journal Article] The conformational features of palytoxin in aqueous solution (2008)
  • Author(s): T. Inuzuka, et al.
  • Journal Title: Tetrahedron 64 Pages: 7718-7723
  • Peer Reviewed
• [Journal Article] Novel cleavage of (E)-allyl vic-diols to aldehydes using the 2nd-generation Grubbs catalyst (2008)
  • Author(s): C. Han, et al.
  • Journal Title: Tetrahedron Lett. 49 Pages: 6988-6990
  • Peer Reviewed
• [Journal Article] Reinvestigation of the bitter compounds in carrots (Daucus carota L. ) by using a molecular sensory science approach (2008)
  • Author(s): L. Schmiech, et al.
  • Journal Title: J. Agric. Food. Chem. 56 Pages: 10252-10260
  • Peer Reviewed
• [Journal Article] 時を越える「ひと」、「もの」、「こころ」 (2008)
  • Author(s): 上村大輔
  • Journal Title: 有機合成化学協会誌 1 Pages: 1-1
• [Journal Article] Biological Activity, Structural Features, and Synthetic Studies of (-)-Ternatin, a Potent Fat-accumulation Inhibitor of 3T3-L1 Adipocytes (2008)
  • Author(s): Shimokawa, K., et. al.
  • Journal Title: Chem. Asian J. 3 Pages: 438-446
  • Peer Reviewed
• [Journal Article] Durinskiol B: A New Durinskiol Congener from the Symbiotic Marine Dinoflagel late Durinskia sp. (2008)
  • Author(s): Siwu, E. R. O., et. al.
  • Journal Title: Chem. Lett. 37 Pages: 236-237
  • Peer Reviewed
• [Journal Article] Cyclic Tetrapeptides from Marine Bacteria Associated with the Seaweed Digineasp. and the Sponge Halisarca Ectofibrosa. (2008)
  • Author(s): Rungprom, W., et. al.
  • Journal Title: Tetrahedron 64 Pages: 3147-3152
  • Peer Reviewed
• [Journal Article] Synthesis and Inhibitory Effect on Fat Accumulation of (-)-Ternatin Derivatives Modified in the (β-OH-D-Leu7 Moiety (2008)
  • Author(s): Shimokawa, K., et. al.
  • Journal Title: Org. Biomol. Chem. (in press)
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Benzyl Benzoate and Its Derivatives on Angiotensin II-Induced Hypertension. (2008)
  • Author(s): Ohno, O., et. al.
  • Journal Title: Bioorg. Med. Chem. (in press)
  • Peer Reviewed
• [Journal Article] Asymmetric Total Synthesis of Pinnaic Acid (2007)
  • Author(s): S. Xu, H. Arimoto, D. Uemura
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 5746-5749
  • Peer Reviewed
• [Journal Article] Symbiodinolide, a novel polyol macrolide that activates N-type Ca^<2+> channel, from the symbiotic marine dinoflagellate Symbiodinium sp (2007)
  • Author(s): M. Kita, N. Ohishi, K. Konishi, M. Kondo, T. Koyama, M. Kitamura, K. Yamada, D. Uemura
  • Journal Title: Tetrahedron 63 Pages: 6241-6251
  • Peer Reviewed
• [Journal Article] Molecular Shape of Palytoxin in Aqueous Solution (2007)
  • Author(s): T. Inuzuka, T. Fujisawa, H. Arimoto, D. Uemura
  • Journal Title: Org. Biomol. Chem. 5 Pages: 897-899
  • Peer Reviewed
• [Journal Article] Identification of Proteins from Venom of the Paralytic Spider Wasp (2007)
  • Author(s): T. Yamamoto, H. Arimoto, T. Kinumi, Y. Oba, D. Uemura
  • Journal Title: Cyphononyx dorsalis, Insect Biochem. Mol. Biol. 37 Pages: 278-286
  • Peer Reviewed
• [Journal Article] Metathesis Approach to a 16-Memberd Macrocycle of Kendomycin (2007)
  • Author(s): Sengoku, T., et. al.
  • Journal Title: Chem. Lett. 36 Pages: 726-727
  • Peer Reviewed
• [Journal Article] Studies toward the Total Synthesis of Nakiterpiosin: Construction of the CDE Ring System by a Transannular Diels-Alder Strategy (2007)
  • Author(s): Ito, T., et. al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 5465-5469
  • Peer Reviewed
• [Journal Article] Concise Synthesis of a Highly Functionalized Cyclopentane Segment: Toward the Total Synthesis of Kansuinine A (2007)
  • Author(s): Shimokawa, K., et. al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 5623-5625
  • Peer Reviewed
• [Journal Article] Convergent Synthesis and in Vivo Inhibitory Effect on Fat Accumulation of (-)-Ternatin, a Highly N-Methylated Cyclic Peptide (2007)
  • Author(s): Shimokawa, K., et. al.
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 4447-4449
  • Peer Reviewed
• [Journal Article] Asymmetric Total Synthesis of Pinnaic Acid (2007)
  • Author(s): Xu, S., et. al.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 5746-5749
  • Peer Reviewed
• [Journal Article] Preparation of Quinoline Hexose Analogs as Novel Chloroquine-Resistant Malaria Treatments(1). Synthesis of 4-Hydroxyquinoline-β-glucosides (2007)
  • Author(s): Suzuki, H., et. al.
  • Journal Title: Chem. Pharm. Bull. (Tokyo) 55 Pages: 821-824
  • Peer Reviewed
• [Journal Article] Revised Structure of Kasarin, an Antibacterial Pyrazinone Compound from the Marine Microorganism Hyphomycetes sp. (2007)
  • Author(s): Kita, M., et. al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 8628-8631
  • Peer Reviewed
• [Journal Article] 最先端の化学:海洋生物は生命の謎をひもとく切れもの分子の宝庫です (2007)
  • Author(s): 上村大輔
  • Journal Title: 化学大好きクラブニュースレター(日本化学会編) 3 Pages: 8-9
• [Journal Article] ケミカルバイオロジー:未解明生命現象 (2007)
  • Author(s): 中村和彦, ほか
  • Journal Title: 蛋白質核酸酵素 52巻13号 Pages: 1661-1666
• [Journal Article] Studies Toward the Total Synthesis of Nakiterpiosin: Construction of the CDE Ring System by a Transannular Diels-Alder Strategy (2007)
  • Author(s): T. Ito, M., et. al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 5465-5469
  • Peer Reviewed
• [Journal Article] Synthesis of Designed Acylquinic Acid Derivatives Involved in Blue Color Development of Hydrangea and Their Co-pigmentation Effect. (2007)
  • Author(s): Toyama-Kato, Y., et. al.
