Development of soft X-ray microscope in Water window wavelength region using Flash LPP light source

• Project/Area Number: 16H03902
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Quantum beam science
• Research Institution: Tohoku University
• Principal Investigator: Ejima Takeo 東北大学, 多元物質科学研究所, 准教授 (80261478)
• Co-Investigator(Kenkyū-buntansha): 加道 雅孝 国立研究開発法人量子科学技術研究開発機構, 量子ビーム科学研究部門, 室長代理(定常) (30360431) ; 刀袮 重信 東京電機大学, 理工学研究科, 特別専任教授 (70211399) ; 東口 武史 宇都宮大学, 工学部, 教授 (80336289)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 水の窓 / UTA放射 / 反射多層膜 / 軟X線顕微鏡 / レーザープラズマ光源 / アポトーシス / リン酸基 / ヌクレオチド / P-L2,3吸収端 / LPP光源 / 軟Ｘ線顕微鏡 / レーザー励起プラズマ光源 / Ⅹ線 / 量子ビーム / 軟Ⅹ線顕微鏡 / レーザー生成プラズマ光源

Outline of Final Research Achievements

Since the shortness of the wavelength and existance of some absorption edges of light elements in “Water window” wavelength region (2.3 - 4.4 nm), a high spatial resolution image will be obtained with high contrast when an unstained organic material is imaged using this wavelength region. In order to enable high spatial resolution imaging of organic materials using a laboratory light source in this wavelength region, we made following studies:
(1) Improvement of efficiency and brightness of laser-produced plasma light source, (2) Development of laboratory type soft x-ray microscope with soft x-ray imaging optics, and (3) Demonstration of soft X-ray images of biological cells in the "carbon window" and "water window" wavelength region. Furthermore, we found newly as an unexpected result that the emission intensity of the soft X-ray in "Water window" wavelength region from the laser produced plasma under N2 atomosphere increases as the increase of the N2 gas pressure.

Academic Significance and Societal Importance of the Research Achievements

基礎医学・臨床応用、薬学、基礎生物学、農学などの生物を対象とする学問はすべて、生物を構成する細胞内の構造を知るために高い空間分解能を持つ顕微鏡を必要としている。本研究はその要求に応えるための一つの方法として「水の窓」波長域（λ=2.3～4.4 nm）を利用した軟X線顕微鏡のための光源、光学系などの要素技術開発を行い、それらを組み合わせて顕微鏡として完成させた。その他、要素技術開発の途中で新たな高輝度光源の動作原理となる可能性のあるプラズマ発光強度のガス圧依存性を見出した。

Research Products

• [Int'l Joint Research] University College Dublin(アイルランド)
• [Int'l Joint Research] Czech Technical University in Prague(チェコ)
• [Int'l Joint Research] School of Nuclear Science and Technology(中国)
• [Journal Article] Quantitative Distribution of DNA, RNA, Histone and Proteins Other than Histone in Mammalian Cells, Nuclei and a Chromosome at High Resolution Observed by Scanning Transmission Soft X-Ray Microscopy (STXM) (2019)
  • Author(s): K. Shinohara, S. Tone, T. Ejima, T. Ohigashi, A. Ito
  • Journal Title: Cells Volume: 8 Issue: 2 Pages: 164-164
  • DOI: 10.3390/cells8020164
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of Apoptotic Nuclei with Infrared Spectra-Microscopy (2018)
  • Author(s): M. Kado, T. Ejima, T. Tone, K. Shinohara
  • Journal Title: SPring-8/SACLA Research Report Volume: 6 Issue: 1 Pages: 35-37
  • DOI: 10.18957/rr.6.1.35
  • NAID: 130007969489
  • ISSN: 2187-6886
  • Year and Date: 2018-01-25
  • Peer Reviewed / Open Access
• [Journal Article] Development of laboratory-type soft X-ray microscope, CXRM, in Water-window using LPP light source (2018)
  • Author(s): Ejima Takeo、Ono Yuichi、Ito Keisuke、Kawasaki Hiromu、Higashiguchi Takeshi、Tone Shigenobu、Hatano Tadashi
  • Journal Title: Microscopy and Microanalysis Volume: 24 Issue: S2 Pages: 214-215
  • DOI: 10.1017/s1431927618013417
  • Peer Reviewed / Open Access
• [Journal Article] Quantum Efficiency of Back-illuminated CMOS Sensor with 1.4×1.4 μm2 Pixel Size (2018)
  • Author(s): Ejima Takeo、Hatano Tadashi
  • Journal Title: Microscopy and Microanalysis Volume: 24 Issue: S2 Pages: 322-323
  • DOI: 10.1017/s1431927618013922
  • Peer Reviewed / Open Access
• [Journal Article] Influence of short pulse duration of carbon dioxide lasers on extreme ultraviolet emission from laser-produced plasmas (2018)
  • Author(s): Amano Reiho、Dinh Thang-Hung、Sasanuma Atsushi、Arai Goki、Hara Hiroyuki、Fujii Yusuke、Hatano Tadashi、Ejima Takeo、Jiang Weihua、Sunahara Atsushi、Takahashi Akihiko、Nakamura Daisuke、Okada Tatsuo、Sakaue Kazuyuki、Miura Taisuke、O’Sullivan Gerry、Higashiguchi Takeshi
  • Journal Title: Japanese Journal of Applied Physics Volume: 57 Issue: 7 Pages: 070311-070311
  • DOI: 10.7567/jjap.57.070311
  • NAID: 210000149245
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characteristics of soft x-ray and extreme ultraviolet (XUV) emission from laser-produced highly charged rhodium ions (2018)
  • Author(s): Barte Ellie Floyd、Hara Hiroyuki、Tamura Toshiki、Gisuji Takuya、Chen When-Bo、Lokasani Ragava、Hatano Tadashi、Ejima Takeo、Jiang Weihua、Suzuki Chihiro、Li Bowen、Dunne Padraig、O'Sullivan Gerry、Sasaki Akira、Higashiguchi Takeshi、Limpouch Ji??
