先端モデル動物支援プラットフォーム

• Project/Area Number: 16H06276
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: 井上 純一郎 (2019) 東京大学, 医科学研究所, 教授
• Principal Investigator(Support): 今井 浩三 (2016-2018) 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha)(Support): 中村 卓郎 公益財団法人がん研究会, がん研究所, 副所長 (00180373) ; 井上 純一郎 東京大学, 医科学研究所, 教授 (70176428) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 山田 泰広 東京大学, 医科学研究所, 教授 (70313872) ; 高橋 智 筑波大学, 医学医療系, 教授 (50271896) ; 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 﨑村 建司 新潟大学, 脳研究所, フェロー (40162325) ; 荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705) ; 八尾 良司 公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095) ; 真下 知士 大阪大学, 大学院医学系研究科, 准教授 (80397554) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 豊國 伸哉 名古屋大学, 大学院医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 長崎大学, 病院(医学系), 准教授 (60275120) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 宮崎 龍彦 岐阜大学, 医学部附属病院, 准教授 (80239384) ; 神田 浩明 埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067) ; 尾藤 晴彦 東京大学, 大学院医学系研究科, 教授 (00291964) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; 高雄 啓三 富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397) ; 池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656) ; 虫明 元 東北大学, 大学院医学系研究科, 教授 (80219849) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623) ; 長田 裕之 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202) ; 井本 正哉 慶應義塾大学, 理工学部, 教授 (60213253) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065) ; 吉田 稔 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617) ; 松浦 正明 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794) ; 牛嶋 大 公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565) ; 吉田 進昭 東京大学, 医科学研究所, 教授 (10250341)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000); Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
• Keywords: モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・プロファイリング / 分子プロファイリング / 分子探索・ブロファイリング / 行動解析

Outline of Annual Research Achievements

①総括支援活動 : 各支援事業の公募をホームページにおいて一元化しているが、本年度は英文での案内を充実させるなど、利便性の一層の向上に努めた。9月5～7日に蓼科において開催した若手支援技術講習会では、92名の若手研究者が参加し活発な発表と情報交換を行った。成果発表会を2月4～5日に大津市で行い、被支援者による研究成果を中心に132名の参加者による先端的な研究紹介があった。
②モデル動物作製支援活動 : 前・後期2回の公募で申請のあった計144件の課題について一次・二次審査を行い、学術的に優れた83件の課題を採択した。それぞれの採択者と個別に協議し、最適な遺伝子改変技術を用いて、遺伝子改変マウスおよびラットを迅速に作製し、研究リソースとして提供した。
③病理形態解析支援活動 : 34件の申請を受け、3回の審査の結果、28件に関して病理形態解析を実施した。研究の方向性を裏付ける多くの成果が得られた。論文の図の作成など、論文が受理されるまで支援を実施した。
④生理機能解析支援活動 : 行動学的解析では24課題、薬理学的解析では11課題、光技術による操作解析では6課題、多機能電極・計測データ解析では11課題をそれぞれ支援し、動物モデルにおける病態・生理学的基盤の解明推進を支援することで、Cell誌などに成果が発表された。
⑤分子プロファイリング支援活動 : 依頼化合物の分子プロファイリング238件、阻害剤キット配付81枚、RNA干渉キット配付・siRNAデザイン合成41件、バーコードshRNAライブラリーによる化合物の標的経路探索18件を実施するとともに、要望に応じて実地指導を行い、解析技術を習得させた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 若手支援技術講習会では、先進ゲノム支援との連携も行われた。成果発表会とともに多くの参加希望者があり、参加者の研究分野の多様性が増して、本支援活動が生命科学の広い分野から注目を集めていることが明示された。
②モデル動物作製支援活動 : 増加傾向にある応募課題に対し、最新技術を導入することで効率化を図り、予算範囲内で最大限の課題数を採択した。遺伝子改変が複雑あるいは困難な課題を進めるために、必要な技術を導入もしくは開発した。年度末には、新型コロナウイルス感染拡大防止策の一環として動物受け入れが困難な施設が出てきたが、支援拠点で凍結胚を作製し、一時保管することなどにより対応した
③病理形態解析支援活動 : 申請数は安定しており、事前相談や再審査によりできるだけ多く若手研究者の支援を行うよう努力している。現在の予算ならびに班員のエフォートにおいてできる最大限の支援活動を実施しており、成果は確実に上がっている。
④生理機能解析支援活動 : モデルマウスを対象にした感覚・運動・認知機能に関わる「網羅的行動テストバッテリー」を用いた行動解析支援を24課題、依存性薬物等の感受性に関連する行動解析および臨床データと遺伝子多型との関連解析を行う規制薬物作用解析支援を11課題、進展著しい光遺伝学に関する最新技術を活用した研究支援を6課題、多機能集積化電極による最先端の技術提供を行う多元的生理機能計測操作支援を11課題で実施した。
⑤分子プロファイリング支援活動 : トライアル的な小規模の課題から構造活性相関など大規模な課題まで、幅広く支援できた。化合物評価支援では被支援者の研究室から学生を派遣してもらい、技術習得させるなど若手育成面でも成果があった。分子探索支援においても、標準阻害剤キットを利用後に改めて寄託化合物ライブラリーを希望するなど、支援成果をもとにさらなる高次支援に展開する被支援者が見られた。

Strategy for Future Research Activity

①総括支援活動 : 支援拠点の活動内容や支援による成果の紹介など、ホームページを用いた広報活動を一層推進する。若手研究者に対してモデル動物の作製や解析の指導を継続する。成果発表会では、支援による成果の紹介を足掛かりにした新たな共同研究の進展を図る。
②モデル動物作製支援活動 : 先端的なゲノム編集技術を用いて、依頼者の要望に応じて遺伝子改変動物を作製・提供し、科研費による学術研究を支援する。さらに、各支援拠点がもつ独自性の高い研究リソースを提供し、また遺伝子改変技術および周辺技術の導入・開発を進めることにより、国内の研究レベル向上に貢献する。作製された遺伝子改変動物は、公共リソースバンクに供出し、学術基盤としての研究リソースの整備を推進する。
③病理形態解析支援活動 : 現状では、予算ならびに班員に関して限界が近い状態となっている。今後は審査をより厳格に行い、少額研究費の若手の申請に十分に対応したい。一旦開始した病理形態支援は論文が受理されるまでサポートする、という基本方針に変化はない。
④生理機能解析支援活動 : 引き続き各拠点における技術力の維持・向上、支援課題の公正な選考、ハイレベルな支援実施体制の継続に努める。また、支援事業の認知度向上のため、学会等での広報活動を行う。技術支援にとどまらず、支援該当部の論文分担執筆を積極的に進め、成果の公表にも貢献する。
⑤分子プロファイリング支援活動 : 前年度に引き続き、広報の強化・解析条件のカスタマイズ対応・支援実施後のフォロー(科学的助言、共同研究の斡旋、高次支援の勧奨)に努める。定例班会議で問題点を洗い出し、常に最善の運用体制で支援を実施する。また、支援担当者と被支援者による共同研究への移行も意識したうえで、適宜展開例を提示しながら支援を進める。
今年度は、新型コロナの影響により活動内容の変更も予想される。幹事班長会議で連携の上対応する予定である。

Research Products

• [Int'l Joint Research] Yale University/Stanford University/Johns Hopkins University(アメリカ)
• [Int'l Joint Research] University of Ottawa/University of Toronto(カナダ)
• [Int'l Joint Research] Helmholtz Zentrum Muenchen/Technische Universitaet Muenchen(ドイツ)
• [Int'l Joint Research] Pohang University of Science and Technology(シンガポール)
• [Int'l Joint Research] 南通大学(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] コロンピア大学/イリノイ大学/タフツ大学（アメリカ合衆国）
• [Int'l Joint Research] ボルドー大学/マリーキューリー医科大学/グルノーブルアルプス大学（フランス）
• [Int'l Joint Research] 江蘇大学/Xi'an Jiaotong University（中華人民共和国）
• [Int'l Joint Research] Seoul national University/韓南大学（大韓民国）
• [Int'l Joint Research] シンガポール国立大学（シンガポール）
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(アメリカ合衆国)
• [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(イギリス)
• [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)
• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア共和国)
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学(アメリカ合衆国)
• [Int'l Joint Research] Harvard Medical School, Boston(アメリカ合衆国)
• [Int'l Joint Research] スタンフォード大学/エール大学(アメリカ合衆国)
• [Int'l Joint Research] 南通大学(中国)
• [Journal Article] A central master driver of psychosocial stress responses in the rat. (2020)
  • Author(s): Kataoka, N., Shima, Y., Nakajima, K., Nakamura, K.