  • Journal Title: Heterocylces 72 Pages: 239-254
  • Peer Reviewed
• [Journal Article] Synthesis of Pelargonidin 3-O-6"-O-acetyl-β-D-glucopyranoside, an Acylated Anthocyanin, via the Corresponding Kaempferol Glucoside. (2007)
  • Author(s): Oyama, K., et. al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 6005-6009
  • Peer Reviewed
• [Journal Article] Analysis of Benzylation Products of (+)-Catechin. (2007)
  • Author(s): Nakamura, S, et. al.
  • Journal Title: Heterocylces 73 Pages: 451-460
  • Peer Reviewed
• [Journal Article] 注目の論文:ハチの性フェロモンを巧妙に利用する寄生昆虫 (2007)
  • Author(s): 北 将樹
  • Journal Title: 化学 62 Pages: 56-57
• [Journal Article] Characterization of a Natural Inducer of Coral Larval Metamorphosis. (2007)
  • Author(s): Kitamura, M. et al.
  • Journal Title: J.Exp.Mar.Biol.Ecol. 340 Pages: 96-102
• [Journal Article] Identification of Proteins from Venom of the Paralytic Spider Wasp, Cyphononyx dorsalis. (2007)
  • Author(s): Yamamoto, T. et al.
  • Journal Title: Insect Biochem.Mol.Biol. 37 Pages: 278-286
• [Journal Article] Cytotoxic Haterumadienone Congeners from the Okinawan Sponge Dysidea sp. (2007)
  • Author(s): Ueda, K. et al.
  • Journal Title: Heterocycles 72 Pages: 655-663
• [Journal Article] Molecular Shape of Palytoxin in Aqueous Solution. (2007)
  • Author(s): Inuzuka, T. et al.
  • Journal Title: Org.Biomol.Chem. Pages: 897-899
• [Journal Article] Symbiodinolide, a novel polyol macrolide that activates N-type Ca^<2+> channel from the symbiotic dinoflagellate Symbiodinium sp. (2007)
  • Author(s): Kita, M. et al.
  • Journal Title: Tetrahedron (in press)
• [Journal Article] Durinskiol A : A Long Carbon-Chain Polyol Compound from the Symbiotic Dinoflagellate Durinskia sp. (2007)
  • Author(s): Kita, M. et al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 3423-3427
• [Journal Article] Relative Stereochemistries of the Ether Rings and Sugar Moieties in Durinskiol A. (2007)
  • Author(s): Kita, M. et al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 3429-3432
• [Journal Article] Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria. (2007)
  • Author(s): Lu, J.et al.
  • Journal Title: Chem.Commun. Pages: 251-253
• [Journal Article] Ring-closing Metathesis Approach to a 16-Memberd Macrocycle of Kendomycin. (2007)
  • Author(s): Sengoku, T. et al.
  • Journal Title: Chem.Lett. (in press)
• [Journal Article] 海洋共生藻由来の超炭素鎖有機分子 (2007)
  • Author(s): 北将樹ら
  • Journal Title: 化学と生物 45 Pages: 58-63
  • NAID: 10020173943
• [Journal Article] 注目の論文:ハチの性フェロモンを巧妙に利用する寄生昆虫 (2007)
  • Author(s): 北将樹
  • Journal Title: 化学 62 Pages: 56-57
• [Journal Article] 最先端の化学:海洋生物は生命の謎をひもとく切れもの分子の宝庫です (2007)
  • Author(s): 上村大輔
  • Journal Title: 化学と工業 (印刷中)
• [Journal Article] Perianth bottom-specific blue color development in tulip cv. Murasakizuisho requires ferric ions. (2007)
  • Author(s): Shoji, K. et al.
  • Journal Title: Plant Cell Physiol. 48 Pages: 243-251
• [Journal Article] Cloning and characterization of ACC oxidase genes from tulip. (2007)
  • Author(s): Momonoi, K. et al.
  • Journal Title: Plant Biotechnology. 24 Pages: 241-246
• [Journal Article] Bioorganic Studies on Marine Natural Products.-Diverse Chemical Structures and Bioactivities- (2006)
  • Author(s): D. Uemura
  • Journal Title: Chem. Rec. 6 Pages: 235-248
  • Peer Reviewed
• [Journal Article] Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp. (2006)
  • Author(s): Washida, K. et al.
  • Journal Title: Tetrahedron Lett. 47 Pages: 2521-2525
• [Journal Article] Hepatoprotective Effect of a Hot-water Extract from the Edible Thomy Oyster Spondylus varius on Carbon Tetrachloride-Induced Liver Injury in Mice. (2006)
  • Author(s): Koyama.T.et al.
  • Journal Title: Biosci.Biotech.Biochem. 70 Pages: 729-731
• [Journal Article] Possibility of a non-amino acid pathway in the biosynthesis of marine-derived oxazoles. (2006)
  • Author(s): Ichino, T. et al.
  • Journal Title: Chem. Commun. Pages: 1742-1744
• [Journal Article] (-)-Ternatin, a highly N-methylated cyclic hepta-peptide that inhibits fat accumulation : structure and synthesis. (2006)
  • Author(s): Shimokawa, K. et al.
  • Journal Title: Tetrahedron Lett. 47 Pages: 4445-4448
• [Journal Article] Stereochemistry of pteriatoxins A, B, and C. (2006)
  • Author(s): Hao, J.et al.
  • Journal Title: J.Am.Chem.Soc. 128 Pages: 7742-7743
• [Journal Article] Haterumadysins A-D : sesquiterpenes from die Okinawan marine sponge Dysidea chlorea. (2006)
  • Author(s): Ueda, K. et al.
  • Journal Title: J.Nat.Prod. 69 Pages: 1077-1079
• [Journal Article] Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp. : isolation, structure elucidation and structure-activity relationship. (2006)
  • Author(s): Uddin, J. et al.
  • Journal Title: Bioorg.Med.Chem. 14 Pages: 6954-6961
• [Journal Article] Stereoselective construction of the octalin unit of symbioimine using an intramolecular Diels-Alder reaction. (2006)
  • Author(s): Sakai, E. et al.
  • Journal Title: Tetrahedron Lett. 47 Pages: 6343-6345
• [Journal Article] Bioorganic Studies on Marine Natural Products. -Diverse Chemical Structures and Bioactivities-. (2006)
  • Author(s): Uemura, D.
  • Journal Title: Chem.Rec. 6 Pages: 235-248
• [Journal Article] Effect of Ascorbic Acid on Chemiluminescence of Polyphenols. (2006)
  • Author(s): Inoue, N. et al.
  • Journal Title: Biosci.Biotechnol.Biochem. Pages: 1517-1520
• [Journal Article] Ferric ions involved in the flower color development of the Himalayan blue poppy, Meconopsis grandis. (2006)
  • Author(s): Yoshida, K. et al.
  • Journal Title: mistry 67 Pages: 992-998
• [Journal Article] A novel and efficient synthesis of cyanidin 3-O-b-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. (2006)
  • Author(s): Kondo, T. et al.
