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The molecular sysytem determining differene among regnerative abilities in species

Research Project

Project/Area Number 16H04794
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental biology
Research InstitutionTottori University

Principal Investigator

TAKEUCHI Takashi  鳥取大学, 医学部, 教授 (70197268)

Co-Investigator(Kenkyū-buntansha) 荻野 肇  広島大学, 両生類研究センター, 教授 (10273856)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords再生現象 / 心臓 / 肝臓 / イベリアトゲイモリ / マウス / イモリ / 心臓肝臓 イモリマウス / 肝臓 イモリマウス / イモリマウス / 細胞周期 / 器官形成 / 器官再生 / 遺伝子発現制御
Outline of Final Research Achievements

We found that cyclin D1, the first cell cycle regulator, is expressed in the mouse liver and newt heart which can regenerate , but not in mouse heart which can not regenerate, suggesting that the expression determines the difference of regenerative abilities. We also produced transgenic mice and newts by which expression of cycin D1 can be monitored. A comprehensive transcriptome resource for Iberian ribbed newt was established. In addition, we showed that the newt genes can be efficiently disrupted by CRISPR/cas 9 system. These results enable knockout experiments for given genes, and enhance future research employing newts as a model animal for regeneration research as well as for investigations in other areas.

Academic Significance and Societal Importance of the Research Achievements

生物が種や組織によって再生できる、できないの違いの分子機構を知ることは再生現象のしくみを理解するため、また、私たちヒトで再生できない組織を再生できる再生医療への発展に重要である。本研究の成果では、イモリとマウス、肝臓と心臓と種や組織が異なっていても共通してサイクリンD1の発現の有無が増殖を伴う再生能に関わることを示した。この結果は再生の機構として損傷後にこの遺伝子を発現させる機構が必ずあることを示している。また、ヒトの再生医療としてこれまで再生できない組織を再生させるためにはこの遺伝子と下流の細胞周期進行因子の安定した発現や活性化を適切に制御することで実現できる可能性を示した。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (81 results)

All 2019 2018 2017 2016 Other

All Journal Article (17 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 14 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (52 results) (of which Int'l Joint Research: 7 results,  Invited: 29 results) Book (3 results) Remarks (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Advanced microinjection protocol for gene manipulation using the model newt Pleurodeles waltl2019

    • Author(s)
      Hayashi Toshinori、Nakajima Mie、Kyakuno Mitsuki、Doi Kanako、Manabe Ikumi、Azuma Shouhei、Takeuchi Takashi
    • Journal Title

      The International Journal of Developmental Biology

      Volume: 63 Issue: 6-7 Pages: 281-286

    • DOI

      10.1387/ijdb.180297th

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive reference transcriptome resource for the Iberian ribbed newt Pleurodeles waltl, an emerging model for developmental and regeneration biology2019

    • Author(s)
      Matsunami Masatoshi、Suzuki Miyuki、Haramoto Yoshikazu、Fukui Akimasa、Inoue Takeshi、Yamaguchi Katsushi、Uchiyama Ikuo、Mori Kazuki、Tashiro Kosuke、Ito Yuzuru、Takeuchi Takashi、Suzuki Ken-ichi T、Agata Kiyokazu、Shigenobu Shuji、Hayashi Toshinori
    • Journal Title

      DNA Research

      Volume: 印刷中 Issue: 3 Pages: 217-229

    • DOI

      10.1093/dnares/dsz003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken.2019

    • Author(s)
      Yamashita S, Kataoka K, Yamamoto H, Kato T, Hara S, Yamaguchi K, Renard-Guillet C, Katou Y, Shirahige K, Ochi H, Ogino H, Uchida T, Inui M, Takada S, Shigenobu S, and Asahara H
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 12560-12560

    • DOI

      10.1038/s41598-019-48979-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Xenopus Resources: Transgenic, Inbred and Mutant Animals, Training Opportunities, and Web-Based Support2019

    • Author(s)
      Horb Marko、Wlizla Marcin、Abu-Daya Anita、McNamara Sean、Gajdasik Dominika、Igawa Takeshi、Suzuki Atsushi、Ogino Hajime、Noble Anna、Centre de Ressource Biologique Xenope team in France
    • Journal Title

      Frontiers in Physiology

      Volume: 10 Pages: 1-10

    • DOI

      10.3389/fphys.2019.00387

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional properties of axolotl transient receptor potential ankyrin 1 revealed by the heterologous expression system2019

