| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Organic fluorescent nanoparticles containing liquid fluorescent dye have been developed. We found that the particle size of fluorescent nanoparticles strongly depends on the viscosity of trialkylsilyl substituted pyrene, and the low viscosity liquid gave the smallest particle size. The fluidity of liquid pyrene is also maintained in the nanoparticle core, and the emission color was successfully tuned based on the new concept of "spontaneous incorporation of the dopant dyes into the nanoparticles". We also synthesized novel liquid fluorescent dyes with outstanding photostability, and examined the effect of the position of the silyl group on the physical properties. Furthermore, we prepared fluorescent nanoparticles containing the liquid dye and found that they are taken up inside the cell by the endocytosis mechanism.
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