  • Journal Title: Org.Lett. 8 Pages: 239-251
• [Journal Article] 海洋由来の生物活性物質の探索 (2006)
  • Author(s): 北将樹ら
  • Journal Title: 有機合成化学協会誌 64 Pages: 471-480
  • NAID: 10017486610
• [Journal Article] ヒマラヤの青いケシの発色機構-シアニジン配糖体-フラボノール-Fe^<3+>の超分子錯体形成の妙 (2006)
  • Author(s): 吉田久美
  • Journal Title: 化学と生物 44 Pages: 726-728
• [Journal Article] Karatungiols A and B, two novel antimicrobial polyol compounds, from the symbiotic marine dinoflagellate Amphidinium sp. (2006)
  • Author(s): K.Washida et al.
  • Journal Title: Tetrahedron Letters 47 Pages: 2521-2525
• [Journal Article] Hepatoprotective Effect of a Hot-water Extract from the Edible Thorny Oyster Spondylus varius on Carbon Tetrachloride-Induced Liver Injury in Mice. (2006)
  • Author(s): T.Koyama et al.
  • Journal Title: Bioscience, Biotechnology, and Biochemistry (印刷中)
• [Journal Article] Possibility of a non-amino acid pathway in the biosynthesis of marine-derived oxazoles. (2006)
  • Author(s): T.Ichino et al.
  • Journal Title: Chemical Communications (印刷中)
• [Journal Article] 海洋由来の生物活性物質の探索 (2006)
  • Author(s): 北将樹ら
  • Journal Title: 有機合成化学協会誌 (印刷中)
  • NAID: 10017486610
• [Journal Article] Iminium Alkaloids from marine Invertebrates : Structure, Biological Activity, and Biogenesis (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Chemistry Letters 34 Pages: 454-459
  • NAID: 10015514686
• [Journal Article] Purification and characterisation of blarinasin, a new tissue kallikrein-like protease from the short-tailed shrew Blarina brevicauda-comparative studies with blarina toxin. (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Biological Chemistry 386 Pages: 177-182
  • NAID: 120000953590
• [Journal Article] Concise Synthesis of the Plant Glowth Regulator Theobroxide (2005)
  • Author(s): H.Arimoto et al.
  • Journal Title: Journal of Agricultural Food Chemistry 53 Pages: 3863-3866
• [Journal Article] Synthetic Studies on Sugar-fused Erinacines (2005)
  • Author(s): A.Sato et al.
  • Journal Title: Organic and Biomolecular Chemistry 3 Pages: 2231-2233
• [Journal Article] Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp. (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Bioorganic Medicinal Chemistry 13 Pages: 5253-5258
• [Journal Article] Synthetic Studies of Norzoanthamine. Preparation of the Diene-yne-diene Precursor of an ABC-ring Fragment. (2005)
  • Author(s): T.Irifune et al.
  • Journal Title: Chemistry Letters 34 Pages: 1058-1059
• [Journal Article] Corallinafuran and Corallinaether, Novel Toxic Compounds from Crustose Coralline Red Algae. (2005)
  • Author(s): M.KItamura et al.
  • Journal Title: Chemistry Letters 34 Pages: 1272-1273
• [Journal Article] Haterumadienone : a new cytotoxic puupehenone congener from the Okinawan marine sponge Dysidea chlorea de Laubenfels (2005)
  • Author(s): K.Ueda et al.
  • Journal Title: Chemistry Letters 34 Pages: 1530-1531
• [Journal Article] Feeding attractants for the muricid gastropod Dupella cornus, a coral predator (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Tetrahedron Letters 46 Pages: 8583-8585
• [Journal Article] Iminium Alkaloids from Marine Invertebrates : Structure, Biological Activity, and Biogenesis (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Chem.Lett. 34 Pages: 454-459
  • NAID: 10015514686
• [Journal Article] Purification and Characterisation of Blarinasin, A New Tissue Kallikrein-like Protease from the Short-tailed Shrew Blarina brevicauda - comparative Studies with Blarina Toxin (2005)
  • Author(s): M.Kita et al.
  • Journal Title: Biol.Chem. 386 Pages: 177-182
  • NAID: 120000953590
• [Journal Article] Concise Synthesis of A Plant Growth Regulator Theobroxide (2005)
  • Author(s): H.Arimoto et al.
  • Journal Title: J.Agr.Food Chem (in press)
• [Journal Article] Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda : isolation and characterization (2004)
  • Author(s): M. Kita, Y. Nakamura, Y. Okumura, S. D. Ohdachi, Y. Oba, M. Yoshikuni, H. Kido, D. Uemura
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 101 Pages: 7542-7547
  • NAID: 120002646891
  • Peer Reviewed
• [Journal Article] Symbioimine Exhibiting Inhibitory Effect of Osteoclast Differentiation, from the Symbiotic Marine Dinoflagellate Symbiodinium sp. (2004)
  • Author(s): M. Kita, M. Kondo, T. Koyama, K. Yamada, T. Matsumoto, K. H. Lee, J. T. Woo, D. Uemura
  • Journal Title: J. Am. Chem. Soc. 126 Pages: 4794-4795
  • Peer Reviewed
• [Journal Article] Bioactive Alkaloids from the Sea : A Review (2004)
  • Author(s): M.Kuramoto, et al.
  • Journal Title: Mar.Drugs 1 Pages: 39-54
• [Journal Article] Enantioselective Synthesis of the Spirotetracyclic Carbon Core of Mangicols using a Stereoselective Transannular Diels-Alder Strategy (2004)
  • Author(s): K.Araki et al.
  • Journal Title: Angew.Chem.Int.Engl. 43 Pages: 81-84
• [Journal Article] Isolation of Tribromoacetamide from an Okinawan Alga and Biological Activities of Its Analogs (2004)
  • Author(s): H.Kigoshi, et al.
  • Journal Title: Chem.Lett. 33 Pages: 98-99
• [Journal Article] Symbioimine Exhibiting Inhibitory Effect of Osteoclast Differentiation, from the Symbiotic Marine Dinoflagellate Symbiodinium sp. (2004)
  • Author(s): M.Kita et al.
  • Journal Title: J.Am.Chem.Soc. 126 Pages: 4794-4795
• [Journal Article] Synthetic Approach to Kendomycin : Preparation of the C-glycosidic Core (2004)
  • Author(s): T.Sengoku et al.
  • Journal Title: Chem.Commun. Pages: 1220-1221
• [Journal Article] Synthesis of the tricyclic core of halichlorine (2004)
  • Author(s): I.Hayakawa et al.
  • Journal Title: Chem.Commun. Pages: 1222-1223
• [Journal Article] Blarina Toxin, A Novel Mammalian Lethal Venom from the Short-tailed Shrew Blarina brevicauda : Isolation and Characterization (2004)
  • Author(s): M.Kita et al.
