A study to elucidate the mechanism by which sterile chronic inflammation occurs in arterial wall and perivascular adipose tissue

• Project/Area Number: 16H05299
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SATA Masataka 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (80345214)
• Co-Investigator(Kenkyū-buntansha): 福田 大受 徳島大学, 大学院医歯薬学研究部(医学域), 特任講師 (40637568) ; 添木 武 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (60393211) ; 平田 陽一郎 東京大学, 医学部附属病院, 助教 (40447397)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 慢性炎症 / 動脈硬化 / メタボリックシンドローム / インスリン抵抗性 / 肥満 / 自然免疫 / 自己核酸 / 糖尿病 / 脂肪 / 生活習慣病 / 脂肪組織 / 循環器・高血圧 / 血管

Outline of Final Research Achievements

We investigated the mechanism by which life style-related diseases cause chronic inflammation in the pathogenesis of atherosclerosis and diabetes mellitus. Overeating, dyslipidemia, and hyperglycemia induced death of vascular cells and adipocytes. Experiments using cultured cells and genetically-modified mice revealed that cell-free DNA released from injured cells stimulated TLR9 on macrophages leading to chronic inflammation in adipose tissues and arteries. It was showed that inhibition of cell death and the inhibitory oligonucleotide against TLR9 would be promising as a new treatment strategy for life style-related diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、肥満や高血圧、高脂血症といった生活習慣病によって、血管や脂肪組織でアポトーシスやピロトーシス、ネクローシスといった細胞死が生じ、慢性炎症が惹起される分子機序を明らかにすることができた。傷害された細胞から遊離される自己の遊離核酸断片がマクロファージの自然免疫受容体TLR9を刺激することで炎症が生じることが明らかになったことから、細胞死や遊離核酸断片、TLR9などを標的として、新しい糖尿病や動脈硬化の診断法や治療法の開発が可能になると期待される。

Research Products

• [Journal Article] Simultaneous Pulmonary Arterial and Venous Round Structures in Pulmonary Aspergillosis (2019)
  • Author(s): Yagi Shusuke、Yamazaki Hiromu、Nishio Susumu、Kusunose Kenya、Yamada Hirotsugu、Sata Masataka
  • Journal Title: Circulation Journal Volume: 83 Issue: 6 Pages: 1416
  • DOI: 10.1253/circj.CJ-18-0898
  • NAID: 130007652733
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-05-24
  • Peer Reviewed / Open Access
• [Journal Article] Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ― (2019)
  • Author(s): Kajikawa Masato、Noma Kensuke、Nakashima Ayumu、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Circulation Journal Volume: 83 Issue: 5 Pages: 1064-1071
  • DOI: 10.1253/circj.CJ-18-1082
  • NAID: 130007636980
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-04-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome (2019)
  • Author(s): Yagi Shusuke、Kondo Daisuke、Yamaguchi Koji、Wakatsuki Tetsuzo、Kawabata Yutaka、Ito Hiroyuki、Saijo Yoshihito、Seno Hiromitsu、Sutou Kumiko、Ueno Rie、Todoroki Takafumi、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Aihara Ken-ichi、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 3 Pages: 272-281
  • DOI: 10.5551/jat.44735
  • NAID: 130007606848
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of alirocumab 150mg every 4 weeks in hypercholesterolemic patients on non-statin lipid-lowering therapy or lowest strength dose of statin: ODYSSEY NIPPON. (2019)
  • Author(s): Teramoto T, Kiyosue A, Ishigaki Y, Harada-Shiba M, Kawabata Y, Ozaki A, Baccara-Dinet MT, Sata M.
