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先端モデル動物支援プラットフォーム

Research Project

Project/Area Number 16H06276
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

井上 純一郎 (2019-2020)  東京大学, 医科学研究所, 特任研究員

今井 浩三 (2016-2018)  東京大学, 医科学研究所, 客員教授 (60117603)

Co-Investigator(Kenkyū-buntansha) 中村 卓郎  公益財団法人がん研究会, がん研究所, 副所長 (00180373)
井上 純一郎  東京大学, 医科学研究所, 教授 (70176428)
高田 昌彦  京都大学, 霊長類研究所, 教授 (00236233)
山田 泰広  東京大学, 医科学研究所, 教授 (70313872)
高橋 智  筑波大学, 医学医療系, 教授 (50271896)
伊川 正人  大阪大学, 微生物病研究所, 教授 (20304066)
﨑村 建司  新潟大学, 脳研究所, フェロー (40162325)
荒木 喜美  熊本大学, 生命資源研究・支援センター, 教授 (90211705)
八尾 良司  公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095)
真下 知士  大阪大学, 大学院医学系研究科, 准教授 (80397554)
小林 和人  福島県立医科大学, 医学部, 教授 (90211903)
豊國 伸哉  名古屋大学, 大学院医学系研究科, 教授 (90252460)
鰐渕 英機  大阪市立大学, 大学院医学研究科, 教授 (90220970)
今井田 克己  香川大学, 医学部, 教授 (90160043)
二口 充  長崎大学, 病院(医学系), 准教授 (60275120)
上野 正樹  香川大学, 医学部, 教授 (30322267)
宮崎 龍彦  岐阜大学, 医学部附属病院, 准教授 (80239384)
神田 浩明  埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067)
尾藤 晴彦  東京大学, 大学院医学系研究科, 教授 (00291964)
宮川 剛  藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
高雄 啓三  富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397)
池田 和隆  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
虫明 元  東北大学, 大学院医学系研究科, 教授 (80219849)
清宮 啓之  公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623)
長田 裕之  国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836)
旦 慎吾  公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202)
井本 正哉  慶應義塾大学, 理工学部, 教授 (60213253)
川田 学  公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808)
田原 栄俊  広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065)
吉田 稔  国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617)
松浦 正明  帝京大学, 大学院公衆衛生学研究科, 教授 (40173794)
牛嶋 大  公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565)
吉田 進昭  東京大学, 医科学研究所, 教授 (10250341)
Project Period (FY) 2016 – 2021
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000)
Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Keywordsモデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・プロファイリング / 分子プロファイリング / 分子探索・ブロファイリング / 行動解析
Outline of Annual Research Achievements

①総括支援活動 : 若手技術講習会を9月11日にオンラインにて開催した。108名の参加者があり、活発な討論が行われた。成果発表会は2月2日にハイブリッド形式で開催し、被支援者による研究成果の紹介を中心に行われ252名の参加者があった。支援拠点の研究者と被支援者が分担で執筆した本支援活動を紹介する「マウス・ラットモデル作製・解析プロフェッショナル」を出版した。
②モデル動物作製支援活動 : 前・後期2回の公募で申請のあった計116件について一次・二次審査を行い、学術的に優れた83件の申請を採択した。それぞれの採択者と個別に協議し、最適な遺伝子改変技術を用いて、遺伝子改変マウスおよびラットを迅速に作製し、研究リソースとして提供した。
③病理形態解析支援活動 : 55件の申請を受け、3回の審査の結果、35件に関して病理形態解析を実施した。研究の方向性を裏付ける多くの成果が得られた。論文の図の作成など、論文が受理されるまで支援を実施した。
④生理機能解析支援活動 : 行動学的解析では26件、薬理学的解析では16件、光技術による操作解析では9件、多機能電極・計測データ解析では13件の申請について支援し、コロナ禍にもかかわらず、4つの支援の全てで、昨年度よりも支援数を増やした。支援は、動物モデルにおける病態・生理学的基盤の解明推進などに寄与し、Nat Commun誌、iScience誌などに成果が発表された。
⑤分子プロファイリング支援活動 : 化合物の分子プロファイリング48件、阻害剤キット配付18件、RNA干渉キット配付・siRNAデザイン合成5件、shRNAライブラリー探索2件、分子間相互作用解析1件(計74件、支援提供回数として505回)に加え、高次情報解析、動物実験に向けた技術相談を行った。被支援者と全班員の意見交換を目的としたユーザー会議を開催した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 今年度はコロナ禍にもかかわらず、若手技術講習会をオンライン開催で、成果発表会をハイブリッド開催で実施することができ、反響も大きかった。また、広報活動の一層の充実を目的として、支援拠点のメンバーによる出版企画を実施することができた。
②モデル動物作製支援活動 : 研究実施計画に沿った支援を行うことができている。コロナ禍にあっても、リモート会議を活用した綿密な打ち合わせを実施した。また、最新技術を導入するとともに、支援拠点で開発されたリソースおよび技術を活用し、効率的な遺伝子改変を行った。さらに、動物受け入れが困難な施設については、支援拠点で凍結胚を作製し、一時保管を行った。
③病理形態解析支援活動 : 申請数は増加しており、事前相談や再審査によりできるだけ多く若手研究者の支援を行うよう努力している。現在の予算ならびに班員のエフォートにおいてできる最大限の支援活動を実施しており、成果は確実に上がっている。今年度は、支援結果の議論にウェブ会議も使用した。
④生理機能解析支援活動 : 支援対象者のモデルマウスを対象にした「網羅的行動テストバッテリー」を用いた行動解析支援を26件、依存性薬物等の感受性に関連する行動解析および規制薬物作用ゲノム関連解析支援を16件、進展著しい光遺伝学に関する最新技術を活用した研究支援を9件、多機能集積化電極による最先端の技術提供を行う多元的生理機能計測操作支援を13件で実施した。
⑤分子プロファイリング支援活動 : コロナ禍の影響が危ぶまれたが、被支援者との事前打ち合わせや日程の弾力的調整により、円滑な支援体制を維持することができた。本年度は被支援者の研究室の若手も含めた技術指導、動物実験・論文構想・特許出願などに関する助言を強化し、多くの案件が共同研究に進展した。寄託化合物ライブラリー支援により、被支援者間の異分野共同研究斡旋にも成果があった。

Strategy for Future Research Activity

①総括支援活動 : WEBを利用した講習会や発表会の内容の向上を図る。特にディスカッションが一層推進されることを目指す。広報活動として、「マウス・ラットモデル作製・解析プロフェッショナル」の紹介に力をいれ、若手研究者に本支援活動をより理解してもらうよう努める。
②モデル動物作製支援活動 : 先端的な遺伝子改変技術の導入および開発とともに、支援拠点が持つ独自のリソース活用することにより、科研費により進められる学術研究を支援する。学術的な価値や成功時の波及効果の高い支援課題については、より高度なリソースの開発・提供を行う。作製された遺伝子改変動物は、公共リソースバンクに供出し、学術基盤としての研究リソースの整備を推進する。
③病理形態解析支援活動 : 現在、予算ならびに班員のエフォートに関して限界に近い状態となっている。今後は審査をより厳格に行うが、少額研究費の若手の申請に特に対応したいと考えている。基本姿勢が、一旦開始した病理形態支援は論文が受理されるまでサポートするという方針に変化はない。
④生理機能解析支援活動 : 5つの拠点への支援申請が何れも安定して多数であるとともに増加していることから、引き続きニーズに応えられるように拠点における技術力を維持・向上させ、公正に支援課題を選考し、支援実施体制をハイレベルに保つ。また、技術支援にとどまらず、支援該当部の論文分担執筆を積極的に進め、成果の公表にも貢献する。
⑤分子プロファイリング支援活動 : 前年度に引き続き、被支援者の要望に応じた解析条件のカスタマイズ対応・支援実施後のフォロー(科学的助言・技術指導、高次支援の勧奨)に努めるとともに、定例班会議とユーザーミーティングで課題を共有し、効果的な共同研究の提案・斡旋を行う。モデル動物研究の起点的役割を担う当班の6年間の実績を俯瞰し、次代の生命科学を牽引する新しい支援の枠組みを提案する。

Report

(7 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report   Interim Assessment Report ( PDF )   Interim Assessment (Comments) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(2511 results)

All 2022 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (28 results) Journal Article (835 results) (of which Int'l Joint Research: 278 results,  Peer Reviewed: 815 results,  Open Access: 593 results,  Acknowledgement Compliant: 67 results) Presentation (1426 results) (of which Int'l Joint Research: 403 results,  Invited: 412 results) Book (44 results) Remarks (149 results) Patent(Industrial Property Rights) (29 results) (of which Overseas: 7 results)

  • [Int'l Joint Research] Johns Hopkins University/Medical University of South Crolina/Van Andel Resarch Institute(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Western Ontario(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Université Claude Bernard Lyonl(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Beijing University of Technology(シンガポール)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Beijing University of Technology/南通大学(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Yale University/Stanford University/Johns Hopkins University(アメリカ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Ottawa/University of Toronto(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Helmholtz Zentrum Muenchen/Technische Universitaet Muenchen(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Pohang University of Science and Technology(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 南通大学(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] コロンピア大学/イリノイ大学/タフツ大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ボルドー大学/マリーキューリー医科大学/グルノーブルアルプス大学(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 江蘇大学/Xi'an Jiaotong University(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Seoul national University/韓南大学(韓国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カルガリー大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] スプリト大学(クロアチア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School, Boston(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] スタンフォード大学/エール大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 南通大学(中国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management.2022

    • Author(s)
      Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
    • Journal Title

      J Neurosci Res

      Volume: 100 Pages: 362-372

    • DOI

      10.1002/jnr.24756

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of Optogenetics for Muscle Cells and Stem Cells.2021

    • Author(s)
      Asano T, Teh DBL, Yawo H.
    • Journal Title

      Adv Exp Med Biol.

      Volume: 1293 Pages: 359-375

    • DOI

      10.1007/978-981-15-8763-4_23

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation2021

    • Author(s)
      M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
    • Journal Title

      J Immunology

      Volume: 206 Pages: 366-375

    • DOI

      10.4049/jimmunol.2000971

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion.2021

    • Author(s)
      Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
    • Journal Title

      Cl in Endocrinol (Oxf).

      Volume: 94 Pages: 544-550

    • DOI

      10.1111/cen.14385

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Behavioral consequences of a combination of Gadl Haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat.2021

    • Author(s)
      Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y.
    • Journal Title

      Front Pharmacol.

      Volume: 12 Pages: 1-10

    • DOI

      10.3389/fphar.2021.646088

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice2021

    • Author(s)
      Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
    • Journal Title

      Nature communications

      Volume: 12(1) Issue: 1 Pages: 1848-1848

    • DOI

      10.1038/s41467-021-22059-6

    • NAID

      120006996978

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain2021

    • Author(s)
      Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 41 Issue: 3 Pages: 1076-1091

    • DOI

      10.1161/atvbaha.120.315789

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4, 3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin2021

    • Author(s)
      Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Pages: 181-191

    • DOI

      10.1093/bbb/zbaa028

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus.2021

    • Author(s)
      Sasaki T, Takei Y.
    • Journal Title

      Jap J Biol Psych.

      Volume: 32 Issue: 2

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α2021

    • Author(s)
      Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
    • Journal Title

      Bioorg Med Chem.

      Volume: 30 Pages: 115949-115949

    • DOI

      10.1016/j.bmc.2020.115949

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues2021

    • Author(s)
      Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
    • Journal Title

      Sensors and Actuators B : Chemical

      Volume: 335 Pages: 129686-129686

    • DOI

      10.1016/j.snb.2021.129686

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences between a therosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery.2021

    • Author(s)
      Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
    • Journal Title

      Int. Heart J.

      Volume: 62 Issue: 2 Pages: 390-395

    • DOI

      10.1536/ihj.20-585

    • NAID

      130008007468

    • ISSN
      1349-2365, 1349-3299
    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis.2021

    • Author(s)
      Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
    • Journal Title

      Exp Hematol

      Volume: 96 Pages: 52-62

    • DOI

      10.1016/j.exphem.2021.02.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Divergent Total Synthesis of Azalamellarins D and N2021

    • Author(s)
      Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
    • Journal Title

      Heterocycles

      Volume: 103

    • DOI

      10.3987/com-20-s(k)53

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons2021

    • Author(s)
      Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 1 Pages: 49-49

    • DOI

      10.3390/biomedicines9010049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.2021

    • Author(s)
      Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K., et al.
    • Journal Title

      Science Translational Medicine

      Volume: 13 Issue: 587 Pages: 7896-7896

    • DOI

      10.1126/scitranslmed.aay7896

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of RORγt overexpression on the murine central nervous system.2021

    • Author(s)
      Sasaki T, Nagata R, Takahashi S, Takei Y
    • Journal Title

      Neuropsychopharmacology Reports

      Pages: 1-9

    • NAID

      120007132525

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex2021

    • Author(s)
      Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
    • Journal Title

      Cerebral Cortex

      Volume: 31 Pages: 2205-2219

    • DOI

      10.1093/cercor/bhaa355

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats.2021

    • Author(s)
      Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
    • Journal Title

      FEBS Open Bio.

      Volume: 11 Pages: 340-353

    • DOI

      10.1002/2211-5463.13065

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GLI3 is associated with neuronal differentiation in SHH-activated and WNT-activated medulloblastoma2021

    • Author(s)
      Natsumeda M, Miyahara H, Yoshimura J, Okada M, Hirato J, Wataya T, Tateishi K, Rodriguez FJ, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 80 Issue: 2 Pages: 129-136

    • DOI

      10.1093/jnen/nlaa141

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.2021

    • Author(s)
      Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
    • Journal Title

      Mol Brain.

      Volume: 14 Pages: 5-5

    • DOI

      10.1186/s13041-020-00713-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] G-quadruplex-forming nucleic acids interact with SF3B2 and suppress innate immune gene expression.2021

    • Author(s)
      Matsumoto K, Okamoto K, Okabe S, Fujii R, Ueda K, Ohashi K, Seimiya H.
    • Journal Title

      Genes Cells

      Volume: 26 Pages: 65-82

    • DOI

      10.1111/gtc.12824

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] His-Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.2021

    • Author(s)
      Dat NQ, Oikawa D, Yoishizato K, Tokunaga F, Pinzani M, Kawada M, et al.
    • Journal Title

      Hepatology.

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ICAM1-Negative Intravascular Large B-Cell Lymphoma of the Pituitary Gland : A Case Report and Literature Review.2021

    • Author(s)
      Kumiko Naito, Sawako Suzuki, Chikako Ohwada, Jun-ichiro Ikeda, Tomoaki Tanaka, Koutaro Yokote.
    • Journal Title

      AACE Clinical Case Reports

      Volume: - Pages: 249-255

    • DOI

      10.1016/j.aace.2021.01.011

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induced genetic ablation of Rest leads to the alteration of stimulus-induced response of the vagal nerve.2021

    • Author(s)
      Aoki H, Abe C, Hara A, Miyazaki T, Morita H, Kunisada T.
    • Journal Title

      Genes Cells.

      Volume: 26 Issue: 2 Pages: 45-55

    • DOI

      10.1111/gtc.12819

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kv11 (ether-a-go-go-related gene)voltage-dependent K^+ channels promote resonance and oscillation of subthreshold membrane potentials2021

    • Author(s)
      Toshinori Matsuoka, Miwako Yamasaki, Manabu Abe, Yukiko Matsuda, Hiroyuki Morino, Hideshi Kawakami, Kenji Sakimura, Masahiko Watanabe, Kouichi Hashimoto
    • Journal Title

      J Physiol .

      Volume: 599(2) Pages: 547-569

    • DOI

      10.1113/jp280342

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor2021

    • Author(s)
      Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y, et al.
    • Journal Title

      Cancer Sci

      Volume: - Pages: 1963-1974

    • DOI

      10.1111/cas.14839

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MEK inhibition preferentially suppresses anchorage-independent growth in osteosarcoma cells and decreases tumors in vivo2021

    • Author(s)
      T Shimizu, K Kimura, E Sugihara, S Yamaguchi - Iwai, H Nobusue, O Sampetrean, Y Otsuki, Y Fukuchi, K Saitoh, K Kato, T Soga, A Muto, H Saya
    • Journal Title

      Journal of Orthopaedic Research

      Volume: - Pages: 2732-2743

    • DOI

      10.1002/jor.25023

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice with a cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial memory tasks2021

    • Author(s)
      M. Asada-Utsugi, K. Uemura, M. Kubota, Y. Noda, Y. Tashiro, T. M. Uemura, H. Yamakado, M. Urushitani, R. Takahashi, S. Hattori, T. Miyakawa, N. Ageta-Ishihara, K. Kobayashi, M. Kinoshita, A. Kinoshita
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 00-00

    • DOI

      10.1186/s13041-021-00738-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice with mutations in Trpml, a gene within the locus of 15q13.3 microdeletion syndrome, display pronounced hyperactivity and decreased anxiety-like behavior.2021

    • Author(s)
      Tesshu Hori, Shohei Ikuta, Satoko Hattori, Keizo Takao, Tsuyoshi Miyakawa, Chieko Koike
    • Journal Title

      Molecular Brain

      Volume: 14:61 Issue: 1 Pages: 1-16

    • DOI

      10.1186/s13041-021-00749-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multimodal Functional Analysis Platform : 4. Optogenetics-Induced Oscillatory Activation to Explore Neural Circuits2021

    • Author(s)
      Mushiake H, Ohshiro T, Osawa SI, Hosaka R, Katayama N, Tanaka T, Yawo H, Osanai M.
    • Journal Title

      optogenetics

      Volume: 1293 Pages: 501-509

    • DOI

      10.1007/978-981-15-8763-4_34

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation2021

    • Author(s)
      Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Yamagata K, Nakamura T, Nakagata N, Tsujita K
    • Journal Title

      Nat Metab

      Volume: 3 Pages: 196-210

    • DOI

      10.1038/s42255-021-00342-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuromodulatory effect of interleukin 1 in the dorsal raphe nucleus on individual differences in aggression2021

    • Author(s)
      Aki Takahashi, Hossein Aleyasin, Tetsuya Sasaki, Sonoko Ogawa, Bruce S. McEwen and Scott J. Russo, et al
    • Journal Title

      Molecular Psychiatry

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics2021

    • Author(s)
      Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Matsumoto H, Miyakawa T, Nakada K.
    • Journal Title

      Pharmacol Res.