  • Journal Title: Journal of Applied Physics Volume: 123 Issue: 18 Pages: 183301-183301
  • DOI: 10.1063/1.5024344
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Selection of target elements for laser-produced plasma soft x-ray sources (2018)
  • Author(s): Tamura Toshiki、Arai Goki、Kondo Yoshiki、Hara Hiroyuki、Hatano Tadashi、Ejima Takeo、Jiang Weihua、Suzuki Chihiro、O’Sullivan Gerry、Higashiguchi Takeshi
  • Journal Title: Optics Letters Volume: 43 Issue: 9 Pages: 2042-2042
  • DOI: 10.1364/ol.43.002042
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] hemical Bonding State Change of Phosphodiester Bonds in Plasmid DNA (2018)
  • Author(s): T. Ejima, T. Ohigashi, M. Kado, and S. Tone
  • Journal Title: UVSOR Activity Report Volume: 2017 Pages: 157-157
• [Journal Article] Development of back-illuminated soft X-ray imaging device with a pixel size of 1.4 × 1.4 μm2 (2018)
  • Author(s): T. Ejima, T. Hatano
  • Journal Title: Photon Factory Activity Report Volume: 34
• [Journal Article] Discrimination of DNA and RNA distribution in a mammalian cell by scanning transmission soft X-ray microscopy (2018)
  • Author(s): Shinohara Kunio、Ito Atsushi、Ohigashi Takuji、Kado Masataka、Tone Shigenobu
  • Journal Title: Journal of X-Ray Science and Technology Volume: 26 Issue: 6 Pages: 877-884
  • DOI: 10.3233/xst-180392
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative analysis of mammalian chromosome by scanning transmission soft X-ray microscopy (2018)
  • Author(s): K. Shinohara, T. Ohigashi, S. Tone, M. Kado, A. Ito
  • Journal Title: Ultramicroscopy, Volume: 194 Pages: 1-6
  • DOI: 10.1016/j.ultramic.2018.07.001
  • Peer Reviewed / Open Access
• [Journal Article] Cilostazol May Decrease Plasma Inflammatory Biomarkers in Patients with Recent Small Subcortical Infarcts: A Pilot Study. (2018)
  • Author(s): Saji N, Tone S, Murotani K, Yagita Y, Kimura K, Sakurai T.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: S1052-3057 Issue: 6 Pages: 30036-3
  • DOI: 10.1016/j.jstrokecerebrovasdis.2018.01.020
  • Peer Reviewed
• [Journal Article] 人工海水の止水飼育下でのベニクラゲの若返り, クラゲ芽形成, 並びに第２回目の若返りの初記録 (2018)
  • Author(s): 大塚玲桜, 藤瀬弦汰, 久保田信, 刀祢重信
  • Journal Title: 日本生物地理学会会報 Volume: 73 Pages: 1901-94
  • NAID: 40021767302
  • Peer Reviewed
• [Journal Article] Development of Soft X-Ray Microscope in Water Window Using Laser-Produced Plasma Light Source (2017)
  • Author(s): T. Ejima, Y. Kondo, Y. Ono, T.-H. Dinh, T. Higashiguchi, and T. Hatano
  • Journal Title: X-Ray Lasers 2016, Springer Proceedings in Physics Volume: 202
  • Peer Reviewed
• [Journal Article] Cr/Sc/Mo multilayer for condenser optics in water window microscopes (2017)
  • Author(s): T. Hatano, T. Ejima, T. Tsuru
  • Journal Title: J. Electron Spectrosc. Relat. Phenom. Volume: 220 Pages: 14-16
  • DOI: 10.1016/j.elspec.2016.12.010
  • Peer Reviewed
• [Journal Article] ncrease of the emission of laser-produced plasmas under N2 gas atmosphere in the 2.9-6 nm region (2017)
  • Author(s): M. Kado, M. Kishimoto, K. Shinohara, and T. Ejima
  • Journal Title: Appl. Phys. Lett. Volume: 111 Issue: 5
  • DOI: 10.1063/1.4996890
  • Peer Reviewed
• [Journal Article] Characteristics of laser produced plasmas of hafnium and tantalum in the 1-7 nm region (2017)
  • Author(s): Bowen Li, Takamitsu Otsuka, Emma Sokell, Padraig Dunne, Gerry O’Sullivan, Hiroyuki Hara, Goki Arai, Toshiki Tamura, Yuichi Ono, Thanh-Hung Dinh, and Takeshi Higashiguchi
  • Journal Title: European Physical Journal D Volume: 71 Issue: 11 Pages: 278-287
  • DOI: 10.1140/epjd/e2017-70830-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opacity effects on soft X-ray spectra from highly charged lanthanide ions in laser-produced plasmas (2017)
  • Author(s): Chihiro Suzuki, Takeshi Higashiguchi, Atsushi Sasanuma, Goki Arai, Yusuke Fujii, Yoshiki Kondo, Thanh-Hung Dinh, Fumihiro Koike, Izumi Murakami, and Gerry O’Sullivan
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section B Volume: 408 Pages: 253-256
  • DOI: 10.1016/j.nimb.2017.03.094
  • NAID: 120007089662
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spectroscopy of Highly Charged Ions for Extreme Ultraviolet Lithography (2017)
  • Author(s): G. O'Sullivan, P. Dunne, T. Higashiguchi, D. Kos, O. Maguire, T. Miyazaki, F. O'Reilly, J. Sheil, E. Sokell, and D. Kilbane
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section B Volume: 印刷中 Pages: 3-8
  • DOI: 10.1016/j.nimb.2017.03.114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Extension of the operational regime of the LHD towards a deuterium experiment (2017)
  • Author(s): Y. Takeiri, T. Higashiguchi et al.
