| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
In this research project, we have investigated developments of new catalytic reactions of terminal alkynes with nucleophilnes using quinolinolato-rhodium complexes as a catalyst. We synthesized a variety of rhodium complexes having a tridentate phosphine-containing quinolinolate ligand (PNO ligand). This (PNO)rhodium complexes showed a unique catalytic activity for reactions of terminal alkynes with nucleophiles such as amines. We used the (PNO)rhodium catalyst in a hydroaminative cyclization reaction of enynes with secondary amines. The reaction of 2-vinylphenylacetylenes with secondary amines gave 2-aminoindenes in good yields via hydroaminative cyclization. The reaction is considered to proceed via carbon-carbon bond formation on a catalytically generated aminocarbene ligand. To the best of our knowledge, this reaction is the first application of aminocarbene ligands catalytically generated in situ from organic substrates to carbon-carbon bond forming reactions.
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