キルギスでのリウマチ熱蔓延の危険因子の分子疫学的解析と拠点集落でのその制圧の試み
Project/Area Number |
16H05845
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Infectious disease medicine
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Research Institution | Tokyo Medical University |
Principal Investigator |
中島 利博 東京医科大学, 医学部, 教授 (90260752)
|
Co-Investigator(Kenkyū-buntansha) |
川原 幸一 大阪工業大学, 工学部, 教授 (10381170)
西 順一郎 鹿児島大学, 医歯学域医学系, 教授 (40295241)
三浦 直樹 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
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Project Period (FY) |
2016 – 2019
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Project Status |
Discontinued (Fiscal Year 2019)
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Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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Keywords | キルギス / リウマチ熱 / バイオマス / 慢性呼吸器疾患 / 溶連菌感染 / リハビリテーション |
Outline of Annual Research Achievements |
キルギスではRheumatic fever : (以下、RF)が未だに猛威を奮っている。さらに、顕在化しないRFの後遺症も含めたRheumatic heart diseases(以下、RHD)が食生活(肉食、ウオッカ)、環境因子(低酸素)と併せて当該地域での死因の過半数を占める60歳までの心不全の潜在的リスクファクターであることを報告していた。10年を超える継続的な医療支援によりキルギスのほぼ全土を網羅する詳細なフィールド調査を行い、RF/RHDの有無、心エコーなど理学的所見、溶連菌など細菌感染症の頻度、家族歴など2000人を超える住民から100を超える項目に関する調査を完遂していた。その結果より、溶連菌以外の細菌感染の陽性率も高く、その一因に未だに主流であるバイオマス燃料による粘膜免疫の低下が考えられることを見出した。呼吸器分野の専門家を加え、感染の遷延化・慢性化に対する宿主因子の探索を行った。さらに細菌感染に対する啓蒙活動を行いその効果を検討した。 キルギスの食生活について循環器疾患や免疫に対する影響を検討するため生理活性を測定した。その結果キルギスの特産として知られるある食物が本国のものと比較して血管内皮細胞に対して高い抗酸化作用を有していることが示唆された。上記の成分を分析しRF/RHDの予防として活用できるのではないかと期待できる。 啓蒙活動についてはロシア語に加えてもう一つの公用語であるキルギス語の母子手帳を作成し、現地JICAを通して国民に配布を開始した。また名誉領事会議において本活動の重要性をキルギス政府に対しても働きかけを行った。既に配布済みであるロシア語が広く使われている都市部においてはRF/RHDの減少が認められることからその効果が期待される。
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Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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Report
(4 results)
Research Products
(153 results)
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[Journal Article] Absence of Relatives Impairs the Approach of Nurses to Cardiopulmonary Resuscitation in Non-Cancer Elderly Patients without a Do-Not-Attempt-Resuscitation Order: A Vignette-Based Questionnaire Study2020
Author(s)
Higuchi A, Takita M, Yoshii A, Akiyama T, Nemoto T, Nakahira R, Nakajima T, Fukahori H, Tsubokura M, Igarashi R.
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 250
Issue: 1
Pages: 71-78
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed / Open Access
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[Journal Article] Concurrent Bacteremia Due to Non-vaccine Serotype 24F Pneumococcus in Twins: A Rapid Increase in Serotype 24F-invasive Pneumococcal Disease and its High Invasive Potential2020
Author(s)
Kawabata T, Tenokuchi Y, Yamakuchi H, Sameshima H, Katayama H, Ota T, Tokunaga M, Takezaki T, Tamae S, Nakamura T, Chang B, Kodama Y, Imuta N, Ooka T, Okamoto Y, Suga S, Nishi J
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Journal Title
Pediatr Infect Dis J
Volume: 39(1)
Issue: 1
Pages: 85-87
DOI
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[Journal Article] Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing2019
Author(s)
Yamada S, Hirao D, Miura N, Iwanaga T, Kawaguchi T, Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R
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Journal Title
Experimental Animals
Volume: 68
Issue: 2
Pages: 137-146
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
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Peer Reviewed / Open Access
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[Journal Article] Liver abscess due to Sterigmatomyces halophilus in a boy with acute lymphoblastic leukemia.2019
Author(s)
Imashioya T, Kodama Y, Ooka T, Nakagawa S, Nishikawa T, Tanabe T, Okamoto Y, Imuta N, Kirishima M, Tanimoto A, Koriyama T, Nishi J, Kawano Y.