  • Journal Title: Science Volume: 367 Pages: 1105-1112
  • DOI: 10.1126/science.aaz4639
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant Cortical Ensembles and Schizophrenia-like Sensory Phenotypes in Setdla+/-Mice. (2020)
  • Author(s): Hamm JP, Shymkiv Y, Mukai J, Gogos JA, Yuste R.
  • Journal Title: Biological Psychiatry
  • DOI: 10.1016/j.biopsych.2020.01.004
  • Description: In press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice. (2020)
  • Author(s): Wada S, Yanagida J, Sasase H, Zhang T, Li X, Kamii H, Domoto M, Deyama S, Hinoi E, Yamanaka A, Nishitani N, Nagayasu K, Kaneko S, Minami M, Kaneda K
  • Journal Title: Neuropharmacology. Volume: 166 Pages: 107968-107968
  • DOI: 10.1016/j.neuropharm.2020.107968
  • Peer Reviewed
• [Journal Article] Adiponectin receptor 1 gene is potentially associated with severity of postoperative pain but not cancer pain (2020)
  • Author(s): Ninagawa J. Sumitani M, Nishizawa D, Nagashima M, Mietani K, Abe H, Inoue R, Hozumi J, Tsuchida R, Ikeda K, Yamada Y
  • Journal Title: Medicine (Baltimore) Volume: 99 Issue: 5
  • DOI: 10.1097/md.0000000000018924
  • Peer Reviewed / Open Access
• [Journal Article] Anosmin-l activates vascular endothelial growth factor receptor and its related signaling pathway for olfactory bulb angiogenesis. (2020)
  • Author(s): Matsushima S, Shimizu A, Kondo M, Asano H, Ueno N, Nakayama H, Sato N, Komeno M, Ogita H, Kurokawa-Seo M.
  • Journal Title: Sci Rep Volume: 10 Pages: 188-188
  • DOI: 10.1038/s41598-019-57040-3
  • Peer Reviewed / Open Access
• [Journal Article] BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model. (2020)
  • Author(s): Kataura T, Saiki S, Ishikawa K, Akamatsu W, Sasazawa Y, Hattori N, Imoto M
  • Journal Title: J Neurochem Volume: － Pages: 81-97
  • DOI: 10.1111/jnc.14997
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Cataloguing and selection of mRNAs localized to dendrites in neurons and regulated by RNA-binding proteins in RNA granules (2020)
  • Author(s): R Ohashi and N Shiina
  • Journal Title: Biomolecules Volume: 10 Pages: 167-167
  • DOI: 10.3390/biom10020167
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of early myoclonic encephalopathy caused by a CDKL5 mutation. (2020)
  • Author(s): Takeda K, Miyamoto Y, Yamamoto H, Ishii A, Hirose S, Yamamoto H.
  • Journal Title: Brain Dev. Volume: 42 Issue: 1 Pages: 73-6
  • DOI: 10.1016/j.braindev.2019.08.003
  • Peer Reviewed
• [Journal Article] Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma. (2020)
  • Author(s): Nakahata S, et al, Saito M, Morishita K.
  • Journal Title: Haematologica Volume: 105 Pages: 1-1
  • DOI: 10.3324/haematol.2019.234096
  • Description: in Press in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Coordinated Changes in Cell Membrane and Cytoplasm During Maturation of Apoptotic Bleb (2020)
  • Author(s): Kana Aoki, Shinsuke Satoi, Shota Harada, Seiichi Uchida, Yoh Iwasa, Junichi Ikenouchi
  • Journal Title: Molecular Biology of the Cell Volume: 31 Pages: 833-844
  • DOI: 10.1091/mbc.e19-12-0691
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Crystal structure of Drosophila Piwi (2020)
  • Author(s): Yamaguchi S. Oe A, Nishida KM, Yamashita K, Kajiya A, Hirano S, Matsumoto N, Dohmae N, Ishitani R, Saito K, Siomi H, Nishimasu H, Siomi MC. Nureki O.
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 1-13
  • DOI: 10.1038/s41467-020-14687-1
  • Peer Reviewed / Open Access
• [Journal Article] Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats. (2020)
  • Author(s): Takeshita N, Kawade N, Suzuki W, Hara S, Horio F, Ichinose H
  • Journal Title: Neurosci Lett Volume: 715 Pages: 134656-134656
  • DOI: 10.1016/j.neulet.2019.134656
  • Peer Reviewed
• [Journal Article] Differential cortical and subcortical projection targets of subfields in the core region of mouse auditory cortex. (2020)
  • Author(s): Nakata S. Takemoto M, Song W-J.
  • Journal Title: Hearing Research Volume: 386 Pages: 107876-107876
  • DOI: 10.1016/j.heares.2019.107876
  • Peer Reviewed
• [Journal Article] Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection (2020)
  • Author(s): Han Y, Nakayama J, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S and Semba K
  • Journal Title: Genes Cells Volume: 25(2) Pages: 111-123
  • DOI: 10.1111/gtc.12743
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer (2020)
  • Author(s): Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Furukawa T & Shoji Natsugoe, et al.
  • Journal Title: Oncogenesis Volume: 9 Pages: 13-13
  • DOI: 10.1038/s41389-020-0190-7
  • Peer Reviewed / Open Access
• [Journal Article] FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. (2020)
  • Author(s): Yoo SM, Yamashita SI, Kim H, Na D, Lee H, Kim SJ, Cho DH, Kanki T, Jung YK.
  • Journal Title: FASEB J. Volume: 34 Issue: 2 Pages: 2944-2957
  • DOI: 10.1096/fj.201901735r
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis. (2020)
  • Author(s): Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K and Arita K
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 6355-63
  • DOI: 10.3390/ijms20246355
  • Peer Reviewed / Open Access
• [Journal Article] Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. (2020)
  • Author(s): Igarashi R, Yamashita SI, Yamashita T, Inoue K, Fukuda T, Fukuchi T, Kanki T.
  • Journal Title: Sci Rep. Volume: 10(1) Issue: 1 Pages: 1-11
  • DOI: 10.1038/s41598-020-58315-w
  • Peer Reviewed / Open Access
• [Journal Article] Identification and characterization of the binding sequences and target genes of p53 lacking the lst transactivation domain. (2020)
  • Author(s): Shiori Suzuki#, Shuichi Tsutsumi#, Yu Chen#, Chikako Ozeki, Atsushi Okabe, Tatsuya Kawase, Hiroyuki Aburatani and Rieko Ohki*.
  • Journal Title: Cancer Science Volume: 111 Pages: 451-466
  • DOI: 10.1111/cas.14279
  • Peer Reviewed / Open Access
• [Journal Article] Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176. (2020)
  • Author(s): Wang T, Nakagawa S, Miyake T, Setsu G, Kunisue S, Goto K, Hirasawa A, Okamura H, Yamaguchi Y, and Doi M
  • Journal Title: Sci. Rep. Volume: 10 Pages: 4429-4429
  • DOI: 10.1038/s41598-020-61370-y
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA. (2020)
  • Author(s): Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
  • Journal Title: Cell Chemical Biology Volume: 27 Pages: 1-11
  • DOI: 10.1016/j.chembiol.2019.11.010
  • Peer Reviewed
• [Journal Article] Identification of Transmembrane Protein 168 Mutation in Familial Brugada Syndrome. (2020)
  • Author(s): Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, ..., Ogita H.
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• [Journal Article] Localization Mechanism of Myosin Id, an ASD Risk Gene Product in Dendritic Spines (2020)
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• [Journal Article] Targeting claudin-4 enhances chemosensitivity in breast cancer. (2020)
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• [Journal Article] Tsukushi is essential for the development of the inner ear. (2020)
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  • Author(s): Shinohara, F., Asaoka, Y., Kamii, H., Minami, M., Kaneda, K.
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• [Journal Article] Suzuki-Miyaura Cross-Coupling of 1.8-Diaminonaphthalene (dan)-Protected Arylboronic Acids (2019)
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  • Journal Title: Chemical Science Volume: 10 Pages: 5686-5698
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• [Journal Article] 骨転移とマイクロRNA (2019)
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• [Journal Article] Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model (2019)
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• [Journal Article] Growth cone phosphoproteomics reveals that GAP-43 phosphorylated by JNK is a marker of axon growth and regeneration. (2019)
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  • Journal Title: iScience. 2 Volume: 4 Pages: 190-203
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• [Journal Article] Analysis of Neuro-Neuronal Synapses Using Embryonic Chick Ciliary Ganglion via Single-Axon Tracing, Electrophysiology, and Optogenetic Techniques. (2019)
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  • Peer Reviewed
• [Journal Article] Structures and biological activities of new carnosic acid- and carnosolrelated compounds generated by heat treatment of rosemary (2019)
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  • Peer Reviewed
• [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm (2019)
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  • Journal Title: Biochem Biophys Res Commun. Volume: 10 Issue: 1 Pages: 1653-1653
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  • Peer Reviewed / Open Access / Int'l Joint Research
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  • Peer Reviewed
• [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1 (2019)
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  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] TFE3 Xpll. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease (2019)
  • Author(s): Masaya Baba, Mitsuko Furuya, Takanobu Motoshima, Martin Lang, Shintaro Funasaki, Wenjuan Ma, Hong-Wei Sun, Hisashi Hasumi, Ying Huang, Ikuma Kato, Tsuyoshi Kadomatsu, Yorifumi Satou, Nicole Morris, Baktiar O, Karim, Lilia Ileva, Joseph D. Kalen, Luh Ade Wilan Krisna, Kimi Araki, et al.
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity (2019)
  • Author(s): Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
  • Journal Title: ChemBioChem Volume: 20 Pages: 1273-1281
  • DOI: 10.1002/cbic.201800815
  • Peer Reviewed
• [Journal Article] Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation (2019)
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  • Journal Title: J Cell Biochem. Volume: 120 Pages: 2259-2270
  • DOI: 10.1002/jcb.27551
  • Peer Reviewed
• [Journal Article] Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo [g] [1] benzopyrano [4, 3-b] indol-6 (13H)-one scaffold (2019)
  • Author(s): Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 27 Issue: 2 Pages: 265-277
  • DOI: 10.1016/j.bmc.2018.11.037
  • NAID: 120006602374
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance. (2019)
  • Author(s): Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
  • Journal Title: EBioMedicine Volume: 41 Pages: 105-119
  • DOI: 10.1016/j.ebiom.2019.01.019
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• [Journal Article] High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. (2019)
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  • Description: Epub ahead of print
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and evaluation of topoisomerase I inhibitors possessing the 5, 13-dihydro-6H-benzo [6, 7] indolo [3, 2-c] quinolin-6-one scaffold (2019)
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  • Journal Title: Heterocycles Volume: 99 Pages: 1032-1032
  • DOI: 10.3987/com-18-s(f)70
  • Peer Reviewed / Open Access
• [Journal Article] mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. (2019)
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  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 176 Pages: 1-5
  • DOI: 10.1016/j.pbb.2018.11.003
  • Peer Reviewed / Open Access
• [Journal Article] Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluAl C-terminal palmitoylation deficient mice. (2019)
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  • Journal Title: Neuropsychopharmacology Reports Volume: 39 Pages: 61-66
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  • Peer Reviewed / Open Access
• [Journal Article] Measuring Nonselective and Selective Autophagy in the Liver (2019)
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  • Journal Title: Methods Mol Biol Volume: 1880 Pages: 535-540
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• [Journal Article] Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD. (2019)
  • Author(s): Kida, S
  • Journal Title: Psychopharmacology Volume: 236 Pages: 49-57
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  • Peer Reviewed / Open Access
• [Journal Article] NSP-C contributes to the upregulation of CLOCK/BMALl-mediated transcription. (2019)
  • Author(s): Hosoda, H., *Kida, S
  • Journal Title: Cytotechnology Volume: 71 Pages: 453-460
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  • Peer Reviewed
• [Journal Article] CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. (2019)
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  • Journal Title: International Journal of Hematology Volume: 110 Pages: 170-178
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  • Peer Reviewed / Open Access
• [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. (2019)
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• [Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling (2019)
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  • Journal Title: Biochemical and Biophysical Research Communications Volume: 509 Issue: 3 Pages: 700-706
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  • Peer Reviewed
• [Journal Article] Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling. (2019)
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• [Journal Article] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole (2019)
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• [Journal Article] Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice. (2019)
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• [Journal Article] The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA. (2019)
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• [Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SODIG93A. (2019)
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• [Journal Article] Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS). (2019)
  • Author(s): Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
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• [Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048. (2019)
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• [Journal Article] Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway. (2019)
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  • Author(s): Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
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• [Journal Article] Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals (2019)
  • Author(s): Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T. Hojo MK, Honma A, Tsurui K
  • Journal Title: Advanced Robotics Volume: 33 Pages: 183-194
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• [Journal Article] Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer. (2019)
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• [Journal Article] Prefrontal-Enriched SLITI Expression in Primate Cortex and its Alteration during Cortical Development (2019)
  • Author(s): Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
  • Journal Title: Japanese Journal of Biological Psychiatry Volume: 20(10) Issue: 10 Pages: 2496-2510
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• [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. (2019)
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• [Journal Article] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs. (2019)
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  • Journal Title: Int Immunol. Volume: 31 Pages: 167-173
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• [Journal Article] ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus. (2019)
  • Author(s): Saitoh, S. I., Y. M. Saitoh, K. Kontani, K. Sato, and K. Miyake.
  • Journal Title: Int Immunol. Volume: 31 Issue: 4 Pages: 225-237
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• [Journal Article] Cholera toxin B induces interleukin-1β production from resident peritoneal macrophages through the pyrin inflammasome as well as the NLRP3 inflammasome (2019)
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  • Journal Title: Int Immunol Volume: 印刷中 Pages: 657-668
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• [Journal Article] SCF(Fbxw7) ubiquilylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation. (2019)
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  • Journal Title: Genes to Cells Volume: 印刷中 Pages: 354-365
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• [Journal Article] RBM10-TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break-apart Fluorescence in situ Hybridization : Study of Ten Cases and a Literature Review (2019)
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  • Journal Title: Histopathology Volume: 印刷中 Pages: 254-265
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• [Journal Article] Identification of specific microRNAs in neutrophils of type 2 diabetic mice : overexpression of microRNA-129-2-3p accelerates diabetic wound healing. (2019)
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  • Journal Title: Diabetes Volume: 68 Issue: 3 Pages: 617-630
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• [Journal Article] Cap-specific terminal N6-methylation of RNA by an RNA polymerase II?associated methyltransferase (2019)
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  • Journal Title: Science Volume: 363 Issue: 363 Pages: 6423-6423
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• [Journal Article] CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy. (2019)
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  • Journal Title: Clin Cancer Res. Volume: 25 Pages: 1936-1947
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• [Journal Article] Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumorgrowth. (2019)
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  • Journal Title: Mol. Cancer Ther. Volume: 18 Pages: 602-612
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• [Journal Article] Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. (2019)
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  • Journal Title: JCI Insight Volume: 4
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• [Journal Article] Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus. (2019)
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  • Journal Title: Mol Brain Volume: 12 Issue: 13 Pages: 1-12
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• [Journal Article] A method of producing genetically manipulated mouse mammary gland (2019)
  • Author(s): Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba
  • Journal Title: Breast Cancer Research Volume: 21, 1 Pages: 1-1
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• [Journal Article] High detection rate of MYD88 mutations in cerebrospinal fluid from patients with central nervous system lymphomas (2019)
  • Author(s): Jun Watanabe, Manabu Natsumeda, Masayasu Okada, Daiki Kobayashi, Yu Kanemaru, Yoshihiro Tsukamoto, Makoto Oishi, Akiyoshi Kakita, Yukihiko Fujii
  • Journal Title: JCO Precision Oncology Volume: 3 Pages: 1-13
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  • Journal Title: Epileptic Disorders Volume: 21 Issue: 1 Pages: 48-54
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• [Journal Article] EGFRvIII is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma (2019)
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  • Journal Title: Neurol. Med. Chir.(Tokyo) Volume: 59 Issue: 3 Pages: 89-97
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• [Journal Article] Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function. (2019)
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  • Journal Title: Life Sci Alliance Volume: 2 Issue: 1
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  • Peer Reviewed / Open Access / Int'l Joint Research
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  • Journal Title: Front Behav Neurosci Volume: 13 Pages: 50-50
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  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains (2019)
  • Author(s): Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tuan Phan, Kazuo Nagasawa
  • Journal Title: Molecules Volume: 24 Pages: 263-263
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  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] 悪性髄膜腫における個別化医療の可能性 (2019)
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  • Journal Title: Precision Medicine Volume: 2 Issue: 1 Pages: 54-58
• [Journal Article] Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle (2019)
  • Author(s): Kawahara I, Goto K, Kodama K, Luo Y, Fujiwara-Tani R, Mori T, Miyagawa Y, Tanaka H, Kodama H, Hirayama A, Hosoito N, Taniguchi Y, Miki Y, Kuniyasu H
  • Journal Title: Pathobiology
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• [Journal Article] Intracellular transport of NMDA receptors and Schizophrenia (2019)
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  • Peer Reviewed
• [Journal Article] Mitochondrial pyruvate carrier I expression controls cancer EMT and radioresistance. (2019)
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• [Journal Article] Regulation of mitochondrial iron homeostasis by sideroflexin 2 (2019)
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• [Journal Article] Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. (2019)
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• [Journal Article] Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells. (2019)
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  • Journal Title: Oncogene Volume: 38 Issue: 2 Pages: 244-260
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• [Journal Article] Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 (2019)
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• [Journal Article] Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients. (2019)
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  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2040-2040
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  • Peer Reviewed / Open Access
• [Journal Article] Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. (2019)
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• [Journal Article] The orphan nuclear receptor NR4A1 promotes FcepsilonRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis. (2019)
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  • Journal Title: Allergy Volume: 74 Pages: 1145-1156
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• [Journal Article] p62/SQSTM1 : ‘Jack of all trades’ in health and cancer. (2019)
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• [Journal Article] Parabrachial-to-amygdala control of aversive learning (2019)
  • Author(s): Nagase, M., Mikami, K., and Watabe, A. M. #(#責任著者)
  • Journal Title: Current Opinion in Behavioral Sciences Volume: 26 Pages: 18-24
  • DOI: 10.1016/j.cobeha.2018.08.005
  • Peer Reviewed
• [Journal Article] Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. (2019)
  • Author(s): Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Mizutani A, et al.
  • Journal Title: J. Med. Chem. Volume: 62 Issue: 7 Pages: 3407-3427
  • DOI: 10.1021/acs.jmedchem.8b01888
  • Peer Reviewed
• [Journal Article] CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. (2019)
  • Author(s): Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.
  • Journal Title: Oncogene Volume: 38 Issue: 14 Pages: 2580-2594
  • DOI: 10.1038/s41388-018-0603-7
  • Peer Reviewed
• [Journal Article] Encoding prediction signals during appetitive and aversive Pavlovian conditioning in the primate lateral hypothalamus. (2019)
  • Author(s): Noritake A, Nakamura K.
  • Journal Title: Journal of neurophysiology Volume: 121 Issue: 2 Pages: 396-417
  • DOI: 10.1152/jn.00247.2018
  • Peer Reviewed
• [Journal Article] Opioid and non-dopamine reward circuitry and state-dcpendent mechanisms. (2019)
  • Author(s): Fujita M, Ide S, Ikeda K
  • Journal Title: Aun NY Acad Sci Volume: 印刷中 Pages: 29-41
  • DOI: 10.1111/nyas.13605
  • Description: in press
  • Peer Reviewed
• [Journal Article] Pharmacological targeting of plasmin prevents lethality in a murine mode of macrophage activation syndrome. (2019)
  • Author(s): Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
  • Journal Title: Blood Volume: 印刷中 Pages: 59-72
  • DOI: 10.1182/blood-2016-09-738096
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice : A model of attention-deficit/hyperactivity disorder. (2018)
  • Author(s): Ide S ; Ikekubo Y ; Hua J ; Takamatsu Y ; Uhi GR ; Sora I
  • Journal Title: Neuropsychopharmacol Rep Volume: 38 Pages: 149-153
  • DOI: 10.1002/npr2.12020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CDC42EP4, a perisynaptic scaffold protein in Bergmann glia, is required for glutamatergic tripartite synapse configuration. (2018)
  • Author(s): Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
  • Journal Title: Neurochemistry International Volume: S0197-0186 Pages: 190-198
  • DOI: 10.1016/j.neuint.2018.01.003
  • NAID: 120006554471
  • Peer Reviewed / Open Access
• [Journal Article] Targeted expression of step-function opsins in transgcnic rats for optogenetic studies. (2018)
  • Author(s): Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 5435-5435
  • DOI: 10.1038/s41598-018-23810-8
  • Peer Reviewed / Open Access
• [Journal Article] Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells (2018)
  • Author(s): Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
  • Journal Title: Scientific Reports Volume: 8 Pages: 14827-14827
  • DOI: 10.1038/s41598-018-33139-x
  • Peer Reviewed / Open Access
• [Journal Article] Resting-state functional connectivity analysis of the mouse brain using intrinsic optical signal imaging of cerebral blood volume dynamics (2018)
  • Author(s): Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Journal Title: Physiological Measurement Volume: 39 Pages: 054003-054003
  • DOI: 10.1088/1361-6579/aac033
  • Peer Reviewed
• [Journal Article] alpha-particle therapy for synovial sarcoma in the mouse using an astatine-211-labeled antibpdy against fizzled homolog 10. (2018)
  • Author(s): Huizi Li, Aya Sugyo, Atsushi Tsuji, Yukie Morokoshi, Katsuyuki Minegishi, Kotaro Nagatsu, Hiroaki Kanda, Yosuke Harada, Satoshi Nagayama, Toyomasa Katagiri, Yusuke Nakamura, Tatsuya Higashi, Sumitaka Hasegawa
  • Journal Title: Cancer Science Volume: 109 Issue: 7 Pages: 2302-2309
  • DOI: 10.1111/cas.13636
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Task-dependent function of striatal cholinergic interneurons (2018)
  • Author(s): Okada K, Nishizawa K, Setogawa S, Hashimoto K, Kobayashi K.
  • Journal Title: Eur J Neurosci Volume: - Issue: 10 Pages: 1174-1183
  • DOI: 10.1111/ejn.13768
  • Peer Reviewed
• [Journal Article] Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXKI. (2018)
  • Author(s): Nakatsumi H., Oka T., Higa T., Shirane M., Nakayama KI.
  • Journal Title: Genes Cells Volume: 23 Pages: 599-605
  • DOI: 10.1111/gtc.12597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative study of the somatosensory sensitization underlying cross-modal plasticity. (2018)
  • Author(s): Abe K, Yawo H.
  • Journal Title: PLoS One Volume: 13 Issue: 12
  • DOI: 10.1371/journal.pone.0208089
  • Peer Reviewed / Open Access
• [Journal Article] The temporal turning window for rat behavioral phenotypes by rotenone (2018)
  • Author(s): M. Ishido*
  • Journal Title: Fundam. Toxicol. Sci. Volume: 5 Issue: 6 Pages: 195-202
  • DOI: 10.2131/fts.5.195
  • NAID: 130007554207
  • ISSN: 2189-115X
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-l, a potential anti-cancer lead derived from debromoaplysiatoxin (2018)
  • Author(s): Hayakawa, K., Hanaki, Y., Tokuda, H., Yanagita, R. C., Nakagawa, Y., Okamura, M., Dan, S. and Irie, K.
  • Journal Title: Heterocycles Volume: 97 Issue: 1 Pages: 478-492
  • DOI: 10.3987/com-18-s(t)37
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of the Retinotopic Map of an Awake Mouse Brain Based upon Intrinsic Optical Signal Imaging Considering the Ocular Position and Variation in Pupil Diameter (2018)
  • Author(s): 外川 龍之介、奥畑 大悟、吉田 侑冬、中尾 光之、片山 統裕
  • Journal Title: TJSBME Volume: 56 Issue: 4 Pages: 157-163
  • DOI: 10.11239/jsmbe.56.157
  • NAID: 130007604778
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• [Journal Article] Self-organizing cortex generated from human iPSCs with combination of FGF2 and ambient oxygen. (2018)
  • Author(s): Eguchi N, Sora I, Muguruma K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 498 Issue: 4 Pages: 729-735
  • DOI: 10.1016/j.bbrc.2018.03.049
  • NAID: 120006462318
  • Peer Reviewed / Open Access
• [Journal Article] Longer telomeres in elderly schizophrenia are associated with long-term hospitalization in the Japanese population. (2018)
  • Author(s): Zhang Y ; Hishimoto A ; Otsuka I ; Watanabe Y ; Numata S ; Yamamori H ; Boku S ; Horai T ; Someya T ; Ohmori T ; Hashimoto R ; Sora I
  • Journal Title: J Psychiatr Res Volume: 103 Pages: 161-166
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• [Journal Article] Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition. (2018)
  • Author(s): Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Rios A, Kawabata M, Kimura M, Sakai Y, *Isomura Y
  • Journal Title: Neuroscience Volume: 388 Pages: 297-316
  • DOI: 10.1016/j.neuroscience.2018.07.039
  • Peer Reviewed
• [Journal Article] Increased serum levels and promoter polymorphisms of macrophage migration inhibitory factor in schizophrenia. (2018)
  • Author(s): Okazaki S, Hishimoto A, Otsuka I, Watanabe Y, Numata S, Boku S, Shimmyo N, Kinoshita M, Inoue E, Ohmori T, Someya T, Sora I.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 83 Pages: 33-41
  • DOI: 10.1016/j.pnpbp.2018.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mitochondrial DNA copy number of peripheral blood in bipolar disorder : The present study and a meta-analysis. (2018)
  • Author(s): Yamaki N ; Otsuka I ; Numata S ; Yanagi M ; Mouri K ; Okazaki S ; Boku S ; Horai T ; Ohmori T ; Shirakawa O ; Sora I ; Hishimoto A
  • Journal Title: Psychiatry Res Volume: 269 Pages: 115-117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Superiority of rat over murine model for studies on the evolution of cancer genome. (2018)
  • Author(s): Akatsuka S, Li GH, Toyokuni S
  • Journal Title: Free Radical Research Volume: 52 Pages: 1323-1327
  • DOI: 10.1080/10715762.2018.1467562
  • Peer Reviewed
• [Journal Article] Loss of chromosome Y in blood, but not in brain, of suicide completers. (2018)
  • Author(s): Kimura A, Hishimoto A, Otsuka I, Okazaki S, Boku S, Horai T, Izumi T, Takahashi M, Ueno Y, Shirakawa O, Sora I.