    • Author(s)
      Oda M, Ogino H, Kubo Y, Saitoh O
    • Journal Title

      Neuroreport

      Volume: 30 Issue: 5 Pages: 323-330

    • DOI

      10.1097/wnr.0000000000001197

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers2019

    • Author(s)
      Suzuki Nanoka、Hirano Kodai、Ogino Hajime、Ochi Haruki
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.43186

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Newts can normalize duplicated proximal-distal disorder during limb regeneration2018

    • Author(s)
      Koriyama Kazuki、Sakagami Risa、Myouga Ayumi、Hayashi Toshinori、Takeuchi Takashi
    • Journal Title

      Developmental Dynamics

      Volume: 247 Issue: 12 Pages: 1276-1285

    • DOI

      10.1002/dvdy.24685

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration.2018

    • Author(s)
      Suzuki M., Hayashi T*., Inoue T., Agata K., Hirayama M., Suzuki M., Shigenobu S., Takeuchi T, Yamamoto T., and Suzuki KT*.
    • Journal Title

      Developmental Biology

      Volume: 447 Issue: 2 Pages: 127-136

    • DOI

      10.1016/j.ydbio.2018.09.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Draft genome of Dugesia japonica provides insights into conserved regulatory elements of the brain restriction gene nou-darake in planarians.2018

    • Author(s)
      5.An, Y., Kawaguchi, A., Zhao, C., Toyoda, A., Sharifi-Zarchi, A., Mousavi, S. A., Bagherzadeh, R., Inoue, T., Ogino, H., Fujiyama, A., Chitsaz, H., Baharvand, H. and Agata, K.
    • Journal Title

      Zoological Lett.

      Volume: 4 Issue: 1

    • DOI

      10.1186/s40851-018-0102-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集 心臓の発生・再生・創生 Ⅳ.心臓の再生 心臓再生が可能な動物と不可能な動物のモデル─その比較から心臓再生を理解する2017

    • Author(s)
      竹内 隆、林 利憲
    • Journal Title

      生体の科学

      Volume: 68 Issue: 6 Pages: 569-573

    • DOI

      10.11477/mf.2425200732

    • ISSN
      0370-9531, 1883-5503
    • Year and Date
      2017-12-15
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Co-accumulation of cis-regulatory and coding mutations during the pseudogenization of the Xenopus laevis homoeologs six6.L and six6.S.2017

    • Author(s)
      Ochi H, Kawaguchi A, Tanouchi M, Suzuki N, Kumada T, Iwata Y, Ogino H.
    • Journal Title

      Developmental Biology

      Volume: 427 Issue: 1 Pages: 84-92

    • DOI

      10.1016/j.ydbio.2017.05.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of cadmium exposure on Iberian ribbed newt (<i>Pleurodeles waltl</i>) testes2017

    • Author(s)
      Ayano Hirako, Yuki Takeoka, Toshinori Hayashi,Takashi Takeuchi, Satoshi Furukawa, and Akihiko Sugiyama
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 30 Issue: 4 Pages: 345-350

    • DOI

      10.1293/tox.2017-0032

    • NAID

      130006176600

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element.2017

    • Author(s)
      Ochi, H., Suzuki, N., Kawaguchi, A. and Ogino, H.
    • Journal Title

      Dev. Biol.

      Volume: 425 Issue: 2 Pages: 152-160

    • DOI

      10.1016/j.ydbio.2017.03.021

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conservatism and variability of gene expression profiles among homeologous transcription factors in Xenopus laevis.2017

    • Author(s)
      Watanabe, M., Yasuoka, Y., Mawaribuchi, S., Kuretani, A., Ito, M., Kondo, M., Ochi, H., Ogino, H., Fukui, A., Taira, M. and Kinoshita, T.
    • Journal Title

      Dev. Biol.