  • Journal Title: J Cardiol. Volume: 73 Issue: 3 Pages: 121-127
  • DOI: 10.1016/j.jjcc.2018.10.004
  • NAID: 120006602926
  • Peer Reviewed
• [Journal Article] Recurrent venous thromboembolism after discontinuation of rivaroxaban therapy in a patient with antiphospholipid syndrome (2019)
  • Author(s): Yagi Shusuke、Nishiyama Seiichi、Abe Toshio、Sata Masataka
  • Journal Title: BMJ Case Reports Volume: 12 Issue: 1 Pages: bcr-2018-227663
  • DOI: 10.1136/bcr-2018-227663
  • NAID: 120006797802
  • Peer Reviewed / Open Access
• [Journal Article] Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II Induced Atherosclerosis (2019)
  • Author(s): Fukuda Daiju、Nishimoto Sachiko、Aini Kunduziayi、Tanaka Atsushi、Nishiguchi Tsuyoshi et al.
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 7
  • DOI: 10.1161/jaha.118.010860
  • NAID: 120006602927
  • Peer Reviewed / Open Access
• [Journal Article] Sequential speckle tracking imaging to detect early stage of cancer therapeutics-related cardiac dysfunction in a patient with breast cancer (2019)
  • Author(s): Saijo Yoshihito、Kusunose Kenya、Yamada Nao、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Sata Masataka
  • Journal Title: Journal of Echocardiography Volume: 印刷中 Issue: 2 Pages: 134-135
  • DOI: 10.1007/s12574-019-00423-2
  • NAID: 120006797338
  • Peer Reviewed
• [Journal Article] Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease (2019)
  • Author(s): Saito Yuko、Yamada Hirotsugu、Kusunose Kenya、Saito Ken、Sata Masataka
  • Journal Title: Journal of Echocardiography Volume: 印刷中 Issue: 4 Pages: 206-212
  • DOI: 10.1007/s12574-019-00421-4
  • Peer Reviewed
• [Journal Article] Epicardial Fat and Pericardial Fat Surrounding the Heart Have Different Characteristics (2018)
  • Author(s): Hirata Yukina、Yamada Hirotsugu、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 10 Pages: 2475-2476
  • DOI: 10.1253/circj.CJ-18-0923
  • NAID: 130007487148
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-09-25
  • Peer Reviewed / Open Access
• [Journal Article] Clinical, Electrocardiographic, and Echocardiographic Parameter Combination Predicts the Onset of Atrial Fibrillation (2018)
  • Author(s): Soeki Takeshi、Matsuura Tomomi、Tobiume Takeshi、Bando Sachiko、Matsumoto Kazuhisa、Nagano Hiromi、Uematsu Etsuko、Kusunose Kenya、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Wakatsuki Tetsuzo、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 9 Pages: 2253-2258
  • DOI: 10.1253/circj.CJ-17-0758
  • NAID: 130007438979
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-08-24
  • Peer Reviewed / Open Access
• [Journal Article] An Occluded Hooklet of an Embedded Inferior Vena Cava Filter (2018)
  • Author(s): Yagi Shusuke、Yamamoto Yousuke、Nishiyama Seiichi、Sata Masataka
  • Journal Title: Internal Medicine Volume: 57 Issue: 15 Pages: 2275-2276
  • DOI: 10.2169/internalmedicine.0505-17
  • NAID: 130007429090
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-08-01
  • Peer Reviewed
• [Journal Article] Prognostic Value of Frailty and Diastolic Dysfunction in Elderly Patients (2018)
  • Author(s): Kusunose Kenya 、Okushi Yuichiro 、Yamada Hirotsugu 、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 8 Pages: 2103-2110
  • DOI: 10.1253/circj.CJ-18-0017
  • NAID: 130007418904
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-07-25
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation (2018)
