| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Most animals belonging to Bilateria have mirror-symmetric body plan along the left-right axis. However, the mechanisms to produce mirror symmetric organs are poorly understood. In C. elegans, gonad has mirror-symmetric structure along the anterior-posterior axis and shaped by mirror-symmetric migration of DTC cells. This mechanism has not been explored. DTCs are produced by asymmetric divisions of their precursor cells (Z1/Z4). We uncovered that polarity of Z1/Z4 is regulated redundantly by three Wnt proteins and a Wnt receptor that functions Wnt-independently. Furthermore, we showed that migratory direction of DTCs are determined by polarity orientation of their mother cells.
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