• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A molecular epidemiological study of the effects of individualization on stress and the development of depression in Indonesia

Research Project

Project/Area Number 16H05828
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene and public health
Research InstitutionThe University of Tokyo

Principal Investigator

Ishida Takafumi  東京大学, 大学院理学系研究科(理学部), 教授 (20184533)

Co-Investigator(Kenkyū-buntansha) 古澤 拓郎  京都大学, アジア・アフリカ地域研究研究科, 准教授 (50422457)
大橋 順  東京大学, 大学院理学系研究科(理学部), 准教授 (80301141)
清水 華  国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 (80401032)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords個人主義化 / ストレス / 遺伝環境 / うつ / インドネシア / 進化医学 / 精神疾患 / 鬱 / 伝統社会 / 社会変容
Outline of Final Research Achievements

It was revealed that people with depression had a collective disposition, higher incomes, and higher education levels. In addition, Bugis-Makassars have higher independent and cooperative temperament than other ethnic groups, suggesting differences in ethnic temperament. Regarding the related four gene polymorphisms, there was a difference in the frequency distribution between patients and healthy subjects. A new stress marker, telomere length, was short in the patient group, suggesting that they are exposed to stress. We have prepared DNA samples of eight ethnic groups from seven islands in Indonesia.

Academic Significance and Societal Importance of the Research Achievements

民族による気質の違いも示唆され、対照研究において、データの一般化には多大な注意を払う必要性を示した。本研究事業が開発したインドネシア語版の尺度は、他の研究でも利用できる高い有効性をもっていた。マカッサル市において、低所得者が精神疾患にかかっても受療できる体制の必要性が提示された。7島8民族にわたるオーストロネシア語民のDNA試料の整備は将来の遺伝疫学的解析の重要な試料となる。インドネシアとの国際共同研究をスマトラ島、ジャワ島、スラウェシ島で展開する基盤が出来た。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2020 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results)

  • [Int'l Joint Research] Hasanuddin University(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ハサヌディン大学/南スマトラ大学(インドネシア)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Admixture and natural selection shaped genomes of an Austronesian-speaking population in the Solomon Islands2020

    • Author(s)
      Isshiki Mariko、Naka Izumi、Watanabe Yusuke、Nishida Nao、Kimura Ryosuke、Furusawa Takuro、Natsuhara Kazumi、Yamauchi Taro、Nakazawa Minato、Ishida Takafumi、Eddie Ricky、Ohtsuka Ryutaro、Ohashi Jun
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 6872-6872

    • DOI

      10.1038/s41598-020-62866-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands2017

    • Author(s)
      Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ricky Eddie, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Ryutaro Ohtsuka, Jun Ohashi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 3 Pages: e0172676-e0172676

    • DOI

      10.1371/journal.pone.0172676

    • NAID

      120006027074

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] グローバル化時代のオセアニア地域研究と人類生態学2018

    • Author(s)
      古澤拓郎
    • Organizer
      日本オセアニア学会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi