先端モデル動物支援プラットフォーム

• Project/Area Number: 16H06276
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator(Support): 今井 浩三 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha)(Support): 中村 卓郎 公益財団法人がん研究会, がん研究所, 副所長 (00180373) ; 井上 純一郎 東京大学, 医科学研究所, 教授 (70176428) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 山田 泰広 東京大学, 医科学研究所, 教授 (70313872) ; 高橋 智 筑波大学, 医学医療系, 教授 (50271896) ; 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 﨑村 建司 新潟大学, 脳研究所, フェロー (40162325) ; 荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705) ; 八尾 良司 公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095) ; 真下 知士 大阪大学, 大学院医学系研究科, 准教授 (80397554) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 豊國 伸哉 名古屋大学, 大学院医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 長崎大学, 病院(医学系), 准教授 (60275120) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 宮崎 龍彦 岐阜大学, 医学部附属病院, 准教授 (80239384) ; 神田 浩明 埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067) ; 尾藤 晴彦 東京大学, 大学院医学系研究科, 教授 (00291964) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; 高雄 啓三 富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397) ; 池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656) ; 虫明 元 東北大学, 大学院医学系研究科, 教授 (80219849) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623) ; 長田 裕之 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202) ; 井本 正哉 慶應義塾大学, 理工学部, 教授 (60213253) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065) ; 吉田 稔 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617) ; 松浦 正明 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794) ; 牛嶋 大 公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565) ; 吉田 進昭 東京大学, 医科学研究所, 教授 (10250341)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2018)
• Budget Amount: ¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000); Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
• Keywords: モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・プロファイリング / 分子プロファイリング / 分子探索・ブロファイリング / 行動解析

Outline of Annual Research Achievements

①総括支援活動 : ホームページ(HP)に改良を加えながら公募の円滑化をさらに進めた。モデル動物作製解析の講習や若手研究者の交流促進を推進する技術講習会を開催した。また成果発表会を開催、全国から127名の参加があり一般口演ならびにポスター発表など、本活動の支援成果を、より幅広い研究分野にアピールした。
②モデル動物作製支援活動 : 利用者の様々な要望に個別に対応し、相同組換えやゲノム編集など先進的な遺伝子改変技術を用いて、遺伝子改変マウスおよびラットを合計83件、迅速に作製し、学術研究を推進するための研究リソースを提供した。
③病理形態解析支援活動 : 昨年より多い52件の申請を受け、2回の審査の結果、42件に関して病理形態解析を実施した。研究の方向性を裏付ける多くの成果が得られた。論文の図の作成にもかかわり、論文が受理されるまで支援を実施した。
④生理機能解析支援活動 : 行動学的解析では23課題、薬理学的解析では9課題、光技術による操作解析では10課題、多機能電極・計測データ解析では16課題をそれぞれ支援し、動物モデルにおける病態・生理学的基盤の解明推進に関する支援を展開した。
⑤分子プロファイリング支援活動 : 依頼化合物の分子プロファイリング308件、阻害剤キット配付102枚、RNA干渉キット配付・siRNAデザイン合成92件、バーコードshRNAライブラリーによる化合物の標的経路探索24件、を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 公募申請と選考作業の効率化が促進された。技術講習会と成果発表会で多くの参加者を得た。参加者対象のアンケートから若手の研究意欲を促進する効果が明らかとなった。参加希望者が前年度よりも増え、参加者の研究分野の多様性が一層顕著になった。
②モデル動物作製支援活動 : 研究実施計画に沿った支援を行うことができている。増加傾向にある応募課題に対し、最新技術を導入することにより効率化を図り、予算が許す範囲で可能な課題数を採択し、支援を行なった。遺伝子改変が複雑あるいは技術的に難しいケースは、必要な技術を導入・開発することにより対応している。
③病理形態解析支援活動 : 年々申請数が増加しており、審査をより厳格に行っている。現在の予算ならびに班員のエフォートにおいてできる最大限の支援活動を実施しており、成果は確実に上がっている。
④生理機能解析支援活動 : 支援対象者のモデルマウスを対象にした感覚・運動・認知機能に関わる「網羅的行動テストバッテリー」を用いた行動解析支援を23課題、依存性薬物等の感受性に関連する行動解析および臨床データと遺伝子多型との関連解析を行う規制薬物作用解析支援を9課題、進展著しい光遺伝学に関する最新技術を活用した研究支援を10課題、多機能集積化電極による最先端の技術提供を行う多元的生理機能計測操作支援を16課題で実施した。
⑤分子プロファイリング支援活動 : 応募課題の審査体制が軌道に乗り、採否決定までの所要日数が前年度と比較して最大10日程度短縮された。応募前の技術相談を積極的に受け付けたことで、幅広い分野から新規ユーザーを獲得することができた。前年度までの支援成果を受けて高次評価に進んだ課題については、複数の支援担当者間での連携が功を奏した。shRNAライブラリー探索支援では実験条件をカスタマイズし、被支援者の特殊なニーズにも応えた。

Strategy for Future Research Activity

①総括支援活動 : 支援により得られた成果の広報にも力を入れるとともに、被支援者にも本支援活動の重要性をアピールしてもらうよう働きかける。技術講習会では4プラットフォームとの連携を推進し、H31年度は先進ゲノム解析研究支援プラットフォームから講師と参加者を受け入れる。
②モデル動物作製支援活動 : 先端的なゲノム編集技術や研究リソース等を用いて、支援活動の拡充を図るとともに、革新的な遺伝子改変技術および周辺技術の導入・開発を進めることにより、学術研究の推進に貢献するとともに、学術基盤としての研究リソースを整備する。
③病理形態解析支援活動 : 現状で予算ならびに支援を担当する班員の対応状況に関して厳しい状態となっていることから、今後は審査をより厳格に行い、成果につながる可能性が高い申請を選択する。基本姿勢として、一旦開始した病理形態支援は論文が受理されるまでサポートするという方針に変化はない。
④生理機能解析支援活動 : 5つの拠点への支援申請が何れも安定して多数あることから、引き続きニーズに応えられるように拠点における技術力を維持・向上させ、支援実施体制をハイレベルに保つ。また、研究者コミュニティーにおける支援事業の認知度を向上させるため、学会等での広報活動を行う。技術支援にとどまらず、支援該当部の論文分担執筆を積極的に進め、成果の公表にも貢献する。
⑤分子プロファイリング支援活動 : H30年度に引き続き、広報活動の強化・解析条件のカスタマイズ対応・支援実施後のフォロー(科学的助言、共同究の斡旋、高次支援の勧奨)に努めるとともに、年2回の定例班会議で問題点を洗い出し、常に最善の運用体制で支援を実施する。支援内容の性質上、個体レベルの研究を行わない研究者層が主要な被支援者層と一致しているが、共同研究や他の支援活動班との連絡を通じて、個体レベルの研究にも展開させたい。

Research Products

• [Int'l Joint Research] コロンピア大学/イリノイ大学/タフツ大学（アメリカ合衆国）
• [Int'l Joint Research] ボルドー大学/マリーキューリー医科大学/グルノーブルアルプス大学（フランス）
• [Int'l Joint Research] 江蘇大学/Xi'an Jiaotong University（中華人民共和国）
• [Int'l Joint Research] Seoul national University/韓南大学（大韓民国）
• [Int'l Joint Research] シンガポール国立大学（シンガポール）
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(アメリカ合衆国)
• [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(イギリス)
• [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)
• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア共和国)
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学(アメリカ合衆国)
• [Int'l Joint Research] Harvard Medical School, Boston(アメリカ合衆国)
• [Int'l Joint Research] スタンフォード大学/エール大学(アメリカ合衆国)
• [Int'l Joint Research] 南通大学(中国)
• [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women : Chiba bone survey. (2020)
  • Author(s): Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
  • Journal Title: Endocr J Volume: 65 Issue: 2 Pages: 193-202
  • DOI: 10.1507/endocrj.ej17-0331 10.1507/endocrj.EJ17-0331
  • NAID: 130006402991
  • ISSN: 0918-8959, 1348-4540
  • Year and Date: 2020-02-05
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the Retinotopic Map of an Awake Mouse Brain Based upon Intrinsic Optical Signal Imaging Considering the Ocular Position and Variation in Pupil Diameter (2019)
  • Author(s): 外川 龍之介、奥畑 大悟、吉田 侑冬、中尾 光之、片山 統裕
  • Journal Title: TJSBME Volume: 56 Issue: 4 Pages: 157-163
  • DOI: 10.11239/jsmbe.56.157
  • NAID: 130007604778
  • ISSN: 1347-443X, 1881-4379
  • Year and Date: 2019-02-27
  • Peer Reviewed / Open Access
• [Journal Article] Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo. (2019)
  • Author(s): Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H.
  • Journal Title: J Physiol Sci. Volume: 69(1) Issue: 1 Pages: 65-77
  • DOI: 10.1007/s12576-018-0618-4
  • NAID: 40021804699
  • Peer Reviewed
• [Journal Article] A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway (2019)
  • Author(s): Saito M, Okumura K, Isogai E, Araki K, Tanikawa C, Matsuda K, Kamijo T, Kominami R, Wakabayashi Y.
