| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
A synthetic method of artificial analogs of biselyngbyaside (BLS), a macrolide glycoside isolated from marine cyanobacteria, has been established. Since glycosylation reactions in the middle or late stage of the synthesis were difficult, sugar moiety was introduced in the early stage. The 18-membered ring construction proceeded in good yields in various cyclization precursors, thus a synthetic method for BLS analogs was established. Natural and synthetic analogs of BLS showed weak antimalarial activities. Affinity purification experiments by using biotin probes of Jahanyne (JHN), a linear lipopeptide isolated from marine cyanobacteria, have identified anti-apoptosis protein (20 kDa) as a candidate of target molecule.
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