  • Journal Title: Proc.Natl.Acad.Sci.U.S.A. 101 Pages: 7542-7547
• [Journal Article] 世界をリードする日本の科学:生物現象に学ぶ天然物化学-生態系ダイナミズムに着目した物質探索- (2004)
  • Author(s): 上村大輔
  • Journal Title: 現代化学 400 Pages: 32-35
• [Journal Article] Chemistry of Biologically and Physiologically Intriguing Phenomena (2004)
  • Author(s): D.Uemura
  • Journal Title: Tetrahedron 60 Pages: 6969-6969
• [Journal Article] Nakiterpiosin and Nakiterpiosinone, Novel Cytotoxic C-nor-D-homosteroids from the Okinawan Sponge Terpios hoshinota (2004)
  • Author(s): T.Teruya et al.
  • Journal Title: Tetrahedron 60 Pages: 6989-6993
• [Presentation] 植物由来クマリン系化合物によるアンジオテンシンII阻害作用 (2009)
  • Author(s): 大野修, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] 好熱性古細菌由来エステラーゼを用いた新規ドミノ型反応の開発 (2009)
  • Author(s): 和田玲奈, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] アリールマロン酸脱炭酸酵素の最適pHの改変に関する研究 (2009)
  • Author(s): 宮内祐介, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] 立体選択的アルコールオキシダーゼの精製とクローニング (2009)
  • Author(s): 藤森久美子, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] トロパ酸脱水素酵素の精製とその反応性に関する研究 (2009)
  • Author(s): 門脇英希, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] マンデル酸誘導体のデラセミ化反応の開発 (2009)
  • Author(s): 佐野知子, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] ハリクロリンの不斉全合成研究 (2009)
  • Author(s): 許述, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] サンゴ幼生に作用する無節サンゴモの他感作用物質(2) (2009)
  • Author(s): 北村誠, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] ウミケムシ由来の炎症惹起物質complanineの全合成 (2009)
  • Author(s): 中村和彦, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-29
• [Presentation] アジサイの青色超分子色素の構造研究 (2009)
  • Author(s): 伊藤大輔, ほか
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-03-29
• [Presentation] カタトゲパンノキ抽出物のアンジオテンシンII誘発血圧上昇抑制作用 (2009)
  • Author(s): 藤原智恵, ほか
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-03-29
• [Presentation] 有毒哺乳動物カモノハシ由来の神経毒に関する生物有機化学的研究 (2009)
  • Author(s): 北将樹, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] アクチン脱重合性マクロリドmycalolide Bの合成研究 (2009)
  • Author(s): 渡辺秀和, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] ポリオールマクロライドsymbiodinolideの第二世代Grubbs触媒を用いた構造解析 (2009)
  • Author(s): 山野喜, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] 渦鞭毛藻の産生するVCAM-1発現阻害物質の研究 (2009)
  • Author(s): 丸範人, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] シンビオジノライドC23-C34フラグメントの合成 (2009)
  • Author(s): 佐野将之
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] シンビオジノライドC33-C42フラグメントの合成および構造決定 (2009)
  • Author(s): 高村浩由, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] シンビオジノライドC79-C96フラグメントの立体選択的合成 (2009)
  • Author(s): 高村浩由, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] Jatrophaneジテルペンと5員環セグメントの合成研究 (2009)
  • Author(s): 下川賢一郎, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] シンビオジノライドC33-C42フラグメントの合成研究 (2009)
  • Author(s): 青山陽子, ほか
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 船橋市
  • Year and Date: 2009-03-28
• [Presentation] 赤小豆種皮に含まれる色素の単離と構造に関する研究 (2009)
  • Author(s): 小西香織, ほか
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-03-28
• [Presentation] ネモフィラ青色花弁に含まれるメタロアントシアニンの構造と発色に関する化学的研究 (2009)
  • Author(s): 山下佳子, ほか
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡市
  • Year and Date: 2009-03-28
• [Presentation] 2008年ノーベル化学賞に輝く下村脩博士-時を超える-「ひと」、「もの」、「こころ」- (2009)
  • Author(s): 上村大輔
  • Organizer: 名古屋大学レクチャー
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-03-26
• [Presentation] アジサイのガク片におけるEST解析 (2009)
  • Author(s): 高橋英之, ほか
  • Organizer: 日本植物生理学会2009年度年会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-03-21
• [Presentation] 生物現象に着目した生物活性天然物の探索研究 (2009)
  • Author(s): 上村大輔
  • Organizer: 内藤財団振興賞受賞講演
  • Place of Presentation: 東京都
  • Year and Date: 2009-03-17
• [Presentation] 微生物・植物を用いた新規素材探索研究 (2009)
  • Author(s): 大野修
  • Organizer: 第4回名古屋大学技術研修会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-03-05
• [Presentation] 医薬分野における海洋生物の有効活用とノーベル賞 (2009)
  • Author(s): 上村大輔
  • Organizer: 慶應義塾大学K^2オープンセミナー
  • Place of Presentation: 川崎市
  • Year and Date: 2009-02-07
• [Presentation] 天然由来化学物質の生物活性に関して (2009)
  • Author(s): 上村大輔
  • Organizer: 健康食品管理士会関東支部設立総会および記念講演会
  • Place of Presentation: 東京都
  • Year and Date: 2009-02-01
• [Presentation] 海洋天然物の多様な構造と生物活性 (2008)
  • Author(s): 上村大輔
  • Organizer: 第13回岡山理科大学ハイテクリサーチセンターシンポジウム
  • Place of Presentation: 岡山市
  • Year and Date: 2008-12-11
• [Presentation] 青色花色発現に関与する液胞膜上の輸送体 (2008)
  • Author(s): 吉田久美
  • Organizer: 特定領域研究シンポジウム「土壌-植物系の物質移行:生産性向上を目指して」
  • Place of Presentation: 東京都
  • Year and Date: 2008-12-05
• [Presentation] 細胞内天然物化学による花色発現機構の解明 (2008)
  • Author(s): 吉田久美
  • Organizer: 植物色素研究会20周年記念大会
  • Place of Presentation: 熊本市
  • Year and Date: 2008-11-29
• [Presentation] 3, 4-ジアセトキシフラバン誘導体を用いたプロシアニジンの合成 (2008)
  • Author(s): 尾山公一, ほか
  • Organizer: 第39回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-08
• [Presentation] 赤アズキ種皮の登熟に伴う色素変化に関する化学的研究 (2008)
  • Author(s): 小西香織, ほか
  • Organizer: 日本農芸化学会中部支部第153回例会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-01
• [Presentation] ネモフィラ青色花弁に含まれるメタロアントシアニンの構造と発色に関する化学的研究 (2008)
  • Author(s): 山下佳子, ほか
  • Organizer: 日本農芸化学会中部支部第153回例会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-01
• [Presentation] 名大の専門家が解説する「小林・益川理論」と「緑色蛍光蛋白質GFP」 (2008)
  • Author(s): 上村大輔
  • Organizer: 第4回名古屋大学ホームカミングデイ 地域と大学で考える「人と地球環境」
