| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
TRAIL is a cytokine which can induce apoptosis against cancer cells, and contribute to cancer prevention. We have focused on TRAIL and examined whether the decline of immunity due to diabetes resulted in the down-regulation of TRAIL expression causing subsequent carcinogenesis and the up-regulation of leptin expression.
We compared the expression of TRAIL mRNA of the organ samples from a type 2 diabetes model of the mouse with those from the control mouse. As the results, TRAIL expressions of cDNA samples derived from lung of the diabetes model animals were lower than those from control mouse. Next, we showed the suppressive effect of leptin against the IFN-activated PBMCs to produce TRAIL. Furthermore, we focused on PED which were reported to be overexpressed in type 2 diabetes mellitus and mediate TRAIL resistance in human non-small cell lung cancer. Therefore, we tried the screening of the down-regulator of PED expression.
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