      Volume: 163 Pages: 105246-105246

    • DOI

      10.1016/j.phrs.2020.105246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide2021

    • Author(s)
      Tatsuya Yamahira, Gen Onodera, Tsutomu Fukuda, Masanari Kimura
    • Journal Title

      Chem. Lett.

      Volume: - Issue: 5 Pages: 853-855

    • DOI

      10.1246/cl.210008

    • NAID

      130008040425

    • ISSN
      0366-7022, 1348-0715
    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids2021

    • Author(s)
      Ying Luo, Bun Chan, Tsutomu Fukuda, Gen Onodera, Masanari Kimura
    • Journal Title

      Synlett

      Volume: -

    • DOI

      10.1055/a-1336-8034

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional intervention for cancer sarcopenia.2021

    • Author(s)
      Mori T, Kido A, Kawahara I, Nukaga S, Miyagawa Y, Goto K, Mori S, Kishi S, Fujii K, Fujiwara-Tani R, Kuniyasu H
    • Journal Title

      Annals of Musculoskeletal Medicine

      Volume: 5 Issue: 1 Pages: 001-004

    • DOI

      10.17352/amm.000024

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function2021

    • Author(s)
      Akira C Saito, Tomohito Higashi, Yugo Fukazawa, Tetsuhisa Otani, Masashi Tauchi, Atsuko Y Higashi, Mikio Furuse, Hideki Chiba
    • Journal Title

      Molecular biology of the cell

      Volume: 32 Pages: 722-738

    • DOI

      10.1091/mbc.e20-07-0464

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palmitoyl piperidinopiperidine, a novel derivative of 10-hydroxy-2-decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines2021

    • Author(s)
      Ando S, Fukamachi K, Yoshimoto E, Matsumoto H, Iinuma M and Suzui M.
    • Journal Title

      Int J Oncol

      Volume: 58 Pages: 251-265

    • DOI

      10.3892/ijo.2020.5160

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates.2021

    • Author(s)
      Okada M, Kawagoe Y, Sato Y, Nozumi M, Ishikawa Y, Tamada A, Yamazaki H, Sekino Y, Kanemura Y, Shinmyo Y, Kawasaki H, Kaneko N, Sawamoto K, Fujii Y, Igarashi M
    • Journal Title

      Mol Brain

      Volume: 14 Issue: 1 Pages: 66-66

    • DOI

      10.1186/s13041-021-00755-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.2021

    • Author(s)
      Hayashi T
    • Journal Title

      British Journal of Pharmacology

      Volume: 178 Pages: 784-797

    • DOI

      10.1111/bph.15050

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma2021

    • Author(s)
      Shinozaki Y, Koizumi S
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 155 Pages: 262-267

    • DOI

      10.1016/j.jphs.2020.12.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prioritized experience replays on a hippocampal predictive map for learning2021

    • Author(s)
      H. Igata, Y. Ikegaya, T. Sasaki
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 118(1)

    • DOI

      10.1073/pnas.2011266118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality.2021

    • Author(s)
      Kakizaki T, Ohshiro T, Itakura M, Konno K, Watanabe M, Mushiake H, Yanagawa Y.
    • Journal Title

      FASEB J.

      Volume: 35 Issue: 2 Pages: 1-15

    • DOI

      10.1096/fj.202001935r

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus2021

    • Author(s)
      Sano F, Shigetomi E, Shinozaki Y, Tsuzukiyama H, Saito K, Mikoshiba K, Sugita K, Aihara M, Koizumi S.
    • Journal Title

      JCI Insight

      Volume: -

    • DOI

      10.1172/jci.insight.135391

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders2021

    • Author(s)
      Johmura Y, Nakanishi M, et al
    • Journal Title

      Science

      Volume: 371 Issue: 6526 Pages: 265-270

    • DOI

      10.1126/science.abb5916

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] (S)-Erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells2021

    • Author(s)
      K. Hikita, Y. Yamakage, H. Okunaga, Y. Motoyama, H. Matsuyama, K. Matsuoka, T. Murata, T. Nakayoshi, A. Oda, K. Kato, H. Tanaka, N. Asao, S. Dan and N. Kaneda
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 30 Pages: 115904-115904

    • DOI

      10.1016/j.bmc.2020.115904

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth.2021

    • Author(s)
      Rahman NIA, Sato A, Tsevelnorov K, Shimizu A, Komeno M, Ahmat Amin MKB, Molla MR, Soh JEC, Nguyen LKC, Wada A, Kawauchi A, Ogita H.
    • Journal Title

      Cancer Res

      Volume: - Pages: 2318-2331

    • DOI

      10.1158/0008-5472.can-20-2331

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant2021

    • Author(s)
      Tsutomu Fukuda, Fumito Ishibashi, Yusuke Oku, Naoyuki Nishiya, Yoshimasa Uehara, Masatomo Iwao
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 34 Pages: 116039-116039

    • DOI

      10.1016/j.bmc.2021.116039

    • NAID

      120006980722

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The KEAP1-NRF2 system as a molecular target of cancer treatment2021

    • Author(s)
      Taguchi K, Yamamoto M
    • Journal Title

      Cancers

      Volume: 13 Pages: 46-46

    • DOI

      10.3390/cancers13010046

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tiny Drosophila makes giant strides in cancer research2021

    • Author(s)
      Yamamura R, Ooshio T & Sonoshita M.
    • Journal Title

      Cancer Sci

      Volume: 112 Pages: 505-514

    • DOI

      10.1111/cas.14747

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis and Biological Evaluation of Oscillatoxin D, E, and F2021

    • Author(s)
      Yusuke Araki, Yusuke Hanaki, Masaki Kita, Koutaro Hayakawa, Kazuhiro Irie, Yoshihiko Nokura, Atsuo Nakazaki, and Toshio Nishikawa
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: in press Pages: 1371-1382

    • DOI

      10.1093/bbb/zbab042

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.2021

    • Author(s)
      Parajuli B, Saito H, Shinozaki Y, Shigetomi E, Miwa H, Yoneda S, Tanimura M, Omachi S, Asaki T, Takahashi K, Fujita M, Nakashima K, Koizumi S
    • Journal Title

      GLIA

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus2021

    • Author(s)
      Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A
    • Journal Title

      The Journal of Immunology

      Volume: 206 Pages: 1528-1539

    • DOI

      10.4049/jimmunol.2001003

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways2021

    • Author(s)
      Miyajima K, Kawamoto C, Hara S, Mori-Kojima M, Ohye T, Sumi-Ichinose C, Saito N, Sasaoka T, Metzger D, Ichinose H
    • Journal Title

      Journal of Biological Chemistry

      Volume: - Pages: 100544-100544

    • DOI

      10.1016/j.jbc.2021.100544

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of 211At-trastuzumab for the Treatment of Metastatic Gastric Cancer in the Liver: Evaluation of a Preclinical α-Radioimmunotherapy Approach in a Clinically-relevant Mouse Model2021

    • Author(s)
      Huizi Keiko Li, Yukie Morokoshi, Satoshi Kodaira, Tamon Kusumoto, Katsuyuki Minegishi, Hiroaki Kanda, Kotaro Nagatsu, and Sumitaka Hasegawa
    • Journal Title

      Journal of Nuclear Medicine

      Volume: in press

    • DOI

      10.2967/jnumed.120.249300

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 環境応答・適応の分子機構2021

    • Author(s)
      田口恵子、山本雅之
    • Journal Title

      日本体質医学学会誌

      Volume: 83

    • Description
      in press
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.2021

    • Author(s)
      Inada R, Miyamoto K, Tanaka N, Moriguchi K, Kadomatsu K, Takeuchi K, Igarashi M, Kusunoki S
    • Journal Title

      Glycobiology.

      Volume: 31 Pages: 260-265

    • DOI

      10.1093/glycob/cwaa072

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combi-CRISPR : combination of NHEJ and HDR provides efficient and precise plasmid-based knock-ins in mice and rats2021

    • Author(s)
      Yoshimi K, Oka Y, Miyasaka Y, Kotani Y, Yasumura M, Uno Y, Hattori K, Tanigawa A, Sato M, Oya M, Nakamura K, Matsushita N, Kobayashi K, Mashimo T
    • Journal Title

      Human Genetics

      Volume: 140 Issue: 2 Pages: 277-287

    • DOI

      10.1007/s00439-020-02198-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defective biosynthesis of ascorbic acid in Sodl-deficient mice results in lethal damage to lung tissue2021

    • Author(s)
      Homma T, Takeda Y, Nakano T, Akatsuka S, Kinoshita D, Kurahashi T, Saitoh S, Yamada KI, Miyata S, Asao H, Goto K, Watanabe T, Watanabe M, Toyokuni S, Fujii J
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 162 Pages: 255-265

    • DOI

      10.1016/j.freeradbiomed.2020.10.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A.2021

    • Author(s)
      36. Chen M, Asanuma M, Takahashi M, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, and Iwasaki S
    • Journal Title

      Cell Chem Biol.

      Volume: 28 Pages: 475-486

    • DOI

      10.1016/j.chembiol.2020.11.008

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities2021

    • Author(s)
      Atsuko Gonda, Koji Takada, Ryo C. Yanagita, Shingo Dan, and Kazuhiro Irie*
    • Journal Title

      Bioscience, Biotechnology and Biochemistry

      Volume: 85 Issue: 1 Pages: 168-180

    • DOI

      10.1093/bbb/zbaa024

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of 5-HT1A receptor-mediated serotonergic transmission in the medial prefrontal cortex in acute restraint stress-induced augmentation of rewarding memory of cocaine in mice2021

    • Author(s)
      Chu J, Deyama S, Li X, Motono M, Otoda A, Saito A, Esaki H, Nishitani N, Kaneda K
    • Journal Title

      Neuroscience Letters

      Volume: 743 Pages: 135555-135555

    • DOI

      10.1016/j.neulet.2020.135555

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of type-IIa receptor protein tyrosine phosphatases as synaptic organizers2021

    • Author(s)
      Fukai S, Yoshida T.
    • Journal Title

      FEBS Journal

      Volume: - Pages: 6913-6926

    • DOI

      10.1111/febs.15666

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The pentatricopeptide repeat protein PGR3 is required for the translation of petL and ndhG by binding their 5'UTRs.2021

    • Author(s)
      Higashi H, Kato Y, Fujita T, Iwasaki S, Nakamura M, Nishimura Y, Takenaka M, and Shikanai T.
    • Journal Title

      Plant Cell Physiol

      Volume: - Pages: 1-10

    • DOI

      10.1093/pcp/pcaa180

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis2021

    • Author(s)
      Kuriyama Y, Shimizu A, Kanai S, Oikawa D, Tokunaga F, Tsukagoshi H, Ishikawa O.
    • Journal Title

      J Am Acad Dermatol.

      Volume: 84 Pages: 1103-1105

    • DOI

      10.1016/j.jaad.2020.05.051

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anomalous atrium associated with persistent left superior vena cava.2021

    • Author(s)
      Shutoh F, Masuda T, Sasaki T, Takei Y.
    • Journal Title

      Anatomical Science International.

      Pages: 1-5

    • DOI

      10.1007/s12565-021-00604-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy2020

    • Author(s)
      Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
    • Journal Title

      JCI Insight

      Volume: 5 Issue: 22

    • DOI

      10.1172/jci.insight.140229

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma.2020

    • Author(s)
      Ichikawa J, Ando T, Kawasaki T, Sasaki T, Shirai T, Tsukiji N, Kimura Y, Aoki K, Hayakawa K, Suzuki-Inoue K, Saitoh M, Haro H.
    • Journal Title

      J Bone Miner Res

      Volume: in press Issue: 9 Pages: 1738-1750

    • DOI

      10.1002/jbmr.4045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.2020

    • Author(s)
      Kataura T, Tashiro E, Nishikawa S, Onodera M, Shin-ya K, et al, Sasazawa Y, Hattori N, Saiki S, and Imoto M
    • Journal Title

      Autophagy

      Volume: Aug 7 Pages: 1-17

    • DOI

      10.1080/15548627.2020.1794590

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity2020

    • Author(s)
      M. Endoh, M. Baba, T. Endoh, A. Hirayama, A. Nakamura-Ishizu, T. Umemoto, M. Hashimoto, K. Nagashima, T. Soga, M. Lang, L. S. Schmidt, W. M. Linehan, T. Suda
    • Journal Title

      Cell Reports

      Volume: 30 Pages: 1823-1834

    • DOI

      10.1016/j.celrep.2020.01.042

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities.2020

    • Author(s)
      Koi H, Takahashi N, Fuchi Y, Umeno T, Muramatsu Y, Seimiya H, Karasawa S, Oguri H.
    • Journal Title

      Org Biomol Chem.

      Volume: 18 Pages: 5339-5343

    • DOI

      10.1039/d0ob00919a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020

    • Author(s)
      Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
    • Journal Title

      Int J Hematol

      Volume: 112 Issue: 3 Pages: 300-306

    • DOI

      10.1007/s12185-020-02935-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors2020

    • Author(s)
      Takahashi H, Yamanaka S, Kuwada S, Higaki K, Kido K, Sato Y, Fukai S, Tokunaga F, Sawasaki T.
    • Journal Title

      Biomedicines

      Volume: 8 Pages: 152-152

    • DOI

      10.3390/biomedicines8060152

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A human neurodevelopmental disease model using human brainstem organoids-Brainstem organoids from human pluripotent stem cells2020

    • Author(s)
      Eura N, Matsui TK, ....Kuniyasu H, Nagamori S, Muotri AR, Shin JW, Sugie K, Mori E
    • Journal Title

      Front Neurosci

      Volume: - Pages: 00538-00538

    • DOI

      10.3389/fnins.2020.00538

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events.2020

    • Author(s)
      Masanori Kawabata, Shogo Soma, Akiko Saiki-Ishikawa, Satoshi Nonomura, Junichi Yoshida, Alain A Rios, Yutaka Sakai, Yoshikazu Isomura
    • Journal Title

      Journal of Neurophysiology

      Volume: 124 Pages: 1923-1941

    • DOI

      10.1152/jn.00200.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation2020

    • Author(s)
      Tsuboyama K., Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., and Tomari Y.
    • Journal Title

      PLoS Biol.

      Volume: 18 Issue: 3 Pages: 3000632-3000632

    • DOI

      10.1371/journal.pbio.3000632

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Action of antiepileptic drugs on neurons2020

    • Author(s)
      Kobayashi K, Endoh F, Ohmori I, Akiyama T.
    • Journal Title

      Brain Dev.

      Volume: 42 Issue: 1 Pages: 2-5

    • DOI

      10.1016/j.braindev.2019.07.006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.2020

    • Author(s)
      Kawakami R, Mashima T, Kawata N, Kumagai K, Migita T, Sano T, Mizunuma N, Yamaguchi K, Seimiya H.
    • Journal Title

      Cancer Sci.

      Volume: 111 Pages: 962-973

    • DOI

      10.1111/cas.14316

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice2020

    • Author(s)
      Gotoh N, Saito Y, Hata S, Saito H, Ojima D, Murayama C, Shigeta M, Abe T, Konno D, Matsuzaki F, Suzuki T, Yamamoto T
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 295 Pages: 9650-9662

    • DOI

      10.1074/jbc.ra119.012386

    • NAID

      120007116485

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-stem cell property of pterostilbene in gastrointestinal cancer cells.2020

    • Author(s)
      Mori S, Kishi S, Honoki K, Fujiwara-Tani R, Moriguchi T, Sasaki T, Fujii K, Tsukamoto S, Fujii H, Kido A, Tanaka Y, Luo Y, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Pages: 9347-9347

    • DOI

      10.3390/ijms21249347

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] APC/C-Cdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit2020

    • Author(s)
      Tsunematsu T, Arakaki R, Kawai H, Ruppert J, Tsuneyama K, Ishimaru N, Earnshaw WC, Pagano M, Kudo Y.
    • Journal Title

      Journal of Cell Science

      Volume: 133 Issue: 18 Pages: 251314-251314

    • DOI

      10.1242/jcs.251314

    • NAID

      120006937581

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autocrine leukemia inhibitory factor promotes esophageal squamous cell carcinoma progression via Src family kinase-dependent Yes-associated protein activation2020

    • Author(s)
      Kawazoe T, Saeki H, Oki E, Oda Y, Maehara Y, Mori, M, Taniguchi K
    • Journal Title

      Molecular Cancer Research

      Volume: 18 Pages: 1876-1888

    • DOI

      10.1158/1541-7786.mcr-20-0186

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model2020

    • Author(s)
      Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Murakami M, Tanaka T, Goda W, Hashimoto T, Miyakawa T, Iwatsubo T, Hata J, Niikura T, Yasui M, et al.
    • Journal Title

      Acta Neuropathol. Commun.