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-18
• [Presentation] 海洋渦鞭毛藻由来の生物活性ポリオール類の単離および新分解反応を用いた構造決定法 (2008)
  • Author(s): 韓春光, ほか
  • Organizer: 第50回天然物有機化合物討論会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-30
• [Presentation] (-)-テルナチンの脂肪蓄積阻害作用機序解明に向けた生物有機化学的研究 (2008)
  • Author(s): 下川賢一郎, ほか
  • Organizer: 第50回天然物有機化合物討論会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-30
• [Presentation] チューリップ花弁の青色発色と鉄輸送機構の解明 (2008)
  • Author(s): 桃井千巳, ほか
  • Organizer: 第50回天然物有機化合物討論会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-30
• [Presentation] 花色素アントシアニンの新規合成法 (2008)
  • Author(s): 近藤忠雄, ほか
  • Organizer: 第50回天然物有機化合物討論会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-09-30
• [Presentation] Mycalolide Bの合成研究 (2008)
  • Author(s): 渡辺秀和, ほか
  • Organizer: 日本化学会第2回関東支部大会
  • Place of Presentation: 桐生市
  • Year and Date: 2008-09-17
• [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products (2008)
  • Author(s): D. Uemura
  • Organizer: The 22nd NaitoConference "Chemical Biorogy I"
  • Place of Presentation: 札幌
  • Year and Date: 2008-09-10
• [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products (2008)
  • Author(s): D. Uemura
  • Organizer: The 22nd Naito Conference "Chemical Biorogy I"
  • Place of Presentation: 札幌市
  • Year and Date: 2008-09-10
• [Presentation] Anesthetic substances and lethal venoms of mammalian origin: shrew and platypus (2008)
  • Author(s): M. Kita
  • Organizer: The 22nd Naito Conference "Chemical Bioroav I"
  • Place of Presentation: 札幌市
  • Year and Date: 2008-09-10
• [Presentation] アントシアニンによる花色発現:細胞内(液胞内)天然物化学による機構解明 (2008)
  • Author(s): 吉田久美
  • Organizer: 第60回日本生物工学会大会 シンポジウム(代謝と物質輸送から眺めた植物の科学と工学)
  • Place of Presentation: 仙台市
  • Year and Date: 2008-08-28
• [Presentation] 赤小豆種皮に含まれるプロシアニジン類の単離と構造 (2008)
  • Author(s): 吉田久美, ほか
  • Organizer: 第5回日本カテキン学会
  • Place of Presentation: 東京都
  • Year and Date: 2008-08-22
• [Presentation] Aspects of Chemical Ecology (2008)
  • Author(s): D. Uemura
  • Organizer: IUPAC International Conference on Biodiversity and Natural Products ICOB-6 & ISCNP-26
  • Place of Presentation: シャーロットタウン(カナダ)
  • Year and Date: 2008-07-18
• [Presentation] Aspects of Chemical Ecology (2008)
  • Author(s): D. Uemura, et al.
  • Organizer: IUPAC International Conference on Biodiversity and Natural Products ICOB-6 $ ISCNP-26
  • Place of Presentation: Charlottetown, Canada
  • Year and Date: 2008-07-18
• [Presentation] Mechanism of Color Change of Chameleon Hydrangea during Maturation and Senescence (2008)
  • Author(s): K. Yoshida, et al.
  • Organizer: XXIVth International Conference on Polyphenols
  • Place of Presentation: Salamanca, SPAIN
  • Year and Date: 2008-07-08
• [Presentation] シンビオジノライド62員環ラクトン部分の絶対立体配置の決定 (2008)
  • Author(s): 韓春光, ほか
  • Organizer: 第3回化学生態学研究会
  • Place of Presentation: 函館市
  • Year and Date: 2008-07-05
• [Presentation] 生態系ダイナミズムに着目した物質探索 (2008)
  • Author(s): 上村大輔
  • Organizer: 日本学術振興会科学研究費補助金学術創成研究費「生態系ダイナミズムに着目した物質探索法」シンポジウム
  • Place of Presentation: 淡路市
  • Year and Date: 2008-06-27
• [Presentation] 新生理活性物質の探索研究 (2008)
  • Author(s): 大野修, ほか
  • Organizer: 日本学術振興会科学研究費補助金学術創成研究費「生態系ダイナミズムに着目した物質探索法」シンポジウム
  • Place of Presentation: 淡路市
  • Year and Date: 2008-06-27
• [Presentation] クロイソカイメン由来新規化合物halichonine B、C及び既知化合物halichlorineの生物活性 (2008)
  • Author(s): 大野修, ほか
  • Organizer: 第12回がん分子標的治療学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2008-06-27
• [Presentation] 哺乳動物由来の麻酔物質および致死毒に関する研究 (2008)
  • Author(s): 北将樹
  • Organizer: 日本学術振興会科学研究費補助金学術創成研究費「生態系ダイナミズムに着目した物質探索法」シンポジウム
  • Place of Presentation: 淡路市
  • Year and Date: 2008-06-26
• [Presentation] 海の化学生態学 (2008)
  • Author(s): 上村大輔
  • Organizer: 第19回万有仙台シンポジウム
  • Place of Presentation: 仙台市
  • Year and Date: 2008-06-21
• [Presentation] 脂肪蓄積阻害活性を有する環状ペプチド(-)-テルナチンに関する生物有機化学的研究 (2008)
  • Author(s): 下川賢一郎, ほか
  • Organizer: 平成20年度新規素材探索研究会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-06-06
• [Presentation] 安息香酸ベンジル及びその誘導体によるAngiotensin II機能阻害活性 (2008)
  • Author(s): 村絵美, ほか
  • Organizer: 平成20年度新規素材探索研究会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-06-06
• [Presentation] トロパ酸脱水素酵素の精製 (2008)
  • Author(s): 門脇英希, ほか
  • Organizer: 平成20年度新規素材探索研究会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-06-06
• [Presentation] Halichlorineは血管平滑筋において電位依存性L型Ca^<2+>チャネルを阻害する (2008)
  • Author(s): 壷阪義記, ほか
  • Organizer: 平成20年度新規素材探索研究会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-06-06
• [Presentation] Bioactive Metabolites from the Symbiotic Dinoflagellate (2008)
  • Author(s): D. Uemura
  • Organizer: The 4th Korea-Japan Chemical Biology Symposium
  • Place of Presentation: 日光市
  • Year and Date: 2008-05-22
• [Presentation] アクチン脱重合活性物質Mycalolide Bの合成研究 (2008)
  • Author(s): 渡辺秀和, ほか
  • Organizer: 第55回有機合成化学協会関東支部シンポジウム
  • Place of Presentation: 野田市
  • Year and Date: 2008-05-09
• [Presentation] フラボノイドの構造と機能研究 (2008)
  • Author(s): 吉田久美
  • Organizer: 21世紀COE講演会
  • Place of Presentation: 静岡県立大学
  • Year and Date: 2008-01-24
• [Presentation] 切れ味の良い天然有機分子を求めて (2008)
  • Author(s): 上村大輔
  • Organizer: 第4回ケミカルバイオロジーシンポジウム:化学-生物融合領域創成の軌跡
  • Place of Presentation: 熱海金城館
• [Presentation] 空色西洋アサガオの開花に伴う青色化と伸長生長におけるItNHXIの役割 (2008)
  • Author(s): 吉田久美, ほか
  • Organizer: 日本植物生理学会2008年度年会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 海洋天然物の多様な構造と生物活性 (2008)
