| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
We performed integrative analysis of secondary metabolite biosynthesis, morphological development, and their regulation on the basis of the Streptomyces genome. (1) We characterized unique biosynthetic machinery for azoxyalkene, and quinone-dependent dehydrogenase. Antitumor activity of lankacidin antibiotics was elucidated. (2) Complete genome analysis of Streptomyces rochei was performed. This linear chromosome comprises 8.36 Mb in size and 35 secondary metabolite gene clusters. (3) We characterized that a pseudo-receptor gene srrB act as a negative regulator for lankacidin and lankamycin production in S. rochei.
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