| Project/Area Number |
16H03046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKETANI Yutaka 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30263825)
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| Co-Investigator(Kenkyū-buntansha) |
増田 真志 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (50754488)
山本 浩範 仁愛大学, 人間生活学部, 教授 (60314861)
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| Research Collaborator |
NARASAKI Yoko
FUKUDA Shiori
HAYASHI Mayu
KISHIMOTO Maki
NII Sachi
IMI Yukiko
NIIDA Yuki
ODA Naoko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | リン / 慢性腎臓病 / エピゲノム / ライフステージ / 高リン食 / 食事調査 / 遺伝子 / ゲノム / トランスレーショナルリサーチ / klotho / 骨 |
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| Outline of Final Research Achievements |
Overintake of phosphate, which is an essential nutrient, has been concerned about the risk factor associated with cariovascular disease and all-cause mortality. In this study, we have explored a novel biomarker reflecting continuous overintake of phosphate in mice and validated the marker in human. We demonstrated that fibroblast growth factor 23 (FGF23), which is a phosphaturic hormone, can be a good biomarker reflecting continuous overintake of phosphate. In addition, we developed a convenient evaluation tool to assess the daily intake of phosphate in human. This tool and the marker, FGF23, are useful tool to determine adequate recommended dietary allowance of phosphate and for nutritional education in chronic kidney disease patients who are required dietary phosphate restriction.
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| Academic Significance and Societal Importance of the Research Achievements |
リン過剰摂取は、慢性腎臓病患者で問題になるだけでなく、健常者においても心血管疾患の発症リスクや総死亡リスクと関連することが指摘されている。リン過剰摂取とこれらの疾患の発症リスクや総死亡リスクとの間をつなぐメカニズムにエピゲノム修飾の存在が推定される。本研究で見出された指標を用い研究を進めることで、健康増進を進めるための適切なリン摂取量の設定あるいは慢性腎臓病患者の適切な食事指導に活用されることが期待される。
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