  • Journal Title: PLoS One Volume: 13 Issue: 1
  • DOI: 10.1371/journal.pone.0190667
  • NAID: 120006382347
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients. (2018)
  • Author(s): Horai T, Hishimoto A, Otsuka I, So T, Mouri K, Shimmyo N, Boku S, Okishio N, Sora I.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 14 Pages: 663-669
  • DOI: 10.2147/ndt.s153360
  • NAID: 120006425682
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of chromosome Y loss in men with schizophrenia. (2018)
  • Author(s): Hirata T ; Hishimoto A ; Otsuka I ; Okazaki S ; Kimura A ; Horai T ; Sora I
  • Journal Title: Neuropsychiatr Dis Treat Volume: 14 Pages: 2115-2122
  • DOI: 10.2147/ndt.s172886
  • NAID: 120006510199
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas (2018)
  • Author(s): Hideaki ABE, Manabu NATSUMEDA, Yu KANEMARU, Jun WATANABE, Yoshihiro TSUKAMOTO, Masayasu OKADA, Junichi YOSHIMURA, Makoto OISHI, and Yukihiko FUJII
  • Journal Title: Neurol. Med. Chir.(Tokyo) Volume: 58 Issue: 7 Pages: 290-295
  • DOI: 10.2176/nmc.ra.2018-0044
  • NAID: 130007405002
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Neurocognitive Impairments Are More Severe in the Binge-Eating/Purging Anorexia Nervosa Subtype Than in the Restricting Subtype. (2018)
  • Author(s): Tamiya Y ; Ouchi A ; Chen R ; Miyazawa S ; Akimoto Y ; Kaneda Y ; Sora I
  • Journal Title: Front Psychiatry Volume: 138 Pages: 9-9
  • DOI: 10.3389/fpsyt.2018.00138
  • Peer Reviewed / Open Access
• [Journal Article] Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice. (2018)
  • Author(s): Sasaki K ; Hall FS ; Uhl GR ; Sora I
  • Journal Title: Front Psychiatry Volume: 9 Pages: 441-441
  • DOI: 10.3389/fpsyt.2018.00441
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gamma-aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain : An exploratory study. (2018)
  • Author(s): Yokoshima Y, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Kato R, Hozumi J, Abe H, Azuma K, Tsuchida R, Yamada Y, Japanese TR-Cancer Pain Research Group.
  • Journal Title: Neuropsychopharmacology Report Volume: 38(4) Pages: 175-181
  • DOI: 10.1002/npr2.12030
  • Peer Reviewed / Open Access
• [Journal Article] 3D culture system containing gellan gum restores oncogene dependence in ROSI rearrangements non-small cell lung cancer. (2018)
  • Author(s): Gong, B., Oh-Hara, T., Fujita, N. and *Katayama, R.
  • Journal Title: Biochem. Biophys. Res. Commun., Volume: 501 Pages: 527-533
  • DOI: 10.1016/j.bbrc.2018.05.031
  • Peer Reviewed / Open Access
• [Journal Article] A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. (2018)
  • Author(s): Zhang Y, Nakano D, Guan Y, Hitomi H, Masaki T, Kobara H, Sugaya Y, Nishiyama A.
  • Journal Title: Kidney Int. Volume: 94 Issue: 3 Pages: 524-535
  • DOI: 10.1016/j.kint.2018.05.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Establishment of a human induced stem cell line (FUi002-A) from Dravet syndrome patient carrying heterozygous R1525X mutation in SCNIA gene. (2018)
  • Author(s): Tanaka Y, Higurashi N, Shirasu N, Yasunaga S, Moreira KM, Okano H, Hirose S.
  • Journal Title: Stem Cell Research Volume: 31 Pages: 11-15
  • DOI: 10.1016/j.scr.2018.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes (2018)
  • Author(s): Liao D, Wang Q, He J, Alexander DB, Abdelgied M, El-Gazzar AM, Futakuchi M, Suzui M, Kanno J, Hirose A, Xu J, Tsuda H
  • Journal Title: Chem Res Toxicol Volume: 31 Issue: 10 Pages: 1025-1031
  • DOI: 10.1021/acs.chemrestox.8b00067
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm : association with immunoblastoid cytomorphology, MYC expression, and drug response. (2018)
  • Author(s): Sakamoto, K., Katayama, R., Asaka, R., Sakata, S., Baba, S., Nakasone, H., Takakuwa, E., Yamazaki, R., Takizawa, J., Maeda, T., Narita, M., Izutsu, K., Kanda, Y., Ohshima, K, and *Takeuchi, K.,
  • Journal Title: Leukemia Volume: 32 Pages: 2590-2603
  • DOI: 10.1038/s41375-018-0154-5
  • Peer Reviewed / Open Access
• [Journal Article] Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells. (2018)
  • Author(s): Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama S
  • Journal Title: Scientific Reports Volume: 8 Pages: 6760-6760
  • DOI: 10.1038/s41598-018-25189-y
  • Peer Reviewed / Open Access
• [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adpocytes and cancer cells. (2018)
  • Author(s): Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 33 Pages: 8370-8375
  • DOI: 10.1073/pnas.1804243115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new method for identifying mouse pancreatic ducts (2018)
  • Author(s): Nakajima C, Kamimoto K, Miyajima K, Matsumoto M, Okazaki Y, Kobayashi-Hattori K, Shimizu M, Yamane T, Oishi Y, Iwatsuki K.
  • Journal Title: Tissue Eng. Volume: 24 Issue: 8 Pages: 480-485
  • DOI: 10.1089/ten.tec.2018.0127
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-137-mediated Src oncogenic signaling promotes cancer progression (2018)
  • Author(s): Kokuda R, Watanabe R, Okuzaki D, Akamatsu H, Oneyama C.
  • Journal Title: Genes Cells Volume: 23 Issue: 8 Pages: 688-701
  • DOI: 10.1111/gtc.12610
  • Peer Reviewed / Open Access
• [Journal Article] FEAT enhances INSL3 expression in testicular Leydig cells. (2018)
  • Author(s): Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A.
  • Journal Title: Genes to cells Volume: 23 Pages: 952-962
  • DOI: 10.1111/gtc.12644
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses. (2018)
  • Author(s): Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T.
  • Journal Title: Oncoscience. Volume: 5 Pages: 103-103
  • DOI: 10.18632/oncoscience.411
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment (2018)
  • Author(s): Futakuchi M, Nitanda T, Ando S, Matsumoto H, Yoshimoto E, Fukamachi K, Suzui M
  • Journal Title: Int J Mol Sci Volume: 19 Issue: 3 Pages: 888-888
  • DOI: 10.3390/ijms19030888
  • NAID: 120006471116
  • Peer Reviewed / Open Access
• [Journal Article] Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer. (2018)
  • Author(s): Shimizu Y1, Tamada S1, Kato M1, Takeyama Y1, Fujioka M2, Kakehashi A2, Nakatani T1, Wanibuchi H2, Gi M2.