  • Journal Title: Journal of Investigative Dermatology Volume: in press Pages: 30032-6
  • DOI: 10.1016/j.jid.2018.12.027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model (2019)
  • Author(s): Htun Y, Nakamura S, Nakao Y, Mitsuie T, Nakamura M, Yamato S, Jinnai W, Koyano K, Ohta K, Morimoto A, Wakabayashi T, Sugino M, Fujioka K, Kato I, Kondo S, Yasuda S, Miki T, Ueno M, Kusaka T
  • Journal Title: Scientific Reports Volume: 9 Pages: 4088-4088
  • DOI: 10.1038/s41598-019-40674-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats. (2019)
  • Author(s): Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 3917-3917
  • DOI: 10.1038/s41598-019-40688-2
  • Peer Reviewed / Open Access
• [Journal Article] Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity (2019)
  • Author(s): Tatsukawa T, Raveau M, Ogiwara I, Hattori S, Miyamoto H, Mazaki E, Itohara S, Miyakawa T, Montal M, Yamakawa K*
  • Journal Title: Mol Autism Volume: 10 Pages: 1-15
  • DOI: 10.1186/s13229-019-0265-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-l, a simplified analog of debromoaplysiatoxin (2019)
  • Author(s): Ashida, Y., Yanagita, R. C., Kawanami, Y., Okamura, M., Dan, S. and Irie, K.
  • Journal Title: Heterocycles Volume: 99
  • DOI: 10.3987/com-18-s(f)60
  • Peer Reviewed
• [Journal Article] Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior. (2019)
  • Author(s): Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, Matsumoto H, Miyakawa T, Nakada K.
  • Journal Title: Journal of Neuroscience Volume: 39 Issue: 9 Pages: 1588-1604
  • DOI: 10.1523/jneurosci.2139-18.2018
  • Peer Reviewed
• [Journal Article] Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques. (2019)
  • Author(s): Egawa R. Yawo H.
  • Journal Title: Curr Protoc Neurosci. Volume: 87
  • DOI: 10.1002/cpns.64
  • Peer Reviewed
• [Journal Article] Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary (2019)
  • Author(s): Yu Buchin, Yuka Sakemi, Ruriko Hamashima, Yuko Morioka, Daisuke Yamanaka, Fumihiko Hakuno, Shin-ichiro Takahashi, Kazutoshi Shindo
  • Journal Title: Phytochemistry Letters Volume: 30 Pages: 43-48
  • DOI: 10.1016/j.phytol.2019.01.005
  • Peer Reviewed
• [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm (2019)
  • Author(s): Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
  • Journal Title: Nat Commun Volume: 10 Issue: 1 Pages: 1653-1653
  • DOI: 10.1038/s41467-019-09710-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex. (2019)
  • Author(s): *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Rfos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y
  • Journal Title: The Journal of Neuroscience Volume: 31 Issue: 3 Pages: 1115-1126
  • DOI: 10.1523/jneurosci
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction. (2019)
  • Author(s): Sulistomo HW, Nemoto T, Yanagita T, Takeya R.
  • Journal Title: J Biol Chem Volume: 294 Pages: 2924-2934
  • DOI: 10.1074/jbc.ra118.005471
  • Peer Reviewed
• [Journal Article] TFE3 Xpll. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease (2019)
  • Author(s): Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O, Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki, et al.
  • Journal Title: Molecular Cancer Research
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity (2019)
  • Author(s): Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
  • Journal Title: ChemBioChem Volume: 20
  • DOI: 10.1002/cbic.201800815
  • Peer Reviewed
• [Journal Article] Forkhead box protein Al confers resistance to transforming growth factor-β-induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation. (2019)
  • Author(s): Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
  • Journal Title: J Cell Biochem. Volume: 120 Pages: 2259-2270
  • DOI: 10.1002/jcb.27551
  • Peer Reviewed
• [Journal Article] Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo [g] [1] benzopyrano [4, 3-b] indol-6 (13H)-one scaffold (2019)
  • Author(s): Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 27 Issue: 2 Pages: 265-277
  • DOI: 10.1016/j.bmc.2018.11.037
  • NAID: 120006602374
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance. (2019)
  • Author(s): Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
  • Journal Title: EBioMedicine Volume: 41 Pages: 105-119
  • DOI: 10.1016/j.ebiom.2019.01.019
  • Peer Reviewed / Open Access
• [Journal Article] High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. (2019)
  • Author(s): Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
  • Journal Title: British Journal of Cancer Volume: 120 Pages: 819-826
  • DOI: 10.1038/s41416-019-0413-x
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• [Journal Article] Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD. (2019)
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• [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. (2019)
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• [Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SODIG93A. (2019)
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• [Journal Article] Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS). (2019)
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• [Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRJM33 at Tyr-524. -610, and -1048. (2019)
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• [Journal Article] Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway. (2019)
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• [Journal Article] Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals (2019)
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• [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. (2019)
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• [Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. (2019)
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• [Journal Article] Quinidine therapy and therapeutic drug monitoring in four patients with KCNTI mutations. (2019)
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• [Journal Article] Targeting claudin-4 enhances CDDP-chemosensitivity of gastric cancer (2019)
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  • Peer Reviewed
• [Journal Article] 悪性髄膜腫における個別化医療の可能性 (2019)
  • Author(s): 平石哲也、棗田学、岡田正康、大石誠、藤井幸彦
  • Journal Title: Precision Medicine Volume: 2 Issue: 1 Pages: 54-58
• [Journal Article] Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle (2019)
  • Author(s): Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
  • Journal Title: Pathobiology
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• [Journal Article] Concurrent expression of CD47 and CD44 in colorectal cancer promotes malignancy (2019)
  • Author(s): Fujiwara-Tani R, Sasaki T, Ohmori H, Luo Y, Goto K, Nishiguchi Y, Mori S, Nakashima C, Mori T, Miyagawa Y, Kawahara I, Fujii K, Kishi S, Tatsumoto N, Kuniyasu H
  • Journal Title: Pathobiology
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• [Journal Article] Intracellular transport of NMDA receptors and Schizophrenia (2019)
  • Author(s): Yosuke Takei, Saki Tome, Tetsuya Sasaki
  • Journal Title: Japanese Journal of Biological Psychiatry
  • Peer Reviewed
• [Journal Article] Mitochondrial pyruvate carrier I expression controls cancer EMT and radioresistance. (2019)
  • Author(s): Takaoka, Y., Konno, M., Koseki, J., Colvin, H., Asai, A., Tamari, K., Satoh, T., Mori, M., Doki, Y., Ogawa, K., Ishii, H.
  • Journal Title: Cancer Sci. Volume: 110 Issue: 4 Pages: 1331-1339
  • DOI: 10.1111/cas.13980
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• [Journal Article] Regulation of mitochondrial iron homeostasis by sideroflexin 2 (2019)
  • Author(s): Non, E.E., *Wei, F.-Y., Ahmad, R.N.R., Yamamoto, T., Moroishi. T., *Tomizawa, K.
  • Journal Title: J. Physiol. Sci. Volume: 69 Pages: 359-373
  • DOI: 10.1007/s12576-018-0652-2
  • NAID: 40021819064
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• [Journal Article] Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. (2019)
  • Author(s): Maeda A. Nishino T, Matsuzaki R, Yokoyama A, Suga H, Yagi T, Konishi H.
  • Journal Title: Biochim Biophys Acta Mol Cell Res. Volume: 1866 Pages: 285-295
  • DOI: 10.1016/j.bbamcr.2018.11.009
  • Description: [Epub ahead of print]
  • Peer Reviewed / Open Access
• [Journal Article] Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells. (2019)
  • Author(s): Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M.
  • Journal Title: Oncogene Volume: 38 Issue: 2 Pages: 244-260
  • DOI: 10.1038/s41388-018-0406-x
  • Peer Reviewed / Open Access
• [Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients. (2019)
  • Author(s): Motohiro Kojima, Yu Chen, Koji Ikeda, Yuichiro Tsukada, Daigoro Takahashi, Shingo Kawano, Kota Amemiya, Masaaki Ito, Rieko Ohki, Atsushi Ochiai.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2040-2040
  • DOI: 10.1038/s41598-018-37707-z
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• [Journal Article] Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. (2019)
  • Author(s): Tominaga, K., Ninato, H., Murayama, T., Sasahara, A., Nishimura, T., Kiyokawa, E., Kanauchi, H., Shimizu, S., Sato, A., Nishioka, K., Tsuji, E., Yano, M., Ogawa, T., Ishii, H., Mori, M., Akashi, K., Okamoto, K., Tanabe, M., Tada, K., Tojo, A., Gotoh, N.
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. Volume: 116 Issue: 2 Pages: 625-630
  • DOI: 10.1073/pnas.1806851116
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• [Journal Article] Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex. (2019)
  • Author(s): Nakanishi K, Niida H, Tabata H, Ito T, Hori Y, Hattori M, Johmura Y, Yamada C, Ueda T, Takeuchi K, Yamada K, Nagata KI, Wakamatsu N, Kishi M, Pan YA, Ugawa S, Shimada S, Sanes JR, Higashi Y, Nakanishi M.
  • Journal Title: Cerebral Cortex Volume: 160 Pages: 1-14
  • DOI: 10.1093/cercor/bhy253
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1 : ‘Jack of all trades’ in health and cancer. (2019)
  • Author(s): Sánchez-Martin P, Saito T, Komatsu M.
  • Journal Title: FEBS J. Volume: 286 Issue: 1 Pages: 8-23
  • DOI: 10.1111/febs.14712
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• [Journal Article] Parabrachial-to-amygdala control of aversive learning (2019)
  • Author(s): Nagase, M., Mikami, K., and Watabe, A. M. #(#責任著者)
  • Journal Title: Current Opinion in Behavioral Sciences Volume: 26 Pages: 18-24
  • DOI: 10.1016/j.cobeha.2018.08.005
  • Peer Reviewed
• [Journal Article] Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. (2019)
  • Author(s): Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
  • Journal Title: Journal of Medicinal Chemistry Volume: 62 Issue: 7 Pages: 3407-3427
  • DOI: 10.1021/acs.jmedchem.8b01888
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• [Journal Article] CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. (2019)
  • Author(s): Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
  • Journal Title: Oncogene Volume: 38 Issue: 14 Pages: 2580-2594
  • DOI: 10.1038/s41388-018-0603-7
  • Peer Reviewed
• [Journal Article] Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus. (2019)
  • Author(s): Noritake A, Nakamura K.
