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先端モデル動物支援プラットフォーム

Research Project

Project/Area Number 16H06276
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo
Principal Investigator(Support) 今井 浩三  東京大学, 医科学研究所, 客員教授 (60117603)
Co-Investigator(Kenkyū-buntansha)(Support) 中村 卓郎  公益財団法人がん研究会, がん研究所, 副所長 (00180373)
井上 純一郎  東京大学, 医科学研究所, 教授 (70176428)
高田 昌彦  京都大学, 霊長類研究所, 教授 (00236233)
山田 泰広  東京大学, 医科学研究所, 教授 (70313872)
高橋 智  筑波大学, 医学医療系, 教授 (50271896)
伊川 正人  大阪大学, 微生物病研究所, 教授 (20304066)
﨑村 建司  新潟大学, 脳研究所, フェロー (40162325)
荒木 喜美  熊本大学, 生命資源研究・支援センター, 教授 (90211705)
八尾 良司  公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095)
真下 知士  大阪大学, 大学院医学系研究科, 准教授 (80397554)
小林 和人  福島県立医科大学, 医学部, 教授 (90211903)
豊國 伸哉  名古屋大学, 大学院医学系研究科, 教授 (90252460)
鰐渕 英機  大阪市立大学, 大学院医学研究科, 教授 (90220970)
今井田 克己  香川大学, 医学部, 教授 (90160043)
二口 充  長崎大学, 病院(医学系), 准教授 (60275120)
上野 正樹  香川大学, 医学部, 教授 (30322267)
宮崎 龍彦  岐阜大学, 医学部附属病院, 准教授 (80239384)
神田 浩明  埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067)
尾藤 晴彦  東京大学, 大学院医学系研究科, 教授 (00291964)
宮川 剛  藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
高雄 啓三  富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397)
池田 和隆  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
虫明 元  東北大学, 大学院医学系研究科, 教授 (80219849)
清宮 啓之  公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623)
長田 裕之  国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836)
旦 慎吾  公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202)
井本 正哉  慶應義塾大学, 理工学部, 教授 (60213253)
川田 学  公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808)
田原 栄俊  広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065)
吉田 稔  国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617)
松浦 正明  帝京大学, 大学院公衆衛生学研究科, 教授 (40173794)
牛嶋 大  公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565)
吉田 進昭  東京大学, 医科学研究所, 教授 (10250341)
Project Period (FY) 2016 – 2021
Project Status Granted (Fiscal Year 2018)
Budget Amount *help
¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000)
Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
Keywordsモデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・プロファイリング / 分子プロファイリング / 分子探索・ブロファイリング / 行動解析
Outline of Annual Research Achievements

①総括支援活動 : ホームページ(HP)に改良を加えながら公募の円滑化をさらに進めた。モデル動物作製解析の講習や若手研究者の交流促進を推進する技術講習会を開催した。また成果発表会を開催、全国から127名の参加があり一般口演ならびにポスター発表など、本活動の支援成果を、より幅広い研究分野にアピールした。
②モデル動物作製支援活動 : 利用者の様々な要望に個別に対応し、相同組換えやゲノム編集など先進的な遺伝子改変技術を用いて、遺伝子改変マウスおよびラットを合計83件、迅速に作製し、学術研究を推進するための研究リソースを提供した。
③病理形態解析支援活動 : 昨年より多い52件の申請を受け、2回の審査の結果、42件に関して病理形態解析を実施した。研究の方向性を裏付ける多くの成果が得られた。論文の図の作成にもかかわり、論文が受理されるまで支援を実施した。
④生理機能解析支援活動 : 行動学的解析では23課題、薬理学的解析では9課題、光技術による操作解析では10課題、多機能電極・計測データ解析では16課題をそれぞれ支援し、動物モデルにおける病態・生理学的基盤の解明推進に関する支援を展開した。
⑤分子プロファイリング支援活動 : 依頼化合物の分子プロファイリング308件、阻害剤キット配付102枚、RNA干渉キット配付・siRNAデザイン合成92件、バーコードshRNAライブラリーによる化合物の標的経路探索24件、を実施した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 公募申請と選考作業の効率化が促進された。技術講習会と成果発表会で多くの参加者を得た。参加者対象のアンケートから若手の研究意欲を促進する効果が明らかとなった。参加希望者が前年度よりも増え、参加者の研究分野の多様性が一層顕著になった。
②モデル動物作製支援活動 : 研究実施計画に沿った支援を行うことができている。増加傾向にある応募課題に対し、最新技術を導入することにより効率化を図り、予算が許す範囲で可能な課題数を採択し、支援を行なった。遺伝子改変が複雑あるいは技術的に難しいケースは、必要な技術を導入・開発することにより対応している。
③病理形態解析支援活動 : 年々申請数が増加しており、審査をより厳格に行っている。現在の予算ならびに班員のエフォートにおいてできる最大限の支援活動を実施しており、成果は確実に上がっている。
④生理機能解析支援活動 : 支援対象者のモデルマウスを対象にした感覚・運動・認知機能に関わる「網羅的行動テストバッテリー」を用いた行動解析支援を23課題、依存性薬物等の感受性に関連する行動解析および臨床データと遺伝子多型との関連解析を行う規制薬物作用解析支援を9課題、進展著しい光遺伝学に関する最新技術を活用した研究支援を10課題、多機能集積化電極による最先端の技術提供を行う多元的生理機能計測操作支援を16課題で実施した。
⑤分子プロファイリング支援活動 : 応募課題の審査体制が軌道に乗り、採否決定までの所要日数が前年度と比較して最大10日程度短縮された。応募前の技術相談を積極的に受け付けたことで、幅広い分野から新規ユーザーを獲得することができた。前年度までの支援成果を受けて高次評価に進んだ課題については、複数の支援担当者間での連携が功を奏した。shRNAライブラリー探索支援では実験条件をカスタマイズし、被支援者の特殊なニーズにも応えた。

Strategy for Future Research Activity

①総括支援活動 : 支援により得られた成果の広報にも力を入れるとともに、被支援者にも本支援活動の重要性をアピールしてもらうよう働きかける。技術講習会では4プラットフォームとの連携を推進し、H31年度は先進ゲノム解析研究支援プラットフォームから講師と参加者を受け入れる。
②モデル動物作製支援活動 : 先端的なゲノム編集技術や研究リソース等を用いて、支援活動の拡充を図るとともに、革新的な遺伝子改変技術および周辺技術の導入・開発を進めることにより、学術研究の推進に貢献するとともに、学術基盤としての研究リソースを整備する。
③病理形態解析支援活動 : 現状で予算ならびに支援を担当する班員の対応状況に関して厳しい状態となっていることから、今後は審査をより厳格に行い、成果につながる可能性が高い申請を選択する。基本姿勢として、一旦開始した病理形態支援は論文が受理されるまでサポートするという方針に変化はない。
④生理機能解析支援活動 : 5つの拠点への支援申請が何れも安定して多数あることから、引き続きニーズに応えられるように拠点における技術力を維持・向上させ、支援実施体制をハイレベルに保つ。また、研究者コミュニティーにおける支援事業の認知度を向上させるため、学会等での広報活動を行う。技術支援にとどまらず、支援該当部の論文分担執筆を積極的に進め、成果の公表にも貢献する。
⑤分子プロファイリング支援活動 : H30年度に引き続き、広報活動の強化・解析条件のカスタマイズ対応・支援実施後のフォロー(科学的助言、共同究の斡旋、高次支援の勧奨)に努めるとともに、年2回の定例班会議で問題点を洗い出し、常に最善の運用体制で支援を実施する。支援内容の性質上、個体レベルの研究を行わない研究者層が主要な被支援者層と一致しているが、共同研究や他の支援活動班との連絡を通じて、個体レベルの研究にも展開させたい。

Report

(5 results)
  • 2018 Annual Research Report   Interim Assessment Report ( PDF )   Interim Assessment (Comments) ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report

Research Products

(1402 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] コロンピア大学/イリノイ大学/タフツ大学(アメリカ合衆国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ボルドー大学/マリーキューリー医科大学/グルノーブルアルプス大学(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] 江蘇大学/Xi'an Jiaotong University(中華人民共和国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Seoul national University/韓南大学(大韓民国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] シンガポール国立大学(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(アメリカ合衆国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(イギリス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] カルガリー大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] スプリト大学(クロアチア共和国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ベイラー医科大学(アメリカ合衆国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School, Boston(アメリカ合衆国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] スタンフォード大学/エール大学(アメリカ合衆国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 南通大学(中国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women : Chiba bone survey.2020

    • Author(s)
      Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
    • Journal Title

      Endocr J

      Volume: 65 Issue: 2 Pages: 193-202

    • DOI

      10.1507/endocrj.ej17-0331

      10.1507/endocrj.EJ17-0331

    • NAID

      130006402991

    • ISSN
      0918-8959, 1348-4540
    • Year and Date
      2020-02-05
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estimation of the Retinotopic Map of an Awake Mouse Brain Based upon Intrinsic Optical Signal Imaging Considering the Ocular Position and Variation in Pupil Diameter2019

    • Author(s)
      外川 龍之介、奥畑 大悟、吉田 侑冬、中尾 光之、片山 統裕
    • Journal Title

      TJSBME

      Volume: 56 Issue: 4 Pages: 157-163

    • DOI

      10.11239/jsmbe.56.157

    • NAID

      130007604778

    • ISSN
      1347-443X, 1881-4379
    • Year and Date
      2019-02-27
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.2019

    • Author(s)
      Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
    • Journal Title

      J Physiol Sci.

      Volume: 69(1) Issue: 1 Pages: 65-77

    • DOI

      10.1007/s12576-018-0618-4

    • NAID

      40021804699

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway2019

    • Author(s)
      Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
    • Journal Title

      Journal of Investigative Dermatology

      Volume: in press Pages: 30032-6

    • DOI

      10.1016/j.jid.2018.12.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model2019

    • Author(s)
      Htun Y, Nakamura S, Nakao Y, Mitsuie T, Nakamura M, Yamato S, Jinnai W, Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 4088-4088

    • DOI

      10.1038/s41598-019-40674-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.2019

    • Author(s)
      Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 3917-3917

    • DOI

      10.1038/s41598-019-40688-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity2019

    • Author(s)
      Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, Yamakawa K*
    • Journal Title

      Mol Autism

      Volume: 10 Pages: 1-15

    • DOI

      10.1186/s13229-019-0265-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-l, a simplified analog of debromoaplysiatoxin2019

    • Author(s)
      Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
    • Journal Title

      Heterocycles

      Volume: 99

    • DOI

      10.3987/com-18-s(f)60

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.2019

    • Author(s)
      Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
    • Journal Title

      Journal of Neuroscience

      Volume: 39 Issue: 9 Pages: 1588-1604

    • DOI

      10.1523/jneurosci.2139-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques.2019

    • Author(s)
      Egawa R. Yawo H.
    • Journal Title

      Curr Protoc Neurosci.

      Volume: 87

    • DOI

      10.1002/cpns.64

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary2019

    • Author(s)
      Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka, Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
    • Journal Title

      Phytochemistry Letters

      Volume: 30 Pages: 43-48

    • DOI

      10.1016/j.phytol.2019.01.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm2019

    • Author(s)
      Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 1653-1653

    • DOI

      10.1038/s41467-019-09710-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex.2019

    • Author(s)
      *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Rfos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
    • Journal Title

      The Journal of Neuroscience

      Volume: 31 Issue: 3 Pages: 1115-1126

    • DOI

      10.1523/jneurosci

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction.2019

    • Author(s)
      Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
    • Journal Title

      J Biol Chem

      Volume: 294 Pages: 2924-2934

    • DOI

      10.1074/jbc.ra118.005471

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TFE3 Xpll. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease2019

    • Author(s)
      Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O, Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki, et al.
    • Journal Title

      Molecular Cancer Research

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity2019

    • Author(s)
      Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
    • Journal Title

      ChemBioChem

      Volume: 20

    • DOI

      10.1002/cbic.201800815

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Forkhead box protein Al confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation.2019

    • Author(s)
      Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
    • Journal Title

      J Cell Biochem.

      Volume: 120 Pages: 2259-2270

    • DOI

      10.1002/jcb.27551

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo [g] [1] benzopyrano [4, 3-b] indol-6 (13H)-one scaffold2019

    • Author(s)
      Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
    • Journal Title

      Bioorganic and Medicinal Chemistry

      Volume: 27 Issue: 2 Pages: 265-277

    • DOI

      10.1016/j.bmc.2018.11.037

    • NAID

      120006602374

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance.2019

    • Author(s)
      Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
    • Journal Title

      EBioMedicine

      Volume: 41 Pages: 105-119

    • DOI

      10.1016/j.ebiom.2019.01.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme.2019

    • Author(s)
      Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
    • Journal Title

      British Journal of Cancer

      Volume: 120 Pages: 819-826

    • DOI

      10.1038/s41416-019-0413-x

    • Description
      Epub ahead of print
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis and evaluation of topoisomerase I inhibitors possessing the 5, 13-dihydro-6H-benzo [6, 7] indolo [3, 2-c] quinolin-6-one scaffold2019

    • Author(s)
      Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
    • Journal Title

      Heterocycles

      Volume: 99

    • DOI

      10.3987/com-18-s(f)70

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model.2019

    • Author(s)
      Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
    • Journal Title

      Pharmacol Biochem Behav.

      Volume: 176 Pages: 1-5

    • DOI

      10.1016/j.pbb.2018.11.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluAl C-terminal palmitoylation deficient mice.2019

    • Author(s)
      Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 39 Pages: 61-66

    • DOI

      10.1002/npr2.12044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring Nonselective and Selective Autophagy in the Liver2019

    • Author(s)
      Ueno T, Kaomatsu M
    • Journal Title

      Methods Mol Biol.

      Volume: 1880 Pages: 535-540

    • DOI

      10.1007/978-1-4939-8873-0_34

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD.2019

    • Author(s)
      Kida, S
    • Journal Title

      Psychopharmacology

      Volume: 236 Pages: 49-57

    • DOI

      10.1007/s00213-018-5086-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NSP-C contributes to the upregulation of CLOCK/BMALl-mediated transcription.2019

    • Author(s)
      Hosoda, H., *Kida, S
    • Journal Title

      Cytotechnology

      Volume: 71 Pages: 453-460

    • DOI

      10.1007/s10616-018-0266-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.2019

    • Author(s)
      Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
    • Journal Title

      J Cell Commun Signal.

      Volume: 13(1) Issue: 1 Pages: 113-118

    • DOI

      10.1007/s12079-018-0487-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deregulated Polycomb functions in myeloproliferative neoplasms.2019

    • Author(s)
      Sashida G, Oshima M, Iwama A.
    • Journal Title

      Int J Hematol

    • DOI

      10.1007/s12185-019-02600-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.2019

    • Author(s)
      Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
    • Journal Title

      Biochem Biophys res Commun

      Volume: 509 Pages: 89-95

    • DOI

      10.1016/j.bbrc.2018.12.068

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-кBsignaling2019

    • Author(s)
      Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 509 Issue: 3 Pages: 700-706

    • DOI

      10.1016/j.bbrc.2018.12.164

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling.2019

    • Author(s)
      Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 511 Pages: 765-771

    • DOI

      10.1016/j.bbrc.2019.02.130

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole2019

    • Author(s)
      Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 27 Issue: 8 Pages: 1742-1746

    • DOI

      10.1016/j.bmc.2019.02.056

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells.2019

    • Author(s)
      Ikeda K, Kaneko R Yanagawa Y, Ogawa M, et al.
    • Journal Title

      Brain Res Bull

      Volume: 144 Pages: 39-45

    • DOI

      10.1016/j.brainresbull.2018.11.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice.2019

    • Author(s)
      Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
    • Journal Title

      Brain Res Bull.