  • Journal Title: Nuclear Fusion Volume: 57
  • NAID: 120007124606
  • Peer Reviewed
• [Journal Article] High ionization states observed in soft x-ray spectra from plasmas of second row transition elements produced by femtosecond laser pulses (2017)
  • Author(s): Ragava Lokasani, Ellie Floyd Barte, Petr Gavrilov, Petr Hribek, Alexandr Jancarek, Domagoj Kos, Michal Nevrkla, Ladislav Pina, Takeshi Higashiguchi, Gerry O’Sullivan, and Jiri Limpouch
  • Journal Title: Journal of Physics B Volume: 50 Issue: 14 Pages: 145001-145001
  • DOI: 10.1088/1361-6455/aa7791
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Generation of the determined vectorial vortex beams by use of an achromatic axially symmetric waveplate (2017)
  • Author(s): Toshitaka Wakayama, Takeshi Higashiguchi, and Yukitoshi Otani
  • Journal Title: Optical Review Volume: 印刷中 Issue: 3 Pages: 449-461
  • DOI: 10.1007/s10043-017-0315-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of soft x-ray emission spectra of laser-produced dysprosium, erbium and thulium plasmas (2017)
  • Author(s): John Sheil, Padraig Dunne, Takeshi Higashiguchi, Domagoj Kos, Elaine Long, Takanori Miyazaki, Fergal O’Reilly, Gerard O’Sullivan, Paul Sheridan, Chihiro Suzuki, Emma Sokell, Elgiva White, and Deirdre Kilbane
  • Journal Title: Journal of Physics B Volume: 50 Issue: 6 Pages: 065006-065006
  • DOI: 10.1088/1361-6455/aa5e62
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lasing and thermal characteristics of Yb:YAG/YAG composite with atomic diffusion bonding (2017)
  • Author(s): Siva Sankar Nagisetty, Patricie Severova, Taisuke Miura, Martin Smrz, Hitoe Kon, Miyuki Uomoto, Takehito Shimatsu, Masato Kawasaki, Takeshi Higashiguchi, Akira Endo, and Tomas Mocek
  • Journal Title: Laser Physics Letters Volume: 14 Issue: 1 Pages: 015001-015001
  • DOI: 10.1088/1612-202x/14/1/015001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Extreme ultraviolet spectroscopy and atomic models of highly charged heavy ions in the Large Helical Device (2017)
  • Author(s): Chihiro Suzuki, Izumi Murakami, Fumihiro Koike, Naoki Tamura, Hroyuki A. Sakaue, Shigeru Morita, Motoshi Goto, Daiji Kato, Hayato Ohashi, Takeshi Higashiguchi, Shigeru Sudo, and Gegard O’Sullivan
  • Journal Title: Plasma Physics and Controlled Fusion Volume: 59 Issue: 1 Pages: 014009-014009
  • DOI: 10.1088/0741-3335/59/1/014009
  • NAID: 120007180784
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intracellular morphological changes in Staphylococcus aureus induced by treatment with sodium hypochlorite (2017)
  • Author(s): Ujimine S, Tone S, Saito M, Yamada S.
  • Journal Title: Med Mol Morphol. Volume: 50 Issue: 3 Pages: 178-184
  • DOI: 10.1007/s00795-017-0159-6
  • Peer Reviewed
• [Journal Article] Source Development for Extreme Ultraviolet Lithography and Water Window Imaging (2017)
  • Author(s): Gerard O’Sullivan, Padraig Dunne, Deirdre Kilbane, Luning Liu, Ragava Lokasani, Elaine Long, Bowen Li, Thomas McCormack, Fergal O’Reilly, John Sheil, Emma Sokell, Chihiro Suzuki, Tao Wu, and Takeshi Higashiguchi
  • Journal Title: AIP Proceedings Volume: 1811 Pages: 170001-170001
  • DOI: 10.1063/1.4975742
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stable Encapsulation Method during Soft X-ray Irradiation for Hydrated Samples (2016)
  • Author(s): T. Ejima, Masataka Kado, Masahiko Ishino
  • Journal Title: SPring-8/SACLA Research Report Volume: 4 Issue: 2 Pages: 157-160
  • DOI: 10.18957/rr.4.2.157
  • NAID: 130007969341
  • ISSN: 2187-6886
  • Year and Date: 2016-07-25
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of unresolved transition arrays in XUV spectral region from highly charged lead ions produced by subnanosecond laser pulse (2016)