      Volume: 426 Issue: 2 Pages: 301-324

    • DOI

      10.1016/j.ydbio.2016.09.017

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome evolution in the allotetraploid frog Xenopus laevis2016

    • Author(s)
      Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A et al.
    • Journal Title

      Nature

      Volume: 538 Issue: 7625 Pages: 336

    • DOI

      10.1038/nature19840

    • NAID

      120006240046

    • URL

      https://pure.teikyo.jp/en/publications/7cb1b606-b88e-4144-9b58-280a85c3c635

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] イモリをマウスと結ぶための新しい実験モデル2016

    • Author(s)
      林 利憲、竹内 隆
    • Journal Title

      生体の科学

      Volume: 67 Pages: 264-269

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 再生生物学の新時代へー古くて新しいモデル生物イベリアトゲイモリ2016

    • Author(s)
      林 利憲、竹内 隆
    • Journal Title

      実験医学

      Volume: 34 Pages: 1473-1476

    • Related Report
      2016 Annual Research Report
  • [Presentation] 有尾両生類の始原生殖細胞決定におけるvasaおよびdazlの機能解析2019

    • Author(s)
      客野瑞月、佐久間哲志、鈴木賢一、山本卓、野瀬俊明、恒川直樹、竹内隆、林利憲
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イベリアトゲイモリにおけるhox遺伝子の機能解析2019

    • Author(s)
      竹内 隆
    • Organizer
      第2回 再生学異分野融合研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Genetic analysis of thr roles of Hox genes in newt limb regeneration2019

    • Author(s)
      Takashi Takeuchi, Fumina Minamitani and Toshinori Hayashi
    • Organizer
      第52回日本発生生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 異なる進化系譜における倍加遺伝子の収斂進化2019

    • Author(s)
      田内幹大,井川武,鈴木誠,鈴木菜花,荻野肇
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネッタイツメガエルを用いた発生遺伝学およびゲノム進化学研究2019

    • Author(s)
      荻野 肇、井川 武、柏木昭彦、柏木啓子、田内幹大、岩田 唯、越智陽城、鈴木菜花、田澤一朗、鈴木 誠
    • Organizer
      日本動物学会第90回大会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ネッタイツメガエル近交系4系統のゲノム解読と系統間の遺伝的変異2019

    • Author(s)
      3.井川 武,松波雅俊,今村美菜子,鈴木 誠,鈴木 菜花,柏木 昭彦,柏木 啓子,越智陽城,前田士郎,荻野 肇
    • Organizer
      第13回日本ツメガエル研究集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 異なる進化系譜における倍加遺伝子の収斂進化2019

    • Author(s)
      田内 幹大,井川 武,鈴木 誠,鈴木 菜花,荻野 肇
    • Organizer
      第13回日本ツメガエル研究集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 両生類研究センターにおけるトランスジェニックツメガエルの開発と収集2019

    • Author(s)
      鈴木 誠,井川 武,鈴木 菜花,越智陽城,荻野 肇
    • Organizer
      第13回日本ツメガエル研究集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Arid3a regulates nephric tuble regeneration through the evolutionary conserved regeneration signal-response enhancers.2019

    • Author(s)
      Suzuki, N., Hirano, K., Ogino, H. and Ochi, H.
    • Organizer
      第52回日本発生生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The functional domain-localized mutations hidden in the allotetraploid genome of Xenopus laevis.2019

    • Author(s)
      Tanouchi, M., Iwata, Y., Igawa, T., Sakagami, K., Suzuki, N. and Ogino, H.
    • Organizer
      第52回日本発生生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネッタイツメガエルバイオリソースの展開とその発生進化研究への応用2019

    • Author(s)
      荻野 肇
    • Organizer
      中国四国地区生物系三学会合同大会 公開講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 有尾両生類の新規モデル動物であるイベリアトゲイモリが可能にする配偶子形成機構の研究2018

    • Author(s)
      林 利憲、客野 瑞月、竹内 隆
    • Organizer
      第12回日本ツメガエル研究集会・第4回次世代両生類研究会 合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 再生できるできないは何が決めるのか?-心臓に注目して2018

    • Author(s)
      竹内 隆、田根 将志、茗荷あゆみ, 林 利憲
    • Organizer
      第1回再生学異分野融合研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 異分野の融合研究を可能にするモデルイモリ、イベリアトゲイモリの紹介2018

    • Author(s)
      林 利憲、竹内 隆
    • Organizer
      第1回再生学異分野融合研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] イモリ四肢再生芽の交換移植において生じる遠近軸上の重複現象の正常化2018

    • Author(s)
      郡山 和貴、坂上 莉彩、茗荷 あゆみ、林 利憲、竹内 隆
    • Organizer
      第1回再生学異分野融合研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Can newts normalize misposition of proximal to distal levels during limb regeneration?2018

