| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
By using synthetic biology to analyze both the mathematical model and the behavior of actual living cells, this study allowed a better understanding for formation of cell populations’ spatial pattern started from a single cell which diversify its gene expression pattern autonomously. One mathematical model we have developed here for colony formation includes the diffusion of intercellular communication molecules and the cell growth rate depending on the internal state of the cell. Another models describes generalization of bifurcation phenomena based on catastrophe theory. Furthermore, for each model, we achieved realization of them as the behavior of an actual living cell population.
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