  • Author(s): Tao Wu, Takeshi Higashiguchi, Bowen Li, Goki Arai, Hiroyuki Hara, Yoshiki Kondo, Takanori Miyazaki, Thanh-Hung Dinh, Fergal O’Reilly, Emma Sokell, and Gerry O’Sullivan
  • Journal Title: Optics Communications Volume: 385 Pages: 143-152
  • DOI: 10.1016/j.optcom.2016.10.053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Characteristics of the soft X-ray emission from laser-produced highly charged platinum plasmas (2016)
  • Author(s): Hiroyuki Hara, Goki Arai, Yoshiki Kondo, Thanh-Hung Dinh, Padraig Dunne, Gerry O’Sullivan, Takeo Ejima, Tadashi Hatano, Weihua Jiang, Masaharu Nishikino, Akira Sasaki, Atsushi Sunahara, and Takeshi Higashiguchi
  • Journal Title: Applied Physics Express Volume: 9 Issue: 6 Pages: 066201-066201
  • DOI: 10.7567/apex.9.066201
  • NAID: 210000137954
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Soft X-ray emission from molybdenum plasmas generated by dual laser pulses (2016)
  • Author(s): Ragava Lokasani, Goki Arai, Yoshiki Kondo, Hiroyuki Hara, Thanh-Hung Dinh, Takeo Ejima, Tadashi Hatano, Weihua Jiang, Tetsuya Makimura, Bowen Li, Padraig Dunne, Gerry O’Sullivan, Takeshi Higashiguchi, and Jiri Limpouch
  • Journal Title: Applied Physics Letters Volume: 109 Issue: 19
  • DOI: 10.1063/1.4967310
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of a flat-field grazing incidence spectrometer for highly charged ion plasma emission in soft x-ray spectral region from 1 to 10 nm (2016)
  • Author(s): Thanh-Hung Dinh, Yoshiki Kondo, Toshiki Tamura, Yuichi Ono, Hiroyuki Hara, Hiroki Oikawa, Yoichi Yamamoto, Masahiko Ishino, Masaharu Nishikino, Tetsuya Makimura, Padraig Dunne, Gerry O’Sullivan, Shigeru Ohta, Ken Kitano, Takeo Ejima, Hatano Tadashi, and Takeshi Higashiguchi
  • Journal Title: Review of Scientific Instruments Volume: 87 Issue: 12 Pages: 123106-123106
  • DOI: 10.1063/1.4971421
  • NAID: 120007135053
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 軟Ⅹ線顕微鏡用サイドエントリー型３軸ゴニオメータの開発 (2016)
  • Author(s): 江島丈雄
  • Journal Title: 真空ジャーナル Volume: 156 Pages: 10-14
• [Journal Article] Role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with recurrent miscarriag (2016)
  • Author(s): Yuki Obayashi, Yasuhiko Ozaki, Satomi Kurakane, Shinobu Goto, Kyoko Kumagai, Tamao Kitaori, Suzumori Nobuhiro, Mayumi Sugiura
  • Journal Title: American Journal of Reproductive Immunology Volume: 75 Issue: 1 Pages: 69-77
  • DOI: 10.1111/aji.12434
  • Peer Reviewed
• [Journal Article] Distribution of DNA and Protein in Mammalian Cell Nuclei calculated using NEXAFS profiles at the N-K and O-K edges (2016)
  • Author(s): A. Ito, T. Ohigashi, K. Shinohara, S. Tone, M. Kado, Y. Inagaki and N. Kosugi
  • Journal Title: UVSOR Activity Report Volume: 2015 Pages: 143-143
• [Journal Article] Characteristics of extreme ultraviolet emission from high-Z plasmas (2016)
  • Author(s): Hayato Ohashi, Takeshi Higashiguchi, Yuhei Suzuki, Masato Kawasaki, Chihiro Suzuki, Kentaro Tomita, Masaharu Nishikino, Shinsuke Fujioka, Akira Endo, Bowen Li, Takamitsu Otsuka, Padraig Dunne, and Gerry O’Sullivan
  • Journal Title: Journal of Physics: Conference Series Volume: 688 Pages: 012079-012079
  • DOI: 10.1088/1742-6596/688/1/012079
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Beyond Extreme Ultra Violet (BEUV) Radiation from Spherically symmetrical High-Z plasmas (2016)
  • Author(s): Kensuke Yoshida, Shinsuke Fujioka, Takeshi Higashiguchi, Teruyuki Ugomori, Nozomi Tanaka, Masato Kawasaki, Yuhei Suzuki, Chihiro Suzuki, Kentaro Tomita, Ryouichi Hirose, Takeo Ejima, Hayato Ohashi, Masaharu Nishikino, Enda Scally, Hiroaki Nshimura, Hiroshi Azechi, and Gerard O’Sullivan