  • Author(s): 上村大輔
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 花色素アントシアニンの化学合成 (2008)
  • Author(s): 吉田久美
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] 配糖化フラボノールの金属還元によるアントシアニンへの変換 (2008)
  • Author(s): 近藤忠雄, ほか
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] シアニンの合成研究 (2008)
  • Author(s): 尾山公一, ほか
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] カメレオンアジサイの花色変化の機構解明 (2008)
  • Author(s): 伊藤大輔, ほか
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] アジサイの青色発色に関与する5-O-アシル化キナ酸の合成研究(2) (2008)
  • Author(s): 関口由紀子, ほか
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] 赤チコリー抽出物のヒト骨髄性白血病由来株細胞に対する増殖抑制効果 (2008)
  • Author(s): 木村卓郎, ほか
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名城大学
• [Presentation] シンビオジノライドの合成研究(1) (2008)
  • Author(s): 高村浩由, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] シンビオジノライドの合成研究(2) (2008)
  • Author(s): 高村浩由, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] Rhizonin Aの合成研究 (2008)
  • Author(s): 中塚宏志, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 脂肪蓄積阻害活性を有する(-)-ternatinの合成と構造活性相関研究(1) (2008)
  • Author(s): 下川賢一郎, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 脂肪蓄積阻害活性を有する(-)-ternatinの合成と構造活性相関研究(2) (2008)
  • Author(s): 岩瀬賢明, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 共生渦鞭毛藻が生産する新規超炭素鎖有機分子symbiospirol Aの化学構造 (2008)
  • Author(s): 恒松雄太, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] Stereochemical assignment of 62-membered macrolactone in symbiodinolide (2008)
  • Author(s): 韓 春光, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] パリトキシンの活性発現機構解明研究 (2008)
  • Author(s): 犬塚俊康, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] クロイソカイメン由来の微量生物活性物質の単離 (2008)
  • Author(s): 吉村英明, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] ハリクロリンの不斉合成研究 (2008)
  • Author(s): 許 述, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 海洋産アルカロイドkasarinの構造決定を目的とした合成研究 (2008)
  • Author(s): 三輪亮佳, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] カイメン共在微生物由来メタゲノムライブラリーの構築 (2008)
  • Author(s): 植村匡詞, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 海洋生物由来の炎症惹起物質 (2008)
  • Author(s): 立川 悠, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] アクチン結合性化合物の結合部位解析法の開発 (2008)
  • Author(s): 岡本和人, ほか
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 立教大学
• [Presentation] 天然有機化合物の魅力を考える (2007)
  • Author(s): 上村大輔
  • Organizer: 平成19年度後期(秋季)有機合成化学講習会
  • Place of Presentation: 日本薬学会長井記念ホール
  • Year and Date: 2007-11-21
• [Presentation] Bioactive Metabolites from the Symbiotic Dinoflagellates (2007)
  • Author(s): D. Uemura
  • Organizer: 1st Brazilian Conference on Natural Products
  • Place of Presentation: サンパウロ(ブラジル)
  • Year and Date: 2007-11-05
• [Presentation] 切れ味のよい天然有機分子を求めて (2007)
  • Author(s): 上村大輔
  • Organizer: 日本技術士会中部支部秋季定例会
  • Place of Presentation: 愛知県産業貿易館
  • Year and Date: 2007-09-29
• [Presentation] Bioactive Secondary Metabolites from Symbiotic Marine Dinoflagellates. (2007)
  • Author(s): M. Kita
  • Organizer: The Royal Australian Chemical Institute New South Wales Natural Products Group Annual Symposium
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2007-09-28
• [Presentation] 海洋生物由来の「切れもの分子」の謎 (2007)
  • Author(s): 上村大輔
  • Organizer: 第53回日本薬学会東海支部総会
  • Place of Presentation: 名城大学薬学部
  • Year and Date: 2007-07-07
• [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products (2007)
  • Author(s): D. Uemura
  • Organizer: The VIth U.S.-JAPAN Symposium on Marine Bioorganic Chemistry
  • Place of Presentation: ソルトレイクシティー(米国)
  • Year and Date: 2007-07-02
• [Presentation] 空色西洋アサガオの開花における花色変化とその制御 (2007)
  • Author(s): 三木直子, ほか
  • Organizer: 日本生化学会中部支部会・例会シンポジウム
  • Place of Presentation: 名古屋大学
  • Year and Date: 2007-05-19
• [Presentation] 一細胞分析によるアジサイの花色変異機構の解明 (2007)
  • Author(s): 伊藤大輔, ほか
  • Organizer: 日本生化学会中部支部会・例会シンポジウム
  • Place of Presentation: 名古屋大学
  • Year and Date: 2007-05-19
• [Presentation] 天然物有機化合物の魅力を考える (2007)
  • Author(s): 上村大輔
  • Organizer: 塾内講演会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2007-04-28
• [Presentation] 切れ味の良い天然有機分子を求めて (2007)
  • Author(s): 上村大輔
  • Organizer: 吉川雄三先生退職記念シンポジウム
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-04-21
• [Presentation] Studies on the Bioactive Compounds from Symbiotic Marine Dinoflagellates. (2007)
  • Author(s): M. Kita
  • Organizer: The 3rd Joint Seminar, Munster Univ. -Nagoya Univ.
  • Place of Presentation: Nagoya Univ.
• [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products (2007)
  • Author(s): Uemura, D.
  • Organizer: XIXth French-Japanese Symposium on Medical and Fine Chemistry-FJS 2007
  • Place of Presentation: Toyama Univ.
• [Presentation] Studies on Long Carbon-chain Polyol Compounds from Symbiotic Marine Dinoflagellates: Isolation and Biological Activity. (2007)
  • Author(s): M. Kita
  • Organizer: 8th Tetrahedron Symposium, Challenges in Organic Chemistry
  • Place of Presentation: Berlin, Germany
• [Presentation] Role of Tonoplast-localized NHX1 in Blue Morning Glory Petals. (2007)
  • Author(s): Yoshida K., et. al.
  • Organizer: 14th International Workshop of Plant Membrane Biology
  • Place of Presentation: Valencia, SPAIN
• [Presentation] Flavonoid components isolated from blue flowers of Veronica persica Poiret. (2007)
  • Author(s): Mori, M., et. al.