  • Author(s): Oba Kageyuki、Maeda Minetaka、Maimaituxun Gulinu、Yamaguchi Satoshi、Arasaki Osamu、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Nishio Susumu、Iwase Takashi、Takao Shoichiro、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 82 Issue: 7 Pages: 1778-1787
  • DOI: 10.1253/circj.CJ-18-0021
  • NAID: 130007410632
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-06-25
  • Peer Reviewed / Open Access
• [Journal Article] Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease ― New Prediction Model in Combination With Framingham Risk Score ― (2018)
  • Author(s): Maimaituxun Gulinu、Shimabukuro Michio、Fukuda Daiju、Yagi Shusuke、Hirata Yukina、Iwase Takashi、Takao Shoichiro、Matsuura Tomomi、Ise Takayuki、Kusunose Kenya、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Harada Masafumi、Sata Masataka
  • Journal Title: Circulation Journal Volume: 82 Issue: 5 Pages: 1369-1378
  • DOI: 10.1253/circj.CJ-17-1289
  • NAID: 130006725981
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele (2018)
  • Author(s): Davy Philip M C、Willcox D Craig、Shimabukuro Michio、Donlon Timothy A、Torigoe Trevor、Suzuki Makoto、Higa Moritake、Masuzaki Hiroaki、Sata Masataka、Chen Randi、Murkofsky Rachel L、Morris Brian J、Lim Eunjung、Allsopp Richard C、Willcox Bradley J
  • Journal Title: The Journals of Gerontology: Series A Volume: 73 Issue: 11 Pages: 1448-1452
  • DOI: 10.1093/gerona/gly071
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E?Deficient Mice (2018)
  • Author(s): Hara Tomoya、Phuong Pham Tran、Fukuda Daiju、Yamaguchi Koji、Murata Chie、Nishimoto Sachiko、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Imoto Issei、Shimabukuro Michio、Sata Masataka
  • Journal Title: Circulation Volume: 138 Issue: 16 Pages: 1706-1719
  • DOI: 10.1161/circulationaha.118.033544
  • NAID: 120006546436
  • Peer Reviewed
• [Journal Article] Cross-sectional and longitudinal associations between serum uric acid and endothelial function in subjects with treated hypertension (2018)
  • Author(s): Tanaka Atsushi、Tomiyama Hirofumi、Ishizu Tomoko、Higashi Yukihito、Takase Bonpei、Ueda Shinichiro、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Ishibashi Yutaka、Maemura Koji、Ohya Yusuke、Furukawa Taiji、Ito Hiroshi、Yamashina Akira、Node Koichi
  • Journal Title: International Journal of Cardiology Volume: 272 Pages: 308-313
  • DOI: 10.1016/j.ijcard.2018.06.017
  • Peer Reviewed / Open Access
• [Journal Article] Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice (2018)
  • Author(s): Ganbaatar Byambasuren、Fukuda Daiju、Salim Hotimah Masdan、Nishimoto Sachiko、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: Atherosclerosis Volume: 275 Pages: 124-132
  • DOI: 10.1016/j.atherosclerosis.2018.05.053
  • Peer Reviewed
• [Journal Article] A clinical application of preload stress echocardiography for predicting future hemodynamic worsening in patients with early-stage heart failure (2018)
  • Author(s): Saijo Yoshihito、Yamada Hirotsugu、Kusunose Kenya、Bando Mika、Nishio Susumu、Torii Yuta、Hirata Yukina、Seno Hiromitsu、Matsuura Tomomi、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Echocardiography Volume: 35 Issue: 10 Pages: 1587-1595
  • DOI: 10.1111/echo.14098
  • Peer Reviewed
• [Journal Article] Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A (2018)
  • Author(s): Maruhashi Tatsuya、Nakashima Ayumu、Goto Chikara、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Journal of the American Heart Association Volume: 7 Issue: 14
  • DOI: 10.1161/jaha.118.008588
  • NAID: 120006556311
  • Peer Reviewed / Open Access
