| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
We found a phenomenon in which optically active compounds with high optical purity were obtained only by reacting prochiral substrates in solution. In this asymmetric expression amplification phenomenon, the reaction of an achiral compound generates a chiral product, and the racemization and preferential crystallization (dynamic preferential crystallization) of the generated asymmetric center occur simultaneously in the system. The scope of application of this method was extended to achieve absolute asymmetric synthesis of amino acids and heterocyclic compounds as pharmaceutical intermediates.
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