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Clarifying the underlying mechanisms of schizophrenia focusing on the abnormalities of neuronal activities and immune responses.

Research Project

Project/Area Number 16H02666
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

kanba Shigenobu  九州大学, 医学研究院, 教授 (50195187)

Co-Investigator(Kenkyū-buntansha) 牧之段 学  奈良県立医科大学, 医学部, 講師 (00510182)
Research Collaborator Hirano Yoji  
Kato Takahiro A.  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Keywords統合失調症 / 脳活動 / ガンマオシレーション / ミクログリア / 橋渡し研究 / サイトカイン / 気分障害 / トランスレーショナルリサーチ / ペリニューロナルネット / 炎症免疫 / 脳波 / 神経免疫 / γオシレーション
Outline of Final Research Achievements

In this study, we have conducted a translational research focusing on the two hypothesis; (1) the neuronal activity abnormality hypothesis and (2) the neuroimmune abnormality hypothesis in psychiatric disorders especially schizophrenia and mood disorders. We have clarified some interesting abnormalities using the EEG analysis and blood biomarker analysis in a variety of psychiatric disorders.

Academic Significance and Societal Importance of the Research Achievements

統合失調症の病態はいまだ十分には解明されていません。本研究では、統合失調症およびその関連精神神経疾患(うつ病、双極性障害、てんかん性精神病、発達障害など)における脳神経活動異常と免疫異常の双方に着目し、その精査をヒトを中心とした橋渡し研究アプローチですすめてきました。3年間の研究で、疾患の判別や重症度に関連する脳波異常や血液マーカーを見出すことに成功しました。今回の知見をさらに深めることで、統合失調症を初めとする多くの精神疾患の病態の本質を解明し、将来的には治療法開発に繋げてゆければ幸いです。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results)

  • [Journal Article] Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies2019

    • Author(s)
      Suzuki H, Ohgidani M, Kuwano N, Chrétien F, Lorin de la Grandmaison G, Onaya M, Tominaga I, Setoyama D, Kang D, Mimura M, Kanba S, Kato TA*
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 13 Pages: 31-31

    • DOI

      10.3389/fncel.2019.00031

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development and validation of the 22-item Tarumi's modern-type depression trait scale; Avoidance of social roles, Complaint and low Self-esteem (TACS-22)2019

    • Author(s)
      Kato TA, Katsuki R, Kubo H, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Umene-akano W, Tateno M, Setoyama D, Kang D, Watabe M, Sakamoto S, Teo AR, Kanba S
    • Journal Title

      Psychiatry and clinical neurosciences

      Volume: in press Issue: 8 Pages: 448-457

    • DOI

      10.1111/pcn.12842

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study.2018

    • Author(s)
      Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
    • Journal Title

      Journal of Affective Disorders

      Volume: 231 Pages: 74-82

    • DOI

      10.1016/j.jad.2018.01.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya2018

    • Author(s)
      Kato Takahiro A.、Kanba Shigenobu
    • Journal Title

      American Journal of Psychiatry

      Volume: 175 Issue: 5 Pages: 483-484

    • DOI

      10.1176/appi.ajp.2018.17121404r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and validation of the 25-item Hikikomori Questionnaire (HQ-25)2018

    • Author(s)
      Teo AR*, Chen JI, Kubo H, Katsuki R, Sato-Kasai M, Shimokawa N, Hayakawa K, Umene-Nakano W, Aikens, JE, Kanba S, Kato TA
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72(10) Issue: 10 Pages: 780-788

    • DOI

      10.1111/pcn.12691

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study2018

    • Author(s)
      Kuwano N, Kato TA*, Mitsuhashi M, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Sakurai T, Kanba S
    • Journal Title

      Journal of Affective Disorders

      Volume: 240 Pages: 88-98

    • DOI

      10.1016/j.jad.2018.07.040

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Microglial CD206 gene has potential as a state marker of bipolar disorder2017

    • Author(s)
      1.Ohgidani M, Kato TA, Haraguchi Y, Matsushima T, Mizoguchi Y, Murakawa-Hirachi T, Sagata N, Monji A, Kanba S.
    • Journal Title

      Frontiers in Immunology

      Volume: 7 Pages: 676-676

    • DOI

      10.3389/fimmu.2016.00676

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM72016

    • Author(s)
      Sato-Kasai M, Kato TA, Ohgidani M, Mizoguchi Y, Sagata N, Inamine S, Horikawa H, Hayakawa K, Shimokawa N, Kyuragi S, Seki Y, Monji A, Kanba S.
    • Journal Title

      Schizophrenia Research

      Volume: 178(1-3) Issue: 1-3 Pages: 35-43

    • DOI

      10.1016/j.schres.2016.08.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Directly induced glial/neuronal cells from human peripheral tissues: A novel translational research for neuropsychiatric disorders2016

    • Author(s)
      Kato TA, Ohgidani M, Sagata N, Kanba S
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 6(2) Issue: 2 Pages: 95-105

    • DOI

      10.3233/nib-160109

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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