    • Author(s)
      Takashi Takeuchi, Kazuki Koriyama, Risa Sakagami, and Toshinori Hayashi
    • Organizer
      第70回日本細胞生物学会・第51回日本発生生物学会合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The functional domain-localized mutations hidden in the allotetraploid genome of Xenopus laevis2018

    • Author(s)
      Tanouchi, M., Iwata, Y., Igawa, T., Sakagami, K., Suzuki, N. and Ogino, H.
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Current trends in Xenopus research2018

    • Author(s)
      Ogino, H
    • Organizer
      The 10th NIBB International Practical Course "Genome Editing and Imaging of Fish and Amphibians"
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ツメガエルを用いたゲノム進化研究とリソース事業について2018

    • Author(s)
      荻野 肇,田内 幹大,岩田 唯,越智 陽城,井川 武,鈴木 菜花,柏木 昭彦,柏木 啓子
    • Organizer
      第12回日本ツメガエル研究集会・第4回次世代両生類研究会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ネッタイツメガエル系統の遺伝的関係と近交度について2018

    • Author(s)
      井川 武,柏木 昭彦,柏木 啓子,鈴木 菜花,渡辺 愛,鈴木 厚,Anna Noble,David E. Simpson,Marko E. Horb,Tamotsu Fujii,住田 正幸,荻野 肇
    • Organizer
      第12回日本ツメガエル研究集会・第4回次世代両生類研究会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Arid3a regulates the nephric tubule regeneration via the evolutionary conserved regeneration signal-response enhancer2018

    • Author(s)
      鈴木 菜花,平野 高大,荻野 肇,越智 陽城
    • Organizer
      第12回日本ツメガエル研究集会・第4回次世代両生類研究会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アフリカツメガエルの偽4倍体ゲノムに潜在する機能ドメイン集中型変異2018

    • Author(s)
      田内 幹大,岩田 唯,井川 武,阪上 起世,鈴木 菜花,荻野 肇
    • Organizer
      第12回日本ツメガエル研究集会・第4回次世代両生類研究会合同シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Geneolgy and pedigrees of inbreeding strains of Xenopus tropicalis2018

    • Author(s)
      Igawa, T., Kashiwagi, A., Kashiwagi, K., Suzuki, N., Watanabe, A., Suzuki, A., Noble, A., Guille, M., Simpson, D. E., Horb, M. E., Fujii, T., Sumida, M. and Ogino, H.
    • Organizer
      17th International Xenopus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The launching of Amphibian Research Center (ARC) at Hiroshima University as the core facility of Xenopus resource in Japan.2018

    • Author(s)
      Ogino, H. and Suzuki, A.
    • Organizer
      17th International Xenopus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 四肢動物モデルとしてのネッタイツメガエルとその発生進化研究への応用-リソース整備の大切さを踏まえて-2018

    • Author(s)
      荻野 肇
    • Organizer
      第19回 Pharmaco-Hematologyシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The hypomorphic mutations hidden in the allotetraploid genome of Xenopus laevis.2018

    • Author(s)
      Tanouchi, M., Ochi, H., Kawaguchi, A., Igawa, T., Iwata, Y., Sakagami, K. and Ogino, H.
    • Organizer
      第70回日本細胞生物学会・第51回日本発生生物学会合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The wild-type Xenopus laevis is an asymptomatic carrier of aniridia-like pax6 mutations.2018

    • Author(s)
      Iwata, Y., Tanouchi, M., Igawa, T., Sakagami, K., Ochi, H. and Ogino, H.
    • Organizer
      第70回日本細胞生物学会・第51回日本発生生物学会合同大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] What determines differences in regenerative abilities between mice and newts?2018

    • Author(s)
      T. Takeuchi
    • Organizer
      International Symposium on Regenerative Medicine at Nagasaki University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of Newt model using Iberian Ribbed Newt (Pleurodeles waltl) for Regeneration Research and more.2018

    • Author(s)
      T. Hayashi, M. Nakajima, M. Kyakuno, I. Manabe, K. Doi, and T. Takeuchi
    • Organizer
      広島大学両生類研究センター国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of cardiac regeneration using new model newt Pleurodeles waltl.2017