  • Journal Title: Journal of neurophysiology Volume: 121 Issue: 2 Pages: 396-417
  • DOI: 10.1152/jn.00247.2018
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• [Journal Article] Opioid and non-dopamine reward circuitry and state-dcpendent mechanisms. (2019)
  • Author(s): Fujita M, Ide S, Ikeda K
  • Journal Title: Aun NY Acad Sci Volume: 印刷中
  • DOI: 10.1111/nyas.13605
  • Description: in press
  • Peer Reviewed
• [Journal Article] Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice : A model of attention-deficit/hyperactivity disorder. (2018)
  • Author(s): Ide S ; Ikekubo Y ; Hua J ; Takamatsu Y ; Uhi GR ; Sora I
  • Journal Title: Neuropsychopharmacol Rep Volume: 38 Pages: 149-153
  • DOI: 10.1002/npr2.12020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration. (2018)
  • Author(s): Asami Kawasaki*, Masayasu Okada*, Atsushi Tamada*, Shujiro Okuda, Motohiro Nozumi, Yasuyuki Ito, Daiki Kobayashi, Tokiwa Yamasaki, Ryo Yokoyama, Takeshi Shibata, Hiroshi Nishina, Yutaka Yoshida, Yukihiko Fujii, Kosei Takeuchi, Michihiro Igarashi (* : These three authors contributed equally)
  • Journal Title: iSCIENCE Volume: 4 Pages: 190-203
  • DOI: 10.1016/j.isci.2018.05.019
  • Peer Reviewed / Open Access
• [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. (2018)
  • Author(s): Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
  • Journal Title: Neurochemistry International Volume: S0197-0186 Pages: 190-198
  • DOI: 10.1016/j.neuint.2018.01.003
  • NAID: 120006554471
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• [Journal Article] Targeted expression of step-function opsins in transgcnic rats for optogenetic studies. (2018)
  • Author(s): Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 5435-5435
  • DOI: 10.1038/s41598-018-23810-8
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• [Journal Article] Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells (2018)
  • Author(s): Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
  • Journal Title: Scientific Reports Volume: 8 Pages: 14827-14827
  • DOI: 10.1038/s41598-018-33139-x
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• [Journal Article] Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics (2018)
  • Author(s): Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Journal Title: Physiological Measurement Volume: 39 Pages: 054003-054003
  • DOI: 10.1088/1361-6579/aac033
  • Peer Reviewed
• [Journal Article] α-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibody against frizzled homolog 10. (2018)
  • Author(s): Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
  • Journal Title: Cancer Science Volume: 109 Issue: 7 Pages: 2302-2309
  • DOI: 10.1111/cas.13636
  • NAID: 120006535011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Task-dependent function of striatal cholinergic interneurons (2018)
  • Author(s): Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
  • Journal Title: Eur J Neurosci Volume: - Issue: 10 Pages: 1174-1183
  • DOI: 10.1111/ejn.13768
  • Peer Reviewed
• [Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXKI. (2018)
  • Author(s): Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
  • Journal Title: Genes Cells Volume: 23 Pages: 599-605
  • DOI: 10.1111/gtc.12597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative study of the somatosensory sensitization underlying cross-modal plasticity. (2018)
  • Author(s): Abe K, Yawo H.
  • Journal Title: PLoS One Volume: 13 Issue: 12
  • DOI: 10.1371/journal.pone.0208089
  • Peer Reviewed / Open Access
• [Journal Article] The temporal turning window for rat behavioral phenotypes by rotenone (2018)
  • Author(s): M. Ishido*
  • Journal Title: Fundam. Toxicol. Sci. Volume: 5 Issue: 6 Pages: 195-202
  • DOI: 10.2131/fts.5.195
  • NAID: 130007554207
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• [Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-l, a potential anti-cancer lead derived from debromoaplysiatoxin (2018)
  • Author(s): Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
  • Journal Title: Heterocycles Volume: 97 Issue: 1 Pages: 478-492
  • DOI: 10.3987/com-18-s(t)37
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• [Journal Article] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen. (2018)
  • Author(s): Eguchi N, Sora I, Muguruma K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 498 Issue: 4 Pages: 729-735
  • DOI: 10.1016/j.bbrc.2018.03.049
  • NAID: 120006462318
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• [Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population. (2018)
  • Author(s): Zhang Y ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Yamamori H ; Boku S ; Horai T ; Someya T ; Ohmori T ; Hashimoto R ; Sora I
  • Journal Title: J Psychiatr Res Volume: 103 Pages: 161-166
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• [Journal Article] Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition. (2018)
  • Author(s): Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Rios A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
  • Journal Title: Neuroscience Volume: 388 Pages: 297-316
  • DOI: 10.1016/j.neuroscience.2018.07.039
  • Peer Reviewed
• [Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia. (2018)
  • Author(s): Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 83 Pages: 33-41
  • DOI: 10.1016/j.pnpbp.2018.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitochondrial DNA copy number of peripheral blood in bipolar disorder : The present study and a meta-analysis. (2018)
  • Author(s): Yamaki N ; Otsuka I ; Numata S ; Yanagi M ; Mouri K ; Okazaki S ; Boku S ; Horai T ; Ohmori T ; Shirakawa O ; Sora I ; Hishimoto A
  • Journal Title: Psychiatry Res Volume: 269 Pages: 115-117
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• [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1 (2018)
  • Author(s): Ida-Yonemochi H, Morita W, Sugiura N, Kawakami R, Morioka Y, Takeuchi Y, Sato T, Shibata S, Watanabe H, Imamura T, Igarashi M, Ohshima H, Takeuchi K
  • Journal Title: Scientific Reports Volume: 8 Pages: 17134-17134
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• [Journal Article] Superiority of rat over murine model for studies on the evolution of cancer genome. (2018)
  • Author(s): Akatsuka S, Li GH, Toyokuni S
  • Journal Title: Free Radical Research Volume: 52 Pages: 1323-1327
  • DOI: 10.1080/10715762.2018.1467562
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• [Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers. (2018)
  • Author(s): Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
  • Journal Title: PLoS One Volume: 13 Issue: 1
  • DOI: 10.1371/journal.pone.0190667
  • NAID: 120006382347
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• [Journal Article] A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients. (2018)
  • Author(s): Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 14 Pages: 663-669
  • DOI: 10.2147/ndt.s153360
  • NAID: 120006425682
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• [Journal Article] Investigation of chromosome Y loss in men with schizophrenia. (2018)
  • Author(s): Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Kimura A ; Horai T ; Sora I
  • Journal Title: Neuropsychiatr Dis Treat Volume: 14 Pages: 2115-2122
  • DOI: 10.2147/ndt.s172886
  • NAID: 120006510199
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas (2018)
  • Author(s): Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
  • Journal Title: Neurol. Med. Chir.(Tokyo) Volume: 58 Issue: 7 Pages: 290-295
  • DOI: 10.2176/nmc.ra.2018-0044
  • NAID: 130007405002
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype. (2018)
  • Author(s): Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
  • Journal Title: Front Psychiatry Volume: 138 Pages: 9-9
  • DOI: 10.3389/fpsyt.2018.00138
  • Peer Reviewed / Open Access
• [Journal Article] Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice. (2018)
  • Author(s): Sasaki K ; Hall FS ; Uhl GR ; Sora I
  • Journal Title: Front Psychiatry Volume: 9 Pages: 441-441
  • DOI: 10.3389/fpsyt.2018.00441
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• [Journal Article] Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain : An exploratory study. (2018)
  • Author(s): Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
  • Journal Title: Neuropsychopharmacology Report Volume: 38(4) Pages: 175-181
  • DOI: 10.1002/npr2.12030
  • Peer Reviewed / Open Access
• [Journal Article] 3D culture system containing gellan gum restores oncogene dependence in ROSI rearrangements non-small cell lung cancer. (2018)
  • Author(s): Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
  • Journal Title: Biochem. Biophys. Res. Commun., Volume: 501 Pages: 527-533
  • DOI: 10.1016/j.bbrc.2018.05.031
  • Peer Reviewed / Open Access
• [Journal Article] A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. (2018)
  • Author(s): Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
  • Journal Title: Kidney Int. Volume: 94 Issue: 3 Pages: 524-535
  • DOI: 10.1016/j.kint.2018.05.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCNIA gene. (2018)
  • Author(s): Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
  • Journal Title: Stem Cell Research Volume: 31 Pages: 11-15
  • DOI: 10.1016/j.scr.2018.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes (2018)
  • Author(s): Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
  • Journal Title: Chem Res Toxicol Volume: 31 Issue: 10 Pages: 1025-1031
  • DOI: 10.1021/acs.chemrestox.8b00067
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm : association with immunoblastoid cytomorphology, MYC expression, and drug response. (2018)
  • Author(s): Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K, and *Takeuchi, K.,
  • Journal Title: Leukemia Volume: 32 Pages: 2590-2603
  • DOI: 10.1038/s41375-018-0154-5
  • Peer Reviewed / Open Access
• [Journal Article] Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells. (2018)
  • Author(s): Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
  • Journal Title: Scientific Reports Volume: 8 Pages: 6760-6760
  • DOI: 10.1038/s41598-018-25189-y
  • Peer Reviewed / Open Access
• [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adpocytes and cancer cells. (2018)
  • Author(s): Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 33 Pages: 8370-8375
  • DOI: 10.1073/pnas.1804243115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new method for identifying mouse pancreatic ducts (2018)
  • Author(s): Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
  • Journal Title: Tissue Eng. Volume: 24 Issue: 8 Pages: 480-485
  • DOI: 10.1089/ten.tec.2018.0127
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression (2018)
  • Author(s): Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
  • Journal Title: Genes Cells Volume: 23 Issue: 8 Pages: 688-701
  • DOI: 10.1111/gtc.12610
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• [Journal Article] FEAT enhances INSL3 expression in testicular Leydig cells. (2018)
  • Author(s): Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
  • Journal Title: Genes to cells Volume: 23 Pages: 952-962
  • DOI: 10.1111/gtc.12644
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses. (2018)
  • Author(s): Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
  • Journal Title: Oncoscience. Volume: 5 Pages: 103-103
  • DOI: 10.18632/oncoscience.411
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment (2018)
  • Author(s): Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
  • Journal Title: Int J Mol Sci Volume: 19 Issue: 3 Pages: 888-888
  • DOI: 10.3390/ijms19030888
  • NAID: 120006471116
  • Peer Reviewed / Open Access
• [Journal Article] Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer. (2018)
  • Author(s): Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
  • Journal Title: Exp Ther Med Volume: 16 Issue: 6 Pages: 4463-4470
  • DOI: 10.3892/etm.2018.6787
  • Peer Reviewed / Open Access
• [Journal Article] An Overview of Development of Quantitative Neurotoxicity Testing In vitro (2018)
  • Author(s): M. Ishido*
  • Journal Title: J. Applied Life Sci. Intl. Volume: 19 Pages: 2394-1103
  • DOI: 10.9734/jalsi/2018/45377
  • Peer Reviewed / Open Access
• [Journal Article] 細胞突起形成抑制による膠芽腫治療戦略 (2018)
  • Author(s): 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
  • Journal Title: 新潟県医師会報 Volume: 814 Issue: 1 Pages: 9-10
  • Peer Reviewed
• [Journal Article] マンガの読みにおける状況モデルの更新 (2018)
  • Author(s): 和田裕一, 三浦知志, 窪俊一
  • Journal Title: マンガ研究 Volume: 24 Pages: 93-114
  • Peer Reviewed
• [Journal Article] Spredl Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. (2018)
  • Author(s): Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
  • Journal Title: Cell Stem Cell Volume: 22 Pages: 713-725
  • DOI: 10.1016/j.stem.2018.04.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia (2018)
  • Author(s): Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I. Nitsos, I., Miller, S. I., Walker, D. W., Wong, F. Y.