  • Journal Title: Journal of Physics: Conference Series Volume: 688 Pages: 012046-012046
  • DOI: 10.1088/1742-6596/688/1/012046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] レーザー生成プラズマEUV光源の最近の動向 (2016)
  • Author(s): 東口 武史
  • Journal Title: 放射線化学 Volume: 102 Pages: 3-9
• [Presentation] BiターゲットLPP光源を用いた軟Ｘ線顕微鏡CXRM (2018)
  • Author(s): 江島丈雄、小野祐一、伊藤圭祐、川崎大夢、羽多野忠、刀祢重信、東口武史
  • Organizer: 第79回応用物理学会秋季学術講演会
• [Presentation] SX-STED用シンチレーターの探索 (2018)
  • Author(s): 江島丈雄、黒澤駿介、山路晃広、羽多野忠、若山俊隆、東口武史、北浦守
  • Organizer: 第79回応用物理学会秋季学術講演会
• [Presentation] ピクセルサイズ1.4×1.4μm2の背面照射型軟Ⅹ線撮像素子の量子効率 (2018)
  • Author(s): 江島丈雄、羽多野 忠
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] Quantum efficiency of back-illuminated CMOS sensor with 1.4×1.4 µm2 pixel size (2018)
  • Author(s): Takeo EJIMA and Tadashi HATANO
  • Organizer: 14th International conference on x-ray microscopy
  • Int'l Joint Research
• [Presentation] Development of laboratory-type soft X-ray microscope, CXRM, in Water-window using LPP light source (2018)
  • Author(s): Takeo Ejima, Yuichi Ono, Keisuke Ito, Hiromu Kawasaki, Takeshi Higashiguchi, Shigenobu Tone and Tadashi Hatano
  • Organizer: 14th International conference on x-ray microscopy
  • Int'l Joint Research
• [Presentation] Analysis of apoptosis induced by actin C-terminal 15 kDa fragment (2018)
  • Author(s): Kamiyama H, Ito N, Tone S, Tanaka M
  • Organizer: American Society of Cell Biology
  • Int'l Joint Research
• [Presentation] アポトーシス研究におけるエレクトロポレーション法の優位性について (2017)
  • Author(s): 刀祢重信
  • Organizer: 第１２２回日本解剖学会
  • Place of Presentation: 長崎大学、長崎県長崎市
  • Year and Date: 2017-03-30
• [Presentation] N2ガス中レーザー生成プラズマからの水の窓軟Ｘ線発光強度 (2017)
  • Author(s): 江島丈雄, 岸本牧, 篠原邦夫, 加道雅孝, 小田切 誠, 角中 昇, 難波慎一
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2017-03-15
• [Presentation] He ガス中レーザー生成プラズマからの8-30nm 軟Ⅹ線発光強度 (2017)
  • Author(s): 江島丈雄、山木賢一
  • Organizer: 第64回応用物理学会春季学術講演会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2017-03-15
• [Presentation] 軟X線発光における誘導放出現象を用いた軟X線STED顕微鏡の可能性 (2017)
  • Author(s): 江島丈雄
  • Organizer: 第26回バイオイメージング学会学術集会
  • Invited
• [Presentation] 軟X線発光における誘導放出現象を用いた軟X線STED顕微鏡 (2017)
  • Author(s): 江島丈雄
  • Organizer: 広島大学第513回物性セミナー
  • Invited
• [Presentation] ピクセルサイズ 1.4×1.4μm2の軟 X 線撮像素子の開発 (2017)
  • Author(s): 江島丈雄
  • Organizer: 第30回日本放射光学会年会
• [Presentation] Heガス中レーザー生成プラズマからの8-30nm軟Ⅹ線発光強度 (2017)
  • Author(s): 江島丈雄, 山木賢一
  • Organizer: 第64回応用物理学会春季学術講演会
• [Presentation] N2ガス中レーザー生成プラズマからの「水の窓」軟Ⅹ線発光強度 (2017)
  • Author(s): 江島丈雄, 岸本牧, 篠原邦夫, 加道雅孝, 小田切誠, 角中昇, 難波愼一
  • Organizer: 第64回応用物理学会春季学術講演会
• [Presentation] 高平均出力水の窓軟X線光源のための薄ディスクレーザーの開発 (2017)
  • Author(s): 東口武史, 山内俊, 篠崎夏美, 小倉拓人, 藤井雄介, 江島丈雄, 坂上和之, 魚本幸, 島津武仁, Mocek Tomas
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] 水の窓軟X線顕微鏡による高分解能撮像に向けて (2017)
  • Author(s): 東口武史, 小野祐一, 田村賢紀, 陳文博, 小倉拓人, 原広行, 近藤芳希, 若山敏隆, 羽多野忠, 江島丈雄
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] 水の窓軟X線領域で高繰り返し動作可能なターゲット元素の選択 (2017)
  • Author(s): 東口武史, 田村賢紀, 小野祐一, 原広行, 近藤芳希, 荒井剛己, 江偉華, 羽多野忠, 江島丈雄
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] Biプラズマ光源水の窓軟X線顕微鏡のための Cr/Sc/Mo 多層膜コンデンサーミラーの開発 (2017)
  • Author(s): 羽多野忠, 江島丈雄, 小野祐一, 陳文博, 近藤芳希, Thanh-Hung Dinh, 田村賢紀, 宜寿次拓弥, 原広行, 荒居剛己, 東口武史
  • Organizer: 第14回Ｘ線結像光学シンポジウム
• [Presentation] βアクチンのC末端側断片は細胞死を誘起する (2017)
  • Author(s): 伊東奈那子、刀祢重信、田中眞人
  • Organizer: 第26回日本Cell Death 学会学術集会
• [Presentation] プロフィリンはβ-アクチンの15kDa-C末端側断片が引き起こす細胞死を抑制する (2017)
  • Author(s): 伊東奈那子、本多弘幸、刀祢重信、田中眞人
  • Organizer: 第26回日本Cell Death 学会学術集会
• [Presentation] C-terminal 15kDa fragment from β-actin causes apoptotic cell death. (2017)
  • Author(s): Ito, N., Tone, S. and Tanaka, M.