• [Journal Article] Right Ventricular Function and Beneficial Effects of Cardiac Rehabilitation in Patients With Systolic Chronic Heart Failure (2018)
  • Author(s): Kusunose Kenya、Seno Hiromitsu、Yamada Hirotsugu、Nishio Susumu、Torii Yuta、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Canadian Journal of Cardiology Volume: 34 Issue: 10 Pages: 1307-1315
  • DOI: 10.1016/j.cjca.2018.06.003
  • NAID: 120006795581
  • Peer Reviewed
• [Journal Article] Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation (2018)
  • Author(s): Maeda Minetaka、Oba Kageyuki、Yamaguchi Satoshi、Arasaki Osamu、Sata Masataka、Masuzaki Hiroaki、Shimabukuro Michio
  • Journal Title: The American Journal of Cardiology Volume: 122 Issue: 10 Pages: 1694-1700
  • DOI: 10.1016/j.amjcard.2018.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Possible Roles of Epicardial Adipose Tissue in the Pathogenesis of Coronary Atherosclerosis (2018)
  • Author(s): Tanaka Kimie、Sata Masataka
  • Journal Title: Annals of Nuclear Cardiology Volume: 4 Issue: 1 Pages: 5-10
  • DOI: 10.17996/anc.18-00079
  • NAID: 130007474581
  • ISSN: 2189-3926, 2424-1741
  • Peer Reviewed
• [Journal Article] Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia (2018)
  • Author(s): Nishimoto Sachiko、Aini Kunduziayi、Fukuda Daiju、Higashikuni Yasutomi、Tanaka Kimie、Hirata Yoichiro、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 5 Pages: 144-144
  • DOI: 10.3389/fcvm.2018.00144
  • NAID: 120006606147
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study (2018)
  • Author(s): Izumi Yuishin、Miyamoto Ryosuke、Fujita Koji、Yamamoto Yuki、Yamada Hirotsugu、Matsubara Tomoyasu、Unai Yuki、Tsukamoto Ai、Takamatsu Naoko、Nodera Hiroyuki、Hayashi Shinya、Oda Masaya、Mori Atsuko、Nishida Yoshihiko、Watanabe Shunsuke、Ogawa Hirohisa、Uehara Hisanori、Murayama Shigeo、Sata Masataka、Kaji Ryuji
  • Journal Title: Frontiers in Neurology Volume: 9 Pages: 1099-1099
  • DOI: 10.3389/fneur.2018.01099
  • NAID: 120006606148
  • Peer Reviewed / Open Access
• [Journal Article] Left atrial functional response after a marathon in healthy amateur volunteers (2018)
  • Author(s): Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Morita Sae、Torii Yuta、Nishio Susumu、Zheng Robert、Saijo Yoshihito、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: - Issue: 4 Pages: 633-643
  • DOI: 10.1007/s10554-018-1502-2
  • NAID: 120006844037
  • Peer Reviewed
• [Journal Article] Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice (2018)
  • Author(s): Sugasawa Noriko、Katagi Ayako、Kurobe Hirotsugu、Nakayama Taisuke、Nishio Chika、Takumi Hiroko、Higashiguchi Fumiharu、Aihara Ken-ichi、Shimabukuro Michio、Sata Masataka、Kitagawa Tetsuya
  • Journal Title: Journal of the American College of Nutrition Volume: 38 Issue: 1 Pages: 15-22
  • DOI: 10.1080/07315724.2018.1468831
  • Peer Reviewed
• [Journal Article] Development and validation of optimal cut-off value in inter-arm systolic blood pressure difference for prediction of cardiovascular events (2018)
  • Author(s): Hirono Akira、Kusunose Kenya、Kageyama Norihito、Sumitomo Masayuki、Abe Masahiro、Fujinaga Hiroyuki、Sata Masataka
  • Journal Title: J Cardiol Volume: 71 Issue: 1 Pages: 24-30
  • DOI: 10.1016/j.jjcc.2017.06.010
  • Peer Reviewed
• [Journal Article] Edoxaban improves acute venous thromboembolism while preserving protein C and protein S levels (2018)
  • Author(s): Yamazaki Hiromu、Yagi Shusuke、Torii Yuta、Amano Rie、Oomichi Yasuyuki、Sangawa Teruaki、Fukuda Daiju、Kadota Muneyuki、Ise Takayuki、Ueno Rie、Hara Tomoya、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamaguchi Koji、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Cardiology Volume: 71 Issue: 3 Pages: 305-309
