| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Tight junctions are cell membrane structures responsible for the barrier function of epithelial cells. Breakdown of the barrier function causes chronic inflammation such as atopic dermatitis and ulcerative colitis. In this study, we elucidated the molecular mechanism involved in the formation of tight junctions and found that cholesterol is essential for tight junction formation. Furthermore, we revealed that plasma membrane cholesterol is up-regulated by the formation of adherens junctions.
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