  • Journal Title: Exp Ther Med Volume: 16 Issue: 6 Pages: 4463-4470
  • DOI: 10.3892/etm.2018.6787
  • Peer Reviewed / Open Access
• [Journal Article] An Overview of Development of Quantitative Neurotoxicity Testing In vitro (2018)
  • Author(s): M. Ishido*
  • Journal Title: J. Applied Life Sci. Intl. Volume: 19 Pages: 2394-1103
  • DOI: 10.9734/jalsi/2018/45377
  • Peer Reviewed / Open Access
• [Journal Article] 細胞突起形成抑制による膠芽腫治療戦略 (2018)
  • Author(s): 岡田正康, 棗田学, 河嵜麻実, 大石誠, 藤井幸彦, 五十嵐道弘
  • Journal Title: 新潟県医師会報 Volume: 814 Issue: 1 Pages: 9-10
  • Peer Reviewed
• [Journal Article] マンガの読みにおける状況モデルの更新 (2018)
  • Author(s): 和田裕一, 三浦知志, 窪俊一
  • Journal Title: マンガ研究 Volume: 24 Pages: 93-114
  • Peer Reviewed
• [Journal Article] Spredl Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. (2018)
  • Author(s): Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi N, Hirao A
  • Journal Title: Cell Stem Cell Volume: 22 Pages: 713-725
  • DOI: 10.1016/j.stem.2018.04.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia (2018)
  • Author(s): Brew N, Nakamura S, Hale, N. Azhan, A., Davies, G. I. Nitsos, I., Miller, S. I., Walker, D. W., Wong, F. Y.
  • Journal Title: Pediatr Res Volume: 83 Issue: 3 Pages: 442-450
  • DOI: 10.1038/s41390-018-0045-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immediate-early promoter-driven transgenic reporter system for neuroethological researches in a hemimetabolous insect (2018)
  • Author(s): Watanabe T., Ugajin A. and Aonuma H.
  • Journal Title: eNeuro Volume: 5 Pages: 0061-18
  • DOI: 10.1523/eneuro.0061-18.2018
  • Peer Reviewed / Open Access
• [Journal Article] Parallel arousal pathways in the lateral hypothalamus. (2018)
  • Author(s): Heiss JE, Yamanaka A, Kilduff TS.
  • Journal Title: eNeuro Volume: 5(4) Pages: 0228-18
  • DOI: 10.1523/eneuro.0228-18.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A stable association with PME-1 may be dispensable for PP2A demethylation-implications for the detection of PP2A methylation and immunoprecipitation (2018)
  • Author(s): Yabe R. Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T*, Sato K
  • Journal Title: FEBS Open Bio Volume: 8 Issue: 9 Pages: 1486-1496
  • DOI: 10.1002/2211-5463.12485
  • Peer Reviewed / Open Access
• [Journal Article] β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. (2018)
  • Author(s): Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.
  • Journal Title: PLOS ONE Volume: 13 Issue: 5
  • DOI: 10.1371/journal.pone.0196946
  • Peer Reviewed / Open Access
• [Journal Article] Glycans in stem cell regulation : from Drosophila tissue stem cells to mammalian pluripotent stem cells. (2018)
  • Author(s): Nishihara S
  • Journal Title: FEBS Lett. Volume: 592 Issue: 23 Pages: 3773-3790
  • Peer Reviewed
• [Journal Article] Structural basis for species-specific activation of mouse Toll-like receptor 9. (2018)
  • Author(s): Ishida, H., U. Ohto, T. Shibata, K, Miyake, and T. Shimizu.
  • Journal Title: FEBS Lett Volume: 592 Issue: 15 Pages: 2636-2646
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  • Peer Reviewed / Open Access
• [Journal Article] Analysis of Interactions between Telomeric i-Motif DNA and a Cyclic Tetraoxazole Compound (2018)
  • Author(s): Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Adrian Marchand, Fernaldo Richtia Winnerdy, Valerie Gabelica, Anh Tuan Phan, Masato Katahira & Kazuo Nagasawa
  • Journal Title: ChemBioChem Volume: 19 Pages: 2268-2272
  • DOI: 10.1002/cbic.201800425
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Platelet-Derived TGF-β Induces Tissue Factor Expression via the Smad3 Pathway in Osteosarcoma Cells. (2018)
  • Author(s): Saito M, Ichikawa J, Ando T. Schoenecker JG, Ohba T, Koyama K, Suzuki-Inoue K, Haro H.
  • Journal Title: J Bone Miner Res. Volume: 33 Issue: 11 Pages: 2048-2058
  • Peer Reviewed
• [Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation (2018)
  • Author(s): Masaya Baba, Mitsuhiro Endoh. Wenjuan Ma, Hirofumi Toyama. Akiyoshi Hirayama, Keiyo Takubo, Hiroyuki Hano. Hisashi Hasumi, Terumasa Umemoto, Michihiro Hashimoto, Nobuko Irie, Chiharu Esumi, Miho Kataoka, Naomi Nakagata, Tomoyoshi Soga, Masahiro Yao, Tomomi Kamba, Takashi Minami, Masaru Ishii, Toshio Suda
  • Journal Title: Journal of Bone and Mineral Research Volume: 33 Issue: 10 Pages: 1785-1798
  • DOI: 10.1002/jbmr.3477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HipOP mesenchymal population has high potential for repairing injured peripheral nerves. (2018)
  • Author(s): Yamauchi Y., Itoh S, et al.
  • Journal Title: J. Cell Biochem. Volume: 印刷中 Issue: 6 Pages: 4836-4844
  • DOI: 10.1002/jcb.26684
  • Peer Reviewed
• [Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells (2018)
  • Author(s): Kikuchi K, Kozuka-Hata H, Oyama M, Seiki M & Koshikawa N
  • Journal Title: Methods in Molecular Biology Volume: 1731 Pages: 29-37
  • DOI: 10.1007/978-1-4939-7595-2_3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Salll regulates microglial morphology cell autonomously in the developing retina (2018)
  • Author(s): Koso H, Nishinakamura R, Watanabe S
  • Journal Title: Adv Exp Med Biol Volume: 1047 Pages: 209-215
  • DOI: 10.1007/978-3-319-75402-4_26
  • Peer Reviewed
• [Journal Article] Tyraminergic modulation of agonistic outcomes in crayfish (2018)
  • Author(s): Momohara Y., Aonuma H. and Nagayama T.
  • Journal Title: J. Comp. Physiol. Volume: 印刷中 Pages: 465-473
  • DOI: 10.1007/s00359-018-1255-3
  • Peer Reviewed
• [Journal Article] NIPA-like domain containing l is a novel tumor-promoting factor in oral squamous cell carcinoma. (2018)
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  • Journal Title: J Cancer Res Clin Oncol Volume: 144 Issue: 5 Pages: 875-82
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• [Journal Article] Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease. (2018)
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  • Journal Title: Int J Hematol. Volume: 108 Issue: 5 Pages: 465-484
  • DOI: 10.1007/s12185-018-2528-x
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  • Journal Title: Cerebellum Volume: 17 Issue: 6 Pages: 722-734
  • DOI: 10.1007/s12311-018-0964-z
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• [Journal Article] Biallelic Variants in CNPY3. Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy. (2018)
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  • Journal Title: Am J Hum Genet Volume: 102 Issue: 2 Pages: 321-329
  • DOI: 10.1016/j.ajhg.2018.01.004
  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] Further characterization of CAPOS/CAOS syndrome with the Glu818Lys mutation in the ATP1A3 gene : A case report. (2018)
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• [Journal Article] Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglels (2018)
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  • Journal Title: Brain & Development Volume: 40 Issue: 10 Pages: 926-30
  • DOI: 10.1016/j.braindev.2018.06.005
  • Peer Reviewed
• [Journal Article] The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis (2018)
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  • Journal Title: Cell Reports Volume: 24 Pages: 2196-2210
  • DOI: 10.1016/j.celrep.2018.07.056
  • NAID: 120006542018
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  • Journal Title: Cell Rep Volume: 25 Pages: 2704-2715
  • DOI: 10.1016/j.celrep.2018.11.016
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• [Journal Article] Recurrent autonomic and sensory neuropathy in a patient with anti-ganglionic acetylcholine receptor antibodies. (2018)
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  • Journal Title: Immunity Volume: 48 Issue: 4 Pages: 649-658
  • DOI: 10.1016/j.immuni.2018.03.013
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  • Journal Title: Immunity Volume: 48 Issue: 5 Pages: 911-922
  • DOI: 10.1016/j.immuni.2018.04.011
  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model. (2018)
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• [Journal Article] Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold (2018)
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• [Journal Article] Design and De Novo Synthesis of 6-Aza-artemisinins (2018)
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• [Journal Article] Design of C2-symmetric alkaloidal chiral amphiphiles and configurational effects on self-assembly (2018)
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• [Journal Article] Interaction between cardiac myosin-binding protein C and formin Fhod3. (2018)
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  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 115 Issue: 19
  • DOI: 10.1073/pnas.1716498115
  • Peer Reviewed / Open Access
• [Journal Article] Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis. (2018)
  • Author(s): Kurihara Y. Makita Y. Kawashima M. Fujita T. Iwasaki S. and Matsui M.