  • Organizer: Annual Meeting 2017 of American Society for Biochemistry and Molecular Biology
  • Int'l Joint Research
• [Presentation] 炭素の窓軟X線光源のスペクトル解析 (2016)
  • Author(s): 原 広行，荒居 剛己，Dinh Thanh-Hung，近藤 芳希，田村 賢紀，小野 祐一，佐々木 明，東口 武史
  • Organizer: 平成28年度核融合科学研究所一般共同研究会・原子分子データ応用フォーラムセミナー合同研究会「プラズマ科学における分光計測の高度化と原子分子過程研究の新展開」
  • Place of Presentation: 核融合科学研究所 (岐阜県土岐市)
  • Year and Date: 2016-12-20
• [Presentation] ガス雰囲気下におけるレーザー生成プラズマからの軟Ｘ線発光強度 (2016)
  • Author(s): 江島丈雄、山木賢一、岸本牧、篠原邦夫、加道雅孝
  • Organizer: レーザー励起Ⅹ線源とその応用研究会
  • Place of Presentation: ほほえみの宿滝の湯（山形県天童市）
  • Year and Date: 2016-12-15
• [Presentation] EUV・軟X線光源データベース実験とレーザー開発 (2016)
  • Author(s): 東口武史
  • Organizer: 高強度レーザー・ビーム技術と短波長光源に関する研究会 [電気学会・東京支部新潟支所講演会]
  • Place of Presentation: まちなかキャンパス長岡 (新潟県長岡市)
  • Year and Date: 2016-12-09
• [Presentation] Recent Results on EUV and Soft X-Ray Emission from Laser Produced Plasmas (2016)
  • Author(s): Gerry O’Sullivan, Padraig Dunne, Takeshi Higashiguchi, Deirdre Kilbane, Domagoj Kos, Luning Liu, Oisin Maguire, Takanori Miyazaki, Fergal O’Reilly, John Sheil, Emma Sokell, Chihiro Suzuki, and Tao Wu
  • Organizer: 高強度レーザー・ビーム技術と短波長光源に関する研究会 [電気学会・東京支部新潟支所講演会]
  • Place of Presentation: まちなかキャンパス長岡 (新潟県長岡市)
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] 高強度ベクトルビームパルスの発生とシングルショット偏光検出によるSTED顕微鏡への応用 (2016)
  • Author(s): 若山 俊隆，及川 大基，笹沼 淳史，荒居 剛己，藤井 雄介，ヂン タンフン，東口 武史
  • Organizer: 高強度レーザー・ビーム技術と短波長光源に関する研究会 [電気学会・東京支部新潟支所講演会]
  • Place of Presentation: まちなかキャンパス長岡 (新潟県長岡市)
  • Year and Date: 2016-12-09
• [Presentation] 炭素の窓軟X線光源のスペクトル制御 (2016)
  • Author(s): 原 広行，荒居 剛己，Dinh Thanh-Hung，佐々木 明，東口 武史
  • Organizer: 高強度レーザー・ビーム技術と短波長光源に関する研究会 [電気学会・東京支部新潟支所講演会]
  • Place of Presentation: まちなかキャンパス長岡 (新潟県長岡市)
  • Year and Date: 2016-12-09
• [Presentation] 高出力・高繰り返し短パルスレーザーについての研究 (2016)
  • Author(s): 藤井 雄介，三浦 泰祐，Tomas Mocek．東口 武史
  • Organizer: 高強度レーザー・ビーム技術と短波長光源に関する研究会 [電気学会・東京支部新潟支所講演会]
  • Place of Presentation: まちなかキャンパス長岡 (新潟県長岡市)
  • Year and Date: 2016-12-09
• [Presentation] Profilins suppress the apoptosis induced by cytoskeletal 15kDa-β-actin in cancer cell lines (2016)
  • Author(s): N. Ito, H. Honda, S. Tone, M. Tanaka
  • Organizer: The American Society for Cell Biology Annual Meeting
  • Place of Presentation: Moscone Center, San Francisco, US
  • Year and Date: 2016-12-03
  • Int'l Joint Research
• [Presentation] プラズマ中の重元素多価イオンからの極端紫外スペクトルに関する系統的研究 (2016)
  • Author(s): 鈴木 千尋，村上 泉，小池 文博，東口 武史，坂上 裕之，田村 直樹，須藤 滋，Gerry O’Sullivan
  • Organizer: プラズマ・核融合学会第33回年会
  • Place of Presentation: 東北大学 (宮城県仙台市)
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Unresolved Transition Array (UTA) Emission from Highly-charged Ions in Heavy-element Plasmas by a Dual-laser Pulse Irradiation (2016)
  • Author(s): Takeshi Higashiguchi
  • Organizer: International Workshop on EUV and Soft X-Ray Sources (2016 Source Workshop)
  • Place of Presentation: Amsterdam Science Park Congress Centre, Science Park, Amsterdam, Netherlands
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Recent results in Utsunomiya University: from laboratory experiments to extreme condition experiments (2016)
  • Author(s): T. Hihashiguchi
  • Organizer: Ireland Japan Collaboration Workshop,
  • Place of Presentation: University College Dublin, Dublin, Ireland
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] Soft x-ray spectroscopy of Dy, Er, and ions excited in laser-produced plasmas (2016)
  • Author(s): John Sheil, Takeshi Higashiguchi, Domagoj Kos, Takanori Miyazaki, Fergal O’Reilly, Gerry O’Sullivan, Emma Sokell, Chihiro Suzuki, and Deirdre Kilbane
  • Organizer: Ireland Japan Collaboration Workshop
  • Place of Presentation: University College Dublin, Dublin, Ireland
  • Year and Date: 2016-11-03
  • Int'l Joint Research
• [Presentation] Emission spectroscopy of laser-produced and electron beam ion trap plasmas with high-Z elements in extreme ultraviolet and soft x-ray region (2016)
  • Author(s): Hayato Ohashi, Hiroyuki Hara, Goki Arai, Yoshiki Kondo, Thanh-Hung Dinh, Bowen Li, Padraig Dunne, Gerry O’Sullivan, Nobuyuki Nakamura, Hiroyuki A. Sakaue, Daiji Kato, Izumi Murakami, and Takeshi Higashiguchi
  • Organizer: The 10th International Conference on Atomic and Molecular Data and Their Applications (ICAMDATA 2016)
  • Place of Presentation: Gunsan, Republic of Korea
  • Year and Date: 2016-09-26
  • Int'l Joint Research / Invited
• [Presentation] Fundamental atomic data for fusion, lithography and other applications (2016)
  • Author(s): Bowen Li, Xi-Meng Chen, Takeshi Higashiguchi, Chen-Zhong Dong, Hayato Ohashi, Padraig Dunne, Gerry O’Sullivan