      Volume: 8 Pages: 67-67

    • DOI

      10.1186/s40478-020-00936-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood and lymphatic systems are segregated by the FLCN tumor suppressor2020

    • Author(s)
      Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Hirashima M, Suzuki Y, Furuya M, Baba M, Kubota Y
    • Journal Title

      Nature Communications volume

      Volume: 11 Pages: 1-12

    • DOI

      10.1038/s41467-020-20156-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brown adipocyte-derived miR-132-3p suppress hepatic Srebfl expression and thereby attenuate expression of lipogenic genes2020

    • Author(s)
      Kariba Y, Yoshizawa T, Sato Y, Tsuyama T, Araki E, Yamagata K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 530 Pages: 500-507

    • DOI

      10.1016/j.bbrc.2020.05.090

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiomyocyte Sirt (Sirt7)7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA42020

    • Author(s)
      Yamamura S, Izumiya Y, Araki S, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K
    • Journal Title

      Hypertension

      Volume: 75 Pages: 98-108

    • DOI

      10.1161/hypertensionaha.119.13357

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway2020

    • Author(s)
      Oikawa D, Hatanaka N, Suzuki T, Tokunaga F.
    • Journal Title

      Front Immunol.

      Volume: 11 Pages: 601926-601926

    • DOI

      10.3389/fimmu.2020.601926

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.2020

    • Author(s)
      Saito M, Kagawa N, Okumura K, Munakata H, Isogai E, Fukagawa T, Wakabayashi Y.
    • Journal Title

      Cancer Science.

      Volume: 111 Pages: 2850-2860

    • DOI

      10.1111/cas.14533

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combination of hydroxyurea and tranilast suppresses gemcitabine resistance induced by ribonucleotide reductase M1 in gemcitabine-resistant cells2020

    • Author(s)
      Noriho Shinagawa, Kentaro Minami, Takayuki Ishida, Hiroshi Hijioka, Masatatsu Yamamoto, Kohichi Kawahara, Tatsuhiko Furukawa, Norifumi Nakamura
    • Journal Title

      Oral Sci Int

      Volume: - Pages: 1-9

    • DOI

      10.1002/osi2.1096

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined administration of medium-chain fatty chain and glucose improved cancer-derived cardiac atrophy in a mouse cachexia model.2020

    • Author(s)
      Nukaga S, Mori T, Miyagawa Y, Fujiwara-Tani R, Sasaki T, Fujii K, Mori S, Goto K, Kishi S, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: 111 Pages: 4605-4615

    • DOI

      10.1111/cas.14656

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Compartmentalized input-output organization of Lugaro cells in the cerebellar cortex2020

    • Author(s)
      Miyazaki T, Yamasaki M, Tanaka KF, Watanabe M.
    • Journal Title

      Neuroscience

      Volume: in press Issue: 20 Pages: 30332-30325

    • DOI

      10.1016/j.neuroscience.2020.05.026

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete chemical structures of human mitochondrial tRNAs2020

    • Author(s)
      Suzuki Ta., ...Mito M., Iwasaki S., Ma D., Zhao X., Asano K., Lin H., Kirino Y., Sakaguchi Y., and Suzuki Ts.
    • Journal Title

      Nat Commun.

      Volume: 11 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41467-020-18068-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CRISPR/Cas9-engineered Gadl elimination in rats leads to complex behavioral changes : implications for schizophrenia.2020

    • Author(s)
      Fujihara K, Yamada K, Ichitani Y, Kakizaki T, Suto T, Watanabe M, Kajita Y, Ohshiro T, Mushiake H, Miyasaka Y, Mashimo T, Yasuda H, Yanagawa Y.
    • Journal Title

      Transl Psychiatry.

      Volume: 10 Pages: 1-13

    • DOI

      10.1038/s41398-020-01108-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crossroads of telomere biology and anticancer drug discovery.2020

    • Author(s)
      Seimiya H.
    • Journal Title

      Cancer Sci.

      Volume: 111 Pages: 3089-3099

    • DOI

      10.1111/cas.14540

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of cellular G-quadruplex by using a loop structure as a structural determinant.2020

    • Author(s)
      Masai H, Kanoh Y, Kakusho N, Fukatsu R.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 531 Pages: 75-83

    • DOI

      10.1016/j.bbrc.2020.05.191

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental and postdevelopmental roles of septins in the brain2020

    • Author(s)
      Ageta-Ishihara N and Kinoshita M
    • Journal Title

      Neuroscience Research

      Volume: S0168-0102(20) Issue: 20 Pages: 30440-30445

    • DOI

      10.1016/j.neures.2020.08.006

    • Description
      Epub ahead of print
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes mellitus is associated with liver metastasis of colorectal cancer2020

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Fujii K, Luo Y, Kishi S, Mori S, Matsushima-Otsuka S, Nishiguchi Y, Mori T, Nukaga S, Goto K, Kawahara I, Kondoh M, Sho M, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 11 Pages: 2982-2994

    • DOI

      10.18632/oncotarget.27674

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in task-phase-dependent time-frequency patterns of local field potentials in the dorsal and ventral regions of the monkey lateral prefrontal cortex2020

    • Author(s)
      KazuhiroSakamoto, NorihikoKawaguchi, HajimeMushiake
    • Journal Title

      Neuroscience Research

      Volume: S0168 Pages: 1-11

    • DOI

      10.1016/j.neures.2019.12.016

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential sensitivity to detect prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice2020

    • Author(s)
      Mukai S, Nakada S, Kamada H, Yaguchi R, Deyama S, Kaneda K
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40 Pages: 297-301

    • DOI

      10.1002/npr2.12124

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct benzylation of amines with benzylic alcohols catalyzed by palladium/phosphine-borane catalyst system2020

    • Author(s)
      Gen Onodera, Hidenobu Kumagae, Daiki Nakamura, Takuto Hayasaki, Tsutomu Fukuda, Masanari Kimura
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Pages: 152537-152537

    • DOI

      10.1016/j.tetlet.2020.152537

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.2020

    • Author(s)
      Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain I, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H.
    • Journal Title

      GLIA

      Volume: - Pages: 2330-2344

    • DOI

      10.1002/glia.23843

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic Axis-Tuned Cells in the Monkey Lateral Prefrontal Cortex during a Path-Planning Task2020

    • Author(s)
      Kazuhiro Sakamoto, Naohiro Saito, Shun Yoshida and Hajime Mushiake
    • Journal Title

      The Journal of Neuroscience

      Volume: 1 Pages: 203-219

    • DOI

      10.1523/jneurosci.2526-18.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Earwig fan designing : biomimetic and evolutionary biology applications2020

    • Author(s)
      Kazuya Saito, Ricardo Prez-de la Fuente, Kichi Arimoto, Young ah Seong, Hitoshi Aonuma, Ryuma Niiyama, Zhong You
    • Journal Title

      Proceedings of the National Academy of Sciences U.S.A.

      Volume: 117 Issue: 30 Pages: 17622-17626

    • DOI

      10.1073/pnas.2005769117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial : The Earliest-Born Cortical Neurons as Multi-Tasking Pioneers : Expanding Roles for Subplate Neurons in Cerebral Cortex Organization and Function2020

    • Author(s)
      Sato M., Chou S. -J.
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 14 Pages: 43-43

    • DOI

      10.3389/fnana.2020.00043

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of proton pump inhibitors on colorectal cancer2020

    • Author(s)
      Sasaki T, Mori S, Kishi S, Fujiwara-Tani R, Ohmori H, Nishiguchi Y, Kawahara I, Nakashima C, Fujii K, Luo Y, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 11 Pages: 3877-3877

    • DOI

      10.3390/ijms21113877

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient engraftment of genetically modified cells is necessary to ameliorate 1 central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.2020

    • Author(s)
      Saori Miwa, Ayako M. Watabe, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Fusao Kato, Hiroyuki Ida, Toya Ohashi
    • Journal Title

      Molecular Genetics and Metabolism

      Volume: 130 Pages: 262-273

    • DOI

      10.1016/j.ymgme.2020.06.007

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro2020

    • Author(s)
      Masami Ishido, Eiko Shimaya
    • Journal Title

      Fund Toxicol Sci

      Volume: 7 Pages: 253-257

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.2020

    • Author(s)
      Nishio M, et al.
    • Journal Title

      Cancer Sci.

      Volume: 111 Pages: 3576-3578

    • DOI

      10.1111/cas.14581

    • NAID

      120006892076

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced homologous recombination by the modulation of targeting vector ends2020

    • Author(s)
      Shinji Hirotsune, Hiroshi Kiyonari, Mingyue Jin, Kanako Kumamoto, Kayo Yoshida, Miki Shinohara, Hitomi Watanabe, Anthony Wynshaw-Boris, Fumio Matsuzaki
    • Journal Title

      Scientific reports

      Volume: 10 Pages: 1-12

    • DOI

      10.1038/s41598-020-58893-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced retrieval of taste associative memory by chemogenetic activation of locus coeruleus norepinephrine neurons2020

    • Author(s)
      Fukabori, R, Iguchi, Y, ..., Benton, R, Kobayashi, K
    • Journal Title

      The Journal of Neuroscience

      Volume: 40 Pages: 8367-8385

    • DOI

      10.1523/jneurosci.1720-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages2020

    • Author(s)
      H. Nasser, P. Adhikary, A. Abdel-Daim, O. Noyori, J. Panaampon, R. Kariya, S. Okada, W. Ma, M. Baba, H. Takizawa, M. Yamane, H. Niwa, S. Suzu
    • Journal Title

      Cell death discovery

      Volume: 63 Pages: 1-14

    • DOI

      10.1038/s41420-020-00300-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of cancer-derived myocardial impairments using a mouse model2020

    • Author(s)
      Miyagawa Y, Nukaga S, Mori T, Fujiwara-Tani R, Fujii K, Mori S, Goto K, Kishi S, Sasaki T, Nakashima C, Ohmori H, Kawahara I, Luo Y, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 11 Pages: 3712-3722

    • DOI

      10.18632/oncotarget.27759

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolution of Intelligence in cephalopods2020

    • Author(s)
      Amodio P., Shigeno, S. Ostojić L.
    • Journal Title

      eLS 77-84829

      Volume: 1 Pages: 77-77

    • DOI

      10.1002/9780470015902.a0029004

    • Related Report
      2020 Annual Research Report
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  • [Journal Article] Expression patterns of SLIT/ROBO mRNAs reveal a characteristic feature in the entorhinal-hippocampal area of macaque monkeys.2020

    • Author(s)
      Sasaki T, Komatsu Y, Yamamori T.
    • Journal Title

      BMC Res Notes

      Volume: 262 Issue: 13 Pages: 1-6

    • DOI

      10.1186/s13104-020-05100-7

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.2020

    • Author(s)
      Yoshida K, Ito MA, Sato N, Obayashi K, Yamamoto K, Koizumi S, Tanaka S, Furuta K, Matsuoka I
    • Journal Title

      J Immunol

      Volume: 204 Pages: 3077-3085

    • DOI

      10.4049/jimmunol.1900954

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      2020 Annual Research Report
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  • [Journal Article] FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland2020

    • Author(s)
      Y. Isono, M. Furuya, T. Kuwahara, D. Sano, K. Suzuki, R. Jikuya, T. Mitome, S. Otake, M. Baba, LS Schmidt, WM Linehan, T. Kodama, M. Yao, N. Oridate, H. Hasumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 522 Pages: 931-938

    • DOI

      10.1016/j.bbrc.2019.11.184

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      2020 Annual Research Report
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  • [Journal Article] Fracture Risk Assessment Tool May Not Indicate Bone Fragility in Women With Type 2 Diabetes2020

    • Author(s)
      Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
    • Journal Title

      Am J Med Sci.

      Volume: S0002-9629 Pages: 30119-1

    • DOI

      10.1016/j.amjms.2020.04.002

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      2020 Annual Research Report
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  • [Journal Article] Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo2020

    • Author(s)
      3, Omori S, Wang TW, Johmura Y, Makoto Nakanishi, et al
    • Journal Title

      Cell Metabolism

      Volume: 32 Pages: 814-828

    • DOI

      10.1016/j.cmet.2020.09.006

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      2020 Annual Research Report
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  • [Journal Article] Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.2020

    • Author(s)
      Yingsong, Lin., Doki, Y., Ishii, Hideshi, Eguchi, H., Mori, Masaki, Matsuo, K.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 3175-3175

    • DOI

      10.1038/s41467-020-16711-w

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      2020 Annual Research Report
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  • [Journal Article] Genome-wide survey of ribosome collision2020

    • Author(s)
      Han P., Shichino Y., Schneider-Poetsch T., Mito M., Hashimoto S., Udagawa T., Kohno K., Yoshida M., Mishima Y., Inada T., and Iwasaki S.
    • Journal Title

      Cell Reports

      Volume: 31(5) Issue: 5 Pages: 107610-107610

    • DOI

      10.1016/j.celrep.2020.107610

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      2020 Annual Research Report
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  • [Journal Article] GPR30-Expressing Gastric Chief Cells Do Not Dedifferentiate But Are Eliminated via PDK-Dependent Cell Competition During Development of Metaplasia2020

    • Author(s)
      1.Hata M, Kinoshita H, Hayakawa Y, Konishi M, Tsuboi M, Oya Y, Hayata Y, Nakagawa H, Tateishi K, Fujiwara H, Hirata Y, Worthley DL, Muranishi Y, Furukawa T, Kon S, Tomita H, Wang TC, Koike K.
    • Journal Title

      Gastroenterology

      Volume: 158 Pages: 1650-1666

    • DOI

      10.1053/j.gastro.2020.01.046

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      2020 Annual Research Report
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  • [Journal Article] G-quadruplex binding protein Rifl, a key regulator of replication timing.2020

    • Author(s)
      Alavi S, Ghadiri H, Dabirmanesh B, Moriyama K, Khajeh K, Masai H.
    • Journal Title

      J Biochem.

      Volume: 169 Pages: 1-14

    • DOI

      10.1093/jb/mvaa128

    • NAID

      40022490610

    • Description
      in press
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      2020 Annual Research Report
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  • [Journal Article] G-quadruplex DNA and RNA : Their roles in regulation of DNA replication and other biological functions.2020

    • Author(s)
      Masai H, Tanaka T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 531 Pages: 25-38

    • DOI

      10.1016/j.bbrc.2020.05.132

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      2020 Annual Research Report
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  • [Journal Article] Hereditary pancreatitis model by blastocyst complementation in mouse.2020

    • Author(s)
      Asai, A., Konno M., Kawamoto K., Isotani, A., Mori, M., Eguchi H., Doki, Y., Arai, T., Ishii, H.
    • Journal Title

      Oncotarget

      Volume: 11 Issue: 22 Pages: 2061-2073

    • DOI

      10.18632/oncotarget.27595

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai2020

    • Author(s)
      Nakayama J, Saito R, Hayashi Y, Kitada N, Tamaki S, Han Y, Semba K and Maki SA
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 7896-7896

    • DOI

      10.3390/ijms21217896

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      2020 Annual Research Report
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  • [Journal Article] Hippocampal 7α-hydroxylated neurosteroids are raised by training and bolster remote spatial memory with increase of the spine densities.2020

    • Author(s)
      Kanako Maehata, Kimiko Shimizu*, Tomoko Ikeno, Qiuyi Wang, Ayaka Sakurai, Zefeng Wei, Yue Pan, Toshifumi Takao and Yoshitaka Fukada
    • Journal Title

      iScience

      Volume: 23 Issue: 10 Pages: 101559-101559

    • DOI

      10.1016/j.isci.2020.101559

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HNFla controls glucagon secretion in pancreatic a-cells through modulation of SGLT12020

    • Author(s)
      Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura K, Yamagata K
    • Journal Title

      BBA - Mol Basis Dis

      Volume: 1866 Pages: 165898-165898

    • DOI

      10.1016/j.bbadis.2020.165898

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      2020 Annual Research Report
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  • [Journal Article] Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy : potential neuroprotective adjuncts in translational research2020

    • Author(s)
      Htun, Y. Nakamura, S. Kusaka, T
    • Journal Title

      Pediatric Research

      Volume: 89 Pages: 753-759

    • DOI

      10.1038/s41390-020-0998-z

    • Description
      in press
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      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of activity-dependent local translation in dendrite using photoconvertible protein.2020

    • Author(s)
      Iwata S, Sasaki T, Takei Y.
    • Journal Title

      Medical Science Digest

      Volume: 45 Issue: 6 Pages: 64-65

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      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of tissue macrophage proliferation on peripheral and systemic insul in resistance in obese mice with diabetes2020

    • Author(s)
      Morita Y, Senokuchi T, Yamada S, Wada T, Furusho T, Matsumura T, Ishii N, Murakami-Nishida S, Nisida S, Motoshima H, Komohara Y, Yamagata K, Araki E
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 8(1)

    • DOI

      10.1136/bmjdrc-2020-001578

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      2020 Annual Research Report
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  • [Journal Article] Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA B receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice2020

    • Author(s)
      Arima-Yoshida F, Raveau M, Shimohata A, Amano K, Fukushima A, Watanave M, Kobayashi S, Hattori S, Usui M, Sago H, Mataga N, Miyakawa T, Yamakawa K, Manabe T.
    • Journal Title

      Scientific Report

      Volume: 10 Pages: 14187-14187

    • DOI

      10.1038/s41598-020-71085-9

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      2020 Annual Research Report
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  • [Journal Article] Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation2020

    • Author(s)
      Nakazawa K. Shichino Y., Iwasaki S., and Shiina N.
    • Journal Title

      J Biol Chem.