      Volume: 144 Pages: 149-157

    • DOI

      10.1016/j.brainresbull.2018.11.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative evaluation of genetically encoded voltage indicators2019

    • Author(s)
      Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
    • Journal Title

      Cell Reports

      Volume: 26 Issue: 3 Pages: 802-813

    • DOI

      10.1016/j.celrep.2018.12.088

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4) : 1033-1043. e5.2019

    • Author(s)
      Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
    • Journal Title

      Cell Rep.

      Volume: 26 Issue: 4 Pages: 1033-1043

    • DOI

      10.1016/j.celrep.2019.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye2019

    • Author(s)
      Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
    • Journal Title

      Exp, Eye Res.

      Volume: 180 Pages: 39-42

    • DOI

      10.1016/j.exer.2018.11.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Iron Addiction with Ferroptosis-resistance in Asbestos-induced Mesothelial Carcinogenesis : Toward the Era of Mesothelioma Prevention.2019

    • Author(s)
      Toyokuni S
    • Journal Title

      Free Radical Biology & Medicine

      Volume: 133 Pages: 206-215

    • DOI

      10.1016/j.freeradbiomed.2018.10.401

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defecation initiates walking in the cricket Gryllus bimaculatus2019

    • Author(s)
      Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
    • Journal Title

      J. Insect Physiol.

      Volume: 112 Pages: 117-122

    • DOI

      10.1016/j.jinsphys.2018.11.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA.2019

    • Author(s)
      Iwasaki S. *, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T. *, and Ingolia NT. *
    • Journal Title

      Mol. Cell

      Volume: 73 Pages: 1-10

    • DOI

      10.1016/j.molcel.2018.11.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.2019

    • Author(s)
      Kurosaki H. Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
    • Journal Title

      Neurochemistry International

      Volume: 125 Pages: 16-24

    • DOI

      10.1016/j.neuint.2019.02.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning.2019

    • Author(s)
      Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
    • Journal Title

      Neurochem Int

      Volume: 126 Pages: 11-18

    • DOI

      10.1016/j.neuint.2019.02.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency.2019

    • Author(s)
      Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
    • Journal Title

      Neuroscience Resarch

      Volume: 139 Pages: 58-62

    • DOI

      10.1016/j.neures.2018.08.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SODIG93A.2019

    • Author(s)
      Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
    • Journal Title

      Neuroscience Resarch

      Volume: 139 Pages: 63-68

    • DOI

      10.1016/j.neures.2018.08.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS).2019

    • Author(s)
      Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
    • Journal Title

      Seizure

      Volume: 65 Pages: 118-123

    • DOI

      10.1016/j.seizure.2019.01.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRJM33 at Tyr-524. -610, and -1048.2019

    • Author(s)
      Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
    • Journal Title

      Oncogene

      Volume: 38 Pages: 635-655

    • DOI

      10.1038/s41388-018-0481-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway.2019

    • Author(s)
      Nam SA, Kim WY, Kim JW, Park SH, Kim Hl, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
    • Journal Title

      Cell Death Dis.

      Volume: 10 Issue: 2 Pages: 535-540

    • DOI

      10.1038/s41419-019-1356-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoRl2019

    • Author(s)
      Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
    • Journal Title

      Nat. Commun.

      Volume: 10 Issue: 1 Pages: 1567-1567

    • DOI

      10.1038/s41467-019-08829-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cdkl-mediated DIAPHI phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase.2019

    • Author(s)
      Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
    • Journal Title

      Nautre communications

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41467-019-08957-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation.2019

    • Author(s)
      Liang L, Teb D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
    • Journal Title

      Nat Commun

      Volume: 10(1) Issue: 1 Pages: 1391-1391

    • DOI

      10.1038/s41467-019-09345-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.2019

    • Author(s)
      Hara S, Fukumura S, Ichinose H
    • Journal Title

      J Biol Chem

      Volume: 294 Pages: 1420-1427

    • DOI

      10.1074/jbc.ra118.005280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals2019

    • Author(s)
      Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T. Hojo MK, Honma A, Tsurui K
    • Journal Title

      Advanced Robotics

      Volume: 33 Pages: 183-194

    • DOI

      10.1080/01691864.2019.1570334

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer.2019

    • Author(s)
      Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
    • Journal Title

      J Exp Med.

      Volume: 216 Pages: 982-1000

    • DOI

      10.1084/jem.20180870

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.2019

    • Author(s)
      Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
    • Journal Title

      J. Exp. Med.

      Volume: 216 Issue: 4 Pages: 950-965

    • DOI

      10.1084/jem.20180900

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prefrontal-Enriched SLITI Expression in Primate Cortex and its Alteration during Cortical Development2019

    • Author(s)
      Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
    • Journal Title

      Japanese Journal of Biological Psychiatry

      Volume: 20(10) Issue: 10 Pages: 2496-2510

    • DOI

      10.1093/cercor/bhp319

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning.2019

    • Author(s)
      Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci.

      Volume: -

    • DOI

      10.1093/gerona/gly282

    • Description
      in press
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.2019

    • Author(s)
      Furusho, K., T. Shibata, R. Sato, R. Fukui, Y, Motoi, Y, Zhang, S. I. Saitoh, T. Ichinohe, M. Moriyama, S. Nakamura, and K. Miyake.
    • Journal Title

      Int Immunol.

      Volume: 31 Pages: 167-173

    • DOI

      10.1093/intimm/dxy075

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.2019

    • Author(s)
      Saitoh, S. I., Y. M. Saitoh, K. Kontani, K. Sato, and K. Miyake.
    • Journal Title

      Int Immunol.

      Volume: 31 Issue: 4 Pages: 225-237

    • DOI

      10.1093/intimm/dxy084

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.2019

    • Author(s)
      Orimo, T., I. Sasaki, H. Hemmi, T. Ozasa, Y. Fukuda-Ohta, T. Ohta, M. Morinaka, M. Kitauchi, T. Yamaguchi, Y. Sato, T. Tanaka, K. Hoshino, K. I. Katayama, S. Fukuda, K. Miyake, M. Yamamoto, T. Satoh, K. Furukawa, E. Kuroda, K. J. Ishii, K. Takeda, and T. Kaisho.
    • Journal Title

      Int Immunol.

      Volume: 印刷中

    • DOI

      10.1093/intimm/dxz004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice.2019

    • Author(s)
      Zhang T, Yanagida J, Kamii H, Wada S, Domoto M, Sasase H, Deyama S, Takarada T, Hinoi E, Sakimura K, Yamanaka A, Maejima T, Mieda M, Sakurai T, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K.
    • Journal Title

      Addict Biol

      Volume: 印刷中

    • DOI

      10.1111/adb.12723

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TUBB1 dysfunction identified in familial platelet disorder causes impaired proplatelet formation and genome instability2019

    • Author(s)
      Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T
    • Journal Title

      Br J Haematol

      Volume: 0 Pages: 0-0

    • DOI

      10.1111/bjh.15835

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SCF(Fbxw7) ubiquilylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation.2019

    • Author(s)
      Sugiyama S., Yumimoto K., Inoue I., Nakayama KI.
    • Journal Title

      Genes Cells

      Volume: 印刷中

    • DOI

      10.1111/gtc.12680

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RBM10-TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break-apart Fluorescence in situ Hybridization : Study of Ten Cases and a Literature Review2019

    • Author(s)
      Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoichi Kameda, Masanori Yasuda, Koshiro Nishimoto, Masafumi Oyama, Toshinari Yamasaki, Osamu Ogawa, Hitoshi Niino, Noboru Nakaigawa, Yuta Yano, Kazumasa Sakamoto, Yoji Urata, Kazuya Mikami, Shigetaka Yamasaki, Reiko Tanaka, Toshio Takagi, Tsunenori Kondo, Yoji Nagashima
    • Journal Title

      Histopathology

      Volume: 印刷中

    • DOI

      10.1111/his.13866

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of specific microRNAs in neutrophils of type 2 diabetic mice : overexpression of microRNA-129-2-3p accelerates diabetic wound healing.2019

    • Author(s)
      Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
    • Journal Title

      Diabetes

      Volume: 68 Issue: 3 Pages: 617-630

    • DOI

      10.1124/jpet.118.253922

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cap-specific terminal N6-methylation of RNA by an RNA polymerase Ⅱ-associated methyltransferase Cap.2019

    • Author(s)
      Akichika S., Hirano S., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.
    • Journal Title

      Science

      Volume: 363 Issue: 363 Pages: 6423-6423

    • DOI

      10.1126/science.aav0080

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.2019

    • Author(s)
      Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S. Eguchi H, Ikawa M, Takehara T, Kikuchi A.
    • Journal Title

      Clin Cancer Res.

      Volume: 25 Pages: 1936-1947

    • DOI

      10.1158/1078-0432.ccr-18-2124

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumorgrowth.2019

    • Author(s)
      Harada, T., Matsumoto, S., Hirota, S., Kimura, H., Fujii, S., Kasahara, Y., Gon, H., Yoshida, T., Itoh, T., Haraguchi, N., Mizushima, T., Noda, T., Eguchi, H., Nojima, S., Morii, E., Fukumoto, T., Obika, S., Kikuchi, A.
    • Journal Title

      Mol. Cancer Ther.

      Volume: 18 Pages: 602-612

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.2019

    • Author(s)
      Shimizu H., Takeishi S., Nakatsumi H., Nakayama KI.
    • Journal Title

      JCI Insight

      Volume: 4

    • DOI

      10.1172/jci.insight.125138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus.2019

    • Author(s)
      Nobuyuki Sakayori, Shigeki Kato, Masateru Sugawara, Susumu Setogawa, Hotaka Fukushima, Rie Ishikawa, Satoshi Kida, Kazuto Kobayashi
    • Journal Title

      Mol Brain

      Volume: 12 Issue: 13 Pages: 13-13

    • DOI

      10.1186/s13041-019-0431-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A method of producing genetically manipulated mouse mammary gland2019

    • Author(s)
      Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba
    • Journal Title

      Breast Cancer Research

      Volume: 21, 1 Pages: 1-1

    • DOI

      10.1186/s13058-018-1086-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas2019

    • Author(s)
      Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
    • Journal Title

      JCO Precision Oncology

      Volume: 3

    • DOI

      10.1200/po.18.00308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quinidine therapy and therapeutic drug monitoring in four patients with KCNTI mutations.2019

    • Author(s)
      Yoshitomi S, Takahashi Y, Yamaguchi T, Oboshi T, Horino A, Ikeda H, Imai K, Okanishi T, Nakashima M, Saitsu H, Matsumoto N, Yoshimoto J, Fujita T, Ishii A, Hirose S, Inoue Y.
    • Journal Title

      Epileptic Disorders

      Volume: 21 Issue: 1 Pages: 48-54

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer2019

    • Author(s)
      Nishiguchi Y, Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Kishi S, Mori S, Goto K, Yasui W, Sho M*, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 2189-2202

    • DOI

      10.18632/oncotarget.26758

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma2019

    • Author(s)
      Takanori NOZAWA, Masayasu OKADA, Manabu NATSUMEDA, Takeyoshi EDA, Hideaki ABE, Yoshihiro TSUKAMOTO, Kouichirou OKAMOTO, Makoto OISHI, Hitoshi TAKAHASHI, Yukihiko FUJII, and Akiyoshi KAKITA
    • Journal Title

      Neurol. Med. Chir.(Tokyo)

      Volume: 59 Issue: 3 Pages: 89-97

    • DOI

      10.2176/nmc.oa.2018-0078

    • NAID

      130007612662

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calvarial Bone Implantation and in vivo Imaging of Tumor Cells in Mice2019

    • Author(s)
      Hashimoto K, Sato S, Ochi H, Takeda S, Futakuchi M
    • Journal Title

      Bio Protoc

      Volume: 9 Issue: 3

    • DOI

      10.21769/bioprotoc.3151

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.2019

    • Author(s)
      Imanishi, T., M. Unno, W. Kobayashi, N. Yoneda, S. Matsuda, K. Ikeda, T. Hoshii, A. Hirao, K. Miyake, G. N. Barber, M. Arita, K. J. Ishii, S. Akira, and T, Saito.
    • Journal Title

      Life Sci Alliance

      Volume: 2 Issue: 1

    • DOI

      10.26508/lsa.201800282

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Opposing roles of dopamine receptor D1-and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice.2019

    • Author(s)
      Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Yamanaka A, Hikida T, Manabe H, Yamaguchi M.
    • Journal Title

      Front Behav Neurosci

      Volume: 13 Pages: 50-50

    • DOI

      10.3389/fnbeh.2019.00050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains2019

    • Author(s)
      Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuan Phan, Kazuo Nagasawa
    • Journal Title

      Molecules

      Volume: 24 Pages: 263-263

    • DOI

      10.3390/molecules24020263

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] tChIP-Sea : cell-type-specific Eepigenome profiling2019

    • Author(s)
      Mito M, Kadota M., Nakagawa S. *, Iwasaki S. *
    • Journal Title

      J. Vis. Exp

      Volume: 143

    • DOI

      10.3791/58298

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 悪性髄膜腫における個別化医療の可能性2019

    • Author(s)
      平石哲也、棗田学、岡田正康、大石誠、藤井幸彦
    • Journal Title

      Precision Medicine

      Volume: 2 Issue: 1 Pages: 54-58

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle2019

    • Author(s)
      Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
    • Journal Title

      Pathobiology

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy2019

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
    • Journal Title

      Pathobiology

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intracellular transport of NMDA receptors and Schizophrenia2019

    • Author(s)
      Yosuke Takei, Saki Tome, Tetsuya Sasaki
    • Journal Title

      Japanese Journal of Biological Psychiatry

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial pyruvate carrier I expression controls cancer EMT and radioresistance.2019

    • Author(s)
      Takaoka, Y., Konno, M., Koseki, J., Colvin, H., Asai, A., Tamari, K., Satoh, T., Mori, M., Doki, Y., Ogawa, K., Ishii, H.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 4 Pages: 1331-1339

    • DOI

      10.1111/cas.13980

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of mitochondrial iron homeostasis by sideroflexin 22019

    • Author(s)
      Non, E.E., *Wei, F.-Y., Ahmad, R.N.R., Yamamoto, T., Moroishi. T., *Tomizawa, K.
    • Journal Title

      J. Physiol. Sci.

      Volume: 69 Pages: 359-373

    • DOI

      10.1007/s12576-018-0652-2

    • NAID

      40021819064

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling.2019

    • Author(s)
      Maeda A. Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
    • Journal Title

      Biochim Biophys Acta Mol Cell Res.

      Volume: 1866 Pages: 285-295

    • DOI

      10.1016/j.bbamcr.2018.11.009

    • Description
      [Epub ahead of print]
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells.2019

    • Author(s)
      Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
    • Journal Title

      Oncogene

      Volume: 38 Issue: 2 Pages: 244-260

    • DOI

      10.1038/s41388-018-0406-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.2019

    • Author(s)
      Motohiro Kojima, Yu Chen, Koji Ikeda, Yuichiro Tsukada, Daigoro Takahashi, Shingo Kawano, Kota Amemiya, Masaaki Ito, Rieko Ohki, Atsushi Ochiai.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 2040-2040

    • DOI

      10.1038/s41598-018-37707-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.2019

    • Author(s)
      Tominaga, K., Ninato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 116 Issue: 2 Pages: 625-630

    • DOI

      10.1073/pnas.1806851116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.2019

    • Author(s)
      Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
    • Journal Title

      Cerebral Cortex

      Volume: 160 Pages: 1-14

    • DOI

      10.1093/cercor/bhy253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p62/SQSTM1 : ‘Jack of all trades’ in health and cancer.2019

    • Author(s)
      Sánchez-Martin P, Saito T, Komatsu M.
    • Journal Title

      FEBS J.

      Volume: 286 Issue: 1 Pages: 8-23

    • DOI

      10.1111/febs.14712

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parabrachial-to-amygdala control of aversive learning2019

    • Author(s)
      Nagase, M., Mikami, K., and Watabe, A. M. #(#責任著者)
    • Journal Title

      Current Opinion in Behavioral Sciences

      Volume: 26 Pages: 18-24

    • DOI

      10.1016/j.cobeha.2018.08.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.2019

    • Author(s)
      Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 62 Issue: 7 Pages: 3407-3427

    • DOI

      10.1021/acs.jmedchem.8b01888

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development.2019

    • Author(s)
      Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
    • Journal Title

      Oncogene

      Volume: 38 Issue: 14 Pages: 2580-2594

    • DOI

      10.1038/s41388-018-0603-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus.2019

    • Author(s)
      Noritake A, Nakamura K.
    • Journal Title

      Journal of neurophysiology

      Volume: 121 Issue: 2 Pages: 396-417

    • DOI

      10.1152/jn.00247.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opioid and non-dopamine reward circuitry and state-dcpendent mechanisms.2019

    • Author(s)
      Fujita M, Ide S, Ikeda K
    • Journal Title

      Aun NY Acad Sci

      Volume: 印刷中

    • DOI

      10.1111/nyas.13605

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice : A model of attention-deficit/hyperactivity disorder.2018

    • Author(s)
      Ide S ; Ikekubo Y ; Hua J ; Takamatsu Y ; Uhi GR ; Sora I
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: 38 Pages: 149-153

    • DOI

      10.1002/npr2.12020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration.2018

    • Author(s)
      Asami Kawasaki*, Masayasu Okada*, Atsushi Tamada*, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi (* : These three authors contributed equally)
    • Journal Title

      iSCIENCE

      Volume: 4 Pages: 190-203

    • DOI

      10.1016/j.isci.2018.05.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration.2018

    • Author(s)
      Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
    • Journal Title

      Neurochemistry International

      Volume: S0197-0186 Pages: 190-198

    • DOI

      10.1016/j.neuint.2018.01.003

    • NAID

      120006554471

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted expression of step-function opsins in transgcnic rats for optogenetic studies.2018

    • Author(s)
      Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 5435-5435

    • DOI

      10.1038/s41598-018-23810-8

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells2018

    • Author(s)
      Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 14827-14827

    • DOI

      10.1038/s41598-018-33139-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics2018

    • Author(s)
      Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
    • Journal Title

      Physiological Measurement

      Volume: 39 Pages: 054003-054003

    • DOI

      10.1088/1361-6579/aac033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10.2018

    • Author(s)
      Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 7 Pages: 2302-2309

    • DOI

      10.1111/cas.13636

    • NAID

      120006535011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Task-dependent function of striatal cholinergic interneurons2018

    • Author(s)
      Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
    • Journal Title

      Eur J Neurosci

      Volume: - Issue: 10 Pages: 1174-1183

    • DOI

      10.1111/ejn.13768

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXKI.2018

    • Author(s)
      Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
    • Journal Title

      Genes Cells

      Volume: 23 Pages: 599-605

    • DOI

      10.1111/gtc.12597

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative study of the somatosensory sensitization underlying cross-modal plasticity.2018

    • Author(s)
      Abe K, Yawo H.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 12

    • DOI

      10.1371/journal.pone.0208089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The temporal turning window for rat behavioral phenotypes by rotenone2018

    • Author(s)
      M. Ishido*
    • Journal Title

      Fundam. Toxicol. Sci.

      Volume: 5 Issue: 6 Pages: 195-202

    • DOI

      10.2131/fts.5.195

    • NAID

      130007554207

    • ISSN
      2189-115X
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-l, a potential anti-cancer lead derived from debromoaplysiatoxin2018

    • Author(s)
      Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
    • Journal Title

      Heterocycles

      Volume: 97 Issue: 1 Pages: 478-492

    • DOI

      10.3987/com-18-s(t)37

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen.2018

    • Author(s)
      Eguchi N, Sora I, Muguruma K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 498 Issue: 4 Pages: 729-735

    • DOI

      10.1016/j.bbrc.2018.03.049

    • NAID

      120006462318

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population.2018

    • Author(s)
      Zhang Y ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Yamamori H ; Boku S ; Horai T ; Someya T ; Ohmori T ; Hashimoto R ; Sora I
    • Journal Title

      J Psychiatr Res

      Volume: 103 Pages: 161-166

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition.2018

    • Author(s)
      Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Rios A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
    • Journal Title

      Neuroscience

      Volume: 388 Pages: 297-316

    • DOI

      10.1016/j.neuroscience.2018.07.039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia.2018

    • Author(s)
      Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 83 Pages: 33-41

    • DOI

      10.1016/j.pnpbp.2018.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitochondrial DNA copy number of peripheral blood in bipolar disorder : The present study and a meta-analysis.2018

    • Author(s)
      Yamaki N ; Otsuka I ; Numata S ; Yanagi M ; Mouri K ; Okazaki S ; Boku S ; Horai T ; Ohmori T ; Shirakawa O ; Sora I ; Hishimoto A
    • Journal Title

      Psychiatry Res

      Volume: 269 Pages: 115-117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-12018

    • Author(s)
      Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 17134-17134

    • DOI

      10.1038/s41598-018-35412-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Superiority of rat over murine model for studies on the evolution of cancer genome.2018

    • Author(s)
      Akatsuka S, Li GH, Toyokuni S
    • Journal Title

      Free Radical Research

      Volume: 52 Pages: 1323-1327

    • DOI

      10.1080/10715762.2018.1467562

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers.2018

    • Author(s)
      Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 1

    • DOI

      10.1371/journal.pone.0190667

    • NAID

      120006382347

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.2018

    • Author(s)
      Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 14 Pages: 663-669

    • DOI

      10.2147/ndt.s153360

    • NAID

      120006425682

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of chromosome Y loss in men with schizophrenia.2018

    • Author(s)
      Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Kimura A ; Horai T ; Sora I
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 14 Pages: 2115-2122

    • DOI

      10.2147/ndt.s172886

    • NAID

      120006510199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas2018

    • Author(s)
      Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
    • Journal Title

      Neurol. Med. Chir.(Tokyo)

      Volume: 58 Issue: 7 Pages: 290-295

    • DOI

      10.2176/nmc.ra.2018-0044

    • NAID

      130007405002

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype.2018

    • Author(s)
      Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
    • Journal Title

      Front Psychiatry

      Volume: 138 Pages: 9-9

    • DOI

      10.3389/fpsyt.2018.00138

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice.2018

    • Author(s)
      Sasaki K ; Hall FS ; Uhl GR ; Sora I
    • Journal Title

      Front Psychiatry

      Volume: 9 Pages: 441-441

    • DOI

      10.3389/fpsyt.2018.00441

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain : An exploratory study.2018

    • Author(s)
      Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
    • Journal Title

      Neuropsychopharmacology Report

      Volume: 38(4) Pages: 175-181

    • DOI

      10.1002/npr2.12030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D culture system containing gellan gum restores oncogene dependence in ROSI rearrangements non-small cell lung cancer.2018

    • Author(s)
      Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
    • Journal Title

      Biochem. Biophys. Res. Commun.,

      Volume: 501 Pages: 527-533

    • DOI

      10.1016/j.bbrc.2018.05.031

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.2018

    • Author(s)
      Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
    • Journal Title

      Kidney Int.

      Volume: 94 Issue: 3 Pages: 524-535

    • DOI

      10.1016/j.kint.2018.05.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCNIA gene.2018

    • Author(s)
      Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
    • Journal Title

      Stem Cell Research

      Volume: 31 Pages: 11-15

    • DOI

      10.1016/j.scr.2018.06.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes2018

    • Author(s)
      Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
    • Journal Title

      Chem Res Toxicol

      Volume: 31 Issue: 10 Pages: 1025-1031

    • DOI

      10.1021/acs.chemrestox.8b00067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm : association with immunoblastoid cytomorphology, MYC expression, and drug response.2018

    • Author(s)
      Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K, and *Takeuchi, K.,
    • Journal Title

      Leukemia

      Volume: 32 Pages: 2590-2603

    • DOI

      10.1038/s41375-018-0154-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.2018

    • Author(s)
      Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 6760-6760

    • DOI

      10.1038/s41598-018-25189-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adpocytes and cancer cells.2018

    • Author(s)
      Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 115 Issue: 33 Pages: 8370-8375

    • DOI

      10.1073/pnas.1804243115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new method for identifying mouse pancreatic ducts2018

    • Author(s)
      Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
    • Journal Title

      Tissue Eng.

      Volume: 24 Issue: 8 Pages: 480-485

    • DOI

      10.1089/ten.tec.2018.0127

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression2018

    • Author(s)
      Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
    • Journal Title

      Genes Cells

      Volume: 23 Issue: 8 Pages: 688-701

    • DOI

      10.1111/gtc.12610

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FEAT enhances INSL3 expression in testicular Leydig cells.2018

    • Author(s)
      Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
    • Journal Title

      Genes to cells

      Volume: 23 Pages: 952-962

    • DOI

      10.1111/gtc.12644

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses.2018

    • Author(s)
      Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
    • Journal Title

      Oncoscience.

      Volume: 5 Pages: 103-103

    • DOI

      10.18632/oncoscience.411

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment2018

    • Author(s)
      Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 3 Pages: 888-888

    • DOI

      10.3390/ijms19030888

    • NAID

      120006471116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer.2018

    • Author(s)
      Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
    • Journal Title

      Exp Ther Med

      Volume: 16 Issue: 6 Pages: 4463-4470

    • DOI

      10.3892/etm.2018.6787

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Overview of Development of Quantitative Neurotoxicity Testing In vitro2018

    • Author(s)
      M. Ishido*
    • Journal Title

      J. Applied Life Sci. Intl.

      Volume: 19 Pages: 2394-1103

    • DOI

      10.9734/jalsi/2018/45377

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞突起形成抑制による膠芽腫治療戦略2018

    • Author(s)
      岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
    • Journal Title

      新潟県医師会報

      Volume: 814 Issue: 1 Pages: 9-10

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マンガの読みにおける状況モデルの更新2018

    • Author(s)
      和田裕一, 三浦知志, 窪俊一
    • Journal Title

      マンガ研究

      Volume: 24 Pages: 93-114

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spredl Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.2018

    • Author(s)
      Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
    • Journal Title

      Cell Stem Cell

      Volume: 22 Pages: 713-725

    • DOI

      10.1016/j.stem.2018.04.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia2018

    • Author(s)
      Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I. Nitsos, I., Miller, S. I., Walker, D. W., Wong, F. Y.
    • Journal Title

      Pediatr Res

      Volume: 83 Issue: 3 Pages: 442-450

    • DOI

      10.1038/s41390-018-0045-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immediate-early promoter-driven transgenic reporter system for neuroethological researches in a hemimetabolous insect2018

    • Author(s)
      Watanabe T., Ugajin A. and Aonuma H.
    • Journal Title

      eNeuro

      Volume: 5 Pages: 0061-18

    • DOI

      10.1523/eneuro.0061-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel arousal pathways in the lateral hypothalamus.2018

    • Author(s)
      Heiss JE, Yamanaka A, Kilduff TS.
    • Journal Title

      eNeuro

      Volume: 5(4) Pages: 0228-18

    • DOI

      10.1523/eneuro.0228-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A stable association with PME-1 may be dispensable for PP2A demethylation-implications for the detection of PP2A methylation and immunoprecipitation2018

    • Author(s)
      Yabe R. Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T*, Sato K
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 9 Pages: 1486-1496

    • DOI

      10.1002/2211-5463.12485

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking2018

    • Author(s)
      Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
    • Journal Title

      PLoS ONE

      Volume: 13 Issue: 5

    • DOI

      10.1371/journal.pone.0196946

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycans in stem cell regulation : from Drosophila tissue stem cells to mammalian pluripotent stem cells.2018

    • Author(s)
      Nishihara S
    • Journal Title

      FEBS Lett.

      Volume: 592 Issue: 23 Pages: 3773-3790

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 9.2018

    • Author(s)
      Ishida, H., U. Ohto, T. Shibata, K, Miyake, and T. Shimizu.
    • Journal Title

      FEBS Lett

      Volume: 592 Issue: 15 Pages: 2636-2646

    • DOI

      10.1002/1873-3468.13176

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound2018

    • Author(s)
      Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
    • Journal Title

      ChemBioChem

      Volume: 19 Pages: 2268-2272

    • DOI

      10.1002/cbic.201800425

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells.2018

    • Author(s)
      Saito M, Ichikawa J, Ando T. Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
    • Journal Title

      J Bone Miner Res.

      Volume: 33 Issue: 11 Pages: 2048-2058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018

    • Author(s)
      Masaya Baba, Mitsuhiro Endoh. Wenjuan Ma, Hirofumi Toyama. Akiyoshi Hirayama, Keiyo Takubo, Hiroyuki Hano. Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 33 Issue: 10 Pages: 1785-1798

    • DOI

      10.1002/jbmr.3477

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HipOP mesenchymal population has high potential for repairing injured peripheral nerves.2018

    • Author(s)
      Yamauchi Y., Itoh S, et al.
    • Journal Title

      J. Cell Biochem.

      Volume: 印刷中 Issue: 6 Pages: 4836-4844

    • DOI

      10.1002/jcb.26684

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells2018

    • Author(s)
      Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
    • Journal Title

      Methods in Molecular Biology

      Volume: 1731 Pages: 29-37

    • DOI

      10.1007/978-1-4939-7595-2_3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salll regulates microglial morphology cell autonomously in the developing retina2018

    • Author(s)
      Koso H, Nishinakamura R, Watanabe S
    • Journal Title

      Adv Exp Med Biol

      Volume: 1047 Pages: 209-215

    • DOI

      10.1007/978-3-319-75402-4_26

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyraminergic modulation of agonistic outcomes in crayfish2018

    • Author(s)
      Momohara Y., Aonuma H. and Nagayama T.
    • Journal Title

      J. Comp. Physiol.

      Volume: 印刷中 Pages: 465-473

    • DOI

      10.1007/s00359-018-1255-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NIPA-like domain containing l is a novel tumor-promoting factor in oral squamous cell carcinoma.2018

    • Author(s)
      Sasahira T. Nishiguchi Y. Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 144 Issue: 5 Pages: 875-82

    • DOI

      10.1007/s00432-018-2612-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.2018

    • Author(s)
      Ichinose H, Inoue KI. Arakawa S. Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO
    • Journal Title

      J Neural Transm

      Volume: 125 Pages: 45-52

    • DOI

      10.1007/s00702-017-1784-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Systematic review of pre-clinical chronic myeloid leukaemia.2018

    • Author(s)
      Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
    • Journal Title

      Int J Hematol.

      Volume: 108 Issue: 5 Pages: 465-484

    • DOI

      10.1007/s12185-018-2528-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum.2018

    • Author(s)
      Kano M, Watanabe T, Uesaka N, Watanabe M.
    • Journal Title

      Cerebellum.

      Volume: 17 Issue: 6 Pages: 722-734

    • DOI

      10.1007/s12311-018-0964-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biallelic Variants in CNPY3. Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.2018

    • Author(s)
      Mutoh, H., M. Kato. T. Akita, T. Shibata, H. Wakamoto, H. Ikeda, H. Kitaura, K. Aoto, M. Nakashima, T. Wang, C. Ohba, S. Miyatake, N. Miyake, A. Kakita, K. Miyake, A. Fukuda, N. Matsumoto, and H. Saitsu.
    • Journal Title

      Am J Hum Genet

      Volume: 102 Issue: 2 Pages: 321-329

    • DOI

      10.1016/j.ajhg.2018.01.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development2018

    • Author(s)
      Kawamura Y, Yamanaka K, Poh B, Kuribayashi H. Koso H, Watanabe S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 503 Issue: 4 Pages: 3023-3030

    • DOI

      10.1016/j.bbrc.2018.08.088

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene : A case report.2018

    • Author(s)
      Hayashida T, Saito Y, Ishii A, Hirose S, Hiraiwa R. Maegaki Y, Ohno K.
    • Journal Title

      Brain & Development

      Volume: 40(7) Issue: 7 Pages: 576-581

    • DOI

      10.1016/j.braindev.2018.03.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglels2018

    • Author(s)
      Jinnai, W. Nakamura, S. Koyano, K. Yamato, S. Wakabayashi, T. Htun, Y. Nakao, Y. Iwase, T. Nakamura, M. Yasuda, S. Ueno, M. Miki, T. Kusaka T
    • Journal Title

      Brain Dev

      Volume: 40 Issue: 8 Pages: 649-661

    • DOI

      10.1016/j.braindev.2018.04.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A patient with a GNAOI mutation with decreased spontaneous movements, hypotonia, and dystonic features.2018

    • Author(s)
      Okumura A. Naruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.
    • Journal Title

      Brain & Development

      Volume: 40 Issue: 10 Pages: 926-30

    • DOI

      10.1016/j.braindev.2018.06.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The autism-related protein CHD8 cooperates with C/EBP β to regulate adipogenesis.2018

    • Author(s)
      Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
    • Journal Title

      Cell Rep.