    • Author(s)
      Toshinori Hayashi, Ayumi Myouga, Eri Tsuchiya, Shohei Azuma, Yukio Sato and Takashi Takeuchi
    • Organizer
      Annual meeting of the Japanese Society of Developmental Biologists Symposium
    • Place of Presentation
      Tower Hall Funabori (Edogawa, Tokyo)
    • Year and Date
      2017-05-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 再生できる動物」と「再生できない動物では何が異なるのか?2017

    • Author(s)
      林 利憲、佐藤 幸夫、竹内 隆
    • Organizer
      再生医療学会 高校生体験企画
    • Place of Presentation
      仙台国際センター(宮城県 仙台市)
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 新規実験モデル動物のイベリアトゲイモリが可能にする新しい再生研究2017

    • Author(s)
      林 利憲、茗荷 あゆみ、東 翔平、土屋 絵莉、竹内 隆
    • Organizer
      日本再生医療学会 シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県 仙台市)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウスとイモリを用いた再生研究~再生能の違いは何が決めるか?2017

    • Author(s)
      竹内 隆
    • Organizer
      CREST研究課題「細胞動態の多様性・不均一性に基づく組織構築原理の解明」研究集会 特別講演
    • Place of Presentation
      松江エクセルホテル東急(島根県 松江市)
    • Year and Date
      2017-02-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウスとイモリを用いた再生の研究 再生能の違いは何が決めるのか?2017

    • Author(s)
      竹内隆
    • Organizer
      第3回幹細胞研究会 幹細胞の基本原理と共通性 植物と動物の比較から
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 肝臓はどのようにサイズを認識して再生するのか? 細胞周期制御因子の動態からの解析2017

    • Author(s)
      園田夕貴、平田早紀、佐藤幸夫、林利憲、竹内隆
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心臓と肝臓の再生能力の違いの原因は何か?~cyclin D1に着目して~2017

    • Author(s)
      平田早紀、園田夕貴、佐藤幸夫、林利憲、竹内隆
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 次世代シークエンスとゲノム編集技術によるイモリの配偶子形成機構の研究2017

    • Author(s)
      林利憲、客野瑞月、中島美英、竹内隆
    • Organizer
      第88回日本動物学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] イモリ始原生殖細胞の決定におけるVASA遺伝子の機能解析2017

    • Author(s)
      客野瑞月、佐久間哲志、鈴木賢一、山本卓、野瀬俊明、恒川直樹、竹内隆、林利憲
    • Organizer
      第88回日本動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イモリの持つがん化耐性能力の解明に向けた研究 p53変異体を用いた解析2017

    • Author(s)
      中島美英、佐久間哲志、山本卓、竹内隆、林利憲
    • Organizer
      第88回日本動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] New approach toward elucidation of the mechanisms for PGC determination in amphibian newts.2017

    • Author(s)
      T. Hayashi, M. Nakajima, M. Kyakuno, I., and T. Takeuchi
    • Organizer
      The International Research Symposium on Regulation of Germ cell development in vivo and in vitro
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of cardiac regeneration using new model newt Pleurodeles waltl.2017

    • Author(s)
      T. Hayashi, A. Myouga, E. Tsuchiya, S. Azuma, Y. Satoh, and T. Takeuchi
    • Organizer
      Annual meeting of the Japanese Society of Developmental Biologists Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ツメガエルを用いたゲノム研究とリソース事業について2017

    • Author(s)
      荻野肇
    • Organizer
      第2回イベリアトゲイモリ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲノム倍加に伴うエンハンサー減衰変異と機能低下型コード変異の共蓄積2017

    • Author(s)
      越智陽城,川口茜,田内幹大,鈴木菜花,熊田樹,岩田唯,荻野肇
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腎組織再生におけるArid3aによる再生シグナル応答エンハンサーの活性化メカニズム2017

    • Author(s)
      鈴木菜花,熊田樹,荻野肇,越智陽城
    • Organizer
      第88回日本動物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アフリカツメガエルにおけるCrispr/Casシステムの条件検討2017

    • Author(s)
      田内幹大,越智陽城,井川武,荻野肇
    • Organizer
      第11回日本ツメガエル研究集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The launching of Amphibian Research Center (ARC) at Hiroshima University as the core facility of Xenopus resource in Japan.2017

    • Author(s)
      Ogino, H. and Suzuki, A
    • Organizer
      Xenopus Resources and Emerging Technologies Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ゲノム倍加後のコード配列進化におけるエンハンサー減衰変異の促進的役割2016