      Volume: 295 Issue: 44 Pages: 15029-15044

    • DOI

      10.1074/jbc.ra120.012715

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      2020 Annual Research Report
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  • [Journal Article] Intravenous Edaravone plus Therapeutic Hypothermia Offers Limited Neuroprotection in the Hypoxic- Ischaemic Newborn Piglet2020

    • Author(s)
      Yamato, S. H. Nakamura, S. Htun, Y. Nakamura, M. Jinnai, W. Nakao, Y. Mitsuie, T. Koyano, K...... Iwase, T. Kondo, S. I. Yasuda, S. Ueno, M. Miki, T. Kusaka, T.
    • Journal Title

      Neonatology

      Volume: 117 Pages: 713-720

    • DOI

      10.1159/000511085

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      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex.2020

    • Author(s)
      Tetsuya Sasaki, Saki Tome, Yosuke Takei
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 93-93

    • DOI

      10.1186/s13041-020-00635-z

    • NAID

      120007132635

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kruppel-Like Factor 4 upregulates Matrix Metalloproteinase 13 expression in chondrocytes via mRNA stabilization.2020

    • Author(s)
      Takeuchi Y., Tatsuta S., Kito A., Fujikawa J., Itoh S., Itoh Y., Akiyama S., Yamashiro T., Wakisaka S., Abe M.
    • Journal Title

      Cell Tissue Research

      Volume: 282(2) Issue: 2 Pages: 307-319

    • DOI

      10.1007/s00441-020-03228-3

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis2020

    • Author(s)
      Fracassi A, Masai H, Yamakoshi Y.
    • Journal Title

      Chem Sci

      Volume: 44 Pages: 11998-12008

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      2020 Annual Research Report
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  • [Journal Article] Linear Consecutive Hexaoxazoles as G4 Ligands Inducing Chair-type Anti-parallel Topology of Telomeric G-Quadruplex2020

    • Author(s)
      Shogo Sasaki, Yue Ma, Takumi Ishizuka, Hong-Liang Bao, Takatsugu Hirokawa, Yan Xu, Masayuki Tera, Kazuo Nagasawa
    • Journal Title

      RSC Adv.

      Volume: 10 Pages: 43319-43323

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Linear ubiquitin code : Its writer, erasers, decoders, inhibitors, and implications in disorders.2020

    • Author(s)
      Oikawa D, Sato Y, Ito H, Tokunaga F.
    • Journal Title

      Int J Mol Sci.

      Volume: 21 Issue: 9 Pages: 3381-3381

    • DOI

      10.3390/ijms21093381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines2020

    • Author(s)
      Sasaki T, Takei Y.
    • Journal Title

      Japanese Journal of Biological Psychiatry

      Volume: 31 Issue: 2 Pages: 93-97

    • DOI

      10.11249/jsbpjjpp.31.2_93

    • NAID

      130007866930

    • ISSN
      2186-6465, 2186-6619
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E22020

    • Author(s)
      T. Adachi, K. Yasuda, T. Muto, S. Serada, T. Yoshimoto, K. J. Ishii, E. Kuroda, K. Araki, M. Ohmuraya, T. Naka and K. Nakanishi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 10 Pages: 637-652

    • DOI

      10.1093/intimm/dxaa031

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Malic enzyme 1 is associated with tumor budding in oral squamous cell carcinomas.2020

    • Author(s)
      Nakashima C, Kirita T, Yamamoto K, Mori S, Luo Y, Sasaki T, Fujii K, Ohmori H, Kawahara I, Mori T, Goto K, Kishi S, Fujiwara-Tani R, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 19 Pages: 7149-7149

    • DOI

      10.3390/ijms21197149

    • Related Report
      2020 Annual Research Report
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  • [Journal Article] Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring's overeating in mice2020

    • Author(s)
      Sakayori, N, Katakura, M, Hamazaki, K, Higuchi, O, Fujii, K, Fukabori, R, Iguchi, Y, Setogawa, S, Takao, K, Miyazawa, T, Arita, M, Kobayashi, K
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-020-01209-4

    • NAID

      120007169782

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meiosis-specific C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination2020

    • Author(s)
      Takemoto K., Tani N., Takada Y., Fujimura S., Tanno N., Yamane M., Okamura K., Sugimoto M., Araki K., Ishiguro K.
    • Journal Title

      Cell Reports

      Volume: 31 Pages: 107686-107686

    • DOI

      10.1016/j.celrep.2020.107686

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      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase2020

    • Author(s)
      Fujiwara Y., Horisawa-Takada Y., Inoue E., Tani N., Shibuya H., Fujimura S., Kariyazono R., Sakata T., Ohta K., Araki K., Okada Y., Ishiguro K.
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 9

    • DOI

      10.1371/journal.pgen.1009048

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      2020 Annual Research Report
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  • [Journal Article] Microtubule elongation along actin filaments induced by microtubule-associated protein 4 contributes to the formation of cellular protrusions.2020

    • Author(s)
      Doki C, Nishida K, Saito S, Shiga M, Ogara H, Kuramoto A, Kuragano M, Nozumi M, Igarashi M, Nakagawa H, Kotani S, Tokuraku K.
    • Journal Title

      J Biochem

      Volume: - Issue: 3 Pages: 295-303

    • DOI

      10.1093/jb/mvaa046

    • NAID

      40022375440

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses2020

    • Author(s)
      Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    • Journal Title

      Commun Biol.

      Volume: 3 Pages: 16-16

    • DOI

      10.1038/s42003-020-0882-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mouse hair significantly lightened through replacement of the cysteine residue in the N-terminal doma in of Mclr using the CRISPR/Cas9 system2020

    • Author(s)
      Hitoshi Suzuki, Gohta Kinoshita, Takeru Tsunoi, Mitsuki Noju, Kimi Araki
    • Journal Title

      Journal of Heredity

      Volume: 111 Issue: 7 Pages: 640-645

    • DOI

      10.1093/jhered/esaa054

    • NAID

      120007160279

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Roles of Vestigial-Like Family Members in Tumor Development.2020

    • Author(s)
      Noritaka Yamaguchi
    • Journal Title

      Frontiers in Oncology

      Volume: 10 Pages: 1266-1266

    • DOI

      10.3389/fonc.2020.01266

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal Signaling Involved in Neuronal Polarization and Growth : Lipid Rafts and Phosphorylation.2020

    • Author(s)
      Igarashi M, Honda A, Kawasaki A, Nozumi M.
    • Journal Title

      Front Mol Neurosci

      Volume: 13 Pages: 1-11

    • DOI

      10.3389/fnmol.2020.00150

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Noradrenaline enhances the excitatory effects of dopamine on medial prefrontal cortex pyramidal neurons in rats.2020

    • Author(s)
      Shinohara S, Arakaki S, Amano T, Minami M, Kaneda K
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 40 Pages: 348-354

    • DOI

      10.1002/npr2.12135

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel method for analyzing flexible locomotion patterns of animals by using polar histogram2020

    • Author(s)
      Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
    • Journal Title

      J. Robot. Mechatron.

      Volume: 32 Issue: 4 Pages: 812-821

    • DOI

      10.20965/jrm.2020.p0812

    • NAID

      130007888807

    • ISSN
      0915-3942, 1883-8049
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.2020

    • Author(s)
      Ikeda H, Muroi M, Kondoh Y, Ishikawa S, Kakeya H, Osada H, Imoto M
    • Journal Title

      ACS Chem. Biol

      Volume: 15 Pages: 2195-2204

    • DOI

      10.1021/acschembio.0c00381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae2020

    • Author(s)
      Saeki N., Eguchi Y., Kintaka R., Makanae K., Shichino Y., Iwasaki S., Kanno M., Kimura N., and Moriya H.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 9500-9500

    • DOI

      10.1038/s41598-020-66307-z

    • NAID

      120006883501

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p53-PHLDA3-Akt Network : The Key Regulators of Neuroendocrine Tumorigenesis.2020

    • Author(s)
      Yu Chen and Rieko Ohki.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 21 Issue: 11 Pages: 4098-4098

    • DOI

      10.3390/ijms21114098

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pakl maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis2020

    • Author(s)
      Okumura K, Saito M, Yoshizawa Y, Ito Y, Isogai E, Araki K, Wakabayashi Y.
    • Journal Title

      Oncogene.

      Volume: - Issue: 24 Pages: 4756-4769

    • DOI

      10.1038/s41388-020-1323-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER&[minus]mitochondria contact sites.2020

    • Author(s)
      Harada, T., Sada, R., Osugi, Y., Matsumoto, S., Matsuda, T., Hayashi-Nishino, M., Nagai, T., Harada, A., Kikuchi, A.
    • Journal Title

      J Cell Sci.

      Volume: 133 Issue: 21

    • DOI

      10.1242/jcs.249045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic roles of retinal glia in glaucoma2020

    • Author(s)
      Shinozaki Y, Koizumi S
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 155 Issue: 2 Pages: 87-92

    • DOI

      10.1254/fpj.19120

    • NAID

      130007804129

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model.2020

    • Author(s)
      Arai H, Takahashi R, Sakamoto Y, Kitano T, Mashita O, Hara S, Yoshikawa S, Kawasaki K, Ichinose H.
    • Journal Title

      Pain

      Volume: 161 Pages: 2520-2531

    • DOI

      10.1097/j.pain.0000000000001946

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion.2020

    • Author(s)
      2. Kohno S*, Linn P*, Nagatani N, Watanabe Y, Kumar S, Soga T and Takahashi C. * equal contribution
    • Journal Title

      Oncogene

      Volume: 39 Pages: 5690-5707

    • DOI

      10.1038/s41388-020-1381-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phosphoproteomic and bioinformatic methods for analyzing signaling in vertebrate axon growth and regeneration.2020

    • Author(s)
      Igarashi M, Kawasaki A, Ishikawa Y, Honda A, Okada M, Okuda S
    • Journal Title

      J Neurosci Methods

      Volume: 339 Pages: 108723-108723

    • DOI

      10.1016/j.jneumeth.2020.108723

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell.2020

    • Author(s)
      Tanno N., Kuninaka S., Fujimura S., Takemoto K., Okamura K., Takeda N., Araki K., Araki M., Saya H. and Ishiguro K.
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 10094-10094

    • DOI

      10.1038/s41598-020-67116-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological functions of junctional adhesion molecules (JAMs) in tight junctions.2020

    • Author(s)
      Christian Hartmann, Ysabel Alessa Schwietzer, Tetsuhisa Otani, Mikio Furuse, Klaus Ebnet
    • Journal Title

      Biochimica et biophysica acta. Biomembranes

      Volume: 1862 Issue: 9 Pages: 183299-183299

    • DOI

      10.1016/j.bbamem.2020.183299

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells2020

    • Author(s)
      Onishi R, Sato K, Murano K, Negishi L, Siomi H, Siomi MC.
    • Journal Title

      Sci. Adv.

      Volume: 6

    • DOI

      10.1126/sciadv.aaz7420

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia2020

    • Author(s)
      Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
    • Journal Title

      NPJ Schizophr

      Volume: 6 Issue: 1 Pages: 36-36

    • DOI

      10.1038/s41537-020-00126-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proliferative Classification of intracranially injected HER2-positive Breast Cancer Cell Lines2020

    • Author(s)
      Kuroiwa Y, Nakayama J, Adachi C, Inoue T, Watanabe S and Semba K
    • Journal Title

      Cancers

      Volume: 12 Pages: 1-18

    • DOI

      10.3390/cancers12071811

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocol for disome profiling to survey ribosome collision in humans and zebrafish.2020

    • Author(s)
      Mito M, Mishima Y, and Iwasaki S
    • Journal Title

      STAR Protocols

      Volume: 1 Issue: 3 Pages: 100168-100168

    • DOI

      10.1016/j.xpro.2020.100168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pterostilbene in Gastrointestinal Cancer Cells.2020

    • Author(s)
      Kuniyasu H
    • Journal Title

      MDPI Scholarly Community Encyclopedia-Topic Review

      Volume: 2020 Pages: 1-3

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Purification and characterization of double-stranded nucleic acid-dependent ATPase activities of tagged Dicer-related helicase 1 and its short isoform in Caenorhabditis elegans2020

    • Author(s)
      Taishi Kobayashi, Takuro Murakami, Yuu Hirose, and Toshihiko Eki
    • Journal Title

      Genes

      Volume: 11 Pages: 734-734

    • DOI

      10.3390/genes11070734

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome2020

    • Author(s)
      Matsuki Y, Matsuo Y, Nakano Y, Iwasaki S, Yoko H, Udagawa T, Li S, Saeki Y, Yoshihisa T, Tanaka K, Ingolia NT, and Inada T.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 19669-19669

    • DOI

      10.1038/s41598-020-76239-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ring box protein-1 is associated with a poor prognosis and tumor progression in esophageal cancer.2020

    • Author(s)
      Kunishige H, Migita K, Matsumoto S, Wakatsuki K, Nakade H, Miyao S, Kuniyasu H, Sho M
    • Journal Title

      Oncol Lett

      Volume: 20 Pages: 2919-2927

    • DOI

      10.3892/ol.2020.11840

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Clostridium perfringens enterotoxin on YAP activation in colonic sessile serrated adenoma/polyp with dysplasia2020

    • Author(s)
      Fujiwara-Tani R, Fujii K, Mori S, Kishi S, Sasaki T, Ohmori H, Nakashima C, Kawahara I, NishiguchiY, Mori T, Sho M, Kondoh M, Luo Y, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 11 Pages: 3840-3840

    • DOI

      10.3390/ijms21113840

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of nuclear claudin-4 in renal cell carcinoma.2020

    • Author(s)
      Owari T, Takamitsu Sasaki T, Fujii K, Fujiwara-Tani R, Kishi S, Mori S, Mori T, Goto K, Kawahara I, .....Luo Y, Tanaka N, Kondoh M, Fujimoto K, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Pages: 8340-8340

    • DOI

      10.3390/ijms21218340

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior2020

    • Author(s)
      Nakayama T, Okimura K, Shen J, Guh Y-J, Tamai K, Shimada A, Minou S, Okushi Y, Shimmura T, Furukawa Y, Kadofusa N, Sato A, Nishimura T, Tanaka M, Nakayama K, Shiina N, Yamamoto N, Loudon A.S, Nishiwaki-Ohkawa T, Shinomiya A, Nabeshima T, Nakane Y, and Yoshimura T
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: - Pages: 1-10

    • DOI

      10.1073/pnas.2000278117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serotonergic control in initiating defensive responses to unexpected tactile stimuli in the trap-jaw ant Odontomachus kuroiwae2020

    • Author(s)
      Aonuma H.
    • Journal Title

      Journal of Experimental Biology

      Volume: 223 Issue: 19

    • DOI

      10.1242/jeb.228874

    • NAID

      120007165392

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sexually dimorphic role of oxytocin in medaka mate choice2020

    • Author(s)
      Yokoi S, Naruse K, Kamei Y, Ansai S, Kinoshita M, Mito M, Iwasaki S., Inoue S, Okuyama T, Nakagawa S, Young LJ, and Takeuchi H.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 117 Issue: 9 Pages: 4802-4808

    • DOI

      10.1073/pnas.1921446117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SGLT2 inhibition mediates protection from diabetic kidney disease by promoting ketone body-induced mTORC1 inhibition.2020

    • Author(s)
      Tomita I, Kume S, Sugahara S, ..., Ogita H, Araki SI, Maegawa H.
    • Journal Title

      Cell Metab.

      Volume: 32 Pages: 404-404

    • DOI

      10.1016/j.cmet.2020.06.020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyxmori2020

    • Author(s)
      Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, Siomi MC.
    • Journal Title

      EMBO J.

      Volume: 39

    • DOI

      10.15252/embj.2020105130

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific Neuroligin3?αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus2020

    • Author(s)
      Uchigashima M, Konno K, Demchak E, Cheung A, Watanabe T, Keener D G, Abe M, Sakimura K, Sasaoka T, Uemura T, Imamura Karasawa Y, Watanabe M, Futai K.
    • Journal Title

      Elife

      Volume: 9

    • DOI

      10.7554/elife.59545

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.2020

    • Author(s)
      Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H.
    • Journal Title

      Biomed Pharmacother.

      Volume: 128 Pages: 110330-110330

    • DOI

      10.1016/j.biopha.2020.110330

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Steroid metabolites for diagnosing and predicting clinicopathological features in cortisol-producing adrenocortical carcinoma.2020

    • Author(s)
      Suzuki S, Minamidate T, Shiga A, Ruike Y, Ishiwata K, Naito K, Ishida A, Deguchi H, Fujimoto M, Koide H, Tatsuno I, Ikeda JI, Yamazaki Y, Sasano H, Yokote K.
    • Journal Title

      BMC Endocr Disord.