      Volume: 23 Pages: 1988-2000

    • DOI

      10.1016/j.celrep.2018.04.050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.2018

    • Author(s)
      Hirotaka Watanabe, et al.
    • Journal Title

      Cell Reports

      Volume: 23 Pages: 3721-3729

    • DOI

      10.1016/j.celrep.2018.05.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents.2018

    • Author(s)
      Tainaka K. Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T. Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A. Ueda HR.
    • Journal Title

      Cell Reports

      Volume: 24 Pages: 2196-2210

    • DOI

      10.1016/j.celrep.2018.07.056

    • NAID

      120006542018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Calcium transient dynamics of neural ensembles in the primary motor cortex of naturally behaving monkeys.2018

    • Author(s)
      Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF. Ushiba J. Okano H.
    • Journal Title

      Cell Rep

      Volume: 24(8) Issue: 8 Pages: 2191-2195

    • DOI

      10.1016/j.celrep.2018.07.057

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output2018

    • Author(s)
      Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
    • Journal Title

      Cell Rep.

      Volume: 25 Pages: 2704-2715

    • DOI

      10.1016/j.celrep.2018.11.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.2018

    • Author(s)
      Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
    • Journal Title

      Cell Rep

      Volume: 25 Issue: 12 Pages: 3371-3381

    • DOI

      10.1016/j.celrep.2018.11.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018

    • Author(s)
      Maruzuru, Y., T. Ichinohe, R. Sato, K. Miyake, T. Okano, T. Suzuki. T. Koshiba, N. Koyanagi, S. Tsuda, M. Watanabe, J. Arii, A. Kato, and Y. Kawaguchi.
    • Journal Title

      Cell Host Microbe

      Volume: 23 Issue: 2 Pages: 254-265

    • DOI

      10.1016/j.chom.2017.12.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD4+ CD521o T-cell expression contributes to the development of systemic lupus erythematosus2018

    • Author(s)
      Umeda M, Koga T, Ichinose K, Igawa T, Sato T, Takatani A, Shimizu T, Fukui S, Nishino A, Horai Y, Birai Y, Kawashiri S. -Y. Iwamoto N, Aramaki T, Tamai M, Nakamura H, Yamamoto K, Abiru N, Origuchi T, Ueki Y and Kawakami A
    • Journal Title

      Clinical Immunology

      Volume: 187 Pages: 50-57

    • DOI

      10.1016/j.clim.2017.10.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2.2018

    • Author(s)
      Hashimoto Y, Hata T, Tada M, Iida M, Watari A, Okada Y, Doi T, Kuniyasu H, Yagi K, Kondoh M
    • Journal Title

      Eur J Pharm Sci

      Volume: 70 Pages: 161-167

    • DOI

      10.1016/j.ejps.2018.02.016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies.2018

    • Author(s)
      Watanabe E, Fujita T, Shimono M, Koike H, Yasumoto S, Hirose S.
    • Journal Title

      eNeurologicalSci

      Volume: 12 Pages: 36-38

    • DOI

      10.1016/j.ensci.2018.08.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.2018

    • Author(s)
      Ohto, U., H. Ishida, T. Shibata, R. Sato, K. Miyake, and T. Shimizu.
    • Journal Title

      Immunity

      Volume: 48 Issue: 4 Pages: 649-658

    • DOI

      10.1016/j.immuni.2018.03.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.2018

    • Author(s)
      Pelka, K., D. Bertheloot, E. Reimer, K. Phulphagar, S. V. Schmidt, A, Christ, R. Stahl. N. Watson, K. Miyake, N. Hacohen, A. Haas, M. M. Brinkmann, A. Marshak-Rothstein, F. Meissner, and E. Latz.
    • Journal Title

      Immunity

      Volume: 48 Issue: 5 Pages: 911-922

    • DOI

      10.1016/j.immuni.2018.04.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ezhl Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.2018

    • Author(s)
      Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
    • Journal Title

      iScience

      Volume: 9 Pages: 161-174

    • DOI

      10.1016/j.isci.2018.10.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis.2018

    • Author(s)
      Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M. Zhang L, Iwakura Y, Nawa H, Higuchi M, Komatsu M, Fujii M.
    • Journal Title

      iScience.

      Volume: 30 Pages: 433-450

    • DOI

      10.1016/j.isci.2018.11.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In-frame Va1216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response2018

    • Author(s)
      Hattori M, Ishikawa O. Oikawa D, Amano H, Yasuda M, Kaira K, Ishida-Yamamoto A, Nakano H, Sawamura D, Terawaki SI, Wakamatsu K, Tokunaga F, Shimizu A.
    • Journal Title

      Journal of Dermatological Science

      Volume: 91 Issue: 1 Pages: 35-42

    • DOI

      10.1016/j.jdermsci.2018.03.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.2018

    • Author(s)
      Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 136 Pages: 93-96

    • DOI

      10.1016/j.jphs.2018.01.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways2018

    • Author(s)
      Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, Isomura Y, Kimura M
    • Journal Title

      Neuron

      Volume: 99(6) Issue: 6 Pages: 1302-1314

    • DOI

      10.1016/j.neuron.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice.2018

    • Author(s)
      Moriya S, Yamashita A. Kawashima S, Nishi R, Yamanaka A, Kuwaki T.
    • Journal Title

      Neuroscience

      Volume: 386 Pages: 16-23

    • DOI

      10.1016/j.neuroscience.2018.06.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reappraising newborn screening for cobalamin C disorder.2018

    • Author(s)
      Tocan V. Ohkubo K, Higashi K, Toda N, Kojima-Ishii K, Nishiyama K, Ishimura M, Takada H, Sakamoto O, Sasaki F, Yoshimura K, Hirose S, Ohga S.
    • Journal Title

      Pediatrics & Neonatology

      Volume: 59 Issue: 4 Pages: 415-417

    • DOI

      10.1016/j.pedneo.2017.11.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia2018

    • Author(s)
      Yukawa t, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R. Takahashi H, Kakita A, Someya T, *Nawa H
    • Journal Title

      Psychiatry Res

      Volume: 270 Pages: 940-946

    • DOI

      10.1016/j.psychres.2018.10.062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men.2018

    • Author(s)
      Fink J, Matsumoto M, Tamura Y.
    • Journal Title

      Steroids

      Volume: 161 Pages: 161-166

    • DOI

      10.1016/j.steroids.2018.08.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines2018

    • Author(s)
      Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
    • Journal Title

      Experimental Cell research

      Volume: 370 Issue: 2 Pages: 699-707

    • DOI

      10.1016/j.yexcr.2018.07.036

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling.2018

    • Author(s)
      Takeuchi Y., Kito A., et al.
    • Journal Title

      Exp. Cell Res.

      Volume: 371 Issue: 2 Pages: 417-425

    • DOI

      10.1016/j.yexcr.2018.09.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues.2018

    • Author(s)
      Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y.
    • Journal Title

      Biochemisty

      Volume: 57 Issue: 38 Pages: 5544-5556

    • DOI

      10.1021/acs.biochem.8b00583

    • NAID

      120006708206

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiroptical Inversion of Europium(Ⅲ) Complexes by Changing a Remote Stereogenic Center of a C2-symmetric Bispyrrolidinoindoline Manifold2018

    • Author(s)
      Tomoaki Taniguchi, Akira Tsubouchi, Yuki Imai, Junpei Yuasa, Hiroki Oguri
    • Journal Title

      J. Org. Chem.

      Volume: 83 Issue: 24 Pages: 15284-15296

    • DOI

      10.1021/acs.joc.8b02550

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and De Novo Synthesis of 6-Aza-artemisinins2018

    • Author(s)
      Karnakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura, Hiroki Oguri
    • Journal Title

      Org. Lett.

      Volume: 20 Issue: 15 Pages: 4667-4671

    • DOI

      10.1021/acs.orglett.8b01987

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A. and N-Fmoc Saframycin Y32018

    • Author(s)
      Ryo Tanifuji, Kento Koketsu, Michiko Takakura, Ryutaro Asano, Atsushi Minami, Hideaki Oikawa, Hiroki Oguri
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 140 Issue: 34 Pages: 1070510709-1070510709

    • DOI

      10.1021/jacs.8b07161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-Ⅲ and Racl.2018

    • Author(s)
      Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H.
    • Journal Title

      Oncogene

      Volume: 37 Pages: 5416-5434

    • DOI

      10.1038/s41388-018-0286-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD22018

    • Author(s)
      Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, Kurumi Nishi, Makiko Meguro-Horike, Soichiro Sasaki, Kenji Kita, Shin-ichi Horike, Kaori Saitoh, Keiko Kato, Kaori Igarashi, Takahiko Murayama, Susumu Kohno, Chiaki Takahashi, Naofumi Mukaida, Seiji Yano, Tomoyoshi Soga, Arinobu Tojo, Noriko Gotoh
    • Journal Title

      Oncogene

      Volume: 38 Issue: 14 Pages: 2464-2481

    • DOI

      10.1038/s41388-018-0589-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.2018

    • Author(s)
      Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
    • Journal Title

      Cell Death. Discovery

      Volume: 4 Issue: 104 Pages: 104-104

    • DOI

      10.1038/s41420-018-0117-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo reprogramming drives Kras-induced cancer development2018

    • Author(s)
      Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito, Yoshiya Kawaguchi, Takuya Yamamoto, Yasuhiro Yamada
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 2081-2081

    • DOI

      10.1038/s41467-018-04449-5

    • NAID

      120006473761

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience.2018

    • Author(s)
      Miyazaki K, Miyazaki KW, Yamanaka A, Tokuda T, Tanaka KF, Doya K.
    • Journal Title

      Nat Commun

      Volume: 9 Pages: 2048-2048

    • DOI

      10.1038/s41467-018-04496-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis2018

    • Author(s)
      Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S. Kawazu M, Mano H. Kitamura T.
    • Journal Title

      Nature Commun.

      Volume: 9 Issue: 1 Pages: 1-18

    • DOI

      10.1038/s41467-018-05085-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix2018

    • Author(s)
      Fukuda M, Yoshizawa T, et al.
    • Journal Title

      Nat Commun

      Volume: 9 Pages: 1-14

    • DOI

      10.1038/s41467-018-05187-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] UBL3 modification influences protein sorting to small extracellular vesicles.2018

    • Author(s)
      Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.
    • Journal Title

      Nature Communications

      Volume: 9 Pages: 1-14

    • DOI

      10.1038/s41467-018-06197-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase l.2018

    • Author(s)
      Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Ishitani R, Tokunaga F, Kasuya G, Nureki O.
    • Journal Title

      Nat Commun.

      Volume: 9 Pages: 4424-4424

    • DOI

      10.1038/s41467-018-06922-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal sirtl regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice.2018

    • Author(s)
      Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O. Suga T. Kobayashi M. Yamanaka A, Harada A, Nakagawa T. Onaka T, Kitamura T.
    • Journal Title

      Nat Commun

      Volume: 9 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41467-018-07033-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis.2018

    • Author(s)
      Sato, R., A. Kato, T. Chimura, S. I. Saitoh, T. Shibata, Y. Murakami, R. Fukui, K. Liu, Y. Zhang, J. Arii, G. H. Sun-Wada. Y. Wada, T. Ikenoue, G. N. Barber, T. Manabe, Y. Kawaguchi, and K. Miyake.
    • Journal Title

      Nat Immunol

      Volume: 19 Issue: 10 Pages: 1071-1082

    • DOI

      10.1038/s41590-018-0203-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-vide distribution of linker histone H1.0 is independent of MeCP22018

    • Author(s)
      Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, zoghbi HY.
    • Journal Title

      Nature Neuroscience

      Volume: 21 Issue: 6 Pages: 794-798

    • DOI

      10.1038/s41593-018-0155-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response.2018

    • Author(s)
      Miyasato Y, Yoshizawa T, et al.
    • Journal Title

      Sci. Rep

      Volume: 8 Pages: 5927-5927

    • DOI

      10.1038/s41598-018-24257-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of cerebellar ataxic gait by injecting Cblnl into the cerebellum of cblnl-null mice2018

    • Author(s)
      Takeuchi E, Ito-Ishida A, Yuzaki M, Yanagihara D.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 6184-6184

    • DOI

      10.1038/s41598-018-24490-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.2018

    • Author(s)
      Takayama Y, Ando T, Ichikawa J, Haro H
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 11320-11320

    • DOI

      10.1038/s41598-018-29669-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model.2018

    • Author(s)
      Aoto Y, Okumura K, Hachiya T, Hase S, Wakabayashi Y, Ishikawa F, Sakakibara Y.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 12994-12994

    • DOI

      10.1038/s41598-018-31349-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis.2018

    • Author(s)
      Tsurumaru, H., Ito. N., Mori, K., Wakai. S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and Harayama, S.,
    • Journal Title

      Scientific Reports 8

      Volume: 8 Pages: 15149-15149

    • DOI

      10.1038/s41598-018-33541-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASXLl and SETBPI mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation2018

    • Author(s)
      Saika M, Inoue D, Nagase R, Sato N, Tsuchiya A, Yabushita T, Kitamura T, Goyama S.
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 15873-15873

    • DOI

      10.1038/s41598-018-33881-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of G-quadruplex ligand for selective induction of parallel-type topology2018

    • Author(s)
      Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
    • Journal Title

      Org. Biomol. Chem.

      Volume: 16 Pages: 7375-7382

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly2018

    • Author(s)
      Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, Hiroki Oguri
    • Journal Title

      Org. Biomol. Chem.

      Volume: 16 Pages: 9305-9313

    • DOI

      10.1039/c8ob02287a

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between cardiac myosin-binding protein C and formin Fhod3.2018

    • Author(s)
      Natsuyama S, Kage Y. Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 115 Issue: 19

    • DOI

      10.1073/pnas.1716498115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis.2018

    • Author(s)
      Kurihara Y. Makita Y. Kawashima M. Fujita T. Iwasaki S. and Matsui M.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 115 Issue: 30 Pages: 7831-7836

    • DOI

      10.1073/pnas.1804971115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anabolic-androgenic steroids : procurement and administration practices of doping athletes.2018

    • Author(s)
      Fink J, Jackney A, Matsumoto M, Maekawa T, Nakazato K, Horie S.
    • Journal Title

      Physician, Sportsmedicine 2

      Volume: 47 Issue: 1 Pages: 10-14

    • DOI

      10.1080/00913847.2018.1526626

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of rat monoclonal antibodies specific for DZIP32018

    • Author(s)
      Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 37 Issue: 3 Pages: 153-157

    • DOI

      10.1089/mab.2018.0005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 12018

    • Author(s)
      Oikawa D, Shiota M, Wanibuchi H. Tokunaga F.
    • Journal Title

      Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

      Volume: 37 Issue: 4 Pages: 180-184

    • DOI

      10.1089/mab.2018.0023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes2018

    • Author(s)
      Kosuke Ishikawa, Yuta Kobayashi, Yutaro wakabayashi, Shinya Watanabe and Kentaro Semba
    • Journal Title

      Biology Methods and Protocols

      Volume: 3

    • DOI

      10.1093/biomethods/bpy003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biallelic UFMI and UFCI mutations expand the essential role of ufmylation in brain development.2018

    • Author(s)
      Nahorski MS, Maddirevula S, Ishimura R, Alsahli S, Brady AF, Begemann A, Mizushima T, Guzman-Vega FJ, Obata M, Ichimura Y, Alsaif HS, Anazi S, Ibrahim N, Abdulwahab F, Hashem M, Monies D, Abouelhoda M, Meyer BF, Alfadhel M, Eyaid W, Zweier M, Steindl K, Rauch A, Arold ST, Woods CG, Komatsu M, Alkuraya FS.
    • Journal Title

      Brain

      Volume: 141 Pages: 1934-1945

    • DOI

      10.1093/brain/awy135

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes2018

    • Author(s)
      Hisashi Hasumi, Mitsuko Furuya, Kenji Tatsuno, Shogo Yamamoto, Masaya Baba, Yukiko Hasumi, Yasuhiro Isono, Kae Suzuki, Ryosuke Jikuya, Shinji Otake, Kentaro Muraoka, Kimito Osaka, Narihiko Hayashi, Kazuhide Makiyama, Yasuhide Miyoshi, Keiichi Kondo, Noboru Nakaigawa, Takashi Kawahara, Koji Izumi, Junichi Teranishi, Yasushi Yumura, Hiroji Uemura, Yoji Nagashima, Adam R Metwalli, Laura S Schmidt,
    • Journal Title

      Human molecular genetics

      Volume: 印刷中 Issue: 15 Pages: 2712-2724

    • DOI

      10.1093/hmg/ddy181

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.2018

    • Author(s)
      Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
    • Journal Title

      Sleep

      Volume: 41(9) Issue: 9

    • DOI

      10.1093/sleep/zsy116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency2018

    • Author(s)
      Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
    • Journal Title

      Journal of Dermatology

      Volume: 45 Issue: 5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.2018

    • Author(s)
      Jin F, Li X. Deng Y, Timilshina M. Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
    • Journal Title

      Allergy

    • DOI

      10.1111/all.13702

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Study on the tumor-induced angiogenesis using mathematical models.2018

    • Author(s)
      Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 15-23

    • DOI

      10.1111/cas.13395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma2018

    • Author(s)
      Sumiyoshi K, Koso H, Watanabe S.
    • Journal Title

      Cancer Sci.

      Volume: 109 Issue: 5 Pages: 1513-1523

    • DOI

      10.1111/cas.13579

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.2018

    • Author(s)
      Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 6 Pages: 2036-2045

    • DOI

      10.1111/cas.13594

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.2018

    • Author(s)
      Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
    • Journal Title

      Cancer Sci

      Volume: 109 Pages: 2497-2508

    • DOI

      10.1111/cas.13695

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PHLDAI, another PHLDA family protein that inhibits AKt.2018

    • Author(s)
      Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 3532-3542

    • DOI

      10.1111/cas.13796

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.2018

    • Author(s)
      Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 12 Pages: 4003-4014

    • DOI

      10.1111/cas.13805

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological and pathological relevance of cell competition in fly to mammals.2018

    • Author(s)
      Shunsuke Kon.
    • Journal Title

      Development, Growth and Differentiation

      Volume: 60 Pages: 14-20

    • DOI

      10.1111/dgd.12415

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transdifferentiation of human somatic cells by ribosome.2018

    • Author(s)
      Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
    • Journal Title

      Development Growth & Differentiation

      Volume: 60(5) Pages: 241-247

    • DOI

      10.1111/dgd.12538

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and functional analysis of inflammation-related miRNAs in skin wound repair.2018

    • Author(s)
      Mori R, Tanaka K, Shimokawa I
    • Journal Title

      Dev Growth Differ

      Volume: 60 Issue: 6 Pages: 306-315

    • DOI

      10.1111/dgd.12542

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma.2018

    • Author(s)
      Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H
    • Journal Title

      Histopathol

      Volume: in press Issue: 4 Pages: 539-48

    • DOI

      10.1111/his.13097

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlcl-over-expressing mice.2018

    • Author(s)
      Kikuchibara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
    • Journal Title

      J Neurochem

      Volume: 147 Issue: 3 Pages: 344-360

    • DOI

      10.1111/jnc.14486

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of exons encoding carboxypeptidase domain of Nnal results in Purkinje cell degeneration (pcd) phenotype.2018

    • Author(s)
      Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
    • Journal Title

      J Neurochem.

      Volume: 147 Pages: 557-572

    • DOI

      10.1111/jnc.14591

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional characterization of recombinant snake venom rhodocytin : rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis.2018

    • Author(s)
      Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
    • Journal Title

      J Thromb Haemost

      Volume: 16 Issue: 5 Pages: 960-972

    • DOI

      10.1111/jth.13987

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.2018

    • Author(s)
      Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.
    • Journal Title

      Sci Transl Med

      Volume: 10 Pages: 447-447

    • DOI

      10.1126/scitranslmed.aao4953

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multisensory enhancement of burst activity in an insect auditory neuron2018

    • Author(s)
      Someya, M, and Ogawa, H.
    • Journal Title

      J Neurophysiol.

      Volume: 印刷中 Pages: 139-148

    • DOI

      10.1152/jn.00798.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images.2018

    • Author(s)
      Toratani, M., Konno, M., Asai. A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
    • Journal Title

      Cancer Res

      Volume: 78

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP42018

    • Author(s)
      Kajiwara C, Fumoto K, Kimura H, Nojima S, Asano K, Odagiri K, Yamasaki M, Hikita H, Takehara T, Doki Y, Morii E, Kikuchi A.
    • Journal Title

      Cancer Res.

      Volume: 78(21) Pages: 3471-3484

    • DOI

      10.1158/0008-5472.can-18-1749

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.2018

    • Author(s)
      Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T*, Sato K
    • Journal Title

      Mol Cancer Res

      Volume: 16 Issue: 3 Pages: 554-563

    • DOI

      10.1158/1541-7786.mcr-17-0393

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.2018

    • Author(s)
      Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
    • Journal Title

      Cancer Discovery

      Volume: 8 Issue: 11 Pages: 1438-1457

    • DOI

      10.1158/2159-8290.cd-17-1203

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.2018

    • Author(s)
      Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
    • Journal Title

      Jounal of Clinical Investigation

      Volume: 128 Issue: 12 Pages: 5603-5619

    • DOI

      10.1172/jci121679

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation.2018

    • Author(s)
      Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
    • Journal Title

      J Clin Invest

      Volume: 128 Issue: 9 Pages: 3872-3886

    • DOI

      10.1172/jci94645

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats2018

    • Author(s)
      Miyazawa, Y., Takahashi, Y., Watabe, A. M. and Kato F.
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 174480691880710-174480691880710

    • DOI

      10.1177/1744806918807102

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System2018

    • Author(s)
      Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
    • Journal Title

      SLAS Discovery

      Volume: 23 Issue: 10 Pages: 1018-1029

    • DOI

      10.1177/2472555218793066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Splice-site mutation causing partial retention of intron in the FLCN gene in Birt-Hogg-Dubé syndrome : a case report2018

    • Author(s)
      Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
    • Journal Title

      BMC medical genomics

      Volume: 42 Pages: 42-42

    • DOI

      10.1186/s12920-018-0359-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.2018

    • Author(s)
      Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
    • Journal Title

      Biomark Res.

      Volume: 6 Pages: 16-16

    • DOI

      10.1186/s40364-018-0130-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucagonoma With Necrolytic Migratory Erythema : Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.2018

    • Author(s)
      Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Niyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 23 Issue: 7 Pages: 2417-2423

    • DOI

      10.1210/jc.2017-02646

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p62/SQSTM1-steering the cell through health and disease.2018

    • Author(s)
      Sánchez-Martin P, Komatsu M.
    • Journal Title

      J Cell Sci.

      Volume: 131

    • DOI

      10.1242/jcs.222836

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hidden Peptides Encoded by Putative Noncoding RNAs2018

    • Author(s)
      Matsumoto A., Nakayama KI.
    • Journal Title

      Cell Struct. Funct.

      Volume: 18;43(1) Issue: 1 Pages: 75-83

    • DOI

      10.1247/csf.18005

    • NAID

      130006742309

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Anti-tumorigenic Role of the Warburg Effect at Emergence of Transformed Cells.2018

    • Author(s)
      Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
    • Journal Title

      Cell Struct. Funct.

      Volume: 43 Issue: 2 Pages: 171-176

    • DOI

      10.1247/csf.18018

    • NAID

      130007420412

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] i-Motif-binding ligand and their effects on the structure and biological functions of i-motif2018

    • Author(s)
      Shadi Sedghi Masoud, Kazuo Nagasawa
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 66 Issue: 12 Pages: 1091-1103

    • DOI

      10.1248/cpb.c18-00720

    • NAID

      130007539147

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UPA-Seq : Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking.2018

    • Author(s)
      Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
    • Journal Title

      RNA

      Volume: 24 Issue: 12 Pages: 1785-1802

    • DOI

      10.1261/rna.067611.118

    • NAID

      120006545959

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Freezing sperm in short straws reduces storage space and allows transport in dry ice.2018

    • Author(s)
      Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
    • Journal Title

      J. Reprod. Dev.

      Volume: 64 Issue: 6 Pages: 541-545

    • DOI

      10.1262/jrd.2018-100

    • NAID

      130007494562

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility.2018

    • Author(s)
      Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T. Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
    • Journal Title

      Journal of Neuroscience

      Volume: 38 Pages: 10220-10235

    • DOI

      10.1523/jneurosci.1590-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New observations in neuroscience using superresolution microscopy2018

    • Author(s)
      *Igarashi M, Nozumi M, Wu LG, Cella Zanacchi F, Katona I, Barna L, Xu P, Zhang M, Xue F. Boyden E
    • Journal Title

      J Neurosci

      Volume: 38 Pages: 9459-9467

    • DOI

      10.1523/jneurosci.1678-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds.2018

    • Author(s)
      de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To. Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
    • Journal Title

      EMBO Mol Med

      Volume: 2018 Issue: 10 Pages: 1-21

    • DOI

      10.15252/emmm.201809024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of PTH in mouse skin tumorigenesis.2018

    • Author(s)
      Okumura K, Saito M, and Wakabayashi Y.
    • Journal Title

      Integrative Cancer Science and Therapeutics

      Volume: 5 Pages: 1-1

    • DOI

      10.15761/icst.1000271

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer2018

    • Author(s)
      Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 37 Pages: 24718-24730

    • DOI

      10.18632/oncotarget.25339

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer2018

    • Author(s)
      Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 100 Pages: 37367-37378

    • DOI

      10.18632/oncotarget.26427

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability2018

    • Author(s)
      Aonuma H., Totani Y., Sakakibara M., Lukowiak K. and Ito E.
    • Journal Title

      BIOPHYSICS

      Volume: 15 Issue: 0 Pages: 129-135

    • DOI

      10.2142/biophysico.15.0_129

    • NAID

      130006736414

    • ISSN
      2189-4779
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prednisolone-responsive Postpartum IgG4-related Hypophysitis.2018

    • Author(s)
      Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
    • Journal Title

      Intern Med

      Volume: 57 Issue: 3 Pages: 367-375

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo2018

    • Author(s)
      Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
    • Journal Title

      Anticancer Res

      Volume: 38 Pages: 4257-4266

    • DOI

      10.21873/anticanres.12722

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA.2018

    • Author(s)
      Fukui, R., C. Yamamoto, F. Matsumoto, M. Onji, T. Shibata, Y. Murakami, A. Kanno, T. Hayashi, N. Tanimura, N. Yoshida, and K. Miyake.
    • Journal Title

      Front Immunol

      Volume: 9 Pages: 1491-1491

    • DOI

      10.3389/fimmu.2018.01491

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.2018

    • Author(s)
      Tel-Karthaus N, Kers-Rebel ED, Looman MW, Ichinose H, de Vries CJ, Ansems M
    • Journal Title

      Front Immunol

      Volume: 9 Pages: 1797-1797

    • DOI

      10.3389/fimmu.2018.01797

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Organelle Optogenetics : Direct Manipulation of Intercellular Ca2+ Dynamics by Light.2018

    • Author(s)
      Asano T, Igarashi H, Ishizuka T, Yawo H
    • Journal Title

      Front Neurosci.

      Volume: 12 Pages: 00561-00561

    • DOI

      10.3389/fnins.2018.00561

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of p62/SQSTM1-Keap1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer.2018

    • Author(s)
      Ichimura Y, Komatsu M.
    • Journal Title

      Front Oncol.

      Volume: 8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inactivation of serotonergic neurons in the rostral medullary raphe attenuates stress-induced tachypnea and tachycardia in mice.2018

    • Author(s)
      Ikoma Y, Kusumoto-Yoshida I, Yamanaka A, Ootsuka Y, Kuwaki T.
    • Journal Title

      Front Physiol

      Volume: 9 Pages: 1-16

    • DOI

      10.3389/fphys.2018.00832

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SK-216, a novel inhibitor of plasminogen activator inhibitor-1, suppresses lung metastasis of human osteosarcoma2018

    • Author(s)
      Tsuge M, Osaki M, Sasaki R, Hirahata M, Okada F
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 3 Pages: 736-736

    • DOI

      10.3390/ijms19030736

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap.2018

    • Author(s)
      Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H.
    • Journal Title

      Int J Mo2 Sci

      Volume: 19 Pages: 1203-1203

    • DOI

      10.3390/ijms19041203

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment.2018

    • Author(s)
      Morinaga T, Yamaguchi N, Nakayama Y, Tagawa M, Yamaguchi N
    • Journal Title

      Int J Mo1 Sci.

      Volume: 19 Issue: 6 Pages: 1811-1811

    • DOI

      10.3390/ijms19061811

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The multifarious functions of pyruvate kinase M2 in oral cancer cells.2018

    • Author(s)
      Kurihara-Shimomura M, Sasahira T, Nakashima C, Kuniyasu H, Shimomura H, Kirita T.
    • Journal Title

      Int J Mol Sci

      Volume: 19 Issue: 10 Pages: 10-10

    • DOI

      10.3390/ijms19102907

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.2018

    • Author(s)
      Shimizu Y, Tamada S, Kato M, Hirayama Y, Takeyama Y, Iguchi T, Sadar MD, Nakatani T.
    • Journal Title

      J Clin Med

      Volume: 7 Issue: 11 Pages: 1-14

    • DOI

      10.3390/jcm7110444

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] c-Met affects gemcitabine resistance during carcinogenesis in a mouse model of pancreatic cancer2018

    • Author(s)
      Noguchi K, Konno M, Eguchi H, Kawamoto K, Mukai R, Nishida N, Koseki J, Wada H, Akita H, Satoh T, Marubashi S, Nagano H, Doki Y, Mori M, Ishii H.
    • Journal Title

      Oncol Lett

      Volume: 16 Issue: 2 Pages: 1892-1898

    • DOI

      10.3892/ol.2018.8793

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intake of medium-chain fatty acids induces oxidative stress and to atrophy the myocardium2018

    • Author(s)
      Miyagawa Y, Mori T, Goto K, Fujiwara-Tani R, Kishi S, Sasaki T, Fujii K, Ohmori H, Kawahara I, Kuniyasu H
    • Journal Title

      Lipids in Health and Disease

      Volume: 17 Pages: 258-258

    • DOI

      10.1186/s12944-018-0908-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of intranuclear angiotensin-Ⅱ type 2 receptor in oral squamous cell carcinoma2018

    • Author(s)
      Natsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 93 Pages: 36561-36574

    • DOI

      10.18632/oncotarget.26337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] “サイズ”で斬る生物学への誘い2018

    • Author(s)
      山本一男
    • Journal Title

      実験医学

      Volume: 36 Issue: 13 Pages: 2168-2173

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 超低周波電磁界の神経幹細胞に及ぼす影響評価に関する研究2018

    • Author(s)
      石堂正美
    • Journal Title

      磁気と健康

      Volume: 30 Pages: 20-25

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Generation of functional oocytes of common marmoset by xeno-transplantation of ovarian tssue2018

    • Author(s)
      Shiori Miura, Yoshitaka Maeda, Jun Miyamoto, Ena Nakatsukasa, Nobuyoshi Fujisawa, Miki Miwa, Katsuki Nakamura, Kenji Sakimura and Toshikuni Sasaoka
    • Journal Title

      Proceedings of International Symposium on Animal Production and Conservation for Sustainable Development 2018

      Pages: 31-33

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Piwi Nuclear Localization and Its Regulatory Mechanism in Drosophila Ovarian Somatic Cells.2018

    • Author(s)
      Yashiro R, Murota Y, Nishida KM, Yamashiro H, Fujii K, Ogai A, Yamanaka S, Negishi L, Siomi H, Siomi MC.
    • Journal Title

      Cell Reports

      Volume: 23 Pages: 3647-3657

    • DOI

      10.1016/j.celrep.2018.05.051

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mobility and biomechanical functions in the aging male : testosterone and the Locomotive Syndrome.2018

    • Author(s)
      Fink J, Jackney A, Matsumoto M, Maekawa T, Nkazato K, Horie S.
    • Journal Title

      Aging Male

      Volume: 29 Pages: 1-8

    • DOI

      10.1080/13685538.2018.1504914

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The interplay between autophagy and tumorigenesis : exploiting autophagy as a means of anticancer therapy.2018

    • Author(s)
      Lorente J. Velandia C, Leal JA, Garcia-Mayea Y, Lyakhovich A, Kondoh H, LLeonart ME.
    • Journal Title

      Biol Rev Camb Philos Soc.