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Journal Title
J Infect Chemother
Volume: 25(12)
Issue: 12
Pages: 1047-1049
DOI
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Peer Reviewed
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[Journal Article] O-antigen biosynthesis gene clusters of Escherichia albertii: their diversity and similarity to Escherichia coli gene clusters and the development of an O-genotyping method.2019
Author(s)
Ooka T, Seto K, Ogura Y, Nakamura K, Iguchi A, Gotoh Y, Honda M, Etoh Y, Ikeda T, Sugitani W, Konno T, Kawano K, Imuta N, Yoshiie K, Hara-Kudo Y, Murakami K, Hayashi T, Nishi J
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Journal Title
Microb Genom
Volume: 5(11)
Issue: 11
DOI
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[Journal Article] The NRF2-PGC-1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, Synoviolin, in a cecal ligation/perforation -induced septic mouse model.2018
Author(s)
Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H, Nakajima T.
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Journal Title
Mol. Med. Rep.
Volume: 18(2)
Pages: 2467-2475
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[Journal Article] An E3 Ubiquitin Ligase, Synoviolin, Is Involved in the Degradation of Homocysteine-Inducible Endoplasmic Reticulum Protein.2018
Author(s)
Maeda T, Fujita Y, Tanabe-Fujimura C, Zou K, Liu J, Liu S, Kikuchi K, Shen X, Nakajima T, Komano H.
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Journal Title
Biol. Pharm. Bull.
Volume: 41(6)
Pages: 915-919
NAID
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[Journal Article] Abatacept in combination with methotrexate in Japanese biologic-naive patients with active rheumatoidarthritis: a randomised placebocontrolledphase IV study.2018
Author(s)
Matsubara T, Inoue H,Nakajima T, Tanimura K, Sagawa A, Sato Y, Osano K, Nagano S, Ueki Y, Hanyu T, Hashizume K, Amano N, Tanaka Y, Takeuchi T.
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Related Report
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[Journal Article] Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.2018
Author(s)
Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T,Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, YamamotoM, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S.
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Journal Title
Sci Rep.
Volume: 8(1)
Issue: 1
Pages: 15844-15844
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model.2018
Author(s)
Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara KI, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H.
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Journal Title
Int J Mol Sci.
Volume: 19(5)
Issue: 5
Pages: 1-9
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and Bacteriologic Analysis of Nontypeable Haemophilus influenzae Strains Isolated from Children with Invasive Diseases, Japan, 2008-2015.2018
Author(s)
Naito S, Takeuchi N, Ohkusu M, Takahashi-Nakaguchi A, Takahashi H, Imuta N, Nishi J, Shibayama K, Matsuoka M, Sasaki Y, Ishiwada N.
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Journal Title
J Clin Microbiol
Volume: 6(7)
Issue: 7
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[Journal Article] Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study.2018
Author(s)
Kakihana Y, Kamikokuryo C, Furubeppu H, Madokoro Y, Futatsuki T, Miyamoto S, Haraura H, Hatanaka K, Eguchi T, Saitoh Y, Miura N, Suzuki H, Ueda Y, Yasuda T, Ito T.
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Journal Title
Adv Exp Med Biol
Volume: 1072
Pages: 83-87
DOI
ISBN
9783319912851, 9783319912875
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma2018
Author(s)
Lai YC, Ushio N, Rahman MM, Katanoda Y, Ogihara K, Naya Y, Moriyama A, Iwanaga T, Saitoh Y, Sogawa T, Sunaga T, Momoi Y, Izumi H, Miyoshi N, Endo Y, Fujiki M, Kawaguchi H, Miura N.
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Journal Title
Vet Comp Oncol.
Volume: in press
Issue: 2
Pages: 0-0
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[Journal Article] Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis.2017
Author(s)
Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K,Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I.
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Journal Title
Oxid Med Cell Longev.
Volume: Article ID 6873281
Issue: 1
Pages: 14-14
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs2017
Author(s)
Yamada S, Kawaguchi H, Yamada T, Guo X, Matsuo K, Hamada T, Miura N, Tasaki T, Tanimoto A.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 24
Issue: 11
Pages: 1150-1166
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs2017
Author(s)
Yamazaki H, Miura N, Lai YC, Takahashi M, Goto-Koshino Y, Yasuyuki M, Nakaichi M, Tsujimoto H, Setoguchi A, Endo Y.