      Volume: 20 Pages: 1-9

    • DOI

      10.1186/s12902-020-00652-y

    • Description
      in press
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress2020

    • Author(s)
      Moe Matsushita, Takanori Nakamura, Hisashi Moriizumi, Hiroaki Miki, Mutsuhiro Takekawa
    • Journal Title

      Science Advances

      Volume: 6 Issue: 26 Pages: 1-1

    • DOI

      10.1126/sciadv.aay9778

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons2020

    • Author(s)
      Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, and Noriyuki Sugo
    • Journal Title

      the Journal of Neuroscience

      Volume: 40 Issue: 47 Pages: 9012-9027

    • DOI

      10.1523/jneurosci.0319-20.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustaining temporal attention prevents habit expression during operant learning in rats2020

    • Author(s)
      Lin, Z, Nishikawa, H, Iguchi, Y, Iwanami, A, Kikuchi, M, Toda, S
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 10303-10303

    • DOI

      10.1038/s41598-020-67304-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and biological activities of simplified aplysiatoxin analogs focused on the CH/pi interaction.2020

    • Author(s)
      Takumi Kobayashi, Ryo, C. Yanagita, Kazuhiro Irie
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Pages: 127657-127657

    • DOI

      10.1016/j.bmcl.2020.127657

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization.2020

    • Author(s)
      Yasuda M, Ma Y, Okabe S, Wakabayashi Y, Su D, Chang YT, Seimiya H, Tera M, Nagasawa K.
    • Journal Title

      Chem Commun

      Volume: 56 Pages: 12905-12908

    • DOI

      10.1039/d0cc04957c

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The antimalarial compound atovaquone inhibits Zika and dengue virus infection by blocking E protein-mediated membrane fusion.2020

    • Author(s)
      Yamamoto, M., Ichinohe, T., Watanabe, A., Kobayashi, A., Zhang, R., Song, J., Kawaguchi, Y., Matsuda, Z. and Inoue, J.
    • Journal Title

      Viruses

      Volume: 12 Pages: 1475-1475

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression2020

    • Author(s)
      Tadashi Nakagawa, Satoko Hattori, Tsuyoshi Miyakawa, Keiko Nakayama
    • Journal Title

      iScience

      Volume: 23 Issue: 4 Pages: 101030-101030

    • DOI

      10.1016/j.isci.2020.101030

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation2020

    • Author(s)
      Mugat B, Nicot S, Chavez CV, Jourdan C, Sato K, Basyuk E, Juge F, Siomi MC, Pelisson A, Chambeyron S.
    • Journal Title

      Nature Com.

      Volume: 11 Pages: 108-120

    • DOI

      10.1038/s41467-020-16635-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis2020

    • Author(s)
      Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K.
    • Journal Title

      eLife

      Volume: なし Pages: 1-29

    • DOI

      10.7554/elife.57381

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of calcium metabolism in keratinocyte differentiation2020

    • Author(s)
      Okumura K, Wakabayashi Y
    • Journal Title

      Trends in Cancer Research

      Volume: 14 Pages: 45-47

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tight Junction Structure and Function Revisited2020

    • Author(s)
      Tetsuhisa Otani, Mikio Furuse
    • Journal Title

      Trends in Cell Biology

      Volume: 30 Issue: 10 Pages: 805-817

    • DOI

      10.1016/j.tcb.2020.08.004

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-restricted G-protein signaling pathways via GPR176. Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus.2020

    • Author(s)
      Nakagawa S, Nguyen Pham KT, Shao X, and Doi M
    • Journal Title

      Int J Mol Sci

      Volume: 21 Pages: 5055-5055

    • DOI

      10.3390/ijms21145055

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Translational landscape of protein-coding and non-protein-coding RNAs upon light exposure in Arabidopsis2020

    • Author(s)
      Kurihara Y., Makita Y., Shimohira H., Fujita T., Iwasaki S., and Matsui M.
    • Journal Title

      Plant Cell Physiol.

      Volume: 61 Issue: 3 Pages: 536-545

    • DOI

      10.1093/pcp/pcz219

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway2020

    • Author(s)
      Naoto Hori, Kazuyuki Okada, Yuki Takakura, Hiroyuki Takano, Naoto Yamaguchi, Noritaka Yamaguchi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Pages: 8798-8807

    • DOI

      10.1074/jbc.ra120.012781

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visually cued fear conditioning test for memory impairment related to cortical function2020

    • Author(s)
      Kuboyama K, Shirakawa Y, Kawada K, Fujii N, Ojima D, Kishimoto Y, Yamamoto T, Yamada MK
    • Journal Title

      Neuropsychopharmacol. Rep.

      Volume: 40 Pages: 371-375

    • DOI

      10.1002/npr2.12146

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん性サルコペニアに対する栄養介入2020

    • Author(s)
      森 拓也, 川原 勲, 額賀翔太, 宮川良博, 後藤 桂, 大森 斉, 國安弘基
    • Journal Title

      奈良医学雑誌

      Volume: 71 Issue: 1-3 Pages: 1-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラットを用いたオプトジェネティクス(光遺伝学)2020

    • Author(s)
      八尾寛, 深沢有吾, 冨田浩史, 五十嵐敬幸
    • Journal Title

      LABI021

      Volume: 80 Pages: 5-8

    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Impact of the mutation of the cis-regulatory element of the core clock gene on the body clock2020

    • Author(s)
      Nguyen Pham Khanh Tien、土居雅夫
    • Journal Title

      生化学

      Volume: 92 Issue: 5 Pages: 735-739

    • DOI

      10.14952/SEIKAGAKU.2020.920735

    • NAID

      40022394518

    • ISSN
      0037-1017
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A central master driver of psychosocial stress responses in the rat.2020

    • Author(s)
      Kataoka, N., Shima, Y., Nakajima, K., Nakamura, K.
    • Journal Title

      Science

      Volume: 367 Pages: 1105-1112

    • DOI

      10.1126/science.aaz4639

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setdla+/-Mice.2020

    • Author(s)
      Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
    • Journal Title

      Biological Psychiatry

    • DOI

      10.1016/j.biopsych.2020.01.004

    • Description
      In press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice.2020

    • Author(s)
      Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
    • Journal Title

      Neuropharmacology.

      Volume: 166 Pages: 107968-107968

    • DOI

      10.1016/j.neuropharm.2020.107968

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain2020

    • Author(s)
      Ninagawa J. Sumitani M, Nishizawa D, Nagashima M, Mietani K, Abe H, Inoue R, Hozumi J, Tsuchida R, Ikeda K, Yamada Y
    • Journal Title

      Medicine (Baltimore)

      Volume: 99 Issue: 5

    • DOI

      10.1097/md.0000000000018924

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anosmin-l activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis.2020

    • Author(s)
      Matsushima S, Shimizu A, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H, Kurokawa-Seo M.
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 188-188

    • DOI

      10.1038/s41598-019-57040-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model.2020

    • Author(s)
      Kataura T, Saiki S, Ishikawa K, Akamatsu W, Sasazawa Y, Hattori N, Imoto M
    • Journal Title

      J Neurochem

      Volume: - Pages: 81-97

    • DOI

      10.1111/jnc.14997

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cataloguing and selection of mRNAs localized to dendrites in neurons and regulated by RNA-binding proteins in RNA granules2020

    • Author(s)
      R Ohashi and N Shiina
    • Journal Title

      Biomolecules

      Volume: 10 Pages: 167-167

    • DOI

      10.3390/biom10020167

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical features of early myoclonic encephalopathy caused by a CDKL5 mutation.2020

    • Author(s)
      Takeda K, Miyamoto Y, Yamamoto H, Ishii A, Hirose S, Yamamoto H.
    • Journal Title

      Brain Dev.

      Volume: 42 Issue: 1 Pages: 73-6

    • DOI

      10.1016/j.braindev.2019.08.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.2020

    • Author(s)
      Nakahata S, et al, Saito M, Morishita K.
    • Journal Title

      Haematologica

      Volume: 105 Pages: 1-1

    • DOI

      10.3324/haematol.2019.234096

    • Description
      in Press in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb2020

    • Author(s)
      Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, Junichi Ikenouchi
    • Journal Title

      Molecular Biology of the Cell

      Volume: 31 Pages: 833-844

    • DOI

      10.1091/mbc.e19-12-0691

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structure of Drosophila Piwi2020

    • Author(s)
      Yamaguchi S. Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC. Nureki O.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-020-14687-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats.2020

    • Author(s)
      Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H
    • Journal Title

      Neurosci Lett

      Volume: 715 Pages: 134656-134656

    • DOI

      10.1016/j.neulet.2019.134656

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex.2020

    • Author(s)
      Nakata S. Takemoto M, Song W-J.
    • Journal Title

      Hearing Research

      Volume: 386 Pages: 107876-107876

    • DOI

      10.1016/j.heares.2019.107876

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection2020

    • Author(s)
      Han Y, Nakayama J, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S and Semba K
    • Journal Title

      Genes Cells

      Volume: 25(2) Pages: 111-123

    • DOI

      10.1111/gtc.12743

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer2020

    • Author(s)
      Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Furukawa T & Shoji Natsugoe, et al.
    • Journal Title

      Oncogenesis

      Volume: 9 Pages: 13-13

    • DOI

      10.1038/s41389-020-0190-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.2020

    • Author(s)
      Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK.
    • Journal Title

      FASEB J.

      Volume: 34 Issue: 2 Pages: 2944-2957

    • DOI

      10.1096/fj.201901735r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis.2020

    • Author(s)
      Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K and Arita K
    • Journal Title

      Int J Mol Sci

      Volume: 20 Pages: 6355-63

    • DOI

      10.3390/ijms20246355

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.2020

    • Author(s)
      Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
    • Journal Title

      Sci Rep.

      Volume: 10(1) Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-020-58315-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and characterization of the binding sequences and target genes of p53 lacking the lst transactivation domain.2020

    • Author(s)
      Shiori Suzuki#, Shuichi Tsutsumi#, Yu Chen#, Chikako Ozeki, Atsushi Okabe, Tatsuya Kawase, Hiroyuki Aburatani and Rieko Ohki*.
    • Journal Title

      Cancer Science

      Volume: 111 Pages: 451-466

    • DOI

      10.1111/cas.14279

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.2020

    • Author(s)
      Wang T, Nakagawa S, Miyake T, Setsu G, Kunisue S, Goto K, Hirasawa A, Okamura H, Yamaguchi Y, and Doi M
    • Journal Title

      Sci. Rep.

      Volume: 10 Pages: 4429-4429

    • DOI

      10.1038/s41598-020-61370-y

    • NAID

      120006822520

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.2020

    • Author(s)
      Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
    • Journal Title

      Cell Chemical Biology

      Volume: 27 Pages: 1-11

    • DOI

      10.1016/j.chembiol.2019.11.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Transmembrane Protein 168 Mutation in Familial Brugada Syndrome.2020

    • Author(s)
      Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, ..., Ogita H.
    • Journal Title

      FASEB J

      Volume: 34 Issue: 5 Pages: 6399-6417

    • DOI

      10.1096/fj.201902991r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.2020

    • Author(s)
      Kato S., Shirai Y., Motozono, C., Kanzaki, H., Mori, S., Kodama, T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: - Issue: 4 Pages: 1025-1031

    • DOI

      10.1016/j.bbrc.2020.02.174

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5-FU2020

    • Author(s)
      Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada T, Furukawa T
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 19 Pages: 2258-2264

    • DOI

      10.3892/ol.2020.11352

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isoform-dependent subcellular localization of LMTK1A and LMTK1B, and their roles in axon outgrowth and spine formation.2020

    • Author(s)
      Wei R, Sugiyama A, Sato Y, Nozumi M, Nishino H, Takahashi M, Saito T, Ando K, Fukuda M, Tomomura M, Igarashi M, *Hisanaga S-i
    • Journal Title

      J Biochem

      Volume: - Pages: 23-32

    • DOI

      10.1093/jb/mvaa019

    • NAID

      40022279141

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamellarin alkaloids : Isolation, synthesis, and biological activity2020

    • Author(s)
      Tsutomu Fukuda, Fumito Ishibashi, Masatomo Iwao
    • Journal Title

      The Alkaloids : Chemistry and Biology

      Volume: 83 Pages: 1-112

    • DOI

      10.1016/bs.alkal.2019.10.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines2020

    • Author(s)
      Tetsuya Sasaki, Yosuke Takei
    • Journal Title

      Jap J Biological Psych.

      Volume: 31 Issue: 2

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism : An ex vivo HPLC-ECD analysis.2020

    • Author(s)
      Hossain MR, Jamal M, Tanoue Y, Ojima D, Takahashi H, Kubota T, Ansary TM, Ito A, Tanaka N, Kinoshita H, Kishimoto Y, Yamamoto T
    • Journal Title

      Neurosci, Lett.

      Volume: 716 Pages: 134677-134677

    • DOI

      10.1016/j.neulet.2019.134677

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells2020

    • Author(s)
      Ishiguro K (Corresponding), Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko S. H. M. Araki K, Niwa H
    • Journal Title

      Developmental Cell

      Volume: 52 Issue: 4 Pages: 429-445

    • DOI

      10.1016/j.devcel.2020.01.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microinjection support system for small biological subject2020

    • Author(s)
      Sugimoto Y., Naniwa K., Aonuma H. and Osuka K.
    • Journal Title

      HardwareX

      Volume: 7

    • DOI

      10.1016/j.ohx.2020.e00103

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] More dynamic, more quantitative, unexpectedly intricate : Advanced understanding on synaptic RNA localization in learning and memory2020

    • Author(s)
      R Roy, N Shiina, and D O Wang
    • Journal Title

      Neurobiol Learn and Mem

      Volume: 168 Pages: 107149-107149

    • DOI

      10.1016/j.nlm.2019.107149

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer2020

    • Author(s)
      Yuji Takeyama, Minoru Kato, Satoshi Tamada, Yukari Azuma, Yasuomi Shimizu, Taro Iguchi, Takeshi Yamasaki, Min Gi, Hideki Wanibuchi, Tatsuya Nakatani
    • Journal Title

      Cancer Lett

      Volume: 479 Pages: 89-99

    • DOI

      10.1016/j.canlet.2020.03.013

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.2020

    • Author(s)
      Sanchez-Martin P, Sou YS, Kageyama S, Koike M, Waguri S, *Komatsu M.
    • Journal Title

      EMBO Rep.

      Volume: 21

    • DOI

      10.15252/embr.201948902

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.2020

    • Author(s)
      Matsumura K, Nakazawa T, et al.
    • Journal Title

      Nature Commun

      Volume: 11(1) Pages: 1-16

    • DOI

      10.1038/s41467-020-14697-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.2020

    • Author(s)
      Kawashima M, Carreras J, Higuchi H, et al
    • Journal Title

      Leukemia.

      Volume: - Pages: 2405-2417

    • DOI

      10.1038/s41375-020-0737-9

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice.2020

    • Author(s)
      Nakano Y, Hirooka K, Chiba Y, Ueno M, Ojima D, Hossain MR, Takahashi H, Yamamoto T, Kiuchi Y
    • Journal Title

      Cell Death Dis.

      Volume: 11 Issue: 3 Pages: 166-166

    • DOI

      10.1038/s41419-020-2363-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of metastasis-related genes in cisplatin chemoresistance in gastric cancer2020

    • Author(s)
      Nishiguchi Y, Oue N, Fujiwara-Tani R, Sasaki T, Ohmori H, Kishi S, Shiori Mori S, Mori T, Ideda N, Matsumoto S, Wakatsuki K, Luo Y, Yasui W, Sho M, Kuniyasu H
    • Journal Title

      Int J Mol Sci

      Volume: 21 Pages: 254-254

    • DOI

      10.3390/ijms21010254

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells2020

    • Author(s)
      Yohei Yamagami, Masashi Kawami, Takamichi Ojima, Sora Futatsugi, Ryoko Yumoto, Mikihisa Takano
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 525 Issue: 3 Pages: 543-548

    • DOI

      10.1016/j.bbrc.2020.02.131

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α2020

    • Author(s)
      Wakita M, Yamagata A, Shiroshima T, Izumi H, Maeda A, Sendo M, Imai A, Kubota K, Goto-Ito S, Sato Y, Mori H, Yoshida T, Fukai S.
    • Journal Title

      Nature Communications

      Volume: 11 Pages: 649-649

    • DOI

      10.1038/s41467-020-14516-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling2020

    • Author(s)
      Yamanaka S, Sato Y, Oikawa D, Goto E, Fukai S, Tokunag F, Sawasaki T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 524 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2019.12.049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] (S)-norketamine and (2S, 6S)-hydroxynorketamine Exert Potent Antidepressant-Like Effects in a Chronic Corticosterone-Induced Mouse Model of Depression2020

    • Author(s)
      横山 玲、樋口 桃子、田邊 航、塚田 信司、内藤 恵、Lu Chen、笠井 淳司、勢力 薫、中澤 敬信、中川 晋作、橋本 謙二、橋本 均、吾郷 由希夫
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 191 Pages: 172876-172876

    • DOI

      10.1016/j.pbb.2020.172876

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tankyrase Inhibitors Target Colorectal Cancer Stem Cells via AXIN-Dependent Downregulation of c-KIT Tyrosine Kinase2020

    • Author(s)
      Jang MK, Mashima T, Seimiya H
    • Journal Title

      Mol Cancer Ther

      Volume: 19 Issue: 3 Pages: 765-776

    • DOI

      10.1158/1535-7163.mct-19-0668

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tankyrase promotes primary precursor miRNA processing to precursor miRNA2020

    • Author(s)
      Mizutani A, Seimiya H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 52 Pages: 945-951

    • DOI

      10.1016/j.bbrc.2019.11.191

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting claudin-4 enhances chemosensitivity in breast cancer.2020

    • Author(s)
      Luo Y, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Goto K, Nishiguchi Y, Mori T, Kawahara I, Kondoh M, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: 111 Pages: 1840-1850

    • DOI

      10.1111/cas.14361

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts2020

    • Author(s)
      Yukako Oda, Taichi Sugawara, Yuko Fukata, Yasushi Izumi, Tetsuhisa Otani, Tomohito Higashi, Masaki Fukata, Mikio Furuse
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 13 Pages: 4289-4302

    • DOI

      10.1074/jbc.ra119.010491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of serotonin in the influence of intense locomotion on the behavior under uncertainty in the mollusk Lymnaea stagnalis2020

    • Author(s)
      Aonuma H., Mezheritskiy M., Boldyshev B., Totani Y., Vorontsov D., Zakharov I. S., Ito E. and Dyakonova V.
    • Journal Title

      Frontiers in Physiology

      Volume: 11 Pages: 221-221

    • DOI

      10.3389/fphys.2020.00221

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Topologies of G-quadruplex : Biological functions and regulation by ligands2020

    • Author(s)
      Yue Ma, Keisuke Iida, Kazuo Nagasawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: -

    • DOI

      10.1016/j.bbrc.2019.12.103

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tsukushi is essential for the development of the inner ear.2020

    • Author(s)
      Toru Miwa, Kunimasa Ohta, Naofumi Ito, Satoko Hattori, Tsuyoshi Miyakawa, Toru Takeo, Naomi Nakagata, Wen-Jie Song & Ryosei Minoda.
    • Journal Title

      Mol Brain

      Volume: 13 Pages: 29-29

    • DOI

      10.1186/s13041-020-00570-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 直鎖状ユビキチン鎖の神経変性疾患への関与とLUBAC阻害剤の開発2020

    • Author(s)
      及川大輔, 伊東秀文, 徳永文稔
    • Journal Title

      生化学

      Volume: 91 Pages: 28-34

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A general model of locomotion of brittle stars with a variable number of arms2020

    • Author(s)
      Wakita D., Kagaya K, and *Aonuma H.
    • Journal Title

      Journal of the Royal Society Interface

      Volume: 17 Pages: 162-162

    • DOI

      10.1098/rsif.2019.0374

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aldosterone reduction rate after saline infusion test may be a novel prediction in patients with primary aldosteronism.2020

    • Author(s)
      Nagano H, Suzuki S, Koide H, Takeshita N, Sakamoto S, Ban T, Yokote K, Nakamura Y, Ichikawa T, Uno T, Tanaka T.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 19 Pages: 319-327

    • DOI

      10.1210/clinem/dgz092

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Armitage determines Piwi-piRISC processing from precursor formation and quality control to inter-organelle translocation2020

    • Author(s)
      Yamashiro H, Negishi M, Kinoshita T, Ishizu H, Ohtani H, Siomi MC.
    • Journal Title

      EMBO Report

      Volume: 21 Issue: 2

    • DOI

      10.15252/embr.201948769

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas2020

    • Author(s)
      Nakashima C, Yamamoto K, Kishi S, Sasaki T, Ohmori H, Fujiwara-Tani R, Mori S, Kawahara I, Nishiguchi Y, Mori T, Kondoh M, Luo Y*, Tadaaki K*, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 11 Pages: 309-321

    • DOI

      10.18632/oncotarget.27424

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain.2020

    • Author(s)
      Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, Kawamura M, Fukazawa Y, Shigemoto R, Yamasaki M, Sakimura K, Watanabe M.
    • Journal Title

      J Comp Neurol .