  • Organizer: The 10th International Conference on Atomic and Molecular Data and Their Applications (ICAMDATA 2016)
  • Place of Presentation: Gunsan, Republic of Korea
  • Year and Date: 2016-09-26
  • Int'l Joint Research / Invited
• [Presentation] Opacity effects on soft X-ray spectra from highly charged lanthanide ions in laser-produced plasmas (2016)
  • Author(s): Chihiro Suzuki, Takeshi Higashiguchi, Atsushi Sasanuma, Goki Arai, Yusuke Fujii, Yoshiki Kondo, Thanh-Hung Dinh, Fumihiro Koike, Izumi Murakami, and Gerry O'Sullivan
  • Organizer: 18th in a series of International Conferences on the Physics of Highly Charged Ions (HCI 2016)
  • Place of Presentation: the Jan Kochanowski University (UJK), Kielce, Porland
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] Spectroscopy of highly charged ions for extreme ultraviolet lithography (2016)
  • Author(s): Gerry O’Sullivan, Padraig Dunne, Fergal O’Reilly, Emma Sokell, and Takeshi Higashiguchi
  • Organizer: 18th in a series of International Conferences on the Physics of Highly Charged Ions (HCI 2016)
  • Place of Presentation: the Jan Kochanowski University (UJK), Kielce, Porland
  • Year and Date: 2016-09-14
  • Int'l Joint Research / Invited
• [Presentation] 多価イオンプラズマ計測用軟X 線射入射分光器の絶対較正 (2016)
  • Author(s): ヂン タンフン、近藤芳希、田村賢紀、荒居剛己、牧村哲也、太田茂、北野謙、山本洋一、石野雅彦、錦野将元、江島丈雄、羽多野忠、東口武史
  • Organizer: 第77回応用物理学会秋季学術講演会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2016-09-13
• [Presentation] 波長 4.0 nm 斜入射ミラー用 Cr/Sc/Mo 多層膜の開発 (2016)
  • Author(s): 羽多野忠、江島丈雄
  • Organizer: 第77回応用物理学会秋季学術講演会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2016-09-13
• [Presentation] QUANTITATIVE STUDY OF MAMMALIAN CELLS BY SCANNING TRANSMISSION SOFT X-RAY MICROSCOPY (2016)
  • Author(s): 篠原邦夫, 大東琢治, 刀祢重信, 加道雅孝, 伊藤敦
  • Organizer: X-Ray Microscopy Conference 2016
  • Place of Presentation: Oxford University, UK
  • Year and Date: 2016-08-15
  • Int'l Joint Research
• [Presentation] Organelle Distribution in a Hydrated Bio-cell by Correlation between Soft X-ray and Fluorescence Images (2016)
  • Author(s): T. Ejima, M. Kado, M. Aoyama, K. Yasuda, S. Tamotsu
  • Organizer: 13th International Conference on X-ray Microscopy
  • Place of Presentation: Oxford University, Oxford, UK
  • Year and Date: 2016-08-15
  • Int'l Joint Research
• [Presentation] Stacked tri-layer structure reflecting soft X-rays in the water window region (2016)
  • Author(s): T. Hatano, T. Ejima
  • Organizer: The 3rd CWRU-Tohoku Joint Workshop
  • Place of Presentation: Tohoku Univ., Sendai, Japan
  • Year and Date: 2016-08-09
  • Int'l Joint Research
• [Presentation] Fundamental Atomic Process in Source Development for Beyond EUV Lithography and other applications (2016)
  • Author(s): Bowen Li, Xi-Meng Chen, Xi-Yu Qiu, Takeshi Higashiguchi, Hayato Ohashi, Chen-Zhong Dong, Padraig Dunne, and Gerry O’Sullivan
  • Organizer: The 6th China-Japan-Korea Joint Seminar on Atomic and Molecular Processes in Plasma (AMPP 2016)
  • Place of Presentation: Nuclear Industry Southwest Physics Academe, Chengdu, China
  • Year and Date: 2016-07-26
  • Int'l Joint Research / Invited
• [Presentation] レーザー生成プラズマ軟X線光源の開発 (2016)
  • Author(s): ヂン タンフン，天野 玲保，笹沼 淳史，荒居 剛己，藤井 雄介，高橋 昭彦，中村 大輔，岡田 龍雄，三浦 泰祐，錦野 将元，東口 武史
  • Organizer: レーザーのカオス・ノイズダイナミクスとその応用研究会
  • Place of Presentation: 日亜化学工業株式会社横浜技術研究所（神奈川県横浜市）
  • Year and Date: 2016-07-19
• [Presentation] EUV spectroscopy and atomic models of highly charged heavy ions in the Large Helical Device (2016)
  • Author(s): Chihiro Suzuki, Izumi Murakami, Fumihiro Koike, Naoki Tamura, Hroyuki A. Sakaue, Shigeru Morita, Motoshi Goto, Daiji Kato, Hayato Ohashi, Takeshi Higashiguchi, Shigeru Sudo, and Gegard O’Sullivan
  • Organizer: The 43rd European Physical Society Conference on Plasma Physics
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 2016-07-05
  • Int'l Joint Research / Invited
• [Presentation] Three element multilayer reflector for condenser optic in water window soft X-ray microscope (2016)
  • Author(s): T. Hatano, T. Ejima
  • Organizer: The 39th International conference on Vacuum Ultraviolet and X-ray Physics
  • Place of Presentation: ETH Zurich, Zurich, Switzerland
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Feature of unresolved transition array emission in carbon window soft x-ray spectral region from a laser-produced Platinum plasma: Structure of enhancement and absorption of the soft x-ray emission (2016)
  • Author(s): Hiroyuki Hara, Goki Arai, Thanh-Hung Dinh, Sasaki Akira, Atsushi Sunahara, and Takeshi Higashiguchi