    • Author(s)
      荻野 肇,越智陽城,川口 茜
    • Organizer
      日本分子生物学会年会 シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県 横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cardiac regeneration in newts achieved based on the compensatory manner.2016

    • Author(s)
      Toshinori Hayashi, Ayumi Myouga, Eri Tsuchiya, Shohei Azuma Yukio Sato and Takashi Takeuchi
    • Organizer
      ICZ/ZSJ Joint Meeting Symposium
    • Place of Presentation
      OIST (Onna-son, Okinawa)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modification of cell differentiation competence by histone H3K27 demethylases and their involvement in tissue regeneration in Xenopus2016

    • Author(s)
      Ogino, H., Sudou, N., Kawaguchi, A., Ochi, H., Kamiguchi, S. and Kasahara, H.
    • Organizer
      ICZ/ZSJ Joint Meeting Symposium
    • Place of Presentation
      OIST (Onna-son, Okinawa)
    • Year and Date
      2016-11-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 革新的イモリ研究の創成~イベリアトゲイモリを用いて2016

    • Author(s)
      竹内 隆
    • Organizer
      オモロイ生き物研究会
    • Place of Presentation
      定山渓ホテル(北海道 札幌市)
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] イモリの再生能力を支える機構をマウスとの比較から明らかにする2016

    • Author(s)
      林 利憲、竹内 隆
    • Organizer
      ユニーク動物研究会 招待講演
    • Place of Presentation
      基礎生物学研究所(愛知県 岡崎市)
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] イベリアトゲイモリを用いた心臓再生における細胞増殖の制御機構の研究2016

    • Author(s)
      林 利憲、茗荷 あゆみ、土屋 絵莉、東 翔平、竹内 隆
    • Organizer
      次世代両生類研究会
    • Place of Presentation
      基礎生物学研究所(愛知県 岡崎市)
    • Year and Date
      2016-08-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 心臓と循環器系の発生、“動物学の百科事典”2018

    • Author(s)
      竹内 隆
    • Total Pages
      808
    • Publisher
      丸善出版
    • ISBN
      9784621303092
    • Related Report
      2018 Annual Research Report
  • [Book] 眼の形成、“動物学の百科事典”2018

    • Author(s)
      荻野 肇、阪上起世、松田孝彦
    • Total Pages
      808
    • Publisher
      丸善出版
    • ISBN
      9784621303092
    • Related Report
      2018 Annual Research Report
  • [Book] 動物学の百科事典2018

    • Author(s)
      竹内隆
    • Publisher
      丸善出版
    • Related Report
      2017 Annual Research Report
  • [Remarks] 鳥取大学医学部生命科学科発生生物学分野

    • URL

      https://www.med.tottori-u.ac.jp/introduction/lifesciences/about/3319/3335/23806.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 鳥取大学医学部生命科学科生体情報学分野 HP

    • URL

      http://takashitakeuchi.blog29.fc2.com/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 広島大学両生類研究センター 進化発生ゲノミクス研究グループ

    • URL

      http://amphibian.hiroshima-u.ac.jp/front-page/evo-devo_genomics/

    • Related Report
      2018 Annual Research Report
  • [Remarks] iNewt-intefrated portal site for the newt,P.waltl.

    • URL

      https://www.nibb.ac.jp/imori/main/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 鳥取大学医学部生命科学科生体情報学分野

    • URL

      https://www.facebook.com/seitai.seimei.toridai?ref=aymt_homepage_panel

    • Related Report
      2017 Annual Research Report
  • [Remarks] 鳥取大学医学部生命科学科生体情報学分野

    • URL

      http://www.med.tottori-u.ac.jp/introduction/lifesciences/about/3319/3335/23806.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 鳥取大学 医学部 生命科学科 生体情報学分野

    • URL

      https://www.facebook.com/seitai.seimei.toridai

    • Related Report
      2016 Annual Research Report
  • [Remarks] 鳥取大学 医学部 生命科学科 生体情報学分野

    • URL

      http://www.med.tottori-u.ac.jp/biosign/5982.html

    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 腫瘍を誘導する変異型p53遺伝子2019

    • Inventor(s)
      林利憲、竹内隆、梅山穂乃香、中島美英、山本卓、佐久間哲史
    • Industrial Property Rights Holder
      林利憲、竹内隆、梅山穂乃香、中島美英、山本卓、佐久間哲史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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