  • Journal Title: Pediatr Res Volume: 83 Issue: 3 Pages: 442-450
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immediate-early promoter-driven transgenic reporter system for neuroethological researches in a hemimetabolous insect (2018)
  • Author(s): Watanabe T., Ugajin A. and Aonuma H.
  • Journal Title: eNeuro Volume: 5 Pages: 0061-18
  • DOI: 10.1523/eneuro.0061-18.2018
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• [Journal Article] Parallel arousal pathways in the lateral hypothalamus. (2018)
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  • Journal Title: eNeuro Volume: 5(4) Pages: 0228-18
  • DOI: 10.1523/eneuro.0228-18.2018
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• [Journal Article] A stable association with PME-1 may be dispensable for PP2A demethylation-implications for the detection of PP2A methylation and immunoprecipitation (2018)
  • Author(s): Yabe R. Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T*, Sato K
  • Journal Title: FEBS Open Bio Volume: 8 Issue: 9 Pages: 1486-1496
  • DOI: 10.1002/2211-5463.12485
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• [Journal Article] β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking (2018)
  • Author(s): Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
  • Journal Title: PLoS ONE Volume: 13 Issue: 5
  • DOI: 10.1371/journal.pone.0196946
  • Peer Reviewed / Open Access
• [Journal Article] Glycans in stem cell regulation : from Drosophila tissue stem cells to mammalian pluripotent stem cells. (2018)
  • Author(s): Nishihara S
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  • Peer Reviewed
• [Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 9. (2018)
  • Author(s): Ishida, H., U. Ohto, T. Shibata, K, Miyake, and T. Shimizu.
  • Journal Title: FEBS Lett Volume: 592 Issue: 15 Pages: 2636-2646
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• [Journal Article] Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound (2018)
  • Author(s): Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
  • Journal Title: ChemBioChem Volume: 19 Pages: 2268-2272
  • DOI: 10.1002/cbic.201800425
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells. (2018)
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  • Journal Title: J Bone Miner Res. Volume: 33 Issue: 11 Pages: 2048-2058
  • Peer Reviewed
• [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation (2018)
  • Author(s): Masaya Baba, Mitsuhiro Endoh. Wenjuan Ma, Hirofumi Toyama. Akiyoshi Hirayama, Keiyo Takubo, Hiroyuki Hano. Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
  • Journal Title: Journal of Bone and Mineral Research Volume: 33 Issue: 10 Pages: 1785-1798
  • DOI: 10.1002/jbmr.3477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HipOP mesenchymal population has high potential for repairing injured peripheral nerves. (2018)
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  • Journal Title: J. Cell Biochem. Volume: 印刷中 Issue: 6 Pages: 4836-4844
  • DOI: 10.1002/jcb.26684
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• [Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells (2018)
  • Author(s): Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
  • Journal Title: Methods in Molecular Biology Volume: 1731 Pages: 29-37
  • DOI: 10.1007/978-1-4939-7595-2_3
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• [Journal Article] Salll regulates microglial morphology cell autonomously in the developing retina (2018)
  • Author(s): Koso H, Nishinakamura R, Watanabe S
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• [Journal Article] Tyraminergic modulation of agonistic outcomes in crayfish (2018)
  • Author(s): Momohara Y., Aonuma H. and Nagayama T.
  • Journal Title: J. Comp. Physiol. Volume: 印刷中 Pages: 465-473
  • DOI: 10.1007/s00359-018-1255-3
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• [Journal Article] NIPA-like domain containing l is a novel tumor-promoting factor in oral squamous cell carcinoma. (2018)
  • Author(s): Sasahira T. Nishiguchi Y. Kurihara-Shimomura M, Nakashima C, Kuniyasu H, Kirita T.
  • Journal Title: J Cancer Res Clin Oncol Volume: 144 Issue: 5 Pages: 875-82
  • DOI: 10.1007/s00432-018-2612-x
  • Peer Reviewed
• [Journal Article] Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease. (2018)
  • Author(s): Ichinose H, Inoue KI. Arakawa S. Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO
  • Journal Title: J Neural Transm Volume: 125 Pages: 45-52
  • DOI: 10.1007/s00702-017-1784-x
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• [Journal Article] Systematic review of pre-clinical chronic myeloid leukaemia. (2018)
  • Author(s): Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
  • Journal Title: Int J Hematol. Volume: 108 Issue: 5 Pages: 465-484
  • DOI: 10.1007/s12185-018-2528-x
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• [Journal Article] Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum. (2018)
  • Author(s): Kano M, Watanabe T, Uesaka N, Watanabe M.
  • Journal Title: Cerebellum. Volume: 17 Issue: 6 Pages: 722-734
  • DOI: 10.1007/s12311-018-0964-z
  • Peer Reviewed
• [Journal Article] Biallelic Variants in CNPY3. Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy. (2018)
  • Author(s): Mutoh, H., M. Kato. T. Akita, T. Shibata, H. Wakamoto, H. Ikeda, H. Kitaura, K. Aoto, M. Nakashima, T. Wang, C. Ohba, S. Miyatake, N. Miyake, A. Kakita, K. Miyake, A. Fukuda, N. Matsumoto, and H. Saitsu.
  • Journal Title: Am J Hum Genet Volume: 102 Issue: 2 Pages: 321-329
  • DOI: 10.1016/j.ajhg.2018.01.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development (2018)
  • Author(s): Kawamura Y, Yamanaka K, Poh B, Kuribayashi H. Koso H, Watanabe S
  • Journal Title: Biochem Biophys Res Commun Volume: 503 Issue: 4 Pages: 3023-3030
  • DOI: 10.1016/j.bbrc.2018.08.088
  • Peer Reviewed
• [Journal Article] Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene : A case report. (2018)
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  • Journal Title: Brain & Development Volume: 40(7) Issue: 7 Pages: 576-581
  • DOI: 10.1016/j.braindev.2018.03.004
  • Peer Reviewed
• [Journal Article] Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglels (2018)
  • Author(s): Jinnai, W. Nakamura, S. Koyano, K. Yamato, S. Wakabayashi, T. Htun, Y. Nakao, Y. Iwase, T. Nakamura, M. Yasuda, S. Ueno, M. Miki, T. Kusaka T
  • Journal Title: Brain Dev Volume: 40 Issue: 8 Pages: 649-661
  • DOI: 10.1016/j.braindev.2018.04.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A patient with a GNAOI mutation with decreased spontaneous movements, hypotonia, and dystonic features. (2018)
  • Author(s): Okumura A. Naruyama K, Shibata M, Kurahashi H, Ishii A, Numoto S, Hirose S, Kawai T, Iso M, Kataoka S, Okuno Y, Muramatsu H, Kojima S.
  • Journal Title: Brain & Development Volume: 40 Issue: 10 Pages: 926-30
  • DOI: 10.1016/j.braindev.2018.06.005
  • Peer Reviewed
• [Journal Article] The autism-related protein CHD8 cooperates with C/EBP β to regulate adipogenesis. (2018)
  • Author(s): Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., Nishiyama M., Nakayama KI.
  • Journal Title: Cell Rep. Volume: 23 Pages: 1988-2000
  • DOI: 10.1016/j.celrep.2018.04.050
  • Peer Reviewed / Open Access
• [Journal Article] Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells. (2018)
  • Author(s): Hirotaka Watanabe, et al.