  • DOI: 10.1016/j.jjcc.2017.09.009
  • Peer Reviewed
• [Journal Article] Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension (2018)
  • Author(s): Tomiyama Hirofumi、Ishizu Tomoko、Higashi Yukihito、Ueda Shinichiro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Node Koichi
  • Journal Title: International Journal of Cardiology Volume: 253 Pages: 161-166
  • DOI: 10.1016/j.ijcard.2017.11.022
  • NAID: 120006956866
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of activated factor X by rivaroxaban attenuates neointima formation after wire-mediated vascular injury (2018)
  • Author(s): Hara Tomoya、Fukuda Daiju、Tanaka Kimie、Higashikuni Yasutomi、Hirata Yoichiro、Yagi Shusuke、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Euro J Pharmacol Volume: 820 Pages: 222-228
  • DOI: 10.1016/j.ejphar.2017.12.037
  • NAID: 120007097698
  • Peer Reviewed
• [Journal Article] Provocation of clinically significant left ventricular outflow tract obstruction by postural change in patients with sigmoid septum (2018)
  • Author(s): Hirata Yukina、Yamada Hirotsugu、Kusunose Kenya、Nishio Susumu、Torii Yuta、Horike Yuki、Sata Masataka
  • Journal Title: J Ecocardiogr Volume: - Issue: 4 Pages: 173-174
  • DOI: 10.1007/s12574-018-0372-x
  • NAID: 120006797803
  • Peer Reviewed
• [Journal Article] Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis (2018)
  • Author(s): Tanaka Kimie、Sata Masataka
  • Journal Title: Frontiers in Physiology Volume: 9-3 Pages: 1-9
  • DOI: 10.3389/fphys.2018.00003
  • NAID: 120006786181
  • Peer Reviewed / Open Access
• [Journal Article] α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study (2017)
  • Author(s): Shimabukuro M, Tanaka A, Sata M, Dai K, Shibata Y, Inoue Y, Ikenaga H, Kishimoto S, Ogasawara K, Takashima A, Niki T, Arasaki O, Oshiro K, Mori Y, Ishihara M, Node K
  • Journal Title: Cardiovascular Diabetology Volume: 16 Issue: 1 Pages: 86-86
  • DOI: 10.1186/s12933-017-0571-1
  • NAID: 120006937640
  • Peer Reviewed / Open Access
• [Journal Article] RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF (2017)
  • Author(s): Kusunose Kenya、Yamada Hirotsugu、Nishio Susumu、Ishii Ayumi、Hirata Yukina、Seno Hiromitsu、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: JACC Cardiovasc Imaging Volume: 10 Issue: 10 Pages: 1240-1249
  • DOI: 10.1016/j.jcmg.2017.03.022
  • Peer Reviewed
• [Journal Article] Age-related changes in morphology of left atrial appendage in patients with atrial fibrillation (2017)
  • Author(s): Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Shimizu Rikuto、Torii Yuta、Nishio Susumu、Saijo Yoshihito、Takao Shoichiro、Soeki Takeshi、Sata Masataka
  • Journal Title: Int J Cardiovasc Imaging Volume: 34 Issue: 2 Pages: 321-328
  • DOI: 10.1007/s10554-017-1232-x
  • Peer Reviewed
• [Journal Article] Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing. (2017)
  • Author(s): Nishio S, Kusunose K, Yamada H, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
  • Journal Title: J Am Soc Echocardiogr Volume: 30 Issue: 10 Pages: 1021-1027
  • DOI: 10.1016/j.echo.2017.06.024
  • Peer Reviewed / Open Access
• [Journal Article] Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome (2017)
  • Author(s): Yagi S, Soeki T, Aihara KI, Fukuda D, Ise T, Kadota M, Bando S, Matsuura T, Tobiume T, Yamaguchi K, Kusunose K, Yamada H, Wakatsuki T, Shimabukuro M, Akaike M, Sata M.