      Volume: 93 Issue: 1 Pages: 152-165

    • DOI

      10.1111/brv.12337

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Complete Sequences of the HTLV-1 Proviral Genomes from Newly Established ATL cell-lines in Oita Prefecture, Japan2018

    • Author(s)
      Takuro Fukumoto, Emi Ikebe, Masao Ogata, Kazuhiro Kohno, Madoka Kuramitsu, Yusuke Sato, Nichole Fife, Takashi Matsumoto, Takaaki Yahiro, Masanori Ikeda, Shuichi Kusano, Akihiko Okayama, Mitsuo Hori, Naoki Hijiya, Yoshiyuki Tsukamoto, Yuka Hirashita, Masatsugu Moriyama, Kamruddin Ahmed, Hiroo Hasegawa, Akira Nishizono, Masumichi Saito*, and Hidekatsu Iha*
    • Journal Title

      Genome Announcements

      Volume: 6 Issue: 25

    • DOI

      10.1128/genomea.00090-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TUFTI interacts with RABGAP1 and regulates mTORCI signaling.2018

    • Author(s)
      Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, Morishita Y, Taguchi L, Morikawa M, Heldin CH, Noda T, Ehata S, Miyazono K, Koinuma D.
    • Journal Title

      Cell Discov.

      Volume: 4 Pages: 1-1

    • DOI

      10.1038/s41421-017-0001-2

    • NAID

      120006707418

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels(VSOP/Hv1)2018

    • Author(s)
      Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y.
    • Journal Title

      Channels

      Volume: 12 Issue: 1 Pages: 43108-43108

    • DOI

      10.1080/19336950.2017.1385684

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptie transmission in cerebellum.2018

    • Author(s)
      Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CI, Long JJ, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ, et al.
    • Journal Title

      Cell Res.

      Volume: 28 Issue: 1 Pages: 90-110

    • DOI

      10.1038/cr.2017.128

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Input-specific NMDAR-Dcpendent potentiation of dendritic GABAergic inhibition.2018

    • Author(s)
      Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ.
    • Journal Title

      Neuron

      Volume: 97 Issue: 2 Pages: 368-377

    • DOI

      10.1016/j.neuron.2017.12.032

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting the SphK1/SIP/S1PR1 axis that links obesity, chronic inflammation and breast cancer metastasis.2018

    • Author(s)
      Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.
    • Journal Title

      Cancer Res.

      Volume: 78 Pages: 1713-1725

    • DOI

      10.1158/0008-5472.can-17-1423

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rctrograde signaling from progranulin to sortl counteracts synapse climination in the developing cerebellum.2018

    • Author(s)
      Ucsaka X, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M.
    • Journal Title

      Ncuron

      Volume: 97 Issue: 4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keratan Sulfate Phenotype in the β-1, 3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea.2018

    • Author(s)
      Littlechild SL, Young RD, Caterson B, Yoshida H, Yamazaki M, Sakimura K, Quantock AJ, Akama TO.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 59 Pages: 1641-1641

    • DOI

      10.1167/iovs.17-22716

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deletion of GIRK2 subunit containing GIRK channcls of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice.2018

    • Author(s)
      Honda, I., Araki, K., Honda S., Soeda, F., Shin, M. C., Misumi, S., Yamamura, K. I. and Takahama, K.
    • Journal Title

      Ncurosci. Lett.

      Volume: 665 Pages: 140-146

    • DOI

      10.1016/j.neulet.2017.11.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WDRll-modiated Hedgchog signalling defects underlie a new ciliopathy related to kallmann syndrome.2018

    • Author(s)
      Kim, Y. J., Osborn, D. P., Lee, J. Y., Araki, M., Araki, K., Mohun, T., Kansakoski, J., Brandstack, N., Kim, H. T., Miralles, F., Kim, C. H., Brown, N. A., Kim, H. G., Martinez-Barbera, J. P., Ataliotis, P., Raivio, T., Layaman, L, C. and Kim, S. H.
    • Journal Title

      EMBO Rep.

      Volume: 19 Pages: 269-289

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defective mitochondrial tRNA taurine modification activates global protcostress and leads to mitochondrial disease.2018

    • Author(s)
      Fakruddin, M., Wei, F. Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T. and Tomizawa, K.
    • Journal Title

      Cell Rep

      Volume: 22 Pages: 482-496

    • DOI

      10.1016/j.celrep.2017.12.051

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci.2018

    • Author(s)
      Li, X., Lyu, Y., Shon, J., Mu, Y., Qiang, L., Liu, L., Araki, K., Imbimbo, B. P., Yamamura, K., Jin, S. and Li, Z.
    • Journal Title

      Lab Invest.

      Volume: 98 Pages: 512-524

    • DOI

      10.1038/s41374-017-0019-y

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Incomplete Clearance of apoptotic cells by core I-derived O-glycan-deficient resident peritoncal macrophages.2018

    • Author(s)
      Wakui H, Fuseya S, Suzuki R, Shimbo M, Okada R, Hamada M, Kuno A, Hagiwara K, Sato T, Narimatsu H, Kudo T, Takahashi S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495 Pages: 2017-2023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acctylgalactosaminyltransferase-l and -2.2018

    • Author(s)
      Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, Okada R, Wakui H, Tsunakawa Y, Watanabe H, Kimate K, Narimatsu H, Kudo T, Takahashi S.
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI

      10.1371/journal.pone.0190333

    • NAID

      120006454805

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcription factor MafB may play an important role in secondary hyperparathyroidism.2018

    • Author(s)
      Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S.
    • Journal Title

      Kidney Int

      Volume: 93 Pages: 54-68

    • DOI

      10.1016/j.kint.2017.06.023

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced antibody responses in a novel NOG transgenic mouse with rostored lymph node organogenesis.2018

    • Author(s)
      Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.
    • Journal Title

      Front Immunol

      Volume: 8 Pages: 2017-2017

    • DOI

      10.3389/fimmu.2017.02017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Application of genome editing technologies in rats for human discase models.2018

    • Author(s)
      Yoshimi K, Mashimo T.
    • Journal Title

      Journal of Human Gonetics

      Volume: 63 Pages: 115-123

    • DOI

      10.1038/s10038-017-0346-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages.2018

    • Author(s)
      Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
    • Journal Title

      Int J Dev Neurosci.

      Volume: 66 Pages: 1-8

    • DOI

      10.1016/j.ijdevneu.2017.11.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redundancy of matrix metalloprotcinases cloaving beta-dystroglycan : Implications for the pathogenesis of sarcoglycanopathy2018

    • Author(s)
      Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
    • Journal Title

      Biochcmical Biophysical Research Communications

      Volume: 30(1) Issue: 2 Pages: 199-205

    • DOI

      10.1016/j.bbrc.2017.08.048

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive behavioral analysis of tryptophan 2,3-dioxygenaso (Tdo2) knockout mice2018

    • Author(s)
      Hattori S, Takao K, Funakoshi H, *Miyakawa T
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 38 Pages: 52-60

    • DOI

      10.1002/npr2.12006

    • NAID

      120006496928

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decroased brain pH as a shared endophenotype of psychiatric disorders2018

    • Author(s)
      Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T
    • Journal Title

      Neuropsychopharmacology

      Volume: 43 Pages: 459-468

    • DOI

      10.1038/npp.2017.167

    • NAID

      120006537072

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bchavioral effccts of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice2018

    • Author(s)
      Shoji H, Irino Y, Yoshida M, Miyakawa T
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 38 Pages: 18-36

    • DOI

      10.1002/npr2.12002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Initial scverity of major depression and efficacy of new generation antidepressants : Individual-participant data meta-analysis.2018

    • Author(s)
      Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S, Cipriani A
    • Journal Title

      Acta Psychiatr Scand

      Volume: 印刷中 Pages: 450-458

    • DOI

      10.1111/acps.12886

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Japanese TR-cancer pain research group, resistin is a novel marker for postoperative pain intensity.2018

    • Author(s)
      Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakabe Y, Yamada Y
    • Journal Title

      Anesth Analg

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Early manifestation of dopressivc-like behavior in transgenic mico that express demcntia with Lcwy bodies-linked mutant beta-synuclein.2018

    • Author(s)
      Fujita M, Hagino Y, Takamatsu Y, Shimizu Y, Takamatsu Y, Ikeda K, Hashimoto M
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: 印刷中 Pages: 95-97

    • DOI

      10.1002/npr2.12009

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association bctweon rs2275913 single-nuclootide polymorphism of the interlcukin-17A gone and perioperative analgesic use in cosmetic orthognathic surgery.2018

    • Author(s)
      Ohka S, Nishizawa D, Hasogawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikoda K
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: e12010 Pages: 67-74

    • DOI

      10.1002/npr2.12010

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between the rs7583431 single-nucleotide polymorphism close to the activating transeription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the cold pain test.2018

    • Author(s)
      Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takehashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
    • Journal Title

      Neuropsychopharmacol. Rep.

      Volume: 印刷中 Pages: 86-91

    • DOI

      10.1002/npr2.12012

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between N-methy1-D-aspartate receptor 2B subunit gene polymorphisms and personality traits in a young Japanese population.2018

    • Author(s)
      Narita S, Yoshihara E, Nishizawa D, Numajiri M, Onozawa Y, Ikeda K, Iwahashi K
    • Journal Title

      East Asian Arch Psychiatry

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized controlled study of the offoct of ifenprodil on alcohol use in patients with alcohol dependence.2018

    • Author(s)
      Sugaya N, Ogai Y, Aikawa Y, Yumoto Y, Takahama M, Tanaka M, Haraguchi A, Umeno M, Ikeda K
    • Journal Title

      Neuropsychopharmacology Rep

      Volume: 38(1) Pages: 9-17

    • DOI

      10.1002/npr2.12001

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgcsic offoct of fentanyl in the prooporative cold pressor-induced pain test.2018

    • Author(s)
      Takahashi K, Nishizawa D, Kasai S, Koukita Y, Fukuda K, Ichinohe T, Ikcda K
    • Journal Title

      J Pharmacol Sci

      Volume: 136(3) Issue: 3 Pages: 107-113

    • DOI

      10.1016/j.jphs.2018.02.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide scan identifies candidate loci related to romifentanil requiroments during laparoscopic-assisted colectomy.2018

    • Author(s)
      Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
    • Journal Title

      Pharmacogenomics

      Volume: 19 Issue: 2 Pages: 113-127

    • DOI

      10.2217/pgs-2017-0109

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gone and severity of both cancer pain and postoperative pain.2018

    • Author(s)
      Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
    • Journal Title

      Pain Med

      Volume: 19(2) Issue: 2 Pages: 348-354

    • DOI

      10.1093/pm/pnx102

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pharmacogenetics approach to pain management.2018

    • Author(s)
      Yoshida K, Nishizawa D, Ide S, Ichinohe T, Fukuda K, Ikeda K
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: 38 Issue: 1 Pages: 2-8

    • DOI

      10.1002/npr2.12003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 創薬開発に向けた産官学連携-Public Private Partnerships, PPPs-2018

    • Author(s)
      池田和隆, 小居秀紀, 菊地哲朗, 森尾保徳, 川上善之, 須原哲也, 中込和幸, 山脇成人
    • Journal Title

      臨床精神医学

      Volume: 47 Pages: 315-319

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 薬剤選択に寄与する研究環境の整備2018

    • Author(s)
      中込和幸, 森尾保徳, 小居秀紀, 池田和隆, 山脇成人
    • Journal Title

      臨床精神薬理

      Volume: 21 Pages: 155-161

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 依存の神経・分子メカニズム解析のための動物モデル2018

    • Author(s)
      井手聡一郎, 池田和隆
    • Journal Title

      分子精神医学

      Volume: 18 Issue: 1 Pages: 15-21

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Delayed Degradation and Impaired Dondritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice.2018

    • Author(s)
      Steward O, Matsudaira Yee K, Farris S, Pirbhoy PS, Worley P, Okamura K, Okuno H, Bito H.
    • Journal Title

      Front Mol Neurosci

      Volume: 10 Pages: 1-1

    • DOI

      10.3389/fnmol.2017.00435

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex2018

    • Author(s)
      Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K
    • Journal Title

      IBRO Reports

      Volume: 4 Pages: 22-37

    • DOI

      10.1016/j.ibror.2018.01.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex2018

    • Author(s)
      Ueno H, Takao K, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Aoki S, Ishihara T
    • Journal Title

      Neurochcm Int

      Volume: 112 Pages: 59-70

    • DOI

      10.1016/j.neuint.2017.11.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormalities in perineuronal nots and behavior in mice lacking CSGalNAcT1, a key cnzymc in chondroitin sulfate synthesis2018

    • Author(s)
      Yoshioka N, Miyata S, Tamada A, Watanabo Y, Kawasaki A, Kitagawa H, Takao K, Miyakawa T, Takeuchi K, Igarashi M
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 47-47

    • DOI

      10.1186/s13041-017-0328-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex2018

    • Author(s)
      Ueno H, Fujii K, Suemitsu S, Murakami S, Kitamura N, Wani K, Aoki S, Okamoto M, Ishihara T, Takao K
    • Journal Title

      IBRO Reports

    • Description
      in press
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.2018

    • Author(s)
      Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K
    • Journal Title

      Biochem Biophys Ros Commun

      Volume: 495 Issue: 1 Pages: 438-445

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.2017

    • Author(s)
      Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y.
    • Journal Title

      Mol Careinog

      Volume: VOL. 56 Issue: 2 Pages: 515-526

    • DOI

      10.1002/mc.22513

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer Transitional Care for Terminally Ill Cancer Patients Can Reduce the Number of Emergency Admissions and Emergency Department Visits.2017

    • Author(s)
      Shimada N, Ishiki H, Iwase S, Chiba T, Fujiwara N, Watanabe A, Kinkawa J, Nojima M, Tojo A, Imai K.
    • Journal Title

      American Journal of Hospiec & Palliative Mcdicine

      Volume: 34 Issue: 9 Pages: 831-837

    • DOI

      10.1177/1049909116658641

    • Description
      Epub ahead of print
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.2017

    • Author(s)
      Taniguchi H, Hoshino D, Moriya C, Zembutsu H, Nishiyama N, Yamamoto H, Kataoka K, Imai K.
    • Journal Title

