Molecular epidemiological study of radiation-free pediatric and adolescent thyroid cancers around the Chernobyl area.
| Project/Area Number |
16H05832
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene and public health
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高村 昇 長崎大学, 原爆後障害医療研究所, 教授 (30295068)
サエンコ ウラジミール 長崎大学, 原爆後障害医療研究所, 准教授 (30343346)
ログノビッチ タチアナ 長崎大学, 原爆後障害医療研究所, 客員研究員 (30423643)
高橋 純平 長崎大学, グローバル連携機構, 助教 (50574026)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 甲状腺がん / チェルノブイリ / 分子疫学 / 遺伝子多型 / 甲状腺癌 |
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| Outline of Final Research Achievements |
In collaboration with researchers from associating institutions in the countries surrounding Chernobyl, we collected radiation-free (sporadic) pediatric thyroid cancer cases and analyzed their genetic polymorphisms associated with the risk of thyroid cancer development, together with previously collected radiation-induced pediatric thyroid cancer and a control population that was exposed but did not develop cancer. The results suggest that rs944289 at the NKX2-1 (PTCSC3) locus on chromosome 14 showed difference in association depending on whether it is radiogenic or sporadic (etiology-dependent). On the other hand, the association between rs11693806 at the DIRC3 locus on chromosome 2 and cancer development was suggested to be different depending on age of onset (age-dependent).
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| Academic Significance and Societal Importance of the Research Achievements |
チェルノブイリ原発事故後に発生した小児甲状腺がんは、放射線誘発であることが確実な非常に貴重な症例群である。これら試料を解析することによって、放射線発がんへの理解が進むものと考えられる。本研究の発症リスクに関連する遺伝子多型の研究によって、放射線誘発甲状腺がんの発症分子メカニズムに、散発性との違いが存在することが示唆され、被ばくによる発がん機序の解明につながる結果が得られた。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] TERT promoter mutation in primary papillary thyroid carcinoma lesions predicts absent or lower 131I uptake in metastases.2019
Author(s)
Meng Z, Matsuse M, Saenko V, Yamashita S, Ren P, Zheng X, Jia Q, Tan J, Li N, Zheng W, Zhao L, Mitsutake N.
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Journal Title
IUBMB Life.
Volume: 71
Issue: 7
Pages: 10301040-10301040
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature.2018
Author(s)
Otsubo R, Mussazhanova Z, Akazawa Y, Sato A, Matsuda K, Matsumoto M, Yano H, Matsuse M, Mitsutake N, Ando T, Niino D, Nagayasu T, Nakashima M.
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Journal Title
Endocrinol Metab
Volume: 31
Issue: 4
Pages: 461-467
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima.2017
Author(s)
Iyama K, Matsuse M, Mitsutake N, Rogounovitch T, Saenko V, Suzuki K, Ashizawa M, Ookouchi C, Suzuki S, Mizunuma H, Fukushima T, Suzuki S, Yamashita S.
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Journal Title
Thyroid
Volume: 印刷中
Issue: 6
Pages: 811-818
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma.2017
Author(s)
Nikitski AV, Rogounovitch TI, Bychkov A, Takahashi M, Yoshiura KI, Mitsutake N, Kawaguchi T, Matsuse M, Drozd VM, Demidchik Y, Nishihara E, Hirokawa M, Miyauchi A, Rubanovich AV, Matsuda F, Yamashita S, Saenko VA.
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Journal Title
Thyroid
Volume: 27
Issue: 2
Pages: 224-235
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 甲状腺乳頭癌における分子マーカーによるリスク分類2016
Author(s)
光武範吏, 松瀬美智子, 薮田智範, Vladimir Saenko, 西原永潤, 廣川満良, 宮内 昭, 山下俊一
Organizer
日本甲状腺外科学会学術集会
Place of Presentation
甲府富士屋ホテル（山梨県・甲府市）
Year and Date
2016-10-27
Related Report
Invited
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[Presentation] Genotype analyses in the Japanese and Belarusian populations reveal independent effects of rs965513 and rs1867277 but do not support the role of FOXE1 polyalanine tract length in conferring risk for papillary thyroid carcinoma2016
Author(s)
ニキツキ アリャクサンドル, サエンコ ウラジミル, ログノビッチ タチアナ,ビチコブ アンドレイ, 高橋めい子, 吉浦孝一郎, 光武範吏, 川口喬久, 松瀬美智子, ドロズド ワレンチナ, デミドチック ユリ, 西原永潤, 廣川満良, 宮内 昭, ルバノビッチ アレクサンドル, 松田文彦, 山下俊一
Organizer
日本内分泌学会学術総会
Place of Presentation
京都国際会議場（京都府・京都市）
Year and Date
2016-04-21
Related Report
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