  • Journal Title: Cell Reports Volume: 23 Pages: 3721-3729
  • DOI: 10.1016/j.celrep.2018.05.081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. (2018)
  • Author(s): Tainaka K. Murakami TC, Susaki EA, Shimizu C, Saito R, Takahashi K, Hayashi-Takagi A, Sekiya H, Arima Y, Nojima S, Ikemura M, Ushiku T, Shimizu Y, Murakami M, Tanaka KF, Iino M, Kasai H, Sasaoka T. Kobayashi K, Miyazono K, Morii E, Isa T, Fukayama M, Kakita A. Ueda HR.
  • Journal Title: Cell Reports Volume: 24 Pages: 2196-2210
  • DOI: 10.1016/j.celrep.2018.07.056
  • NAID: 120006542018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Calcium transient dynamics of neural ensembles in the primary motor cortex of naturally behaving monkeys. (2018)
  • Author(s): Kondo T, Saito R, Otaka M, Yoshino-Saito K, Yamanaka A, Yamamori T, Watakabe A, Mizukami H, Schnitzer MJ, Tanaka KF. Ushiba J. Okano H.
  • Journal Title: Cell Rep Volume: 24(8) Issue: 8 Pages: 2191-2195
  • DOI: 10.1016/j.celrep.2018.07.057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output (2018)
  • Author(s): Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
  • Journal Title: Cell Rep. Volume: 25 Pages: 2704-2715
  • DOI: 10.1016/j.celrep.2018.11.016
  • Peer Reviewed / Open Access
• [Journal Article] Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. (2018)
  • Author(s): Zhang, Z., U. Ohto, T. Shibata, M. Taoka, Y. Yamauchi, R. Sato, N. M. Shukla, S. A. David, T. Isobe, K. Miyake, and T. Shimizu.
  • Journal Title: Cell Rep Volume: 25 Issue: 12 Pages: 3371-3381
  • DOI: 10.1016/j.celrep.2018.11.081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication. (2018)
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  • Journal Title: Cell Host Microbe Volume: 23 Issue: 2 Pages: 254-265
  • DOI: 10.1016/j.chom.2017.12.014
  • Peer Reviewed / Open Access
• [Journal Article] CD4+ CD521o T-cell expression contributes to the development of systemic lupus erythematosus (2018)
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  • Journal Title: Clinical Immunology Volume: 187 Pages: 50-57
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Safety evaluation of a human chimeric monoclonal antibody that recognizes the extracellular loop domain of claudin-2. (2018)
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  • Journal Title: Eur J Pharm Sci Volume: 70 Pages: 161-167
  • DOI: 10.1016/j.ejps.2018.02.016
  • Peer Reviewed
• [Journal Article] Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies. (2018)
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  • Journal Title: eNeurologicalSci Volume: 12 Pages: 36-38
  • DOI: 10.1016/j.ensci.2018.08.001
  • Peer Reviewed / Open Access
• [Journal Article] Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation. (2018)
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  • Journal Title: Immunity Volume: 48 Issue: 4 Pages: 649-658
  • DOI: 10.1016/j.immuni.2018.03.013
  • Peer Reviewed / Open Access
• [Journal Article] The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. (2018)
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  • Journal Title: Immunity Volume: 48 Issue: 5 Pages: 911-922
  • DOI: 10.1016/j.immuni.2018.04.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ezhl Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome. (2018)
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  • Journal Title: iScience Volume: 9 Pages: 161-174
  • DOI: 10.1016/j.isci.2018.10.008
  • Peer Reviewed / Open Access
• [Journal Article] USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. (2018)
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  • Journal Title: iScience. Volume: 30 Pages: 433-450
  • DOI: 10.1016/j.isci.2018.11.006
  • Peer Reviewed / Open Access
• [Journal Article] In-frame Va1216-Ser217 deletion of KIT in mild piebaldism causes aberrant secretion and SCF response (2018)
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  • Journal Title: Journal of Dermatological Science Volume: 91 Issue: 1 Pages: 35-42
  • DOI: 10.1016/j.jdermsci.2018.03.012
  • Peer Reviewed
• [Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. (2018)
  • Author(s): Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
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  • Journal Title: Neuron Volume: 99(6) Issue: 6 Pages: 1302-1314
  • DOI: 10.1016/j.neuron.2018.08.002
  • Peer Reviewed
• [Journal Article] Acute aversive stimuli rapidly increase the activity of ventral tegmental area dopamine neurons in awake mice. (2018)
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  • Journal Title: Neuroscience Volume: 386 Pages: 16-23
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• [Journal Article] Reappraising newborn screening for cobalamin C disorder. (2018)
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  • Journal Title: Pediatrics & Neonatology Volume: 59 Issue: 4 Pages: 415-417
  • DOI: 10.1016/j.pedneo.2017.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia (2018)
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• [Journal Article] Potential application of testosterone replacement therapy as treatment for obesity and type 2 diabetes in men. (2018)
  • Author(s): Fink J, Matsumoto M, Tamura Y.
  • Journal Title: Steroids Volume: 161 Pages: 161-166
  • DOI: 10.1016/j.steroids.2018.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines (2018)
  • Author(s): Shimamura M, Yamamoto K, Kurashige T, Nagayama Y
  • Journal Title: Experimental Cell research Volume: 370 Issue: 2 Pages: 699-707
  • DOI: 10.1016/j.yexcr.2018.07.036
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• [Journal Article] Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling. (2018)
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• [Journal Article] Red-Tuning of the Channelrhodopsin Spectrum Using Long Conjugated Retinal Analogues. (2018)
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  • Journal Title: Biochemisty Volume: 57 Issue: 38 Pages: 5544-5556
  • DOI: 10.1021/acs.biochem.8b00583
  • NAID: 120006708206
  • Peer Reviewed
• [Journal Article] Chiroptical Inversion of Europium(Ⅲ) Complexes by Changing a Remote Stereogenic Center of a C2-symmetric Bispyrrolidinoindoline Manifold (2018)
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  • Journal Title: J. Org. Chem. Volume: 83 Issue: 24 Pages: 15284-15296
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  • Peer Reviewed
• [Journal Article] Design and De Novo Synthesis of 6-Aza-artemisinins (2018)
  • Author(s): Karnakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Omura, Hiroki Oguri
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  • Peer Reviewed
• [Journal Article] Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A. and N-Fmoc Saframycin Y3 (2018)
  • Author(s): Ryo Tanifuji, Kento Koketsu, Michiko Takakura, Ryutaro Asano, Atsushi Minami, Hideaki Oikawa, Hiroki Oguri
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• [Journal Article] Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-Ⅲ and Racl. (2018)
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  • Journal Title: Oncogene Volume: 37 Pages: 5416-5434
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  • Peer Reviewed / Open Access
• [Journal Article] Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 (2018)
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  • Journal Title: Oncogene Volume: 38 Issue: 14 Pages: 2464-2481
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  • Peer Reviewed / Open Access
• [Journal Article] Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells. (2018)
  • Author(s): Tamari, K., Konno, M., Asai, A., Koseki., Jun., Hayashi, K., Kawamoto, K., Murai, N., Matsufuji, S., Isohashi, F., Satoh, T., Goto, N., Tanaka, S., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
  • Journal Title: Cell Death. Discovery Volume: 4 Issue: 104 Pages: 104-104
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  • Peer Reviewed / Open Access
• [Journal Article] In vivo reprogramming drives Kras-induced cancer development (2018)
  • Author(s): Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito, Yoshiya Kawaguchi, Takuya Yamamoto, Yasuhiro Yamada
  • Journal Title: Nature Communications Volume: 9 Pages: 2081-2081
  • DOI: 10.1038/s41467-018-04449-5
  • NAID: 120006473761
  • Peer Reviewed / Open Access
• [Journal Article] Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience. (2018)
  • Author(s): Miyazaki K, Miyazaki KW, Yamanaka A, Tokuda T, Tanaka KF, Doya K.
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• [Journal Article] Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis (2018)
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix (2018)
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  • Journal Title: Nat Commun Volume: 9 Pages: 1-14
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] UBL3 modification influences protein sorting to small extracellular vesicles. (2018)
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  • Journal Title: Nature Communications Volume: 9 Pages: 1-14
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  • Peer Reviewed / Open Access / Int'l Joint Research
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  • Peer Reviewed / Open Access
• [Journal Article] Neuronal sirtl regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice. (2018)
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  • Journal Title: Nat Commun Volume: 9 Issue: 1 Pages: 1-17
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  • Peer Reviewed / Open Access
• [Journal Article] Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis. (2018)
  • Author(s): Sato, R., A. Kato, T. Chimura, S. I. Saitoh, T. Shibata, Y. Murakami, R. Fukui, K. Liu, Y. Zhang, J. Arii, G. H. Sun-Wada. Y. Wada, T. Ikenoue, G. N. Barber, T. Manabe, Y. Kawaguchi, and K. Miyake.
  • Journal Title: Nat Immunol Volume: 19 Issue: 10 Pages: 1071-1082
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-vide distribution of linker histone H1.0 is independent of MeCP2 (2018)
  • Author(s): Ito-Ishida A, Yamalanchili HK, Shao Y, Baker SA, Heckman LD, Lavery LA, Kim JY, Lombardi LM, Sun Y, Liu Z, zoghbi HY.
