| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
Silicon quantum dots are known to have high biocompatibility and biodegradability, and are expected as new nanofluorescent materials that replace conventional heavy metal-based quantum dots in the biophotonics field. The purpose of this study was to establish the fundamental technology that is essential for the application of silicon quantum dots to biophotonics. For water-dispersible silicon quantum dots developed by our group, optimization of the structure, reduction of the size distribution, development of surface modification technology, and development of the technology to bind antibody were performed. Furthermore, fluorescent bioimaging by using the silicon quantum dots was demonstrated and the cytotoxicity was examined. Development of a plasmonic substrate for the enhancement of the sensitivity of fluorescent biosensors was performed and a high performance plasmonic substrate was realized.
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