      Volume: 528 Issue: 6 Pages: 1003-1027

    • DOI

      10.1002/cne.24792

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice2020

    • Author(s)
      Matsuzaka T, Kuba M, Koyasu S, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.
    • Journal Title

      Hepatology

      Volume: 71 Pages: 1609-1625

    • DOI

      10.1002/hep.30953

    • NAID

      120007132717

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immune-resistant mechanisms in cancer immunotherapy2020

    • Author(s)
      Kawakami Y, Ohta S, Sayem MA, Tsukamoto N, Yaguchi T
    • Journal Title

      Int J Clin Oncol

      Volume: 25 Pages: 810-817

    • DOI

      10.1007/s10147-019-01611-x

    • Description
      in press
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of autophagy impairs physiological steatosis by accumulation of NCoR1.2020

    • Author(s)
      Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M.
    • Journal Title

      Life Sci Alliance.

      Volume: 3 Pages: 201900513-201900513

    • DOI

      10.26508/lsa.201900513

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation.2020

    • Author(s)
      Shotaro Yamano, Makoto Kimura, Yu Chen, Naoko Imamoto* and Rieko Ohki*.
    • Journal Title

      Experimental Cell Research

      Volume: 386 Issue: 1 Pages: 111686-111686

    • DOI

      10.1016/j.yexcr.2019.111686

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physiological Stress Response by Selective Autophagy.2020

    • Author(s)
      Sanchez-Martin P, Komatsu M.
    • Journal Title

      J Mol Biol.

      Volume: 432 Pages: 53-62

    • DOI

      10.1016/j.jmb.2019.06.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Store-operated calcium channels are involved in spontaneous slow calcium oscillations in striatal neurons.2020

    • Author(s)
      Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M
    • Journal Title

      Fronticrs in Cellutar Neuroscience

      Volume: 13 Pages: 547-547

    • DOI

      10.3389/fncel.2019.00547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and properties of anionic ruthenium thionitrosyl and selenonitrosyl complexes that contain tetraanionic 2-hydroxybenzamidobenzene ligands2020

    • Author(s)
      Chi-Wai Fung, Go Fukada, Yuichiro Mutoh, Noriko Tsuchida, Shinchi Saito
    • Journal Title

      DALTON TRANSACTIONS

      Volume: 49 Pages: 613-624

    • DOI

      10.1039/c9dt04219a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Helical 3,3' -Bridged-2,2' -bibenzo[g]quinolines2020

    • Author(s)
      Yamazaki, Y. ; Mizuma, R. ; Abe, H. ; Aoki, R. ; Mutoh, Y. ; Saito, S.
    • Journal Title

      Chem. Lett.

      Volume: 49 Issue: 2 Pages: 133-136

    • DOI

      10.1246/cl.190803

    • NAID

      130007795155

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of lactone-fused pyrroles by ruthenium-catalyzed 1,2-carbon migration-cycloisomerization2020

    • Author(s)
      Takuma Watanabe, Yuichiro Mutoh, and Shinichi Saito
    • Journal Title

      ORG BIOMOL CHEM

      Volume: 18 Pages: 81-85

    • DOI

      10.1039/c9ob02363a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells.2020

    • Author(s)
      Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Yoshimura A, et al
    • Journal Title

      Cancer Res

      Volume: 80 Pages: 471-483

    • DOI

      10.1158/0008-5472.can-19-1196

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.2020

    • Author(s)
      Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
    • Journal Title

      Scientific reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-40688-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.2020

    • Author(s)
      Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
    • Journal Title

      Addict Biol

      Volume: 印刷中 Pages: 1-11

    • DOI

      10.1111/adb.12723

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TUBB1 dysfunction identified in familial platelet disorder causes impaired proplatelet formation and genome instability2020

    • Author(s)
      Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T
    • Journal Title

      Developmental Biology,

      Volume: 0 Pages: 0-0

    • DOI

      10.1111/bjh.15835

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.2020

    • Author(s)
      Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
    • Journal Title

      Cereb Cortex.

      Volume: 160 Pages: 1-14

    • DOI

      10.1093/cercor/bhy253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infcction.2019

    • Author(s)
      Katahira Y, Higuchi H, Matsushita H, Yahata T, Yamamoto Y, Koike R, Ando K, Sato K, Imadome KI, Kotani A.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 13445-13445

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods.2019

    • Author(s)
      Igarashi M
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 95 Issue: 7 Pages: 358-377

    • DOI

      10.2183/pjab.95.026

    • NAID

      130007689028

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells2019

    • Author(s)
      Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
    • Journal Title

      Cancer Research

      Volume: in press Issue: 12 Pages: 3088-3099

    • DOI

      10.1158/0008-5472.can-18-2693

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism2019

    • Author(s)
      吾郷 由希夫、田邊 航、樋口 桃子、塚田 信司、田中 辰典、五十嵐 久人、横山 玲、勢力 薫、笠井 淳司、中澤 敬信、中川 晋作、橋本 謙二、橋本 均
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 22 Issue: 10 Pages: 665-674

    • DOI

      10.1093/ijnp/pyz041

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter2019

    • Author(s)
      Nishizawa Y, Ikeda R, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Nitta M. Terazono H, Akiyama S, Furukawa T, Takeda Y
    • Journal Title

      Anticancer Res

      Volume: 39 Pages: 4129-4136

    • DOI

      10.21873/anticanres.13571

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A carrier protein is essential for the action of silver nanoparticles in an animal experiment2019

    • Author(s)
      Masami Ishido
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 6 Issue: 7 Pages: 277-279

    • DOI

      10.2131/fts.6.277

    • NAID

      130007731820

    • ISSN
      2189-115X
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.2019

    • Author(s)
      Miramontes-Gonzalez JP, Hightower M, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Ichinose H, O'Connor DT
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 5055-5055

    • DOI

      10.1038/s41598-019-41504-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway2019

    • Author(s)
      Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
    • Journal Title

      Journal of Investigative Dermatology

      Volume: in press Issue: 7 Pages: 1459-1469

    • DOI

      10.1016/j.jid.2018.12.027

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aberrant Calcium Signals in Reactive Astrocytes : A Key Process in Neurological Disorders.2019

    • Author(s)
      Shigetomi E, Saito K, Sano F, Koizumi S.
    • Journal Title

      Int J Mol Sci

      Volume: 20 Pages: 1-18

    • DOI

      10.3390/ijms20040996

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model.2019

    • Author(s)
      Koki Mimura, Tomofumi Oga, Tetsuya Sasaki, Koichi Saito, Izuru Miyawaki, Tetsuya Suhara, Ichio Aoki, Noritaka Ichinohe.
    • Journal Title

      Neuroimage

      Volume: 印刷中 Pages: 243-251

    • DOI

      10.1016/j.neuroimage.2019.04.006

    • NAID

      120007133606

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMPA受容体の分子修飾変化とてんかん2019

    • Author(s)
      林 崇
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 1268-1270

    • Related Report
      2019 Annual Research Report
  • [Journal Article] An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5.2019

    • Author(s)
      Huber J, Obata M, Gruber J, Akutsu M, L?hr F, Rogova N, Guntert P, Dikic I, Kirkin V, Komatsu M, Dotsch V, Rogov VV.
    • Journal Title

      Autophagy

      Volume: 16 Pages: 1-15

    • DOI

      10.1080/15548627.2019.1606637

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between changes in subcutaneous fat mass and heart failure-induced cachexia : a case report2019

    • Author(s)
      Mori T, Oku K, Miyagawa Y, Nukaga S, Kanto S, Kudo E, Imagita H, Kawahara I
    • Journal Title

      J Phys Ther Sci

      Volume: 31 Issue: 5 Pages: 462-465

    • DOI

      10.1589/jpts.31.462

    • NAID

      130007645061

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autism-associated protein kinase D2 regulates embryonic cortical neuron development.2019

    • Author(s)
      Matsumura K, Nakazawa T, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 519(3) Pages: 626-632

    • DOI

      10.1016/j.bbrc.2019.09.048

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdc7 activates replication checkpoint by phosphorylating the Chk1 binding domain of Claspin in human cells.2019

    • Author(s)
      Yang, C-C., Kato, H., Shindo, M. and *Masai. H.
    • Journal Title

      E-life

      Volume: 8

    • DOI

      10.7554/elife.50796

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cdc7 kinase stimulates Aurora B kinase in M-phase.2019

    • Author(s)
      Ito, S., Goto, H., Kuniyasu, K., Shindo, M., Yamada, M., Tanaka, K., Toh, G-K., Sawa, S., Inagaki, M., Bartek, B., and *Masai. H.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 18622-18622

    • DOI

      10.1038/s41598-019-54738-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of KCNQ2 variants causing cither benign neonatal epilepsy or developmental and epileptic encephalopathy.2019

    • Author(s)
      Goto A, Ishii A, Shibata M, Ihara Y, Cooper EC, Hirose S.
    • Journal Title

      Epilepsia

      Volume: 60 Issue: 9 Pages: 1870-1880

    • DOI

      10.1111/epi.16314

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity2019

    • Author(s)
      Tetsuhisa Otani, Thanh Phuong Nguyen, Shinsaku Tokuda, Kei Sugihara, Taichi Sugawara, Kyoko Furuse, Takashi Miura, Klaus Ebnet, Mikio Furuse
    • Journal Title

      Journal of Cell Biology

      Volume: 218 Pages: 3372-3396

    • DOI

      10.1083/jcb.201812157

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy2019

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    • Journal Title

      Pathobiology

      Volume: 86 Pages: 182-189

    • DOI

      10.1159/000496027

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Copy number variation analysis in 83 children with early-onset developmental and epileptic encephalopathy after targeted resequencing of a 109-epilepsy gene panel.2019

    • Author(s)
      Hirabayashi K, Uehara DT, Abe H, Ishii A, Moriyama K, Hirose S, Inazawa J.
    • Journal Title

      J Hum Genet

      Volume: 64 Issue: 11 Pages: 1097-1106

    • DOI

      10.1038/s10038-019-0661-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cue-dependent safety and fear learning in a discriminative auditory fear conditioning paradigm in the mouse.2019

    • Author(s)
      Takemoto M, Song W-J.
    • Journal Title

      Learning & Memory

      Volume: 26 Pages: 284-290

    • DOI

      10.1101/lm.049577.119

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decentralized control mechanism for determination of moving direction in brittle stars with penta-radially symmetric body2019

    • Author(s)
      Kano T., Kanauchi D., Aonuma H., Clark E. G. and IshiguroA.
    • Journal Title

      Frontiers in Neuroroboties

      Volume: 13 Pages: 1-1

    • DOI

      10.3389/fnbot.2019.00066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental synapse remodeling in the cerebellum and visual thalamus.2019

    • Author(s)
      Kano M, Watanabe T.
    • Journal Title

      F1000Res.

      Volume: 8 Pages: 1191-1191

    • DOI

      10.12688/f1000research.18903.1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different synchrony in rhythmic movement caused by morphological difference between five- and six-armed brittle stars2019

    • Author(s)
      Wakita D, Hayase Y and Aonuma H.
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 8298-8298

    • DOI

      10.1038/s41598-019-44808-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential changes in the lateralized activity of identified projection neurons of motor cortex in hemiparkinsonian rats.2019

    • Author(s)
      Rios A, Soma S, Yoshida J, Nonomura S, Kawabata M, Sakai Y, Isomura Y
    • Journal Title

      eNeuro

      Volume: 6 Issue: 4 Pages: 0110-119

    • DOI

      10.1523/eneuro.0110-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice2019

    • Author(s)
      Chowdhury S, Hung CJ, Izawa S, Inutsuka A, Kawamura M, Kawashima T, Bito H, Imayoshi I, Abe M, Sakimura K, *Yamanaka A
    • Journal Title

      eLife

      Volume: 8 Pages: 1-25

    • DOI

      10.7554/elife.44927

    • NAID

      120006888021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis.2019

    • Author(s)
      Ishizu H, Kinoshita T, Hirakata S, Komatsuzaki C, Siomi MC.
    • Journal Title

      Cell Report

      Volume: 27 Issue: 6 Pages: 1822-1835

    • DOI

      10.1016/j.celrep.2019.04.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct Methylation Levels of Mature MicroRNAs in Gastrointestinal Cancers.2019

    • Author(s)
      Konno, M., Koseki, J., Ishii, H
    • Journal Title

      Nature Commun.

      Volume: 10 Pages: 3888-3888

    • DOI

      10.1038/s41467-019-11826-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor : establishment and xenograft of a cell line to predict clinical efficacy2019

    • Author(s)
      Kanemaru Y, Natsumeda M, Okada M, Saito R, Watanabe J, Saito S, Tsukamoto Y, Oishi M, Saito H, Nagahashi M, Sasaki T, Hashizume R, Kakita A, Fujii Y, et. al.
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 7 Pages: 1-11

    • DOI

      10.1186/s40478-019-0774-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and tolerability of perampanel in pediatric patients with Dravet syndrome.2019

    • Author(s)
      Yoshitomi S, Takahashi Y, Yamaguchi T, Imai K, Ishii A, Hirose S, Inoue Y.
    • Journal Title

      Epilepsy Res.

      Volume: 154 Pages: 34-38

    • DOI

      10.1016/j.eplepsyres.2019.02.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons.2019

    • Author(s)
      Fukabori, R., Iguchi, Y., Kato, S...... Benton, R., & Kobayashi, K.
    • Journal Title

      bioRxiv. Advance online publication.

      Volume: --

    • DOI

      10.1101/831313

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing2019

    • Author(s)
      Osumi K, Sato K, Murano K, Siomi H, Siomi MC.
    • Journal Title

      EMBO Report

      Volume: 20 Issue: 12

    • DOI

      10.15252/embr.201948296

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of parameters for cancer-induced sarcopenia in patients autopsied after death from colorectal cancer.2019

    • Author(s)
      Ohmori H, Kawahara I, Mori T, Nukaga S, Luo Y, Kishi S, Fujiwara-Tani R, Mori S, Goto K, Sasaki T. Kuniyasu H
    • Journal Title

      Pathobiology

      Volume: 86 Pages: 306-314

    • DOI

      10.1159/000503037

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evolutionary analysis of proline-directed phosphorylation sites in the mammalian growth cone identified using phosphoproteomics.2019

    • Author(s)
      Igarashi M, Okuda S
    • Journal Title

      Mol Brain

      Volume: 12 Pages: 53-53

    • DOI

      10.1186/s13041-019-0476-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells.2019

    • Author(s)
      Tanaka S, Ishihara N, Suzuki S, Watanabe Y, Nagayama D, Yamaguchi T, Ohira M, Saiki A, Tanaka T, Tatsuno I.
    • Journal Title

      Sci Rep.