  • Journal Title: Nature Neuroscience Volume: 21 Issue: 6 Pages: 794-798
  • DOI: 10.1038/s41593-018-0155-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sirtuin 7 deficiency ameliorates cisplatin-induced acute kidney injury through regulation of the inflammatory response. (2018)
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  • Journal Title: Sci. Rep Volume: 8 Pages: 5927-5927
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Improvement of cerebellar ataxic gait by injecting Cblnl into the cerebellum of cblnl-null mice (2018)
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  • Journal Title: Sci. Rep. Volume: 8 Issue: 1 Pages: 6184-6184
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  • Peer Reviewed / Open Access
• [Journal Article] Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs. (2018)
  • Author(s): Takayama Y, Ando T, Ichikawa J, Haro H
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 11320-11320
  • DOI: 10.1038/s41598-018-29669-z
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• [Journal Article] Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model. (2018)
  • Author(s): Aoto Y, Okumura K, Hachiya T, Hase S, Wakabayashi Y, Ishikawa F, Sakakibara Y.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 12994-12994
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  • Peer Reviewed / Open Access
• [Journal Article] An extracellular [NiFe] hydrogenase mediating iron corrosion is encoded in a genetically unstable genomic island in Methanococcus maripaludis. (2018)
  • Author(s): Tsurumaru, H., Ito. N., Mori, K., Wakai. S., Uchiyama, T., Iino, T., Hosoyama, A., Ataku, H., Nishijima, K., Mise, M., Shimizu, A., Harada, T., Horikawa, H., Ichikawa, N., Sekigawa, T., Jinno, K., Tanikawa, S., Yamazaki, J., Sasaki, K., Yamazaki, S., Fujita, N., and Harayama, S.,
  • Journal Title: Scientific Reports 8 Volume: 8 Pages: 15149-15149
  • DOI: 10.1038/s41598-018-33541-5
  • Peer Reviewed / Open Access
• [Journal Article] ASXLl and SETBPI mutations promote leukaemogenesis by repressing TGFb pathway genes through histone deacetylation (2018)
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• [Journal Article] Development of G-quadruplex ligand for selective induction of parallel-type topology (2018)
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  • Journal Title: Org. Biomol. Chem. Volume: 16 Pages: 7375-7382
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• [Journal Article] Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly (2018)
  • Author(s): Nana Tsuchiya, Yunosuke Ryu, Takahiro Muraoka, Hiroki Oguri
  • Journal Title: Org. Biomol. Chem. Volume: 16 Pages: 9305-9313
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• [Journal Article] Interaction between cardiac myosin-binding protein C and formin Fhod3. (2018)
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  • Peer Reviewed / Open Access
• [Journal Article] Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis. (2018)
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  • Journal Title: Proc Natl Acad Sci USA Volume: 115 Issue: 30 Pages: 7831-7836
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• [Journal Article] Anabolic-androgenic steroids : procurement and administration practices of doping athletes. (2018)
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  • Journal Title: Physician, Sportsmedicine 2 Volume: 47 Issue: 1 Pages: 10-14
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• [Journal Article] Generation of rat monoclonal antibodies specific for DZIP3 (2018)
  • Author(s): Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Issue: 3 Pages: 153-157
  • DOI: 10.1089/mab.2018.0005
  • Peer Reviewed / Open Access
• [Journal Article] Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1 (2018)
  • Author(s): Oikawa D, Shiota M, Wanibuchi H. Tokunaga F.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Issue: 4 Pages: 180-184
  • DOI: 10.1089/mab.2018.0023
  • Peer Reviewed / Open Access
• [Journal Article] A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes (2018)
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  • Journal Title: Biology Methods and Protocols Volume: 3
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• [Journal Article] Biallelic UFMI and UFCI mutations expand the essential role of ufmylation in brain development. (2018)
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  • Journal Title: Brain Volume: 141 Pages: 1934-1945
  • DOI: 10.1093/brain/awy135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes (2018)
  • Author(s): Hisashi Hasumi, Mitsuko Furuya, Kenji Tatsuno, Shogo Yamamoto, Masaya Baba, Yukiko Hasumi, Yasuhiro Isono, Kae Suzuki, Ryosuke Jikuya, Shinji Otake, Kentaro Muraoka, Kimito Osaka, Narihiko Hayashi, Kazuhide Makiyama, Yasuhide Miyoshi, Keiichi Kondo, Noboru Nakaigawa, Takashi Kawahara, Koji Izumi, Junichi Teranishi, Yasushi Yumura, Hiroji Uemura, Yoji Nagashima, Adam R Metwalli, Laura S Schmidt,
  • Journal Title: Human molecular genetics Volume: 印刷中 Issue: 15 Pages: 2712-2724
  • DOI: 10.1093/hmg/ddy181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration. (2018)
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  • Journal Title: Sleep Volume: 41(9) Issue: 9
  • DOI: 10.1093/sleep/zsy116
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• [Journal Article] Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency (2018)
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  • Journal Title: Journal of Dermatology Volume: 45 Issue: 5
  • Peer Reviewed
• [Journal Article] The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis. (2018)
  • Author(s): Jin F, Li X. Deng Y, Timilshina M. Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW
  • Journal Title: Allergy
  • DOI: 10.1111/all.13702
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• [Journal Article] Study on the tumor-induced angiogenesis using mathematical models. (2018)
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  • Journal Title: Cancer Science Volume: 109 Pages: 15-23
  • DOI: 10.1111/cas.13395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma (2018)
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  • Journal Title: Cancer Sci. Volume: 109 Issue: 5 Pages: 1513-1523
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  • Journal Title: Cancer Sci Volume: in press Issue: 6 Pages: 2036-2045
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas. (2018)
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  • Journal Title: Cancer Sci Volume: 109 Pages: 2497-2508
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  • Peer Reviewed / Open Access
• [Journal Article] PHLDAI, another PHLDA family protein that inhibits AKt. (2018)
  • Author(s): Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
  • Journal Title: Cancer Science Volume: 109 Pages: 3532-3542
  • DOI: 10.1111/cas.13796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. (2018)
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  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4003-4014
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• [Journal Article] Physiological and pathological relevance of cell competition in fly to mammals. (2018)
  • Author(s): Shunsuke Kon.
  • Journal Title: Development, Growth and Differentiation Volume: 60 Pages: 14-20
  • DOI: 10.1111/dgd.12415
  • Peer Reviewed / Open Access
• [Journal Article] Transdifferentiation of human somatic cells by ribosome. (2018)
  • Author(s): Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
  • Journal Title: Development Growth & Differentiation Volume: 60(5) Pages: 241-247
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  • Peer Reviewed / Open Access
• [Journal Article] Identification and functional analysis of inflammation-related miRNAs in skin wound repair. (2018)
  • Author(s): Mori R, Tanaka K, Shimokawa I
  • Journal Title: Dev Growth Differ Volume: 60 Issue: 6 Pages: 306-315
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• [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma. (2018)
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  • Journal Title: Histopathol Volume: in press Issue: 4 Pages: 539-48
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• [Journal Article] Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlcl-over-expressing mice. (2018)
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  • Journal Title: J Neurochem Volume: 147 Issue: 3 Pages: 344-360
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• [Journal Article] Deletion of exons encoding carboxypeptidase domain of Nnal results in Purkinje cell degeneration (pcd) phenotype. (2018)
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  • Journal Title: J Neurochem. Volume: 147 Pages: 557-572
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional characterization of recombinant snake venom rhodocytin : rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis. (2018)
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  • Journal Title: J Thromb Haemost Volume: 16 Issue: 5 Pages: 960-972
  • DOI: 10.1111/jth.13987
  • Peer Reviewed
• [Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy. (2018)
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  • Journal Title: Sci Transl Med Volume: 10 Pages: 447-447
  • DOI: 10.1126/scitranslmed.aao4953
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multisensory enhancement of burst activity in an insect auditory neuron (2018)
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  • Journal Title: J Neurophysiol. Volume: 印刷中 Pages: 139-148
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  • Peer Reviewed
• [Journal Article] Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images. (2018)
  • Author(s): Toratani, M., Konno, M., Asai. A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
  • Journal Title: Cancer Res Volume: 78
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• [Journal Article] p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4 (2018)
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  • Journal Title: Cancer Res. Volume: 78(21) Pages: 3471-3484
  • DOI: 10.1158/0008-5472.can-18-1749
  • Peer Reviewed
• [Journal Article] Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. (2018)
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  • Journal Title: Mol Cancer Res Volume: 16 Issue: 3 Pages: 554-563
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• [Journal Article] Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. (2018)
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  • Journal Title: Cancer Discovery Volume: 8 Issue: 11 Pages: 1438-1457
  • DOI: 10.1158/2159-8290.cd-17-1203
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer. (2018)
  • Author(s): Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
  • Journal Title: Jounal of Clinical Investigation Volume: 128 Issue: 12 Pages: 5603-5619
  • DOI: 10.1172/jci121679
  • Peer Reviewed / Open Access
• [Journal Article] Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation. (2018)
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  • Journal Title: J Clin Invest Volume: 128 Issue: 9 Pages: 3872-3886
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats (2018)
  • Author(s): Miyazawa, Y., Takahashi, Y., Watabe, A. M. and Kato F.
  • Journal Title: Molecular Pain Volume: 14 Pages: 174480691880710-174480691880710
  • DOI: 10.1177/1744806918807102
  • Peer Reviewed / Open Access
• [Journal Article] High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System (2018)
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  • Journal Title: SLAS Discovery Volume: 23 Issue: 10 Pages: 1018-1029
  • DOI: 10.1177/2472555218793066
  • Peer Reviewed
• [Journal Article] Splice-site mutation causing partial retention of intron in the FLCN gene in Birt-Hogg-Dubé syndrome : a case report (2018)
  • Author(s): Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
  • Journal Title: BMC medical genomics Volume: 42 Pages: 42-42
  • DOI: 10.1186/s12920-018-0359-5
  • Peer Reviewed / Open Access
• [Journal Article] Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation. (2018)
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  • Journal Title: Biomark Res. Volume: 6 Pages: 16-16
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glucagonoma With Necrolytic Migratory Erythema : Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene. (2018)
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  • Journal Title: J Clin Endocrinol Metab Volume: 23 Issue: 7 Pages: 2417-2423
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1-steering the cell through health and disease. (2018)
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  • Peer Reviewed / Open Access
• [Journal Article] Hidden Peptides Encoded by Putative Noncoding RNAs (2018)
  • Author(s): Matsumoto A., Nakayama KI.