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 720-723
  • DOI: 10.1536/ihj.16-278
  • NAID: 130006179141
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure (2017)
  • Author(s): Takagawa Y, Yagi S. Ise T, Ishii A, Nishikawa K, Fukuda D, Kusunose K, Matsuura T, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Katoh S, Aihara KI, Akaike M, Sata M.
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 746-751
  • DOI: 10.1536/ihj.16-454
  • NAID: 130006179122
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus. (2017)
  • Author(s): Yagi S, Hirata Y, Ise T, Kusunose K, Yamada H, Fukuda D, Salim HM, Maimaituxun G, Nishio S, Takagawa Y, Hama S, Matsuura T, Yamaguchi K, Tobiume T, Soeki T, Wakatsuki T, Aihara KI, Akaike M, Shimabukuro M, Sata M.
  • Journal Title: Diabetol Metab Syndr. Volume: 9 Issue: 1 Pages: 78-78
  • DOI: 10.1186/s13098-017-0275-4
  • NAID: 120006939620
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats (2017)
  • Author(s): Kinouchi Tomoya、Kitazato Keiko T.、Shimada Kenji、Yagi Kenji、Tada Yoshiteru、Matsushita Nobuhisa、Kurashiki Yoshitaka、Satomi Junichiro、Sata Masataka、Nagahiro Shinji
  • Journal Title: Transl Stroke Res Volume: - Issue: 3 Pages: 306-316
  • DOI: 10.1007/s12975-017-0577-8
  • NAID: 120007042447
  • Peer Reviewed / Open Access
• [Journal Article] Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue (2016)
  • Author(s): Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M.
  • Journal Title: Sci Adv. Volume: 2(3) Issue: 3
  • DOI: 10.1126/sciadv.1501332
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Implications of Non-Invasive Vascular Function Tests in High-Risk Atherosclerosis Patients (2016)
  • Author(s): Kusunose K, Sato M, Yamada H, Saijo Y, Bando M, Hirata Y, Nishio S, Hayashi S, Sata M
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 1034-1040
  • DOI: 10.1253/circj.CJ-15-1356
  • NAID: 130005139577
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of transthoracic echocardiographic simulator training on performance and satisfaction in medical students. (2016)
  • Author(s): Kusunose K, Yamada H, Suzukawa R, Hirata Y, Yamao M, Ise T, Yagi S, Akaike M, Sata M
  • Journal Title: J Am Soc Echocardiogr. Volume: 29 Issue: 4 Pages: 375-377
  • DOI: 10.1016/j.echo.2015.12.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Noninvasive quantitative tissue characterization of carotid plaque using color-coded mapping based on ultrasound integrated backscatter. (2016)
  • Author(s): Bando M, Yamada H, Kusunose K, Fukuda D, Amano R, Tamai R, Torii Y, Hirata Y, Nishio S, Satomi J, Nagahiro S, Sata M
  • Journal Title: JACC Cardiovasc Imaging. Volume: 9 Issue: 5 Pages: 625-627
  • DOI: 10.1016/j.jcmg.2015.02.017
  • Peer Reviewed
• [Journal Article] Combination of n-3 polyunsaturated fatty acids reduces atherogenesis in apolipoprotein E-deficient mice by inhibiting macrophage activation (2016)
  • Author(s): Takashima A, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Nishimoto S, Yagi S, Yamada H, Soeki T, Wakatsuki T, Taketani Y, Shimabukuro M, Sata M
  • Journal Title: Atherosclerosis Volume: 254 Pages: 142-150
  • DOI: 10.1016/j.atherosclerosis.2016.10.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glycemic control with ipragliflozin, a novel selective SGLT2 inhibitor, ameliorated endothelial dysfunction in streptozotocin-induced diabetic mouse (2016)
