Exploring of non-visual functions mediated by Opn5.
Project/Area Number |
16H02515
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Ritsumeikan University (2017-2018) Kyoto University (2016) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山下 高廣 京都大学, 理学研究科, 助教 (50378535)
今元 泰 京都大学, 理学研究科, 准教授 (80263200)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2018: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2017: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2016: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
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Keywords | 光受容 / オプシン / 機能多様性 / 分子メカニズム / モデル動物 |
Outline of Final Research Achievements |
Animal photoreceptor proteins, opsins, have been widely diversified to acquire various new physiological functions in the course of molecular evolution. In this study, we found that the Opn5 group, which we started to study independently, has diversified into four subgroups (Opn5L1, Opn5L2, Opn5m, Opn5n) in vertebrates. The detailed molecular properties of opsins in four subgroups were elucidated, and the physiological functions of Opn5L1 and Opn5n were identified by generation of knockout animals. Furthermore, we obtained insights into the molecular properties and functional diversification of visual opsin group that was as diversified as Opn5 group in vertebrates.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の意義は2つに大別される。1つは、動物における視覚・非視覚機能の広範な多様性について、分子レベルでのメカニズムの理解につながる。これにより、ヒトに至る高度な視覚・非視覚機能の元になる進化を分子レベルで明らかにすることができる。もう1つは、光受容タンパク質を光操作ツールとして利用するオプトジェネティクスへの応用である。これにより、脳機能や各種の生物機能の解明に最適な光操作ツールを提供することができる。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Genotype determination of the OPN1LW/OPN1MW genes: novel disease-causing mechanisms in Japanese patients with blue cone monochromacy.2018
Author(s)
Katagiri S, Iwasa M, Hayashi T, Hosono K, Yamashita T, Kuniyoshi K, Ueno S, Kondo M, Ueyama H, Ogita H, Shichida Y, Inagaki H, Kurahashi H, Kondo H, Ohji M, Hotta Y, Nakano T.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 11507-11507
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.2018
Author(s)
Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
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Journal Title
Biochemistry
Volume: 57
Issue: 38
Pages: 5544-5556
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates2018
Author(s)
Keita Sato, Takahiro Yamashita, Keiichi Kojima, Kazumi Sakai, Yuki Matsutani, Masataka Yanagawa, Yumiko Yamano, Akimori Wada, Naoyuki Iwabe, Hideyo Ohuchi, Yoshinori Shichida
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Journal Title
Communications Biology
Volume: 1
Issue: 1
Pages: 156-156
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] 脊椎動物の光受容体Opn5L1 は逆行性・自己再生能をもつ新しいタイプのオプシンである2018
Author(s)
佐藤 恵太, 山下 高廣, 大内 淑代, 竹内 敦子, 後藤 人志, 小野 勝彦, 水野 操, 水谷 泰久, 友成 さゆり, 酒井 佳寿美, 今元 泰, 和田 昭盛, 七田 芳則
Organizer
日本生物物理学会第56回年会
Related Report
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