  • Organizer: 18th International Congress on Plasma Physics (ICPP 2016)
  • Place of Presentation: Kaohsiung Exhibition Center, Kaohsiung, Taiwan
  • Year and Date: 2016-06-28
  • Int'l Joint Research
• [Presentation] Efficient EUV and soft x-ray sources with unresolved transition array from highly charged ions in high-Z plasmas (2016)
  • Author(s): Takeshi Higashiguchi
  • Organizer: 23rd International Conference on Spectral Line Shapes
  • Place of Presentation: Culture and Congress Centre Jordanki, Toru, Poland
  • Year and Date: 2016-06-21
  • Int'l Joint Research
• [Presentation] A 10-Hz short pulse CO2 laser system for extreme ultraviolet source (2016)
  • Author(s): Reiho Amano, Thanh-Hung Dinh, Atsushi Sasanuma, Goki Arai, Yusuke Fujii, Akihiko Takahashi, Daisuke Nakamura, Tatsuo Okada, Taisuke Miura, and Takeshi Higashiguchi
  • Organizer: 15th International Conference on X-Ray Lasers 2016
  • Place of Presentation: Nara Kasugano International Forum, Iraka, Nara
  • Year and Date: 2016-05-24
  • Int'l Joint Research
• [Presentation] Characteristics of water window soft x-ray emission from dual laser-produced Bi plasmas (2016)
  • Author(s): Goki Arai, Hiroyuki Hara, Thanh-Hung Dinh, Masaharu Nishikino, Akira Sasaki, Atsushi Sunahara, and Takeshi Higashiguchi
  • Organizer: 15th International Conference on X-Ray Lasers 2016
  • Place of Presentation: Nara Kasugano International Forum, Iraka, Nara
  • Year and Date: 2016-05-24
  • Int'l Joint Research
• [Presentation] Feature of soft x-ray emission from laser-produced multi-charged Pt ions (2016)
  • Author(s): Hiroyuki Hara, Goki Arai, Thanh-Hung Dinh, Masaharu Nishikino, Akira Sasaki, Atsushi Sunahara, and Takeshi Higashiguchi
  • Organizer: 15th International Conference on X-Ray Lasers 2016
  • Place of Presentation: Nara Kasugano International Forum, Iraka, Nara
  • Year and Date: 2016-05-24
  • Int'l Joint Research
• [Presentation] Development of soft X-ray microscope in Water Window using laser produced plasma light source (2016)
  • Author(s): T. Ejima, Y. Kondo, Y. Ono, T. -H. Dinh, T. Higashiguchi, T. Hatano
  • Organizer: The 15th International Conference on X-Ray Lasers
  • Place of Presentation: Nara Kasugano International Forum, Iraka, Nara
  • Year and Date: 2016-04-22
  • Int'l Joint Research
• [Presentation] Evaluation of a flat-field grazing incidence spectrometer for highly charged ion plasma emission in 1－10 nm (2016)
  • Author(s): Y. Kondo, T. Dinh, T. Tamura, S. Ohta, K. Kitano, T. Ejima, T. Hatano, T. Higashiguchi
  • Organizer: The 15th International Conference on X-Ray Lasers
  • Place of Presentation: Nara Kasugano International Forum, Iraka, Nara
  • Year and Date: 2016-04-22
  • Int'l Joint Research
• [Presentation] 重元素高温プラズマの生成と多価イオンプラズマのトムソン散乱診断 (2016)
  • Author(s): ヂン タンフン，東口 武史，藤岡 慎介，松隈 啓，松尾 一輝，Law King Fai Farley，大島 亜弓，原 広行，宜寿次 拓弥，田村 賢紀，富田 健太郎，佐藤 祐太，江口 寿明，鈴木 千尋，佐々木 明，砂原 淳
  • Organizer: レーザー研シンポジウム2016
  • Place of Presentation: 大阪大学銀杏会館 (大阪府吹田市)
  • Year and Date: 2016-04-19
• [Presentation] 重元素による軟X線-EUV光源プラズマの放射流体解析とCRモデルの改良 (2016)
  • Author(s): ヂン タンフン，東口 武史，藤岡 慎介，長友 英夫，砂原 淳
  • Organizer: レーザー研シンポジウム2016
  • Place of Presentation: 大阪大学銀杏会館 (大阪府吹田市)
  • Year and Date: 2016-04-19
• [Presentation] 高輝度軟X線源を用いた軟X線顕微鏡による細胞内器官の高解像観察 (2016)
  • Author(s): 加道雅孝
  • Organizer: レーザー研シンポジウム2016
  • Place of Presentation: 大阪大学（大阪府吹田市）
  • Year and Date: 2016-04-16
• [Presentation] Source development for extreme ultraviolet lithography and water window imaging (2016)
  • Author(s): Gerard O’Sullivan, Padraig Dunne, Deirdre Kilbane, Luning Liu, Ragava Lokasani, Elaine Long, Bowen Li, Thomas McCormack, Fergal O’Reilly, John Sheil, Emma Sokell, Chihiro Suzuki, Tao Wu, and Takeshi Higashiguchi
  • Organizer: 19th International Conference on Atomic Processes in Plasmas
  • Place of Presentation: Congress Center Les Cordeliers, Paris, France
  • Year and Date: 2016-04-06
  • Int'l Joint Research / Invited
• [Patent(Industrial Property Rights)] 軟Ｘ線光源、露光装置および顕微鏡 (2017)
  • Inventor(s): 江島丈雄、加道雅孝、篠原邦夫、岸本牧
  • Industrial Property Rights Holder: 国立大学法人 東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 軟Ｘ線光源および露光装置 (2016)
  • Inventor(s): 江島丈雄、加道雅孝、篠原邦夫、岸本牧
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-160860
  • Filing Date: 2016-08-16
• [Patent(Industrial Property Rights)] 広帯域レーザー出力装置 (2016)
  • Inventor(s): 東口 武史
  • Industrial Property Rights Holder: 宇都宮大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-127278
  • Filing Date: 2016-06-28