  • Organizer: 12th Asian Chemical Congress (International Symposium on Natural Products and Medicinal Chemistry 2007).
  • Place of Presentation: Kuala Lumpur, MALAYSIA
• [Presentation] Chemical Studies on Color Development and Variation of Hydrangea macrophylla. (2007)
  • Author(s): Ito, D., et. al.
  • Organizer: 12th Asian Chemical Congress (International Symposium on Natural Products and Medicinal Chemistry 2007).
  • Place of Presentation: Kuala Lumpur, MALAYSIA
• [Presentation] Synthesis of Kaempferol 3-ο-Glucoside and Kaempferol 3-ο-6"-ο-Acetyl-β-D-Glucopyranoside. (2007)
  • Author(s): Oyama, K., et. al.
  • Organizer: 12th Asian Chemical Congress (International Symposium on Natural Products and Medicinal Chemistry 2007).
  • Place of Presentation: Kuala Lumpur, MALAYSIA
• [Presentation] Studies On Cytotoxic Compounds From Red Algae And Sponge (2007)
  • Author(s): Maru, N., et. al.
  • Organizer: Korea-Japan Young Scientists Meeting on Bioorganic and Natural Products Chemistry
  • Place of Presentation: Pusan, Korea
• [Presentation] Synthetic Studies on Symbiodinolide (2007)
  • Author(s): Murata, T., et. al.
  • Organizer: Korea-Japan Young Scientists Meeting on Bioorganic and Natural Products Chemistry
  • Place of Presentation: Pusan, Korea
• [Presentation] Trial to Access Unknown Natural Products by Using the Genome of Unculturable Bacteria from Marine Sponges (2007)
  • Author(s): Ohno O.
  • Organizer: The 4th joint IRTG SYMPOSIUM between Nagoya University and University of Munster
  • Place of Presentation: Munster, Germany
• [Presentation] Natural Inducers for Coral Larval Metamorphosis (2007)
  • Author(s): Kitamura, M., et. al.
  • Organizer: 4th Asia-Pacific Conference on Chemical Ecology
  • Place of Presentation: Tsukuba Int. Cong. Center
• [Presentation] Bioactive Metabolites from the Symbiotic Dinoflagellates (2007)
  • Author(s): Uemura, D., et. al.
  • Organizer: 1st Brazilian Conference on Natural Products
  • Place of Presentation: Sao Paulo, Brazil
• [Presentation] 哺乳動物由来の麻酔物質および致死性タンパク毒に関する研究 (2007)
  • Author(s): 北 将樹
  • Organizer: 第42回天然物化学談話会
  • Place of Presentation: 秋保リゾートホテル
• [Presentation] 海洋共生藻由来の超炭素鎖有機分子の構造と機能 (2007)
  • Author(s): 北 将樹, ほか
  • Organizer: 第49回天然物有機化合物討論会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] カリウドバチ毒液の化学成分と生物活性 (2007)
  • Author(s): 山本 剛, ほか
  • Organizer: 第49回天然物有機化合物討論会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] 単一細胞分析によるアジサイの花色変異機構の解明 (2007)
  • Author(s): 伊藤大輔, ほか
  • Organizer: 第49回天然有機化合物討論会
  • Place of Presentation: 札幌コンベンションセンター
• [Presentation] チューリップACC酸化酵素遺伝子の解析と花粉ベクター法による抑制個体の作出 (2007)
  • Author(s): 桃井千巳, ほか
  • Organizer: 園芸学会平成19年度秋季大会
  • Place of Presentation: 香川大学
• [Presentation] シアル酸転移酵素阻害剤の探索およびその反応速度論的性状解析 (2007)
  • Author(s): 左 一八, ほか
  • Organizer: 第80回日本生化学会大会日本分子生物学会第30回年会合同大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Allelochemicals of Crustose Coralline Red Algae for Coral Larvae (2006)
  • Author(s): D. Uemura
  • Organizer: Gordon Coference 2006-Marine Natural Products-
  • Place of Presentation: ベンチュラ(米国)
  • Year and Date: 2006-02-27
• [Presentation] Bioorganic Studies of Super-carbon-chain Metabolites from Symbiotic Dinoflagellate (2005)
  • Author(s): D. Uemura
  • Organizer: Pacifichem 2005
  • Place of Presentation: ハワイ(米国)
  • Year and Date: 2005-12-16
• [Presentation] Bioactive Iminium Alkaloids from Marine Invertibrates (2005)
  • Author(s): D. Uemura
  • Organizer: 20th International Congress of Heterocyclic Chemistry (ICHC2005)
  • Place of Presentation: パレルモ(イタリア)
  • Year and Date: 2005-08-01
• [Book] Pheromones of marine invertebrates and algae. in Comprehensive Natural Products Chemistry(Elsevier, Amsterdam)(Ed. K. Mori)(Vol.4) (2009)
  • Author(s): M. Kita, M. Kitamura, D. Uemura
  • Publisher: 2nd Edition(in press)
• [Book] Pheromones of marine invertebrates and algae. in Comprehensive Natural Products Chemistry. 2nd Edition. Vol. 4 Ed. K. Mori (2009)
  • Author(s): M. Kita, M. Kitamura, D. Uemura,
  • Publisher: Elsevier, Amsterdam(in press)
• [Book] 入門ケミカルバイオロジー(入門ケミカルバイオロジー編集委員会編) (2008)
  • Author(s): 上村大輔、中村和彦
  • Publisher: オーム社
• [Book] 新規素材探索-医薬品リード化合物・食品素材を求めて- (2008)
  • Author(s): 上村大輔監修
  • Total Pages: 313
  • Publisher: (株)シーエムシー出版
• [Book] 新規素材探索-医薬品リード化合物・食品素材を求めて- (2008)
  • Author(s): 上村大輔, 監修
  • Total Pages: 313
  • Publisher: (株)シーエムシー出版
• [Book] 入門ケミカルバイオロジー (2008)
  • Author(s): 入門ケミカルバイオロジー編集委員会編
  • Total Pages: 189
  • Publisher: オーム社
• [Book] Bioactive Marine Metabolities from Okinawan Water, in Studies in Natural Product Chemistry (Bioactive Natural Products). (2007)
  • Author(s): Ueda, K. et al.
  • Total Pages: 43
  • Publisher: Elsevier Science Publishers
• [Book] 花色素、「天然物化学-植物編-」 (2007)
  • Author(s): 吉田久美
  • Total Pages: 9
  • Publisher: アイピーシー、東京
• [Book] 生命科学への展開、岩波講座現代化学への入門第15巻 (2006)
  • Author(s): 上村大輔、袖岡幹子(共著)
  • Total Pages: 246
  • Publisher: 岩波書店
• [Book] Shellfish poisons. in Marine Molecular Biotechnolog(Eds W. E. G. Muller and H. G. Schroder)(Springer-Verlag Press, D-Berlin) (2006)
  • Author(s): M. Kita, D. Uemura
  • Publisher: Heidelberg
• [Book] Shellfish poisons. in Marine Molecular Biotechnology. (2006)
  • Author(s): Kita, M. et al.