  • Journal Title: Cell Struct. Funct. Volume: 18;43(1) Issue: 1 Pages: 75-83
  • DOI: 10.1247/csf.18005
  • NAID: 130006742309
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  • Peer Reviewed / Open Access
• [Journal Article] An Anti-tumorigenic Role of the Warburg Effect at Emergence of Transformed Cells. (2018)
  • Author(s): Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
  • Journal Title: Cell Struct. Funct. Volume: 43 Issue: 2 Pages: 171-176
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  • NAID: 130007420412
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] i-Motif-binding ligand and their effects on the structure and biological functions of i-motif (2018)
  • Author(s): Shadi Sedghi Masoud, Kazuo Nagasawa
  • Journal Title: CHEMICAL & PHARMACEUTICAL BULLETIN Volume: 66 Issue: 12 Pages: 1091-1103
  • DOI: 10.1248/cpb.c18-00720
  • NAID: 130007539147
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  • Peer Reviewed / Open Access
• [Journal Article] UPA-Seq : Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking. (2018)
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  • Journal Title: RNA Volume: 24 Issue: 12 Pages: 1785-1802
  • DOI: 10.1261/rna.067611.118
  • NAID: 120006545959
  • Peer Reviewed / Open Access
• [Journal Article] Freezing sperm in short straws reduces storage space and allows transport in dry ice. (2018)
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  • Journal Title: J. Reprod. Dev. Volume: 64 Issue: 6 Pages: 541-545
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• [Journal Article] Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility. (2018)
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• [Journal Article] New observations in neuroscience using superresolution microscopy (2018)
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• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gone and severity of both cancer pain and postoperative pain. (2018)
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  • Journal Title: Cancer Discovery Volume: 7 Pages: 522-538
  • DOI: 10.1158/2159-8290.cd-16-0932
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cireulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes (2017)
  • Author(s): Klcmis, V., Ghura, H., Federico, G., Wurfel, C., Bontmann, A., Gretz, N., Miyazaki, T., Grone, H. J., Nakchbandi, I. A.
  • Journal Title: Kidney Int Volume: 91 Pages: 1374-1385
  • DOI: 10.1016/j.kint.2016.12.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer (2017)
  • Author(s): Kobayashi, K., Tomita, H., Shimizu, M., Tanaka, T., Suzui, N., Miyazaki, T., Hara, A.
  • Journal Title: Int J Mol Sci Volume: 18
  • Peer Reviewed / Open Access
• [Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo (2017)
  • Author(s): M. Kawada, H. Inoue, M. Kajikawa, M. Sugiura, S. Sakamoto, S. Urano, C. Karasawa, I. Usami, M. Futakuchi, T. Masuda.
  • Journal Title: Sci Rep Volume: 7 Pages: 40400-40400
  • DOI: 10.1038/srep40400
  • Peer Reviewed / Open Access
• [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gone polymorphisms and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Yoshihara E, Nishizawa D, Kawai A, Ikeda K, Iwahashi K
  • Journal Title: 日本アルコール薬物医学会雑誌 Volume: 52 Issue: 5 Pages: 156-167
  • Peer Reviewed
• [Journal Article] Rolc of NMDA receptor GluN2D subunit in the antideprossant effects of onantiomers of ketamine. (2017)
  • Author(s): Idc S, Ikokubo Y, Mishina M, Hashimoto K, Ikeda K
  • Journal Title: J Pharmacol Sci Volume: 135(3) Issue: 3 Pages: 138-140
  • DOI: 10.1016/j.jphs.2017.11.001
  • Peer Reviewed / Open Access
• [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nuclcotide polymorphism and older age in Japanese. (2017)
  • Author(s): Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
  • Journal Title: Cancer Chemother Pharmacol Volume: 79(6) Issue: 6 Pages: 1179-1186
  • DOI: 10.1007/s00280-017-3314-9
  • Peer Reviewed / Open Access
• [Journal Article] Light/dark phase-dopendent spontancous activity is maintained in dopamine-doficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikcda K
  • Journal Title: Mol Brain Volume: 10 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s13041-017-0329-4
  • Peer Reviewed / Open Access
• [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students. (2017)
  • Author(s): Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
  • Journal Title: Psychiatry Investigation Volume: 14(5) Issue: 5 Pages: 681-686
  • DOI: 10.4306/pi.2017.14.5.681
  • Peer Reviewed / Open Access
• [Journal Article] Opioid dose and neuropathic pain before-and-after electroconvulsive therapy. (2017)
  • Author(s): Iwata K, Kobayashi Y, Mera H, Doi N, Suwa H, Ikeda K
  • Journal Title: JJSPC Volume: 24(2) Issue: 2 Pages: 116-120
  • DOI: 10.11321/jjspc.16-0024
  • NAID: 130006832066
  • ISSN: 1340-4903, 1884-1791
  • Peer Reviewed / Open Access
• [Journal Article] ゲノムワイド関連解析を利用したオピオイドのデーラーメイド医療への試み。 (2017)
  • Author(s): 三枝勉, 西澤大輔, 福田謙一, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 麻酔・集中治療とテクノロジー2017 Pages: 16-21
  • Open Access
• [Journal Article] JSNP Excellent Presentation Award for CINP2016 : Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Iwahashi K, Yoshihara E, Kawai A, Nishizawa D, Ikeda K
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 3 Pages: 97-98
• [Journal Article] JSNP Excollent Prosentation Award for CINP2016 : 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化。 (2017)
  • Author(s): 井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 2 Pages: 49-50
  • Int'l Joint Research
• [Journal Article] JSNP Excellent Presentation Award for CINP2016 : ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定。 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 2 Pages: 53-54
• [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発 (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: ペインクリニック Volume: 38
• [Journal Article] ペインクリニックにおける精密医療 (2017)
  • Author(s): 池田和隆
  • Journal Title: ペインクリニック Volume: 38 Pages: 557-558
  • Peer Reviewed
• [Journal Article] Higher Arc Nucleus-to-Cytoplasm Ration during Sleep in the Superficial Layers of the Mouse Cortex. (2017)
  • Author(s): Honjoh S, de Vivo L, Okuno H, Bito H, Tononi G, Cirelli C.
  • Journal Title: Front Neural Circuits. Volume: 11 Pages: 60-60
  • DOI: 10.3389/fncir.2017.00060
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Are restores juvenile plasticity in adult mouse visual cortex. (2017)
  • Author(s): Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shephord JD.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 114 Pages: 9182-9187
  • DOI: 10.1073/pnas.1700866114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histaminc modulation of the basal ganglia circuitry in the dovelopment of pathological grooming. (2017)
  • Author(s): Rapanclli M, Frick L, Bito H, Pittenger C
  • Journal Title: Proc Natl Aead Sci USA. Volume: 114 Pages: 6599-6604
  • DOI: 10.1073/pnas.1704547114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Calmodulin kinases : essential regulators in health and disease. (2017)
  • Author(s): Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
  • Journal Title: J Neurochem. Volume: - Pages: 808-818
  • DOI: 10.1111/jnc.14020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Optogenctic activation of the sensorimotor cortex reveals "local inhibitory and global excitatory" inputs to the basal ganglia. (2017)
  • Author(s): Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakao N, Nambu A.
  • Journal Title: Cereb Cortex. Volume: 27 Pages: 5716-5726
  • DOI: 10.1093/cercor/bhx234
  • Peer Reviewed / Open Access
• [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice (2017)
  • Author(s): Umcda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
  • Journal Title: Acta Neuropathol Commun Volume: 5 Pages: 59-59
  • DOI: 10.1186/s40478-017-0461-5
  • NAID: 120006371271
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice (2017)
  • Author(s): Umemura M ; Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 11 Pages: 125-125
  • DOI: 10.3389/fnbeh.2017.00125
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cohesin in the brain leads to defective synapse devclopmont and anxicty-related behavior. (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
  • Journal Title: The Journal of Experiment Medicine Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice (2017)
  • Author(s): Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 11 Pages: 125-125
  • Peer Reviewed / Open Access
• [Journal Article] Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis (2017)
  • Author(s): Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
  • Journal Title: Journal of Neurochemistry Volume: 141 Issue: 1 Pages: 124-136
  • DOI: 10.1111/jnc.13963
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities. (2017)
  • Author(s): Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, Saito N, Yanagita RC, Irie K.
  • Journal Title: Molecules Volume: 22 Issue: 4 Pages: 631-631
  • DOI: 10.3390/molecules22040631
  • NAID: 120006363289
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiopheno analogue and thoir antiproliferative activities against human cancer cell lines. (2017)
  • Author(s): Matsumoto T, Kojima N, Akatsuka A, Yamori T, Dan S, Iwasaki H, Yamashita M.
  • Journal Title: Tetrahedron Volume: 73 Issue: 17 Pages: 2359-2366
  • DOI: 10.1016/j.tet.2017.03.011
  • Peer Reviewed
• [Journal Article] Allantopyrone a activates Keapl-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death. (2017)
  • Author(s): Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI
  • Journal Title: Journal of Antibiotics Volume: 70 Issue: 4 Pages: 429-434
  • DOI: 10.1038/ja.2016.99
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. (2017)
  • Author(s): Robke I., Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
  • Journal Title: Angewandte Chemie International Edition Volume: 56 Issue: 28 Pages: 8153-8157
  • DOI: 10.1002/anie.201703738
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• [Journal Article] Development of a terpenoid-production platform in streptomyces reveromyceticus SN-593. (2017)
  • Author(s): Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S
  • Journal Title: ACS Synthctic Biology Volume: 6 Issue: 12 Pages: 233-2349
  • DOI: 10.1021/acssynbio.7b00249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. (2017)
  • Author(s): Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, Ishikawa S, Katagiri T, Imoto M.