  • Journal Title: Proc Natl Acad Sci USA Volume: 115 Issue: 30 Pages: 7831-7836
  • DOI: 10.1073/pnas.1804971115
  • Peer Reviewed / Open Access
• [Journal Article] Anabolic-androgenic steroids : procurement and administration practices of doping athletes. (2018)
  • Author(s): Fink J, Jackney A, Matsumoto M, Maekawa T, Nakazato K, Horie S.
  • Journal Title: Physician, Sportsmedicine 2 Volume: 47 Issue: 1 Pages: 10-14
  • DOI: 10.1080/00913847.2018.1526626
  • Peer Reviewed / Open Access
• [Journal Article] Generation of rat monoclonal antibodies specific for DZIP3 (2018)
  • Author(s): Oikawa D, Shiota M, Tokunaga F, Wanibuchi H.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Issue: 3 Pages: 153-157
  • DOI: 10.1089/mab.2018.0005
  • Peer Reviewed / Open Access
• [Journal Article] Generation of rat monoclonal antibodies against a deubiquitinase, ovarian tumor domain-containing protein 1 (2018)
  • Author(s): Oikawa D, Shiota M, Wanibuchi H. Tokunaga F.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Issue: 4 Pages: 180-184
  • DOI: 10.1089/mab.2018.0023
  • Peer Reviewed / Open Access
• [Journal Article] A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes (2018)
  • Author(s): Kosuke Ishikawa, Yuta Kobayashi, Yutaro wakabayashi, Shinya Watanabe and Kentaro Semba
  • Journal Title: Biology Methods and Protocols Volume: 3
  • DOI: 10.1093/biomethods/bpy003
  • Peer Reviewed / Open Access
• [Journal Article] Biallelic UFMI and UFCI mutations expand the essential role of ufmylation in brain development. (2018)
  • Author(s): Nahorski MS, Maddirevula S, Ishimura R, Alsahli S, Brady AF, Begemann A, Mizushima T, Guzman-Vega FJ, Obata M, Ichimura Y, Alsaif HS, Anazi S, Ibrahim N, Abdulwahab F, Hashem M, Monies D, Abouelhoda M, Meyer BF, Alfadhel M, Eyaid W, Zweier M, Steindl K, Rauch A, Arold ST, Woods CG, Komatsu M, Alkuraya FS.
  • Journal Title: Brain Volume: 141 Pages: 1934-1945
  • DOI: 10.1093/brain/awy135
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of variants in chromatin remodeling genes (2018)
  • Author(s): Hisashi Hasumi, Mitsuko Furuya, Kenji Tatsuno, Shogo Yamamoto, Masaya Baba, Yukiko Hasumi, Yasuhiro Isono, Kae Suzuki, Ryosuke Jikuya, Shinji Otake, Kentaro Muraoka, Kimito Osaka, Narihiko Hayashi, Kazuhide Makiyama, Yasuhide Miyoshi, Keiichi Kondo, Noboru Nakaigawa, Takashi Kawahara, Koji Izumi, Junichi Teranishi, Yasushi Yumura, Hiroji Uemura, Yoji Nagashima, Adam R Metwalli, Laura S Schmidt,
  • Journal Title: Human molecular genetics Volume: 印刷中 Issue: 15 Pages: 2712-2724
  • DOI: 10.1093/hmg/ddy181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration. (2018)
  • Author(s): Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS
  • Journal Title: Sleep Volume: 41(9) Issue: 9
  • DOI: 10.1093/sleep/zsy116
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Generalized verrucosis caused by various human papillomaviruses in a patient with GATA2 deficiency (2018)
  • Author(s): Kuriyama Y, Hattori M, Mitsui T, Nakano H, Oikawa D, Tokunaga F, Ishikawa O, Shimizu A.
  • Journal Title: Journal of Dermatology Volume: 45 Issue: 5
  • Peer Reviewed
• [Journal Article] Study on the tumor-induced angiogenesis using mathematical models. (2018)
  • Author(s): Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ.
  • Journal Title: Cancer Sci Volume: 109 Pages: 15-23
  • DOI: 10.1111/cas.13395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spontaneous development of intratumoral heterogeneity in a transposon-induced mouse model of glioma (2018)
  • Author(s): Sumiyoshi K, Koso H, Watanabe S.
  • Journal Title: Cancer Sci. Volume: 109 Issue: 5 Pages: 1513-1523
  • DOI: 10.1111/cas.13579
  • Peer Reviewed / Open Access
• [Journal Article] Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. (2018)
  • Author(s): Nakashima C, Yamamoto K, Fujiwara-Tani R, Luo Y, Matsushima S, Fujii K, Ohmori H, Sasahira T, Sasaki T, Kitadai Y, Kirita T, Kuniyasu H
  • Journal Title: Cancer Sci Volume: in press Issue: 6 Pages: 2036-2045
  • DOI: 10.1111/cas.13594
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas. (2018)
  • Author(s): Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A.
  • Journal Title: Cancer Sci Volume: 109 Pages: 2497-2508
  • DOI: 10.1111/cas.13695
  • Peer Reviewed / Open Access
• [Journal Article] PHLDAI, another PHLDA family protein that inhibits AKt. (2018)
  • Author(s): Yu Chen, Masahiro Takikawa, Shuichi Tsutsumi, Yoko Yamaguchi, Atsushi Okabe, Mayuna Shibata, Tatsuya Kawase, Akane Sada, Issei Ezawa, Yuhei Takano, Kisaburo Nagata, Yutaka Suzuki, Kentaro Semba, Hiroyuki Aburatani, Rieko Ohki.
  • Journal Title: Cancer Science Volume: 109 Pages: 3532-3542
  • DOI: 10.1111/cas.13796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model. (2018)
  • Author(s): Mizutani A, Yashiroda Y, Muramatsu Y, Yoshida H, Chikada T, Tsumura T, Okue M, Shirai F, Fukami T, Yoshida M, Seimiya H.
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4003-4014
  • DOI: 10.1111/cas.13805
  • Peer Reviewed / Open Access
• [Journal Article] Physiological and pathological relevance of cell competition in fly to mammals. (2018)
  • Author(s): Shunsuke Kon.
  • Journal Title: Development, Growth and Differentiation Volume: 60 Pages: 14-20
  • DOI: 10.1111/dgd.12415
  • Peer Reviewed / Open Access
• [Journal Article] Transdifferentiation of human somatic cells by ribosome. (2018)
  • Author(s): Ito N., Mohammad B., A., Shah A., I., A., and Ohta K.
  • Journal Title: Development Growth & Differentiation Volume: 60(5) Pages: 241-247
  • DOI: 10.1111/dgd.12538
  • Peer Reviewed / Open Access
• [Journal Article] Identification and functional analysis of inflammation-related miRNAs in skin wound repair. (2018)
  • Author(s): Mori R, Tanaka K, Shimokawa I
  • Journal Title: Dev Growth Differ Volume: 60 Issue: 6 Pages: 306-315
  • DOI: 10.1111/dgd.12542
  • Peer Reviewed / Open Access
• [Journal Article] Pancreatic adenocarcinoma upregulated factor has oncogenic functions in oral squamous cell carcinoma. (2018)
  • Author(s): Sasahira T, Kurihara M, Nishiguchi Y, Nakashima C, Kirita T, Kuniyasu H
  • Journal Title: Histopathol Volume: in press Issue: 4 Pages: 539-48
  • DOI: 10.1111/his.13097
  • Peer Reviewed / Open Access
• [Journal Article] Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlcl-over-expressing mice. (2018)
  • Author(s): Kikuchibara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.
  • Journal Title: J Neurochem Volume: 147 Issue: 3 Pages: 344-360
  • DOI: 10.1111/jnc.14486
  • Peer Reviewed
• [Journal Article] Deletion of exons encoding carboxypeptidase domain of Nnal results in Purkinje cell degeneration (pcd) phenotype. (2018)
  • Author(s): Zhou L, Hossain MI, Yamazaki M, Abe M, Natsume R, Konno K, Kageyama S, Komatsu M, Watanabe M, Sakimura K, Takebayashi H.