  • Author(s): Salim HM, Fukuda D, Yagi S, Soeki T, Shimabukuro M, Sata M
  • Journal Title: Front Cardiovasc Med Volume: 3 Pages: 43-43
  • DOI: 10.3389/fcvm.2016.00043
  • NAID: 120006937668
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between local production of microRNA-328 and atrial substrate remodeling in atrial fibrillation. (2016)
  • Author(s): Soeki T, Matsuura T, Bando S, Tobiume T, Uematsu E, Ise T, Kusunose K, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M
  • Journal Title: J Cardiol. Volume: 印刷中 Issue: 6 Pages: 472-477
  • DOI: 10.1016/j.jjcc.2015.12.007
  • Peer Reviewed
• [Presentation] Gender disparities of distribution of epicardial adipose tissue and its impact on coronary artery disease (2018)
  • Author(s): Gulinu Maimaituxun, Shimabukuro M, Fukuda D, Yagi S, Hirata Y, Iwase T, Matsuura T, Ise T , Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Localization of myocardial injury in anthracycline-induced cardiotoxicity: evaluation using two-dimensional speckle tracking echocardiography (2018)
  • Author(s): Saijo Y, Kusunose K, Bando M, Seno H, Zheng R, Nishio S, Hirata Y, Tori Y, Amano R, Yamada H, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Atheroprotective effects of ticagrelor, a P2Y12 antagonist, in apolipoprotein-E-deficient mice (2018)
  • Author(s): Byambasuren Ganbaatar, Fukuda D, Salim HM, Yagi S, Soeki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Growth of vasa vasorum is associated with local inflammation around coronary plaque in fresh cadavers (2018)
  • Author(s): Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Todoroki T, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] C-type natriuretic peptide improves left ventricular diastolic dysfunction and ischemia/reperfusion injury-associated ventricular arrhythmias. (2018)
  • Author(s): Soeki T, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018 6.
  • Int'l Joint Research
• [Presentation] Inhibition of S1P2 receptor ameliorates endothelial dysfunction and prevents atherogenesis in apolipoprotein-E-deficient Mice. (2018)
  • Author(s): Byambasuren Ganbaatar, Fukuda D, Yagi S, Soeki T, Sata M.
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research
• [Presentation] Role of epicardial fat in cardiovascular disease (2018)
  • Author(s): Sata M
  • Organizer: ESC2018,Munich,August 25-28,2018
  • Int'l Joint Research / Invited
• [Presentation] Epicardial Adipose Tissue Thickness Measured by Echocardiography is Useful Marker for Predicting Coronary Artery Disease (2018)
  • Author(s): Hirata Y, Kusunose K, Yamada H, Nishio S, Harada O, Miyazato N, Haraguni A, Ito A, Yamaguchi K, Soeki T, Wakatsuki T, Sata M.
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] A Deep Learning Approach for Automated Diagnosis of Regional Wall Motion Abnormality on Echocardiography (2018)
  • Author(s): Kusunose K, Abe T, Haga A, Yamada H, Fukuda D, Harada M, Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Right Ventricular Contractile Function Predicts Cardiac Events in Passive and Reactive Pulmonary Hypertension. (2018)
  • Author(s): Saijo Y, Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T,Wakatsuki T,Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Inhibition of Thrombin-PARs Signaling by Dabigatran, a Direct Thrombin Inhibitor, Attenuates Endothelial Dysfunction in Diabetic Mice (2018)
  • Author(s): Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M.
