| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Respiratory epithelium functions as a first defender against infectious agents by separating the body from external environment and by initially producing inflammatory cytokines. As a result of the cytokine response, macrophages and neutrophils are migrated to the infected tissues to eliminate infectious agents. In this study, we analyzed the inflammatory response mechanism in respiratory epithelial cells and identified respiratory epithelium-specific inflammasome receptors. We also identified host factors that are utilized by influenza virus to evade the inflammatory response.
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