      Oncotarget

      Volume: 6(28) Issue: 29 Pages: 10448-10458

    • DOI

      10.18632/oncotarget

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma.2017

    • Author(s)
      Tsuji S, Washimi K, Kageyama T, Yamashita M, Matsuura R, Yokose T, Kamada Y, Hayashi H, Morohoshi T, Tsuura Y, Yusa T, Sato T, Togayachi A, Narimatsu H, Nagasaki T, Nakamoto K, Moriwaki Y, Misawa H, Hiroshima K, Miyagi Y, Imai K.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 45768-45768

    • DOI

      10.1038/srep45768

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of PRDM14 expression in pancrcatic cancer suppresses cancer stem-like properties and liver mctastasis in mice.2017

    • Author(s)
      Moriya C, Taniguchi H, Imai K.
    • Journal Title

      Carcinogenesis

      Volume: 38 Issue: 6 Pages: 638-648

    • DOI

      10.1093/carcin/bgx040

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a refined culture mothod for rat colon organoids.2017

    • Author(s)
      Isshiki H, Arimura Y, Nagaishi K, Kawakami K, Onodera K, Yamashita K, Naishiro Y, Fujimiya M, Imai K, Shinomura Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 489 Issue: 3 Pages: 305-311

    • DOI

      10.1016/j.bbrc.2017.05.142

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling alvcolar soft part sarcoma unveils novcl mechanisms of metastasis.2017

    • Author(s)
      Tanaka M, Homme M, Yamazaki Y, Shimizu R, Takazawa Y, Nakamura T.
    • Journal Title

      Cancer Res

      Volume: 77 Pages: 897-904

    • DOI

      10.1158/0008-5472.can-16-2486

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] CIC-DUX4 induces small round cell sarcomas distinct from ewing sarcoma2017

    • Author(s)
      Yoshimoto T, Tanaka M, Homme M, Yamazaki Y, Takazawa Y, Antonescu CR, Nakamura T
    • Journal Title

      Cancer Res

      Volume: 印刷中 Pages: 2927-2937

    • DOI

      10.1158/0008-5472.can-16-3351

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The use of an optimized chimeric envclope glycoprotein cnhances the cfficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primatc brain.2017

    • Author(s)
      Tanabe S, Inoue K, Tsuge H, Uczono S, Nagaya K, Fijiwara M, Kato S, Kobayashi K, Takada M
    • Journal Title

      Neurosci Res

      Volume: 印刷中 Pages: 45-52

    • DOI

      10.1016/j.neures.2017.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High-specd and scalable whole-brain imaging in rodents and primates.2017

    • Author(s)
      Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Wascheck JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe
    • Journal Title

      Neuron

      Volume: 94 Issue: 6 Pages: 1085-1100

    • DOI

      10.1016/j.neuron.2017.05.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The number and distribution of AMPA reccptor channcls containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses dupend on the target cells.2017

    • Author(s)
      Rubio Mar?a E.、Matsui Ko、Fukazawa Yugo、Kamasawa Naomi、Harada Harumi、Itakura Makoto、Moln?r Elek、Abe Manabu、Sakimura Kenji、Shigemoto Ryuichi
    • Journal Title

      Brain Struct Funct.

      Volume: 222 Issue: 8 Pages: 3375-3393

    • DOI

      10.1007/s00429-017-1408-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Purkinje cells are more vulnerable to the specific dcpletion of cathcpsin D than to that of atg72017

    • Author(s)
      Koike M, Shinbata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
    • Journal Title

      Am. J. Pathol.

      Volume: 187 Issue: 7 Pages: 1586-1600

    • DOI

      10.1016/j.ajpath.2017.02.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgencsis.2017

    • Author(s)
      Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
    • Journal Title

      Autophagy

      Volume: May17 Pages: 43-114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.2017

    • Author(s)
      Kawai T, Okochi Y, Ozaki T, Imura Y, Koizumi S, Yamazaki M, Abe M, Sakimura K, Yamashita T, Okamura Y.
    • Journal Title

      J Neurochem.

      Volume: 142 Issue: 5 Pages: 686-699

    • DOI

      10.1111/jnc.14106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrograde BDXF to TrkB signaling promotes synapse elimination in the developing cerebellum.2017

    • Author(s)
      Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M.
    • Journal Title

      Nature Communications

      Volume: 8(1) Issue: 1 Pages: 195-195

    • DOI

      10.1038/s41467-017-00260-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.2017

    • Author(s)
      Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, Matsuo K, Nakayama T, Satoh R, Sugiura R, Abe M, Sakimura K, Wakana S, Ohsaki H, Kamoshida S, Mukai H.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 7663-7663

    • DOI

      10.1038/s41598-017-07936-9

    • NAID

      120006366660

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drebrin E regulates neroblast proliferation and chain migration in the adult brain2017

    • Author(s)
      Kajita Y, Kojima N, Koganezawa N, Yamazaki H, Sakimura K, Shirao T
    • Journal Title

      Eur J Neurosci.

      Volume: 46(6) Issue: 6 Pages: 2214-2228

    • DOI

      10.1111/ejn.13668

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Netrin-1 derived from the ventricular zone, but not the floor platc, direcls hindbrain commissural axons to the ventral midlinc.2017

    • Author(s)
      Yamauchi K, Yamazaki. M, Abc M, Sakimura K, Lickert H, Kawasaki T, Murakami F, Hirata T.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 11962-11962

    • DOI

      10.1038/s41598-017-12269-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chondroitin sulfate is required for onset and offset of critical pcriod plasticity in visual corlex.2017

    • Author(s)
      Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takouchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 12646-12646

    • DOI

      10.1038/s41598-017-04007-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An RSA-binding protoin, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhosion signaling.2017

    • Author(s)
      Hayakawa-Yano Y, Suyama S, Nogami M, Yugami M, Koya I, Furukawa T, Zhou L, Abe M, Sakimura K, Takcbayashi H, Nakanishi A, Okano H, Yano M.
    • Journal Title

      Genes Dev.

      Volume: 31 Issue: 18 Pages: 1910-1925

    • DOI

      10.1101/gad.300822.117

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potentiation of excitatory synaptic transmission ameliorates aggrossion in mice with Stxbpl haploinsufficiency.2017

    • Author(s)
      Miyamoto H, Shimohata A, Abe M, Abe T, Mazaki E, Amano K, Suzuki T, Tatsukawa T, Itohara S, Sakimura K, Yamakawa K.
    • Journal Title

      Hum Mol Genet

      Volume: 26 Issue: 24 Pages: 4961-4974

    • DOI

      10.1093/hmg/ddx379

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rufy3 is an adapter protein for smail GTPascs that activatcs a Rac guaninc nucleotide cxchange factor to control neuronal polarity.2017

    • Author(s)
      Honda A, Usui H, Sakimura K, Igarashi M.
    • Journal Title

      J Biol Chem.

      Volume: 292 Issue: 51 Pages: 20936-20946

    • DOI

      10.1074/jbc.m117.809541

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orcxin modulates behavioral fear expression through the locus coeruleus.2017

    • Author(s)
      Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T.
    • Journal Title

      Nat Commun.

      Volume: 8 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41467-017-01782-z

    • NAID

      120006368277

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNG105/caprinl, an RNA granule protein for dendritic mRNA localization, is esscntial for long-term memory formation.2017

    • Author(s)
      Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abc M, Fujikawa A, Shigenobu S, Futatsugi A, Noda M, Mikoshiba K, Furuichi T, Sakimura K, Shiina N.
    • Journal Title

      Elife.

      Volume: 6 Pages: 1-32

    • DOI

      10.7554/elife.29677

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocadherin-αC2 is required for diffuse projections of serotonergic axons.2017

    • Author(s)
      Katori S, Noguchi-Katori Y, Okayama A, Kawamura Y, Luo W, Sakimura K, Hirabayashi T, Iwasato T, Yagi T.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 15908-15908

    • DOI

      10.1038/s41598-017-16120-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maturation of cercbellar purkinje cell population activity during postnatal refinemcnt of climbing fiber network.2017

    • Author(s)
      Good JM, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M.
    • Journal Title

      Cell Rep

      Volume: 21(8) Issue: 8 Pages: 2066-2073

    • DOI

      10.1016/j.celrep.2017.10.101

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Corrigcndum : conditional knockout of cav2.1 disrupts the accuracy of spatial reeognition of CA1 place cclls and spatial/contextual recognition behavior.2017

    • Author(s)
      Jung D, Hwang YJ, Ryu H, Kano M, Sakimura K, Cho J.
    • Journal Title

      Front Behav Neurosci.

      Volume: 11 Pages: 242-242

    • DOI

      10.3389/fnbeh.2017.00242

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human globozoospermia-rclatcd gcne spata16 ls required for sperm formation revcaled by CRISPR/Cas9-mediatcd mouse modcls.2017

    • Author(s)
      Fujihara Y, Oji A, Larasati T, Kojima-Kita K, Ikawa M.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18 Pages: 2208-2208

    • DOI

      10.3390/ijms18102208

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A delayed sperm penetration of cumulus laycrs by disruption of acrosin gene in rats.2017

    • Author(s)
      Isotani A, Matsumura T, Ogawa M, Tanaka T, Yamagata K, Ikawa M, Okabc M.
    • Journal Title

      Biology of Reproduction

      Volume: 97(1) Pages: 61-68

    • DOI

      10.1093/biolre/iox066

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TCTEI is a conserved component of the dynein regulatory complex and is required for motility and mctablism in mouse spermatozoa.2017

    • Author(s)
      Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM and Liu M
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 114(27)

    • DOI

      10.1073/pnas.1621279114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rcscue of retinal morphology and funetion in a humanizcd mousc at the mouse retinol-binding proteinlocus.2017

    • Author(s)
      Liu, L., Suzuki, T., Shon, J., Wakana, S., Araki, K., Yamamura, K., Lei, L, and Li, Z.
    • Journal Title

      Lab Invest

      Volume: 97 Pages: 395-408

    • DOI

      10.1038/labinvest.2016.156

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ANGPTL2 expression in intestinal stem cell niche controls epithelial rogeneration and homeostasis.2017

    • Author(s)
      Horiguchi, H., Endo, M., Kawane, K., Kadomatsu, T., Terada, K., Morinaga, J., Araki, K., Miyata, K. and Oike, Y.
    • Journal Title

      EMBO J.

      Volume: 36 Pages: 409-424

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drivestumor progression.2017

    • Author(s)
      Tsukamoto H., Fujieda K., Hirayama M., Ikeda T., Yuno A., Matsumura K., Fukuma D, Araki K., Hiroshi M., Nakayama H., Senju S, and Nishimura Y.
    • Journal Title

      Cancer Res

      Volume: 14 Pages: 2279-2291

    • DOI

      10.1158/0008-5472.can-16-2446

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an officient scrcening system to identify novcl bone metabolism-relatcd goncs using the exchangcable gene trap mutagenesis mouse models.2017

    • Author(s)
      Kurogi, S., Sekimoto, T., Funamoto, T., Ota, T., Nakamura, S., Nagai, T., Nakahara, M., Yoshinobu, K., Araki, K., Araki, M. and Chosa, E.
    • Journal Title

      Sci Rop

      Volume: 7 Pages: 40692-40692

    • DOI

      10.1038/srep40692

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MiR-142 Is required for staphylococcus aureus clearance at skin wound wites via small GTPasc-mediated regulation of thenNeutrophil actin cytoskeleton.2017

    • Author(s)
      Tanaka, K., Kim, S. E., Yano, H., Matsumoto, G., Ohuchida, R., Ishikura, Y., Araki, M., Araki, K., Park, S., Komatsu, T., Hayashi, H., Ikematsu, K., Hirano, A., Martin. P., Shimokawa, I. and Mori. R
    • Journal Title

      J. Invest. Dermatol.

      Volume: 137 Pages: 931-940

    • DOI

      10.1016/j.jid.2016.11.018

    • NAID

      40021436657

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.2017

    • Author(s)
      Goswami, D., Marz, S., Li, Y. T., Artz, A., Schafer, K., Seelige, R., Pacheco-Blanco, M., Jing, D., Bixel, M, G., Araki, M., Araki, K., Yamamura, K. and vestweber, D.
    • Journal Title

      Blood.

      Volume: 129 Pages: 1811-1822

    • DOI

      10.1182/blood-2016-08-733394

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MaTB is a critical regulator of complement component Clq.2017

    • Author(s)
      Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y, Fujii R, Usui T, Kulathung K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T, Takahashi S.
    • Journal Title

      Nat Commun.

      Volume: 8 Pages: 1700-1700

    • DOI

      10.1038/s41467-017-01711-0

    • NAID

      120006370809

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.2017

    • Author(s)
      Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A.
    • Journal Title

      Nat Med

      Volume: in press Pages: 723-732

    • DOI

      10.1038/nm.4312

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Simple generation of hairless mice for in vivo imaging.2017

    • Author(s)
      Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami KI, Sugiyama F
    • Journal Title

      Exp. Anim.

      Volume: 66(4) Issue: 4 Pages: 437-445

    • DOI

      10.1538/expanim.17-0049

    • NAID

      130006187194

    • ISSN
      1341-1357, 1881-7122
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] WNT rogulation of embryonic development likely involves pathways independent of nuclear CTNNBI.2017

    • Author(s)
      Tribulo P, Moss JI, Ozawa M, Jiang Z, Tian C, Hansen PJ.
    • Journal Title

      Reproduction

      Volume: 153 Pages: 405-419

    • DOI

      10.1530/rep-16-0610

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations2017

    • Author(s)
      Oh, Y. -M., Karube, F., Takahashi, S., Kobayashi, K., Takada, M., Uchigashima, M., Watanabe, M., Nishizawa, K., Kobayashi, K., and Fujiyama, F.
    • Journal Title

      Brain Str. Funct.