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Journal Title
Journal of Veterinary Medical Science
Volume: 79
Issue: 7
Pages: 1225-1229
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Adult IPDSG. Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: disease characteristics and serotype distribution.2017
Author(s)
Fukusumi M, Chang B, Tanabe Y, Oshima K, Maruyama T, Watanabe H, Kuronuma K, Kasahara K, Takeda H, Nishi J, Fujita J, Kubota T, Sunagawa T, Matsui T, Oishi K
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Journal Title
BMC Infect Dis
Volume: 17(1)
Issue: 1
Pages: 2-2
DOI
Related Report
Peer Reviewed
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[Journal Article] Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression.2016
Author(s)
Yukio S, Mabuchi Y, Miyamoto K, Araki D, Niibe K, Houlihan DD, Morikawa S, Nakagawa T, Nakajima T, Akazawa C, Hori S, Okano H, Matsuzaki Y
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Journal Title
PLOS ONE
Volume: 11(11)
Issue: 11
Pages: 0165946-0165946
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[Journal Article] Cut-off values of latent infection in patients with rapid migration following bipolar hip hemiarthroplasty.2016
Author(s)
Setoguchi T, Kawakami H, Ishidou Y, Kawamura H, Nishi J, Yoshioka T, Kakoi H, Nagano S, Yokouchi M, Tanimoto A, Komiya S.
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Journal Title
BMC Musculoskelet Disord.
Volume: 17
Issue: 1
Pages: 37-37
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phylogenetic analysis of enteroaggregative Escherichia coli (EAEC) isolates from Japan reveals emergence of CTX-M-14-producing EAEC O25:H4 clones related to sequence type 131.2016
Author(s)
Imuta N, Ooka T, Seto K, Kawahara R, Koriyama T, Kojyo T, Iguchi A, Tokuda K, Kawamura H, Yoshiie K, Ogura Y, Hayashi T, Nishi J
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Journal Title
J Clin Microbiol
Volume: 54(8)
Issue: 8
Pages: 2128-2134
DOI
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[Presentation] Genomic comparison of Stx2f phages from Escherichia coli and Escherichia albertii.2018
Author(s)
Ooka T, Islam MR, Ochiai S, Ogura Y, Seto K, Isobe J, Ikeda T, Seto J, Gotoh Y, Nishi J, Hayashi T.
Organizer
VTEC 2018
Related Report
Int'l Joint Research
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[Presentation] Syndromic surveillance led by local health authorities in evacuation centers following the April 2016 Kumamoto earthquakes.2017
Author(s)
Tokuda K, Kawamura H, Torigoe, K, Ogawa S, Yoshimori M, Miyahara H, Tachiwana S, Yoshimitsu K, Matsuo T, Tsuchiya K, Nishi J
Organizer
Association for Professionals in Infection and Epidemiology (APIC) 44th annual conference
Related Report
Int'l Joint Research
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[Presentation] Effect of oral vancomycin administration on the outcome of children receiving hematopoietic stem cell transplantation.2017
Author(s)
Kodama Y, Okamoto Y, Nakagawa S, Nishikawa T, Tanabe T, Kawamura H, Nishi J, Kawano Y
Organizer
IDWeek 2017, A joint meeting of the Infectious Diseases Society of America, the Society for Healthcare Epidemiology, the HIV Medicine Association, and the Pediatric Infectious Diseases Society
Related Report
Int'l Joint Research
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[Presentation] Monitoring of brain oxygenation during and after cardiopulmonary resuscitation - A prospective porcine study.2017
Author(s)
Y. Kakihana, C. Kamikokuryo, H. Furubeppu, Y. Madokoro, T. Futatsuki, S. Miyamoto, H. Haraura, K. Hatanaka, Y. Saito, N. Miura, H. Suzuki, Y. Ueda, T. Yasuda, T. Ito
Organizer
45th. Annual meeting of ISOTT (International Society on Oxygen Transport to Tissue)
Related Report
Int'l Joint Research
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[Presentation] Central venous catheter system with a mechanical valve needleless connector has a higher risk of catheter related blood stream infection than that with a split septum connector in a pediatric oncology ward.2016
Author(s)
Kodama Y, Tokuda K, Nakagawa S, Nishikawa T, Tanabe T, Okamoto Y, Kawamura H, Nishi J, Kawano Y
Organizer
IDWeek 2016,(IDSA), (HIVMA), (SHEA), (HIVMA), (PIDS)
Place of Presentation
New Orleans(USA)
Year and Date
2016-10-26
Related Report
Int'l Joint Research
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[Presentation] The multivariable analysis for the risk of orthopedic MRSA SSIs among non-MRSA carriers.2016
Author(s)
Kawamura H, Shigemi A, Tominaga H, Nagano S, Komiya S, Tokuda K, Nishi J
Organizer
IDWeek 2016,(IDSA), (HIVMA), (SHEA), (HIVMA), (PIDS)
Place of Presentation
New Orleans(USA)
Year and Date
2016-10-26
Related Report
Int'l Joint Research
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[Presentation] シノビオリン阻害剤の探索。2016
Author(s)
藤田英俊、荒谷聡子、西岡久寿樹、中島利博
Organizer
日本線維筋痛症学会第 8 回学術集会
Place of Presentation
KFC Hall & Rooms(東京 墨田区)
Year and Date
2016-09-17
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