      Volume: 10 Pages: 100009-100009

    • DOI

      10.1038/s41598-019-46461-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flexible coordination of flexible limbs : decentralized control scheme for inter- and intra-limb coordination in brittle stars' locomotion2019

    • Author(s)
      Kano T., Kanauchi D., Ono T, Aonuma H and Ishiguro A.
    • Journal Title

      Frontiers in Neurorobotics

      Volume: 13 Pages: 104-104

    • DOI

      10.3389/fnbot.2019.00104

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice2019

    • Author(s)
      Chowdhury S, Matsubara T, Miyazaki T, Ono D, Fukatsu N, Abe M, Sakimura K, Sudo Y, Yamanaka A*
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.44928

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice2019

    • Author(s)
      Murata K, Kinoshita T, Fukazawa Y, Kobayashi Ke, Kobayashi Ka, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H.
    • Journal Title

      Scientific reports

      Volume: 9 Pages: 7132-7132

    • DOI

      10.1038/s41598-019-43580-1

    • NAID

      120006862679

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans2019

    • Author(s)
      Koichiro Abe, Allison Cox, Nobuhiko Takamatsu, ..., Alexander Bassuk, Helmut Fuchs, Polly Ferguson, Martin Hrabe de Angelis
    • Journal Title

      PNAS

      Volume: 116 Pages: 11872-11877

    • DOI

      10.1073/pnas.1819825116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability2019

    • Author(s)
      Ryo Tanifuji, Kaori Tsukakoshi, Kazunori Ikebukuro, Hideaki Oikawa, Hiroki Oguri
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 29 (14) Pages: 1807-1811

    • DOI

      10.1016/j.bmcl.2019.05.009

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Giving combined medium-chain fatty acids and glucose protects against cancer-associated skeletal muscle atrophy.2019

    • Author(s)
      Mori T, Ohmori H, Luo Y, Mori S, Miyagawa Y, Nukaga S, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Kawahara I, Kuniyasu H.
    • Journal Title

      Cancer Sci

      Volume: 110 Pages: 3391-3399

    • DOI

      10.1111/cas.14170

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy.2019

    • Author(s)
      Chernyshova K, Inoue K, Yamashita SI, Fukuchi T, Kanki T.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 60(10) Issue: 10 Pages: 3625-3625

    • DOI

      10.1167/iovs.19-27184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heart rate variability in a patient with alternating hemiplegia.2019

    • Author(s)
      Nakashima T, Yasuda K, Kobayashi M, Wada H, Ishii A, Hirose S.
    • Journal Title

      IRDR

      Volume: 8 Issue: 2 Pages: 134-137

    • DOI

      10.5582/irdr.2019.01060

    • NAID

      130007663250

    • ISSN
      2186-361X, 2186-3644
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.2019

    • Author(s)
      Horigome Y, Ida-Yonemochi H, Waguri S, Shibata S, Endo N, Komatsu M.
    • Journal Title

      Autophagy

      Volume: 16 Pages: 501-511

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human tyrosine hydroxylase in Parkinson's disease and in related disorders.2019

    • Author(s)
      Nagatsu T, Nakashima A, Ichinose H, Kobayashi K
    • Journal Title

      J Neural Transm

      Volume: 126(4) Pages: 397-409

    • DOI

      10.1007/s00702-018-1903-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperosmotic Stress Induces Unconventional Autophagy Independent of the U1K1 Complex.2019

    • Author(s)
      Tamura N, Kageyama S, Komatsu M, Waguri S.
    • Journal Title

      Mol Cell Biol.

      Volume: 39

    • DOI

      10.1128/mcb.00024-19

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a Novel Arthritis-Associated Osteoclast Precursor Macrophage Regulated by FoxM12019

    • Author(s)
      Hasegawa T, Kikuta J, Sudo T, Matsuura Y, Matsui T, Simmons S, Ebina K, Hirao M, Okuzaki D, Yoshida Y, Hirao A, Kalinichenko VV, Yamaoka K, Takeuchi T, Ishii M.
    • Journal Title

      Nat Immunol

      Volume: 20 Pages: 1631-1643

    • DOI

      10.1038/s41590-019-0526-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Identification of KLRC2 as a candidate marker for brain tumor-initiating cells2019

    • Author(s)
      shihara E, Takahashi S, Fukaya R, Ohta S, Yoshida K, Toda M.
    • Journal Title

      Neurol Res

      Volume: 41 Issue: 11 Pages: 1043-1049

    • DOI

      10.1080/01616412.2019.1672390

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of neuron-type specific promoters in monkey genome and their functional validation in mice.2019

    • Author(s)
      Nagai Y, Nishitani N, Yasuda M, Ueda Y, Fukui Y, Andoh C, Shirakawa H, Nakagawa T, Inoue KI, Nagayasu K, Kasparov S, Nakamura K, Kaneko S.
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 518 Issue: 4 Pages: 614-624

    • DOI

      10.1016/j.bbrc.2019.08.101

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of topoisomerases as molecular targets of cytosporolide C and its analog2019

    • Author(s)
      Keisuke Otake, Kana Yamada, Kazuki Miura, Yukiko Sasazawa, So Miyazaki, Yuki Niwa, Akihiro Ogura, Ken-ichi Takao, Siro Simizu
    • Journal Title

      Bioorganic & Medicinal Chemistry.

      Volume: 27 Pages: 3334-3338

    • DOI

      10.1016/j.bmc.2019.06.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer.2019

    • Author(s)
      Tatsuya Kawase, Yu Chen, Ricko Ohki*.
    • Journal Title

      Heat Shock Proteins

      Volume: 17 Pages: 253-272

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells.2019

    • Author(s)
      Mashima T, Iwasaki R, Kawata N, Kawakami R, Kumagai K, Migita T, Sano T, Yamaguchi K, Seimiya H.
    • Journal Title

      Br J Cancer

      Volume: 121 Pages: 846-856

    • DOI

      10.1038/s41416-019-0600-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells2019

    • Author(s)
      Sonoko Chikamatsu, Ken Saijo, Hiroo Imai, Koichi Narita, Yoshifumi Kawamura, Tadashi Katoh, Chikashi Ishioka
    • Journal Title

      Cancer Medicine

      Volume: 8 Pages: 5662-5672

    • DOI

      10.1002/cam4.2409

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.2019

    • Author(s)
      Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 13257-13257

    • DOI

      10.1038/s41598-019-49744-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.2019

    • Author(s)
      Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M., Miyazawa, M.
    • Journal Title

      J Exp Med.

      Volume: 216 Pages: 2736-2747

    • DOI

      10.1084/jem.20190557

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intimal regeneration after coronary cndarterectomy and onlay grafting in coronary artery bypass grafting.2019

    • Author(s)
      Okada T, Minato N, Kanemoto SY, Zempo N, Saiga K, Namikawa K, Kanno S, Ueno H.
    • Journal Title

      General thoracic and cardiovascular surgery

      Volume: 67 Issue: 8 Pages: 677-683

    • DOI

      10.1007/s11748-019-01083-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis : Toward the Era of Mesothelioma Prevention.2019

    • Author(s)
      Toyokuni S
    • Journal Title

      Free Radic Biol Med

      Volume: 133 Pages: 206-215

    • DOI

      10.1016/j.freeradbiomed.2018.10.401

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KIF17-mediated transport of NMDA receptors and schizophrenia.2019

    • Author(s)
      Takei Y, Tome S, Sasaki T.
    • Journal Title

      Japanese Journal of Biological Psychiatry

      Volume: 30 Issue: 3 Pages: 101-104

    • DOI

      10.11249/jsbpjjpp.30.3_101

    • NAID

      130007777402

    • ISSN
      2186-6465, 2186-6619
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor kinematics and EMG activity during quadrupedal versus bipedal gait in the Japanese macaque2019

    • Author(s)
      Yasuo Higurashi, Marc A, Maier, Katsumi Nakajima, Kazunori Morita, Soichiro Fujiki, Shinya Aoi, Futoshi Mori, Akira Murata, Masahiko Inase
    • Journal Title

      J. Neurophysiol

      Volume: 122 Pages: 398-412

    • DOI

      10.1152/jn.00803.2018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term administration of excess zinc impairs learning and memory in aged mice2019

    • Author(s)
      Yoshida K, Gi M, Fujioka M, Teramoto I, Wanibuchi H
    • Journal Title

      J. Toxicol. Sci.

      Volume: 44 Issue: 10 Pages: 681-691

    • DOI

      10.2131/jts.44.681

    • NAID

      130007723827

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice2019

    • Author(s)
      Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, and OikeY
    • Journal Title

      Circ J

      Volume: 83 Issue: 2 Pages: 335-340

    • DOI

      10.1253/circj.cj-18-0925

      10.1253/circj.CJ-18-0925

    • NAID

      130007557092

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Magnetic Hyperthermia Using Self-Controlled Heating Elements Consisting of Fe-Al Milling Alloy Induces Cancer Cell Apoptosis while Preserving Skeletal Muscle.2019

    • Author(s)
      Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hosoito N, Taniguchi Y, Kuniyasu H.
    • Journal Title

      Pathobiology

      Volume: 86 Pages: 254-262

    • DOI

      10.1159/000501524

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs.2019

    • Author(s)
      Saori Shinoda, Sho Kitagawa, Shinichi Nakagawa, Fan-Yan Wei, Kazuhito Tomizawa, Kimi Araki, Masatake Araki, Takeo Suzuki and Tsutomu Suzuki.
    • Journal Title

      Nucleic Acids Res.

      Volume: 47 Pages: 8734-8745

    • DOI

      10.1093/nar/gkz575

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MCRIP1 promotes the expression of lung-surfactant protcins in mice by disrupting CtBP-mediated epigenetic gene silencing2019

    • Author(s)
      Jane S. Weng, Takanori Nakamura, Hisashi Moriizumi, Hiroshi Takano, Ryoji Yao & Mutsuhiro Takekawa
    • Journal Title

      Communications Biology

      Volume: 2 Pages: 227-227

    • DOI

      10.1038/s42003-019-0478-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.2019

    • Author(s)
      Fujikawa A, Noda Y, Yamamoto H, Tanga N, Sakaguchi G, Hattori S, Song W-J, Sora I, Nabeshima T, Katsuura G, Noda M.
    • Journal Title

      PLoS ONE

      Volume: 14

    • DOI

      10.1371/journal.pone.0221205

    • NAID

      120006733151

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microglial ROCK is cssential for chronic methylmercury-induced neurodegeneration.2019

    • Author(s)
      Shinozaki Y, Danjo Y, Koizumi S.
    • Journal Title

      J Neurochem

      Volume: 151 Pages: 64-78

    • DOI

      10.1111/jnc.14817

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple neuronal circuits for variable objcct-action choices based on short-and long-term memories.2019

    • Author(s)
      Hikosaka, O., Yasuda, M., Nakamura, K., Isoda, M., Kim, H. F., Terao, Y., Amita, H., Maeda, K.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of Amcrica

      Volume: 116 Issue: 52 Pages: 26313-26320

    • DOI

      10.1073/pnas.1902283116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019

    • Author(s)
      Yamada N, ..., Zankov DP, Shimizu A, ..., Ogita H, ..., Takashima S.
    • Journal Title

      Circulation

      Volume: In press Pages: 2157-2169

    • DOI

      10.1161/circulationaha.118.036761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Newborn screening for Pompe disease in Japan : report and literature review of mutations in the GAA gene in Japanese and Asian patients.2019

    • Author(s)
      Momosaki K, Kido J, Yoshida S, Sugawara K, Miyamoto T, Inoue T, Okumiya T, Matsumoto S, Endo F, Hirose S, Nakamura K.
    • Journal Title

      J Hum Genet.

      Volume: 64 Issue: 8 Pages: 741-755

    • DOI

      10.1038/s10038-019-0603-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.2019

    • Author(s)
      Doi M, Shimatani H, Atobe Y, Murai I, Hayashi H, Takahashi Y, Fustin JM, Yamaguchi Y, Kiyonari H, Koike N, Yagita K, Lee C, Abe M, Sakimura K, and Okamura H
    • Journal Title

      Nature Commun.

      Volume: 10 Pages: 2563-2563

    • DOI

      10.1038/s41467-019-10532-2

    • NAID

      120006644061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nuclear RNA cxport factor variant initiates piRNA-guided co-transcriptional silencing2019

    • Author(s)
      Murano K, Iwasaki YW, Ishizu H, Mashiko A, Shibuya A, kondo S, Adachi S, Suzuki S, Saito K, Natsume T, Siomi MC, Siomi H
    • Journal Title

      EMBO J

      Volume: 印刷中 Issue: 17 Pages: 1-20

    • DOI

      10.15252/embj.2019102870

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orchestrated ensemble activities constitute a hippocampal memory engram.2019

    • Author(s)
      Ghandour K, Ohkawa N, Chung C, Fung A, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, Inokuchi K
    • Journal Title

      Nature Communications

      Volume: 10 Pages: 1-14

    • DOI

      10.1038/s41467-019-10683-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota2019

    • Author(s)
      Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R
    • Journal Title

      J Pediatr Surg

      Volume: 54 Issue: 12 Pages: 2514-2519

    • DOI

      10.1016/j.jpedsurg.2019.08.048

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation sites of microtubule-associated protein 1B (MAP1B) involved in axon growth and regeneration.2019

    • Author(s)
      Ishikawa Y, Okada M, Honda A, Ito Y, Tamada A, Endo N, *Igarashi M
    • Journal Title

      Mol Brain

      Volume: 12 Pages: 31711525-31711525

    • DOI

      10.1186/s13041-019-0510-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation2019

    • Author(s)
      Hayata-Takano A, Kamo T, Kijima H, Seiriki K, Ogata K, Ago Y, Nakazawa T, Shintani Y, Higashino K, Nagayasu K, Shintani N, Kasai A, Waschek JA, Hashimoto H.
    • Journal Title

      Journal of Neuroscience

      Volume: 印刷中 Issue: 22 Pages: 4208-4220

    • DOI

      10.1523/jneurosci.2468-18.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postnatal Development of Cerebellar Neural Circuits2019

    • Author(s)
      Watanabe T, Suzuki H, Kano M
    • Journal Title

      BRAIN and NERVE

      Volume: 71(12) Issue: 12 Pages: 1373-1383

    • DOI

      10.11477/mf.1416201457

    • NAID

      40022089156

    • ISSN
      1344-8129, 1881-6096
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Prefrontal-Enriched SLIT1 Expression in Primate Cortex and its Alteration during Cortical Development.2019

    • Author(s)
      Sasaki T, Komatsu Y, Yamamori T.
    • Journal Title

      Japanese Journal of Biological Psychiatry

      Volume: 30 Issue: 2 Pages: 81-85

    • DOI

      10.11249/jsbpjjpp.30.2_81

    • NAID

      130007777409

    • ISSN
      2186-6465, 2186-6619
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRRT2 mutations in Japanese patients with benign infantile epilepsy and paroxysmal kinesigenic dyskinesia.2019

    • Author(s)
      Okumura A, Shimojima K, Kurahashi H, Numoto S, Shimada S, Ishii A, Hirose S, Yamamoto T, et al.
    • Journal Title

      Seizure

      Volume: 71 Pages: 43835-43835

    • DOI

      10.1016/j.seizure.2019.05.017

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.2019

    • Author(s)
      Baba M, Nakazawa T, et al.
    • Journal Title

      Neuropsychopharmacology

      Volume: 44(12) Pages: 2125-2135

    • DOI

      10.1038/s41386-019-0441-5

    • NAID

      130007811380

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics.2019

    • Author(s)
      Inoue M, Takeuchi A, Manita S, Horigane SI, Sakamoto M, Kawakami R, Yamaguchi K, Otomo K, Yokoyama H, Kim R, Yokoyama T, Takemoto-Kimura S, Abe M, Okamura M, Kondo Y, Quirin S, Ramakrishnan C, Imamura T, Sakimura K, Nemoto T, Kano M, Fujii H, Deisseroth K, Kitamura K, Bito H.
    • Journal Title

      Cell

      Volume: 177 Pages: 1346-1360

    • DOI

      10.1016/j.cell.2019.04.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setdla-Deficient Mice2019

    • Author(s)
      Mukai J, Cannavo E, Crabtree GW, Sun Z, Diamantopoulou A, Thakur P, Chang CY, Cai Y, Lomvardas S, Takata A, Xu B, Gogos JA.
    • Journal Title

      Neuron

      Volume: 104 Pages: 471-487

    • DOI

      10.1016/j.neuron.2019.09.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reconstitution of Organismal Liver Clock Function Requires Light.2019

    • Author(s)
      Miyake T, and Doi M
    • Journal Title

      Trends Endocrinol Metab.

      Volume: 30 Pages: 569-571

    • DOI

      10.1016/j.tem.2019.07.017

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovll.2019

    • Author(s)
      Isokawa M, Sassa T, Hattori S, Miyakawa T, Kihara A
    • Journal Title

      FASEB BioAdvances

      Volume: 1 Pages: 747-759

    • DOI

      10.1096/fba.2019-00067

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.2019

    • Author(s)
      Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff TS, Yamanaka A*
    • Journal Title

      Science

      Volume: 365 Issue: 6459 Pages: 1308-1313

    • DOI

      10.1126/science.aax9238

    • NAID

      120006777541

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice2019

    • Author(s)
      Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus-Peter Lesch, F. Scotl Hall, George R. Uhl, Ichiro Sora
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: - Issue: 2 Pages: 130-133

    • DOI

      10.1002/npr2.12049

    • NAID

      120006996916

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.2019

    • Author(s)
      Hirakata S, Ishizu H, Fujita A, Tomoe Y, Siomi MC.
    • Journal Title

      EMBO Rep.

