| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
We investigated the physiological significance of glucocorticoid (GC) in skeletal muscle metabolism and function, focusing on GC receptor (GR)-mediated gene expression. The role of the signal axis between skeletal muscle, liver, and adipose tissue in the control of whole body energy metabolism was clarified by the inhibitory effects on muscle protein degradation and liver and adipose tissue metabolism. Using Cushing's syndrome model mice and ob/ob mice, we found that molecules other than alanine and FGF21 were also involved as key factors in the skeletal muscle-liver-fat axis. From the above, it was shown that the energy metabolism at the individual level is precisely controlled by various factors via inter-organ interaction according to the metabolic state.
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