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Rivaroxaban, a Direct Inhibitor of Factor Xa, Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mice Through the Inhibition of Protease-Activated Receptor 2 Signaling (2018)
  • Author(s): ham Tran Phuong, Fukuda D, Yagi S, Kusunose K,Yamada H, Soeki T, Shimabukuro M, Sata M
  • Organizer: AHA 2018, Chicago, November 10-12,2018
  • Int'l Joint Research
• [Presentation] Direct Slow Pathway Capture: A New Electrophysiological Method of Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia (2017)
  • Author(s): Matsuura T, Tobiume T, Soeki T, Kato R, Hara M, Takayuki Ise, Kenya Kusunose, Yamaguchi K, Yagi S, Yamada H, Wakatsuki Tetsuzo , Sata M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Pre-Discharge LV Filling Pressure and Pulmonary Artery Pressure Were Associated With Hospital Readmission in Heart Failure With Reduced and Preserved Ejection Fraction (2017)
  • Author(s): Torii Y, Kusunose K, Yamada H, Saijo Y, Seno H, Nishio S, Hirata Y, Sata M
  • Organizer: Pre-Discharge LV Filling Pressure and Pulmonary Artery Pressure Were Associated With Hospital Readmission in Heart Failure With Reduced and Preserved Ejection Fraction
  • Int'l Joint Research
• [Presentation] Preserved Endothelial Function and Suppressed Local Coagulative and Inflammatory Response (2017)
  • Author(s): Yamaguchi K, Wakatsuki T, Kawabata Y, Ito H, Matsuura T, Ise T, Kusunose K, Tobiume T, Yagi S, Yamada H, Soeki T, Sata M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Activated Factor X Signaling Pathway via Protease-Activated Receptor-2 is a Novel Therapeutic Target to Prevent Atrial Fibrillation (2017)
  • Author(s): Takeshi Soeki, Tomomi Matsuura, Daiju Fukuda, Etsuko Uematsu, Takeshi Tobiume, Tomoya Hara, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masataka Sata
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low Gradient Aortic Stenosis (2017)
  • Author(s): Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Seno H, Saijo Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Local Epicardial Adipose Tissue Thickness in Left Anterior Descending Artery Provides a New Prediction Model for Coronary Artery Disease (2017)
  • Author(s): Gulinu Maimaituxun, Shimabukuro M, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Detection of Coronary Artery Stenosis by Epicardial Adipose Tissue Thickness in Type 2 Diabetes (2017)
  • Author(s): Hirata Y, Kusunose K, Yamada H, Kuwahata J, Torii Y, Nishio S, Seno H, Saijo Y, Yamaguchi K, Wakatsuki T, Sara M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Epicardial Adipose Tissue Produces Proinflammatory Cytokines and Influences the Pathogenesis of Atrial Fibrillation (2017)
  • Author(s): Soeki T, Matsuura T, Uematsu E, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Sata M
  • Organizer: AHA Scientific Sessions2017
  • Int'l Joint Research
• [Presentation] Longitudinal Strain Distribution is a Powerful Predictor for Functional Recovery in Patients With Tachycardia-induced Cardiomyopathy (2016)
  • Author(s): Kusunose K, Yamada H, Saijo Y, Seno H, Hirata Y, Torii Y, Nishio S, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M
  • Organizer: AHA Scientific Sessions 2016
  • Place of Presentation: New Orleans, America
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Effect of Sitagliptin on Left Ventricular Function in Patients With Type 2 Diabetes a Sub Analysis of the PROLOGUE Study (2016)
  • Author(s): Seno H, Yamada H, Kusunose K, Amano R, Matsushita M, Nanasato M, Murohara T, Kamiya H, Sata M AHA Scientific Sessions 2016, , Novemeber 12-16, 2016
  • Organizer: AHA Scientific Sessions 2016
  • Place of Presentation: New Orleans, America
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Role of innate immunity in chronic inflammation in arterial wall and adipose tissue (2016)
  • Author(s): Masataka Sata
  • Organizer: 19th International Vascular Biology Meeting
  • Place of Presentation: Boston, America
  • Year and Date: 2016-10-30
  • Int'l Joint Research / Invited
• [Book] Mouse models of vascular dieseases (2016)
  • Author(s): Masataka Sata ed.
  • Total Pages: 296
  • Publisher: Springer Japan