      Volume: 印刷中 Pages: 2359-2378

    • DOI

      10.1007/s00429-016-1346-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] From engineering to editing the rat genome.2017

    • Author(s)
      Meek S, Mashimo T, Burdon T.
    • Journal Title

      Mammalian Genome

      Volume: 28 Pages: 302-314

    • DOI

      10.1007/s00335-017-9705-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endocytosis following dopamine D2 recoptor activation is critical for nouronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.2017

    • Author(s)
      Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabc M, Sasahara M, Fukunaga K
    • Journal Title

      Molecular Psychiatry

      Volume: 印刷中 Issue: 8 Pages: 1205-1222

    • DOI

      10.1038/mp.2016.200

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor.2017

    • Author(s)
      Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
    • Journal Title

      Xeuroscience Letters

      Volume: 654 Pages: 99-106

    • DOI

      10.1016/j.neulet.2017.06.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal.2017

    • Author(s)
      Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
    • Journal Title

      Investigative Ophthalmology and Visual Science(IOVS)

      Volume: 58 Issue: 9 Pages: 3795-3795

    • DOI

      10.1167/iovs.17-21746

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forroptosis : a regulated cell death nexus linking metabolism, redox biology, and disease.2017

    • Author(s)
      Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti
    • Journal Title

      Cell

      Volume: 171 Pages: 273-285

    • DOI

      10.1016/j.cell.2017.09.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Iron and thiol redox signaling in cancer : an exquisite balance to escape ferroptosis.2017

    • Author(s)
      Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
    • Journal Title

      Free Radic Biol Med

      Volume: 108 Pages: 610-616

    • DOI

      10.1016/j.freeradbiomed.2017.04.024

    • NAID

      120006343681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gut microbiota promotes obcsity-associatcd liver cancer through PGE2-mediated suppression of antitumor immunity2017

    • Author(s)
      Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N, et al.
    • Journal Title

      Cancer Discovery

      Volume: 7 Pages: 522-538

    • DOI

      10.1158/2159-8290.cd-16-0932

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cireulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes2017

    • Author(s)
      Klcmis, V., Ghura, H., Federico, G., Wurfel, C., Bontmann, A., Gretz, N., Miyazaki, T., Grone, H. J., Nakchbandi, I. A.
    • Journal Title

      Kidney Int

      Volume: 91 Pages: 1374-1385

    • DOI

      10.1016/j.kint.2016.12.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer2017

    • Author(s)
      Kobayashi, K., Tomita, H., Shimizu, M., Tanaka, T., Suzui, N., Miyazaki, T., Hara, A.
    • Journal Title

      Int J Mol Sci

      Volume: 18

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo2017

    • Author(s)
      M. Kawada, H. Inoue, M. Kajikawa, M. Sugiura, S. Sakamoto, S. Urano, C. Karasawa, I. Usami, M. Futakuchi, T. Masuda.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 40400-40400

    • DOI

      10.1038/srep40400

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gone polymorphisms and alcohol dependence in a Japanese population.2017

    • Author(s)
      Narita S, Yoshihara E, Nishizawa D, Kawai A, Ikeda K, Iwahashi K
    • Journal Title

      日本アルコール薬物医学会雑誌

      Volume: 52 Issue: 5 Pages: 156-167

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rolc of NMDA receptor GluN2D subunit in the antideprossant effects of onantiomers of ketamine.2017

    • Author(s)
      Idc S, Ikokubo Y, Mishina M, Hashimoto K, Ikeda K
    • Journal Title

      J Pharmacol Sci

      Volume: 135(3) Issue: 3 Pages: 138-140

    • DOI

      10.1016/j.jphs.2017.11.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nuclcotide polymorphism and older age in Japanese.2017

    • Author(s)
      Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 79(6) Issue: 6 Pages: 1179-1186

    • DOI

      10.1007/s00280-017-3314-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light/dark phase-dopendent spontancous activity is maintained in dopamine-doficient mice.2017

    • Author(s)
      Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikcda K
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 49-49

    • DOI

      10.1186/s13041-017-0329-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students.2017

    • Author(s)
      Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
    • Journal Title

      Psychiatry Investigation

      Volume: 14(5) Issue: 5 Pages: 681-686

    • DOI

      10.4306/pi.2017.14.5.681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opioid dose and neuropathic pain before-and-after electroconvulsive therapy.2017

    • Author(s)
      Iwata K, Kobayashi Y, Mera H, Doi N, Suwa H, Ikeda K
    • Journal Title

      JJSPC

      Volume: 24(2) Issue: 2 Pages: 116-120

    • DOI

      10.11321/jjspc.16-0024

    • NAID

      130006832066

    • ISSN
      1340-4903, 1884-1791
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ゲノムワイド関連解析を利用したオピオイドのデーラーメイド医療への試み。2017

    • Author(s)
      三枝勉, 西澤大輔, 福田謙一, 池田和隆, 北村晶, 林田眞和
    • Journal Title

      麻酔・集中治療とテクノロジー2017

      Pages: 16-21

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] JSNP Excellent Presentation Award for CINP2016 : Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population.2017

    • Author(s)
      Narita S, Iwahashi K, Yoshihara E, Kawai A, Nishizawa D, Ikeda K
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 37 Issue: 3 Pages: 97-98

    • Related Report
      2017 Annual Research Report
  • [Journal Article] JSNP Excollent Prosentation Award for CINP2016 : 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化。2017

    • Author(s)
      井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 37 Issue: 2 Pages: 49-50

    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] JSNP Excellent Presentation Award for CINP2016 : ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定。2017

    • Author(s)
      西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 37 Issue: 2 Pages: 53-54

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発2017

    • Author(s)
      西澤大輔, 福田謙一, 林田眞和, 池田和隆
    • Journal Title

      ペインクリニック

      Volume: 38

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ペインクリニックにおける精密医療2017

    • Author(s)
      池田和隆
    • Journal Title

      ペインクリニック

      Volume: 38 Pages: 557-558

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher Arc Nucleus-to-Cytoplasm Ration during Sleep in the Superficial Layers of the Mouse Cortex.2017

    • Author(s)
      Honjoh S, de Vivo L, Okuno H, Bito H, Tononi G, Cirelli C.
    • Journal Title

      Front Neural Circuits.

      Volume: 11 Pages: 60-60

    • DOI

      10.3389/fncir.2017.00060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Are restores juvenile plasticity in adult mouse visual cortex.2017

    • Author(s)
      Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shephord JD.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: 114 Pages: 9182-9187

    • DOI

      10.1073/pnas.1700866114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histaminc modulation of the basal ganglia circuitry in the dovelopment of pathological grooming.2017

    • Author(s)
      Rapanclli M, Frick L, Bito H, Pittenger C
    • Journal Title

      Proc Natl Aead Sci USA.

      Volume: 114 Pages: 6599-6604

    • DOI

      10.1073/pnas.1704547114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Calmodulin kinases : essential regulators in health and disease.2017

    • Author(s)
      Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
    • Journal Title

      J Neurochem.

      Volume: - Pages: 808-818

    • DOI

      10.1111/jnc.14020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optogenctic activation of the sensorimotor cortex reveals "local inhibitory and global excitatory" inputs to the basal ganglia.2017

    • Author(s)
      Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakao N, Nambu A.
    • Journal Title

      Cereb Cortex.

      Volume: 27 Pages: 5716-5726

    • DOI

      10.1093/cercor/bhx234

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice2017

    • Author(s)
      Umcda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
    • Journal Title

      Acta Neuropathol Commun

      Volume: 5 Pages: 59-59

    • DOI

      10.1186/s40478-017-0461-5

    • NAID

      120006371271

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice2017

    • Author(s)
      Umemura M ; Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 11 Pages: 125-125

    • DOI

      10.3389/fnbeh.2017.00125

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased cohesin in the brain leads to defective synapse devclopmont and anxicty-related behavior.2017

    • Author(s)
      Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
    • Journal Title

      The Journal of Experiment Medicine

      Volume: 印刷中 Issue: 5 Pages: 1431-1452

    • DOI

      10.1084/jem.20161517

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice2017

    • Author(s)
      Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 11 Pages: 125-125

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis2017

    • Author(s)
      Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
    • Journal Title

      Journal of Neurochemistry

      Volume: 141 Issue: 1 Pages: 124-136

    • DOI

      10.1111/jnc.13963

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities.2017

    • Author(s)
      Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, Saito N, Yanagita RC, Irie K.
    • Journal Title

      Molecules

      Volume: 22 Issue: 4 Pages: 631-631

    • DOI

      10.3390/molecules22040631

    • NAID

      120006363289

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiopheno analogue and thoir antiproliferative activities against human cancer cell lines.2017

    • Author(s)
      Matsumoto T, Kojima N, Akatsuka A, Yamori T, Dan S, Iwasaki H, Yamashita M.
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 17 Pages: 2359-2366

    • DOI

      10.1016/j.tet.2017.03.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allantopyrone a activates Keapl-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.2017

    • Author(s)
      Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Issue: 4 Pages: 429-434

    • DOI

      10.1038/ja.2016.99

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34.2017

    • Author(s)
      Robke I., Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 56 Issue: 28 Pages: 8153-8157

    • DOI

      10.1002/anie.201703738

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of a terpenoid-production platform in streptomyces reveromyceticus SN-593.2017

    • Author(s)
      Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S
    • Journal Title

      ACS Synthctic Biology

      Volume: 6 Issue: 12 Pages: 233-2349

    • DOI

      10.1021/acssynbio.7b00249

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor.2017

    • Author(s)
      Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, Ishikawa S, Katagiri T, Imoto M.
    • Journal Title

      Cancer Science

      Volume: 108 Pages: 785-794

    • DOI

      10.1111/cas.13175

    • Description
      Epub ahead of print
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.2017

    • Author(s)
      Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
    • Journal Title

      Cancer Science

      Volume: 108 Pages: 772-784

    • DOI

      10.1111/cas.13172

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47.2017

    • Author(s)
      Saito S, Fujimaki T, Panbangred W, Sawa R, Igarashi Y, Imoto M
    • Journal Title

      Journal of Antibiotics

      Volume: 印刷中 Pages: 595-600

    • DOI

      10.1038/ja.2017.6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Arabilin overcomes resistance to AR-targeted therapy.2017

    • Author(s)
      Fujimaki T, Saito S, and Imoto M.
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Pages: 328-330

    • DOI

      10.1038/ja.2016.162

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metacycloprodigiosin (mcPG) induced cell death selectively in beta-catenin mutated tumor colls.2017

    • Author(s)
      Ikeda H, Shikata Y, Watanapokasin R, Tashiro E, Imoto M
    • Journal Title

      Journal of Antibiotics

      Volume: 70 Pages: 109-112

    • DOI

      10.1038/ja.2016.75

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocylic hexaoxazole2017

    • Author(s)
      Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 3605-3605

    • DOI

      10.1038/s41598-017-03785-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice.2017

    • Author(s)
      Funato H, et al.
    • Journal Title

      Nature.

      Volume: 539(7629) Issue: 46 Pages: 378-383

    • DOI

      10.1038/nature20142

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.2017

    • Author(s)
      Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M.
    • Journal Title

      FASEB J.

      Volume: in press Pages: 2252-2266

    • DOI

      10.1096/fj.201600642r

    • Description
      Epub ahead of print
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mechanics clarifying counterclockwise rotation in most IVF eggs in mice.2017

    • Author(s)
      Ishimoto K, Ikawa M, Okabe M.
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 43456-43456

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SHISA6 confers resistance to differentiation-promoting Wnt/6-catenin aignaling in mouse spermatogenic stem cells.2017

    • Author(s)
      Tokue M, Jkami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
    • Journal Title

      Stem Cell Reports

      Volume: 8 Pages: 561-575

    • DOI

      10.1016/j.stemcr.2017.01.006

    • NAID

      120006224053

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pharmacological targeting of plasmin prevents lethality in a murine mode of macrophage activation syndrome.2017

    • Author(s)
      Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
    • Journal Title

      Blood

      Volume: 印刷中 Pages: 59-72

    • DOI

      10.1182/blood-2016-09-738096

    • Description
      Epub ahead of print
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia2017

    • Author(s)
      Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 7 Pages: 1-11

    • DOI

      10.1038/srep45050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of NDRG2 expression confers oral squamous cell carcinoma with enhanced metastatic potential2017

    • Author(s)
      T. Tamura, T. Ichikawa, S. Nakahata, Y. Kondo, Y. Tagawa, K. Yamamoto, K. Nagai, T. Baba, R. Yamaguchi, M. Futakuchi, Y. Yamashita, K. Morishita
    • Journal Title

      Cancer Research

      Volume: 印刷中 Pages: 2363-2374

    • DOI

      10.1158/0008-5472.can-16-2114

    • Description
      Epub ahead of print
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017

    • Author(s)
      Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T.
    • Journal Title

      Sci Rep.

    • NAID

      120006535017

    • Description
      In press
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.2017

    • Author(s)
      Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
    • Journal Title

      Exp Neurol

      Volume: S0014-4886(17) Pages: 1-12

    • DOI

      10.1016/j.expneurol.2017.03.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Combination treatment with naftopidil increases the efficacy of radiotherapy in PC-3 human prostate cancer cells2017

    • Author(s)
      Iwamoto Y, Ishii K, Kanda H, Kato M, Miki M, Kajiwara S, Arima K, Shiraishi T, Sugimura Y.
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 印刷中 Pages: 933-939

    • DOI

      10.1007/s00432-017-2367-9

    • Description
      Epub ahead of print
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B2017

    • Author(s)
      Takase S, Kurokawa R, Arai D, Kanto KK, Okino T, Nakao Y, Kushiro T, Yoshida M, Matsumoto K.
    • Journal Title

      Sci Rep

    • Description
      In press
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-62017

    • Author(s)
      Yamaguchi N, Nakayama Y, Yamaguchi N.
    • Journal Title

      J Biol Chem

      Volume: 印刷中

    • DOI

      10.1074/jbc.m116.763276

    • Description
      Epub ahead of print
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cancer stem cells in human gastrointestinal cancer.2016

    • Author(s)
      Taniguchi H, Moriya C, Igarashi H, Saitoh A, Yamamoto H, Adachi Y, Imai K.
    • Journal Title

      Cancer Sci

      Volume: 107 Issue: 11 Pages: 1556-1562

    • DOI

      10.1111/cas.13069

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer.2016

    • Author(s)
      Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano H, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 26699-26699

    • DOI

      10.1038/srep26699

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway.2016

    • Author(s)
      Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 11 Pages: 12704-120717

    • DOI

      10.18632/oncotarget.7260

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer.2016

    • Author(s)
      Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Pages: 557-566

    • DOI

      10.3748/wjg.v22.i2.557

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease.2016

    • Author(s)
      Yamamoto M, Takahashi H, Shimizu Y, Yajima H, Suzuki C, Naishiro Y, Imai K, Shinomura Y.
    • Journal Title

      Mod Rheumatol.

      Volume: 26 Issue: 1 Pages: 161-2

    • DOI

      10.3109/14397595.2014.995893

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report.2016

    • Author(s)
      Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
    • Journal Title

      Cancer Science

      Volume: 107(3) Issue: 3 Pages: 369-371

    • DOI

      10.1111/cas.12889

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fertilization defects in sperm from Cysteine-rich secretory protein 2(Crisp2) knockout mice : Implications for fertility disorders.2016

    • Author(s)
      Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, DaRos VG, Cuasnú PS.
    • Journal Title

      Mol Hum Reprod.

      Volume: 22 Issue: 4 Pages: 240-51

    • DOI

      10.1093/molehr/gaw005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GPI-AP release in cellular, developmental, and reproductive biology.2016

    • Author(s)
      Fujihara Y, Ikawa M.
    • Journal Title

      J Lipid Res.

      Volume: 57 Issue: 4 Pages: 538-45

    • DOI

      10.1194/jlr.r063032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of Hprt-disrupted rat through mouse <- rat ES chimeras2016

    • Author(s)
      Isotani A, Yamagata K, Okabe M, Ikawa M.
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 24215-24215

    • DOI

      10.1038/srep24215

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice.2016

    • Author(s)
      Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N.
    • Journal Title

      Biol Reprod

      Volume: 94 Pages: 1-11

    • DOI

      10.1095/biolreprod.115.135988

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TARP γ-2 and γ-8 differentially control AMPAR density across Schaffer collateral/commissural synapsee in the hippocampal CA1 area.2016

    • Author(s)
      Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M.
    • Journal Title

      J Neurosci.

      Volume: 36 Issue: 15 Pages: 4296-312

    • DOI

      10.1523/jneurosci.4178-15.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] GluD2 endows parallel fiber-Purkinje cell synapses with a high regenerative capacity2016

    • Author(s)
      Ichikawa R, Sakimura K, Watanabe M.
    • Journal Title

      J Neurosci.

      Volume: 36 Issue: 17 Pages: 4846-4858

    • DOI

      10.1523/jneurosci.0161-16.2016

    • NAID

      120005853072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kidney-specific knockout of Savl in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway.2016

    • Author(s)
      Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
    • Journal Title

      J Pathol.

      Volume: 印刷中 Issue: 1 Pages: 97-108

    • DOI

      10.1002/path.4706

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction.2016

    • Author(s)
      Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H.
    • Journal Title

      J Cell Sci.

      Volume: 未定 Issue: 9 Pages: 19401949-19401949

    • DOI

      10.1242/jcs.182220

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The importance of basonuclin 2 in adult mice and its relation to basonuclinl.2016

    • Author(s)
      Vanhoutteghem, A., Delhomme, B., Herve, F., Nondier, I., Petit, J. M., Araki, M., Araki, K. and Djian, P.
    • Journal Title

      Mech. Dev.

      Volume: Feb 29 Pages: 1-21

    • DOI

      10.1016/j.mod.2016.02.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.2016

    • Author(s)
      Shimbo M, Kudo T, Hamada M, Jeon H, Ikawa M, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Shiba D, Takahashi S.
    • Journal Title

      Exp.