| Budget Amount *help |
¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
By using artificial DNA sequences, we constructed a unique system that is capable of labeling cells with a single sister chromatid fusion. We analyzed the fate of sister chromatid fusion using this system. We found that a single sister chromatid fusion is enough to induce chromosome aberrations such as micronuclei and chromosome scattering. Besides, we attempted to elucidate the molecular mechanism of mitotic telomere deprotection, which we originally discovered. We have successfully identified factors such as telomere binding protein TRF1 and DNA helicase BLM as factors involved in this phenomenon. Also, we found that the combination of TRF1 and BLM contributed to this phenomenon.
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