  • Total Pages: 26
  • Publisher: Spninger-Verlag Press, D-Berlin, Heidelberg
• [Book] 「生命科学への展開」岩波講座 現代化学への入門 第15巻 (2006)
  • Author(s): 上村大輔ら
  • Total Pages: 246
  • Publisher: 岩波書店
• [Book] Bioactive heterocyclic alkaloids from marine origin, in Topics in Heterocycles. (2006)
  • Author(s): Kita, M. et al.
  • Total Pages: 22
  • Publisher: Springer-Verlag Press
• [Book] Shellfish poisons.in Marine Molecular Biotechnology.Vol.46 (2006)
  • Author(s): M.Kita et al.
  • Publisher: Springer-Verlag Press,D-Berlin,Heidelberg
• [Book] Bioactive heterocyclic alkaloids from marine origin.in Topics in Heterocycles.Vol.6. (2006)
  • Author(s): M.Kita et al.
  • Publisher: Springer-Verlag Press
• [Book] 「生物現象を司る鍵化学物質」第19回「大学と科学」公開シンポジウム「不思議な生物現象の化学」講演集録集 (2005)
  • Author(s): 上村大輔
  • Total Pages: 9
  • Publisher: クバプロ
• [Book] Important Natural Products" in "Quaternary Stereocenters - Challenges for Organic Synthesis"(eds., J.Christoffers and A.Baro) (2005)
  • Author(s): H.Arimoto, D.Uemura
  • Publisher: Wiley(未定)
• [Book] Shellfish Poisons in "Marine Molecular Biotechnology, the volume Mollusks"(eds., W.E.G.Muller and H.G.Schroder) (2005)
  • Author(s): M.Kita, D.Uemura
  • Publisher: Springer-Verlag Press(未定)
• [Remarks]
  • URL: http://www.bio.keio.ac.jp/labs/uemura/gakujutsu/results.html
• [Remarks] 研究代表者所属研究室ホームページ
  • URL: http://www.bio.keio.ac.jp/labs/uemura/
• [Remarks] 学術創成研究費「生態系ダイナミズムに着目した物質探索法」
  • URL: http://org.chem.nagoya-u.ac.jp/gakujutu/
• [Remarks] 慶應義塾大学理工学部生命情報学科 生物有機化学研究室
  • URL: http://www.bio.keio.ac.jp/labs/uemura/
• [Remarks] 名古屋大学大学院理学研究科 有機化学研究室
  • URL: http://org.chem.nagoya-u.ac.jp/
• [Remarks] 名古屋大学大学院情報科学研究科 吉田研究室
  • URL: http://www.human.nagoya-u.ac.jp/lab/yoshida/
• [Patent(Industrial Property Rights)] ルテニウム錯体を用いる1, 2-ジオールの開裂反応 (2008)
  • Inventor(s): 上村大輔、韓春光
  • Industrial Property Rights Holder: 上村大輔
  • Industrial Property Number: 2008-219516
  • Filing Date: 2008-08-28
• [Patent(Industrial Property Rights)] ルテニウム錯体を用いる1, 2-ジオールの開裂反応 (2008)
  • Inventor(s): 上村大輔, 韓春光
  • Industrial Property Rights Holder: 上村大輔
  • Industrial Property Number: 2008-219516
  • Filing Date: 2008-08-28
• [Patent(Industrial Property Rights)] アントシアニジン類の製造方法及びフラベノール誘導体 (2007)
  • Inventor(s): 吉田久美、近藤忠雄、尾山公一
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2007-317648
  • Filing Date: 2007-12-07
• [Patent(Industrial Property Rights)] 環状ヘプタペプチド及びその用途 (2007)
  • Inventor(s): 上村大輔、下川賢一郎、岩瀬賢明、山田薫
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2007-220131
  • Filing Date: 2007-08-27
• [Patent(Industrial Property Rights)] アントシアニジン類の製造方法及びフラベノール誘導体 (2007)
  • Inventor(s): 吉田久美, ほか
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2007-317648
  • Filing Date: 2007-12-07
• [Patent(Industrial Property Rights)] 環状ヘプタペプチド及びその用途 (2007)
  • Inventor(s): 上村大輔, ほか
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 2007-220131
  • Filing Date: 2007-08-27
• [Patent(Industrial Property Rights)] スピロ[1-アザビシクロ[4.4.0]デカ-3エン-9,1'-シクロペンタン]誘導体 (2006)
  • Inventor(s): 上村大輔、倉本誠、周丹、山田薫
  • Industrial Property Rights Holder: 上村大輔
  • Industrial Property Number: 平08-022200
  • Filing Date: 2006-11-17
• [Patent(Industrial Property Rights)] 新規安息香酸ベンジル誘導体及び医薬 (2005)
  • Inventor(s): 上村大輔、北将樹、松本漠、諏佐智之、山田薫、矢澤一良、山口宏二、叶茂
  • Industrial Property Rights Holder: 名古屋大学、東京海洋大学
  • Industrial Property Number: 2005-366790
  • Filing Date: 2005-12-20
• [Patent(Industrial Property Rights)] 脂肪細胞の脂肪蓄積阻害剤 (2005)
  • Inventor(s): 上村大輔、北将樹、大野美季、山田薫、大野智弘
  • Industrial Property Rights Holder: 株式会社ファンケル
  • Industrial Property Number: 2005-028203
  • Filing Date: 2005-02-03
• [Patent(Industrial Property Rights)] 血圧降下剤 (2005)
  • Inventor(s): 上村大輔ら
  • Industrial Property Number: 2005-212545
  • Filing Date: 2005-07-22
• [Patent(Industrial Property Rights)] 血圧降下剤 (2005)
  • Inventor(s): 上村大輔ら
  • Industrial Property Number: 2005-212547
  • Filing Date: 2005-07-22
• [Patent(Industrial Property Rights)] 新規安息香酸ベンジル誘導体及び医薬 (2005)
  • Inventor(s): 上村大輔ら
  • Industrial Property Number: 2005-366790
  • Filing Date: 2005-12-20
• [Patent(Industrial Property Rights)] 脂肪細胞の脂肪蓄積阻害剤 (2005)
  • Inventor(s): 上村 大輔ら
  • Industrial Property Rights Holder: 未定
  • Industrial Property Number: 2005-028203
  • Filing Date: 2005-02-03
• [Patent(Industrial Property Rights)] 新規ペプチド誘導体及びこれを有効成分とする抗癌剤 (2005)
  • Inventor(s): 上村 大輔ら
  • Industrial Property Rights Holder: 未定
  • Filing Date: 2005-03-10