      Volume: 印刷中 Issue: 7

    • DOI

      10.15252/embr.201947708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevetion by the thrombin/thrombomodulin system in rodents : negative impact of anticoagulants2019

    • Author(s)
      Maho Tsubota, ... Shuji Wakatsuki, ..., Atsufumi Kawabata
    • Journal Title

      J Neuroinflamm

      Volume: 16 Pages: 199-199

    • DOI

      10.1186/s12974-019-1581-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.2019

    • Author(s)
      Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 17548-17548

    • DOI

      10.1038/s41598-019-54082-5

    • NAID

      120006996939

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ruthenium-Catalyzed (Z)-Selective Hydroboration of Terminal Alkynes with Naphthalene-1.8-diaminatoborane2019

    • Author(s)
      Kensuke Yamamoto, Yusei Mohara, Yuichiro Mutoh, and Shinichi Saito
    • Journal Title

      J AM CHEM SOC

      Volume: 141 Pages: 17042-17047

    • DOI

      10.1021/jacs.9b06910

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Segmented Ibal-positive processes of microglia in autism model marmosets2019

    • Author(s)
      Tomomi Sanagi, Tetsuya Sasaki, Takafumi Minamimoto, Shin-ichi Kohsaka, and Noritaka Ichinohe
    • Journal Title

      Front Cell Neurosci, section Cellular Neuropathology

      Volume: 13 Pages: 344-350

    • DOI

      10.3389/fncel.2019.00344

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.2019

    • Author(s)
      Toshio Fujino and Tetsuya Mitsudomi
    • Journal Title

      Journal of thoracic oncology

      Volume: 14 Pages: 1753-1765

    • DOI

      10.1016/j.jtho.2019.06.023

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SIRT7 regulates the nuclear export of NF-kB p65 by deacetylating Ran.2019

    • Author(s)
      Sobuz SU, Sato Y, Yoshizawa T, Karim MF, Ono K, Sawa T, Miyamoto Y, Oka Y, Yamagata K
    • Journal Title

      BBA-Mol Cell Res

      Volume: 1866 Pages: 1355-1367

    • DOI

      10.1016/j.bbamcr.2019.05.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice : Involvement of dopamine D1 receptor in the medial prefrontal cortex.2019

    • Author(s)
      Numa C, Nagai H, Taniguchi M, Nagai M, Shinohara R, Furuyashiki T.
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 16670-16670

    • DOI

      10.1038/s41598-019-52997-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.2019

    • Author(s)
      Shinohara, F., Asaoka, Y., Kamii, H., Minami, M., Kaneda, K.
    • Journal Title

      Addiction Biology

      Volume: 印刷中 Pages: 509-521

    • DOI

      10.1111/adb.12617

    • NAID

      120006627077

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suzuki-Miyaura Cross-Coupling of 1.8-Diaminonaphthalene (dan)-Protected Arylboronic Acids2019

    • Author(s)
      Yuichiro Mutoh, Kensuke Yamamoto, Shinichi Saito
    • Journal Title

      ACS CATAL

      Volume: 10 Pages: 352-357

    • DOI

      10.1021/acscatal.9b03667

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer2019

    • Author(s)
      Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 2189-2202

    • DOI

      10.18632/oncotarget.26758

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting claudin-4 enhances chemosensitivity of pancreatic ductal carcinomas.2019

    • Author(s)
      Sasaki T, Fujiwara-Tani R, Kishi S, Mori S, Luo Y, Ohmori H, Goto K, Nishiguchi Y, Mori T, Sho M, Kondo M, Kuniyasu H
    • Journal Title

      Cancer Med

      Volume: 8 Pages: 6700-6708

    • DOI

      10.1002/cam4.2547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.2019

    • Author(s)
      Braganza, CD., Shibata, K., Fujiwara, A., Motozono, C., Sonoda, KH., Yamasaki, S., Stocker, BL., Timmer, MSM
    • Journal Title

      Org Biomol Chem.

      Volume: 17 Pages: 8992-9000

    • DOI

      10.1039/c9ob01436e

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis.2019

    • Author(s)
      Ahmat Amin MKB, Shimizu A, Ogita H.
    • Journal Title

      Cancers

      Volume: 11 Pages: 1620-1620

    • DOI

      10.3390/cancers11111620

    • NAID

      120006766857

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional fluorescence imaging using the transport of intensity equation.2019

    • Author(s)
      Rajput SK, Kumar M, Quan X, Morita M, Furuyashiki T, Awatsuji Y, Tajahuerce E, Matoba O.
    • Journal Title

      J Biomed Opt

      Volume: 25 Pages: 03004-03004

    • DOI

      10.1117/1.jbo.25.3.032004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter2019

    • Author(s)
      Hirao N, Iwata T, Tanaka K, Nishio H, Nakamura M, Morisada T, Morii K, Maruyama N, Katoh Y, Yaguchi T, Ohta S, Kukimoto I Aoki D, Kawakami Y
    • Journal Title

      Gynccol Oncology

      Volume: 155 Issue: 2 Pages: 31478-31487

    • DOI

      10.1016/j.ygyno.2019.08.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy.2019

    • Author(s)
      Williams RH, Tsunematsu T, Thomas AM, Bogyo K, Yamanaka A*. Kilduff TS*.
    • Journal Title

      J Neurosci

      Volume: 39(47) Issue: 47 Pages: 9435-9452

    • DOI

      10.1523/jneurosci.0311-19.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Visualization of brain activity in a neuropathic pain model using quantitative activity-dependent manganese magnetic resonance imaging.2019

    • Author(s)
      Inami C, Tanihira H, Kikuta S, Ogasawara O, Sobue K, Kume K, Osanai M, Ohsawa M
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 13 Pages: 74-74

    • DOI

      10.3389/fncir.2019.00074

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-brain Block-Face Serial Microscopy Tomography at Subcellular Resolution Using FAST2019

    • Author(s)
      Seiriki K, Kasai A, Nakazawa T, Niu M, Naka Y, Tanuma M, Igarashi H, Yamaura K, Hayata-Takano A, Ago Y, Hashimoto H.
    • Journal Title

      Nat Protoc

      Volume: 印刷中 Issue: 5 Pages: 1509-1529

    • DOI

      10.1038/s41596-019-0148-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zn (OTf)2-mediated annulations of N-propargylated tetrahydrocarbolines : divergent synthesis of four distinct alkaloidal scaffolds2019

    • Author(s)
      Sadaiwa Yorimoto, Akira Tsubouchi, Haruki Mizoguchi, Hideaki Oikawa, Yoshiaki Tsunekawa, Tomoya Ichino, Satoshi Maeda and Hiroki Oguri
    • Journal Title

      Chemical Science

      Volume: 10 Pages: 5686-5698

    • DOI

      10.1039/c9sc01507h

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨転移とマイクロRNA2019

    • Author(s)
      佐藤信吾
    • Journal Title

      BIO Clinica

      Volume: 34 Issue: 9 Pages: 794-798

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 定量的マンガン造影MRIを用いた疾患モデル動物の神経活動計測2019

    • Author(s)
      菊田 里美, 笠原 二郎, 小山内 実
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 75 Issue: 8 Pages: 799-804

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.2019

    • Author(s)
      Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
    • Journal Title

      J Physiol Sci.

      Volume: 69(1) Issue: 1 Pages: 65-77

    • DOI

      10.1007/s12576-018-0618-4

    • NAID

      40021804699

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model2019

    • Author(s)
      Htun Y, Nakamura S, Nakao Y, Mitsuie T, Nakamura M, Yamato S, Jinnai W, Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 4088-4088

    • DOI

      10.1038/s41598-019-40674-8

    • NAID

      120006599245

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity2019

    • Author(s)
      Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, Yamakawa K*
    • Journal Title

      Mol Autism

      Volume: 10 Pages: 1-15

    • DOI

      10.1186/s13229-019-0265-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-l, a simplified analog of debromoaplysiatoxin2019

    • Author(s)
      Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
    • Journal Title

      Heterocycles

      Volume: 99

    • DOI

      10.3987/com-18-s(f)60

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration.2019

    • Author(s)
      Asami Kawasaki*, Masayasu Okada*, Atsushi Tamada*, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi (* : These three authors contributed equally)
    • Journal Title

      iScience. 2

      Volume: 4 Pages: 190-203

    • DOI

      10.1016/j.isci.2018.05.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.2019

    • Author(s)
      Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
    • Journal Title

      Journal of Neuroscience

      Volume: 39 Issue: 9 Pages: 1588-1604

    • DOI

      10.1523/jneurosci.2139-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.2019

    • Author(s)
      Egawa R. Yawo H.
    • Journal Title

      Current Protocols in Neuroscience

      Volume: 87

    • DOI

      10.1002/cpns.64

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary2019

    • Author(s)
      Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka, Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
    • Journal Title

      Phytochemistry Letters

      Volume: 30 Pages: 43-48

    • DOI

      10.1016/j.phytol.2019.01.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019

    • Author(s)
      Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 10 Issue: 1 Pages: 1653-1653

    • DOI

      10.1038/s41467-019-09710-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.2019

    • Author(s)
      *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Rfos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
    • Journal Title

      The Journal of Neuroscience

      Volume: 39 Issue: 3 Pages: 485-502

    • DOI

      10.1523/jneurosci.1584-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-12019

    • Author(s)
      Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
    • Journal Title

      Sci Rep. 2018 Nov 20;8(1)

      Volume: 8 Pages: 17134-17134

    • DOI

      10.1038/s41598-018-35412-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction.2019

    • Author(s)
      Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
    • Journal Title

      J Biol Chem

      Volume: 294 Pages: 2924-2934

    • DOI

      10.1074/jbc.ra118.005471

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TFE3 Xpll. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease2019

    • Author(s)
      Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O, Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki, et al.
    • Journal Title

      Molecular Cancer Research

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity2019

    • Author(s)
      Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
    • Journal Title

      ChemBioChem

      Volume: 20 Pages: 1273-1281

    • DOI

      10.1002/cbic.201800815

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation2019

    • Author(s)
      Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
    • Journal Title

      J Cell Biochem.

      Volume: 120 Pages: 2259-2270

    • DOI

      10.1002/jcb.27551

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo [g] [1] benzopyrano [4, 3-b] indol-6 (13H)-one scaffold2019

    • Author(s)
      Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
    • Journal Title

      Bioorganic and Medicinal Chemistry

      Volume: 27 Issue: 2 Pages: 265-277

    • DOI

      10.1016/j.bmc.2018.11.037

    • NAID

      120006987774

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.2019

    • Author(s)
      Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
    • Journal Title

      EBioMedicine

      Volume: 41 Pages: 105-119

    • DOI

      10.1016/j.ebiom.2019.01.019

    • NAID

      120006892063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.2019

    • Author(s)
      Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
    • Journal Title

      British Journal of Cancer

      Volume: 120 Pages: 819-826

    • DOI

      10.1038/s41416-019-0413-x

    • Description
      Epub ahead of print
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and evaluation of topoisomerase I inhibitors possessing the 5, 13-dihydro-6H-benzo [6, 7] indolo [3, 2-c] quinolin-6-one scaffold2019

    • Author(s)
      Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
    • Journal Title

      Heterocycles

      Volume: 99 Pages: 1032-1032

    • DOI

      10.3987/com-18-s(f)70

    • NAID

      120006988387

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.2019

    • Author(s)
      Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 176 Pages: 1-5

    • DOI

      10.1016/j.pbb.2018.11.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluAl C-terminal palmitoylation deficient mice.2019

    • Author(s)
      Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Pages: 61-66

    • DOI

      10.1002/npr2.12044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring Nonselective and Selective Autophagy in the Liver2019

    • Author(s)
      Ueno T, Kaomatsu M
    • Journal Title

      Methods Mol Biol

      Volume: 1880 Pages: 535-540

    • DOI

      10.1007/978-1-4939-8873-0_34

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD.2019

    • Author(s)
      Kida, S
    • Journal Title

      Psychopharmacology

      Volume: 236 Pages: 49-57

    • DOI

      10.1007/s00213-018-5086-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NSP-C contributes to the upregulation of CLOCK/BMALl-mediated transcription.2019

    • Author(s)
      Hosoda, H., *Kida, S
    • Journal Title

      Cytotechnology

      Volume: 71 Pages: 453-460

    • DOI

      10.1007/s10616-018-0266-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.2019

    • Author(s)
      Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
    • Journal Title

      J Cell Commun Signal.

      Volume: 13(1) Issue: 1 Pages: 113-118

    • DOI

      10.1007/s12079-018-0487-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deregulated Polycomb functions in myeloproliferative neoplasms.2019

    • Author(s)
      Sashida G, Oshima M, Iwama A.
    • Journal Title

      International Journal of Hematology

      Volume: 110 Pages: 170-178

    • DOI

      10.1007/s12185-019-02600-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.2019

    • Author(s)
      Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 509 Pages: 89-95

    • DOI

      10.1016/j.bbrc.2018.12.068

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling2019

    • Author(s)
      Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 509 Issue: 3 Pages: 700-706

    • DOI

      10.1016/j.bbrc.2018.12.164

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.2019

    • Author(s)
      Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 511 Pages: 765-771

    • DOI

      10.1016/j.bbrc.2019.02.130

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole2019

    • Author(s)
      Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 27 Issue: 8 Pages: 1742-1746

    • DOI

      10.1016/j.bmc.2019.02.056

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.2019

    • Author(s)
      Ikeda K, Kaneko R Yanagawa Y, Ogawa M, et al.
    • Journal Title

      Brain Res Bull

      Volume: 144 Pages: 39-45

    • DOI

      10.1016/j.brainresbull.2018.11.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.2019

    • Author(s)
      Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
    • Journal Title

      Brain Res Bull.

      Volume: 144 Pages: 149-157

    • DOI

      10.1016/j.brainresbull.2018.11.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative evaluation of genetically encoded voltage indicators2019

    • Author(s)
      Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
    • Journal Title

      Cell Reports

      Volume: 26 Issue: 3 Pages: 802-813

    • DOI

      10.1016/j.celrep.2018.12.088

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4) : 1033-1043. e5.2019

    • Author(s)
      Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
    • Journal Title

      Cell Rep.

      Volume: 26 Issue: 4 Pages: 1033-1043

    • DOI

      10.1016/j.celrep.2019.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye2019

    • Author(s)
      Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
    • Journal Title

      Exp, Eye Res.

      Volume: 180 Pages: 39-42

    • DOI

      10.1016/j.exer.2018.11.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defecation initiates walking in the cricket Gryllus bimaculatus2019

    • Author(s)
      Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
    • Journal Title

      Journal of Insect Physiology

      Volume: 112 Pages: 117-122

    • DOI

      10.1016/j.jinsphys.2018.11.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.2019

    • Author(s)
      Iwasaki S. *, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T. *, and Ingolia NT. *
    • Journal Title

      Mol. Cell

      Volume: 73 Pages: 1-10

    • DOI

      10.1016/j.molcel.2018.11.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.2019

    • Author(s)
      Kurosaki H. Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
    • Journal Title

      Neurochemistry International

      Volume: 125 Pages: 16-24

    • DOI

      10.1016/j.neuint.2019.02.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.2019

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Journal Title

      Neurochem Int

      Volume: 126 Pages: 11-18

    • DOI

      10.1016/j.neuint.2019.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.2019

    • Author(s)
      Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
    • Journal Title

      Neuroscience Resarch

      Volume: 139 Pages: 58-62

    • DOI

      10.1016/j.neures.2018.08.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SODIG93A.2019

    • Author(s)
      Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
    • Journal Title

      Neuroscience Resarch

      Volume: 139 Pages: 63-68

    • DOI

      10.1016/j.neures.2018.08.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).2019

    • Author(s)
      Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
    • Journal Title

      Seizure

      Volume: 65 Pages: 118-123

    • DOI

      10.1016/j.seizure.2019.01.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.2019

    • Author(s)
      Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
    • Journal Title

      Oncogene

      Volume: 38 Pages: 635-655

    • DOI

      10.1038/s41388-018-0481-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.2019

    • Author(s)
      Nam SA, Kim WY, Kim JW, Park SH, Kim Hl, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
    • Journal Title

      Cell Death Dis.

      Volume: 10 Issue: 2 Pages: 535-540

    • DOI

      10.1038/s41419-019-1356-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoRl2019

    • Author(s)
      Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
    • Journal Title

      Nature Communication

      Volume: 10 Issue: 1 Pages: 1567-1567

    • DOI

      10.1038/s41467-019-08829-3

    • NAID

      120006884308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cdkl-mediated DIAPHI phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.2019

    • Author(s)
      Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
    • Journal Title

      Nat commun.

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41467-019-08957-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation.2019

    • Author(s)
      Liang L, Teb D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
    • Journal Title

      Nat Commun

      Volume: 10(1) Issue: 1 Pages: 1391-1391

    • DOI

      10.1038/s41467-019-09345-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.2019

    • Author(s)
      Hara S, Fukumura S, Ichinose H
    • Journal Title

      J Biol Chem

      Volume: 294 Pages: 1420-1427

    • DOI

      10.1074/jbc.ra118.005280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals2019

    • Author(s)
      Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T. Hojo MK, Honma A, Tsurui K
    • Journal Title

      Advanced Robotics

      Volume: 33 Pages: 183-194

    • DOI

      10.1080/01691864.2019.1570334

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.2019

    • Author(s)
      Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
    • Journal Title

      Journal of Experimental Medicine

      Volume: 216 Pages: 982-1000

    • DOI

      10.1084/jem.20180870

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.2019

    • Author(s)
      Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
    • Journal Title

      J. Exp. Med.

      Volume: 216 Issue: 4 Pages: 950-965

    • DOI

      10.1084/jem.20180900

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prefrontal-Enriched SLITI Expression in Primate Cortex and its Alteration during Cortical Development2019

    • Author(s)
      Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
    • Journal Title

      Japanese Journal of Biological Psychiatry

      Volume: 20(10) Issue: 10 Pages: 2496-2510

    • DOI

      10.1093/cercor/bhp319

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.2019

    • Author(s)
      Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci.

      Volume: -

    • DOI

      10.1093/gerona/gly282

    • NAID

      120006988174

    • Description
      in press
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019

    • Author(s)
      Furusho, K., T. Shibata, R. Sato, R. Fukui, Y, Motoi, Y, Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
    • Journal Title

      Int Immunol.

      Volume: 31 Pages: 167-173

    • DOI

      10.1093/intimm/dxy075

    • Related Report
      2018 A