  • Journal Title: Cancer Science Volume: 108 Pages: 785-794
  • DOI: 10.1111/cas.13175
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. (2017)
  • Author(s): Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
  • Journal Title: Cancer Science Volume: 108 Pages: 772-784
  • DOI: 10.1111/cas.13172
  • Peer Reviewed / Open Access
• [Journal Article] Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47. (2017)
  • Author(s): Saito S, Fujimaki T, Panbangred W, Sawa R, Igarashi Y, Imoto M
  • Journal Title: Journal of Antibiotics Volume: 印刷中 Pages: 595-600
  • DOI: 10.1038/ja.2017.6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Arabilin overcomes resistance to AR-targeted therapy. (2017)
  • Author(s): Fujimaki T, Saito S, and Imoto M.
  • Journal Title: Journal of Antibiotics Volume: 70 Pages: 328-330
  • DOI: 10.1038/ja.2016.162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metacycloprodigiosin (mcPG) induced cell death selectively in beta-catenin mutated tumor colls. (2017)
  • Author(s): Ikeda H, Shikata Y, Watanapokasin R, Tashiro E, Imoto M
  • Journal Title: Journal of Antibiotics Volume: 70 Pages: 109-112
  • DOI: 10.1038/ja.2016.75
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocylic hexaoxazole (2017)
  • Author(s): Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
  • Journal Title: Sci Rep Volume: 7 Pages: 3605-3605
  • DOI: 10.1038/s41598-017-03785-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice. (2017)
  • Author(s): Funato H, et al.
  • Journal Title: Nature. Volume: 539(7629) Issue: 46 Pages: 378-383
  • DOI: 10.1038/nature20142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. (2017)
  • Author(s): Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M.
  • Journal Title: FASEB J. Volume: in press Pages: 2252-2266
  • DOI: 10.1096/fj.201600642r
  • Description: Epub ahead of print
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• [Journal Article] The mechanics clarifying counterclockwise rotation in most IVF eggs in mice. (2017)
  • Author(s): Ishimoto K, Ikawa M, Okabe M.
  • Journal Title: Sci Rep. Volume: 7 Pages: 43456-43456
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• [Journal Article] SHISA6 confers resistance to differentiation-promoting Wnt/6-catenin aignaling in mouse spermatogenic stem cells. (2017)
  • Author(s): Tokue M, Jkami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
  • Journal Title: Stem Cell Reports Volume: 8 Pages: 561-575
  • DOI: 10.1016/j.stemcr.2017.01.006
  • NAID: 120006224053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pharmacological targeting of plasmin prevents lethality in a murine mode of macrophage activation syndrome. (2017)
  • Author(s): Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
  • Journal Title: Blood Volume: 印刷中 Pages: 59-72
  • DOI: 10.1182/blood-2016-09-738096
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia (2017)
  • Author(s): Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
  • Journal Title: Sci Rep Volume: 7 Issue: 7 Pages: 1-11
  • DOI: 10.1038/srep45050
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Loss of NDRG2 expression confers oral squamous cell carcinoma with enhanced metastatic potential (2017)
  • Author(s): T. Tamura, T. Ichikawa, S. Nakahata, Y. Kondo, Y. Tagawa, K. Yamamoto, K. Nagai, T. Baba, R. Yamaguchi, M. Futakuchi, Y. Yamashita, K. Morishita
  • Journal Title: Cancer Research Volume: 印刷中 Pages: 2363-2374
  • DOI: 10.1158/0008-5472.can-16-2114
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics. (2017)
  • Author(s): Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T.
  • Journal Title: Sci Rep.
  • NAID: 120006535017
  • Description: In press
  • Peer Reviewed / Open Access
• [Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. (2017)
  • Author(s): Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
  • Journal Title: Exp Neurol Volume: S0014-4886(17) Pages: 1-12
  • DOI: 10.1016/j.expneurol.2017.03.009
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Combination treatment with naftopidil increases the efficacy of radiotherapy in PC-3 human prostate cancer cells (2017)
  • Author(s): Iwamoto Y, Ishii K, Kanda H, Kato M, Miki M, Kajiwara S, Arima K, Shiraishi T, Sugimura Y.
  • Journal Title: J Cancer Res Clin Oncol Volume: 印刷中 Pages: 933-939
  • DOI: 10.1007/s00432-017-2367-9
  • Description: Epub ahead of print
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B (2017)
  • Author(s): Takase S, Kurokawa R, Arai D, Kanto KK, Okino T, Nakao Y, Kushiro T, Yoshida M, Matsumoto K.
  • Journal Title: Sci Rep
  • Description: In press
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• [Journal Article] Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6 (2017)
  • Author(s): Yamaguchi N, Nakayama Y, Yamaguchi N.
  • Journal Title: J Biol Chem Volume: 印刷中
  • DOI: 10.1074/jbc.m116.763276
  • Description: Epub ahead of print
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• [Journal Article] Cancer stem cells in human gastrointestinal cancer. (2016)
  • Author(s): Taniguchi H, Moriya C, Igarashi H, Saitoh A, Yamamoto H, Adachi Y, Imai K.
  • Journal Title: Cancer Sci Volume: 107 Issue: 11 Pages: 1556-1562
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• [Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer. (2016)
  • Author(s): Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano H, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
  • Journal Title: Scientific Reports Volume: 6 Pages: 26699-26699
  • DOI: 10.1038/srep26699
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. (2016)
  • Author(s): Kurihara H, Maruyama R, Ishiguro K, Kanno S, Yamamoto I, Ishigami K, Mitsuhashi K, Igarashi H, Ito M, Tanuma T, Sukawa Y, Okita K, Hasegawa T, Imai K, Yamamoto H, Shinomura Y, Nosho K.
  • Journal Title: Oncotarget Volume: 7 Issue: 11 Pages: 12704-120717
  • DOI: 10.18632/oncotarget.7260
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. (2016)
  • Author(s): Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y.
  • Journal Title: World J Gastroenterol Volume: 22 Pages: 557-566
  • DOI: 10.3748/wjg.v22.i2.557
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• [Journal Article] Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease. (2016)
  • Author(s): Yamamoto M, Takahashi H, Shimizu Y, Yajima H, Suzuki C, Naishiro Y, Imai K, Shinomura Y.
  • Journal Title: Mod Rheumatol. Volume: 26 Issue: 1 Pages: 161-2
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• [Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report. (2016)
  • Author(s): Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.
  • Journal Title: Cancer Science Volume: 107(3) Issue: 3 Pages: 369-371
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• [Journal Article] Fertilization defects in sperm from Cysteine-rich secretory protein 2(Crisp2) knockout mice : Implications for fertility disorders. (2016)
  • Author(s): Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, DaRos VG, Cuasnú PS.
  • Journal Title: Mol Hum Reprod. Volume: 22 Issue: 4 Pages: 240-51
  • DOI: 10.1093/molehr/gaw005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GPI-AP release in cellular, developmental, and reproductive biology. (2016)
  • Author(s): Fujihara Y, Ikawa M.
  • Journal Title: J Lipid Res. Volume: 57 Issue: 4 Pages: 538-45
  • DOI: 10.1194/jlr.r063032
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• [Journal Article] Generation of Hprt-disrupted rat through mouse <- rat ES chimeras (2016)
  • Author(s): Isotani A, Yamagata K, Okabe M, Ikawa M.
  • Journal Title: Sci Rep. Volume: 6 Pages: 24215-24215
  • DOI: 10.1038/srep24215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice. (2016)
  • Author(s): Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N.
  • Journal Title: Biol Reprod Volume: 94 Pages: 1-11
  • DOI: 10.1095/biolreprod.115.135988
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] TARP γ-2 and γ-8 differentially control AMPAR density across Schaffer collateral/commissural synapsee in the hippocampal CA1 area. (2016)
  • Author(s): Yamasaki M, Fukaya M, Yamazaki M, Azechi H, Natsume R, Abe M, Sakimura K, Watanabe M.
  • Journal Title: J Neurosci. Volume: 36 Issue: 15 Pages: 4296-312
  • DOI: 10.1523/jneurosci.4178-15.2016
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] GluD2 endows parallel fiber-Purkinje cell synapses with a high regenerative capacity (2016)
  • Author(s): Ichikawa R, Sakimura K, Watanabe M.
  • Journal Title: J Neurosci. Volume: 36 Issue: 17 Pages: 4846-4858
  • DOI: 10.1523/jneurosci.0161-16.2016
  • NAID: 120005853072
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Kidney-specific knockout of Savl in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway. (2016)
  • Author(s): Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, Matsuura K, Moriyama M.
  • Journal Title: J Pathol. Volume: 印刷中 Issue: 1 Pages: 97-108
  • DOI: 10.1002/path.4706
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction. (2016)
  • Author(s): Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H.
  • Journal Title: J Cell Sci. Volume: 未定 Issue: 9 Pages: 19401949-19401949
  • DOI: 10.1242/jcs.182220
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The importance of basonuclin 2 in adult mice and its relation to basonuclinl. (2016)
  • Author(s): Vanhoutteghem, A., Delhomme, B., Herve, F., Nondier, I., Petit, J. M., Araki, M., Araki, K. and Djian, P.
  • Journal Title: Mech. Dev. Volume: Feb 29 Pages: 1-21
  • DOI: 10.1016/j.mod.2016.02.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. (2016)
  • Author(s): Shimbo M, Kudo T, Hamada M, Jeon H, Ikawa M, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Shiba D, Takahashi S.
  • Journal Title: Exp.