  • Journal Title: J Neurochem. Volume: 147 Pages: 557-572
  • DOI: 10.1111/jnc.14591
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional characterization of recombinant snake venom rhodocytin : rhodocytin mutant blocks CLEC-2/podoplanin-dependent platelet aggregation and lung metastasis. (2018)
  • Author(s): Sasaki T, Shirai T, Tsukiji N, Otake S, Tamura S, Ichikawa J, Osada M, Satoh K, Ozaki Y, Suzuki-Inoue K.
  • Journal Title: J Thromb Haemost Volume: 16 Issue: 5 Pages: 960-972
  • DOI: 10.1111/jth.13987
  • Peer Reviewed
• [Journal Article] Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy. (2018)
  • Author(s): Thannickal TC, John J, Shan L, Swaab DF, Wu MF, Ramanathan L, McGregor R, Chew KT, Cornford M, Yamanaka A, Inutsuka A, Fronczek R, Lammers GJ, Worley PF, Siegel JM.
  • Journal Title: Sci Transl Med Volume: 10 Pages: 447-447
  • DOI: 10.1126/scitranslmed.aao4953
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Multisensory enhancement of burst activity in an insect auditory neuron (2018)
  • Author(s): Someya, M, and Ogawa, H.
  • Journal Title: J Neurophysiol. Volume: 印刷中 Pages: 139-148
  • DOI: 10.1152/jn.00798.2017
  • Peer Reviewed
• [Journal Article] Ability of a convolutional neural network to differentiate between mouse and human cell lines and their radioresistant clones using microscopic images. (2018)
  • Author(s): Toratani, M., Konno, M., Asai. A., Koseki, J., Kawamoto, K., Tamari, K., Li, Z., Sakai, D., Kudo, T., Satoh, T., Sato, K., Motooka, D., Okuzaki, D., Doki, Y., Mori, M., Ogawa, K., Ishii, H.
  • Journal Title: Cancer Res Volume: 78
  • Peer Reviewed / Open Access
• [Journal Article] p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4 (2018)
  • Author(s): Kajiwara C, Fumoto K, Kimura H, Nojima S, Asano K, Odagiri K, Yamasaki M, Hikita H, Takehara T, Doki Y, Morii E, Kikuchi A.
  • Journal Title: Cancer Research Volume: 78(21) Pages: 3471-3484
  • DOI: 10.1158/0008-5472.can-18-1749
  • Peer Reviewed
• [Journal Article] Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. (2018)
  • Author(s): Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T*, Sato K
  • Journal Title: Mol Cancer Res Volume: 16 Issue: 3 Pages: 554-563
  • DOI: 10.1158/1541-7786.mcr-17-0393
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. (2018)
  • Author(s): Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger G, Wang J, Dong Y, Zhou Y, Wang J, Wu LY, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, et al.
  • Journal Title: Cancer Discovery Volume: 8 Issue: 11 Pages: 1438-1457
  • DOI: 10.1158/2159-8290.cd-17-1203
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer. (2018)
  • Author(s): Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M.
  • Journal Title: Jounal of Clinical Investigation Volume: 128 Issue: 12 Pages: 5603-5619
  • DOI: 10.1172/jci121679
  • Peer Reviewed / Open Access
• [Journal Article] Ezh2 loss propagates hypermethylation at T-cell differentiation-regulating genes to promote leukemic transformation. (2018)
  • Author(s): Wang C, Oshima M, Sato D, Matsui H, Kubota S, Aoyama K, Nakajima-Takagi Y, Koide S, Matsubayashi J, Mochizuki-Kashio M, Nakano-Yokomizo T, Bai J, Nagao T, Kanai A, Iwama A, Sashida G.
  • Journal Title: J Clin Invest Volume: 128 Issue: 9 Pages: 3872-3886
  • DOI: 10.1172/jci94645
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predominant synaptic potentiation and activation of the right central amygdala are independent of bilateral paracrachial activation in the hemilateral trigeminal inflammatory pain model of rats (2018)
  • Author(s): Miyazawa, Y., Takahashi, Y., Watabe, A. M. and Kato F.
  • Journal Title: Molecular Pain Volume: 14 Pages: 174480691880710-174480691880710
  • DOI: 10.1177/1744806918807102
  • Peer Reviewed / Open Access
• [Journal Article] High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System (2018)
  • Author(s): Katsuya K, Hori Y, Oikawa D, Yamamoto T, Umetani K, Urashima T, Kinoshita T, Ayukawa K, Tokunaga F, Tamaru M.
  • Journal Title: SLAS Discovery Volume: 23 Issue: 10 Pages: 1018-1029
  • DOI: 10.1177/2472555218793066
  • Peer Reviewed
• [Journal Article] Splice-site mutation causing partial retention of intron in the FLCN gene in Birt- Hogg-Dube syndrome: a case report (2018)
  • Author(s): Mitsuko Furuya, Hironori Kobayashi, Masaya Baba, Takaaki Ito, Reiko Tanaka, Yukio Nakatani
  • Journal Title: BMC medical genomics Volume: 42 Pages: 42-42
  • DOI: 10.1186/s12920-018-0359-5
  • Peer Reviewed / Open Access
• [Journal Article] Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation. (2018)
  • Author(s): Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.
  • Journal Title: Biomark Res. Volume: 6 Pages: 16-16
  • DOI: 10.1186/s40364-018-0130-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glucagonoma With Necrolytic Migratory Erythema : Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene. (2018)
  • Author(s): Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Niyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
  • Journal Title: J Clin Endocrinol Metab Volume: 23 Issue: 7 Pages: 2417-2423
  • DOI: 10.1210/jc.2017-02646
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p62/SQSTM1-steering the cell through health and disease. (2018)
  • Author(s): Sánchez-Martin P, Komatsu M.
  • Journal Title: Journal of Cell Science Volume: 131 Pages: 222836-222836
  • DOI: 10.1242/jcs.222836
  • Peer Reviewed / Open Access
• [Journal Article] Hidden Peptides Encoded by Putative Noncoding RNAs (2018)
  • Author(s): Matsumoto A., Nakayama KI.
  • Journal Title: Cell Struct. Funct. Volume: 18;43(1) Issue: 1 Pages: 75-83
  • DOI: 10.1247/csf.18005
  • NAID: 130006742309
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access
• [Journal Article] An Anti-tumorigenic Role of the Warburg Effect at Emergence of Transformed Cells. (2018)
  • Author(s): Kojiro Ishibashi, Riku Egami, Kazuki Nakai, Shunsuke Kon
  • Journal Title: Cell Struct. Funct. Volume: 43 Issue: 2 Pages: 171-176
  • DOI: 10.1247/csf.18018
  • NAID: 130007420412
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] i-Motif-binding ligand and their effects on the structure and biological functions of i-motif (2018)
  • Author(s): Shadi Sedghi Masoud, Kazuo Nagasawa
  • Journal Title: CHEMICAL & PHARMACEUTICAL BULLETIN Volume: 66 Issue: 12 Pages: 1091-1103
  • DOI: 10.1248/cpb.c18-00720
  • NAID: 130007539147
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed / Open Access
• [Journal Article] UPA-Seq : Prediction of Functional LncRNAs Using Differential Sensitivity to UV Crosslinking. (2018)
  • Author(s): Taiwa K, Yokoi S, Mito M2, Fujii K, Kimura Y, Iwasaki S, Nakagawa S.
  • Journal Title: RNA Volume: 24 Issue: 12 Pages: 1785-1802
  • DOI: 10.1261/rna.067611.118
  • NAID: 120006545959
  • Peer Reviewed / Open Access
• [Journal Article] Freezing sperm in short straws reduces storage space and allows transport in dry ice. (2018)
  • Author(s): Kaneko R, Kakinuma T, Sato S, Jinno-Oue A.
  • Journal Title: J. Reprod. Dev. Volume: 64 Issue: 6 Pages: 541-545
  • DOI: 10.1262/jrd.2018-100
  • NAID: 130007494562
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women : Chiba bone survey. (2018)
  • Author(s): Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
  • Journal Title: Endocr J Volume: 65 Issue: 2 Pages: 193-202
  • DOI: 10.1507/endocrj.ej17-0331 10.1507/endocrj.EJ17-0331
  • NAID: 130006402991
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Deficiency of AMPA receptor-palmitoylation aggravates seizure susceptibility. (2018)
  • Author(s): Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T. Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T
  • Journal Title: Journal of Neuroscience Volume: 38 Pages: 10220-10235
  • DOI: 10.1523/jneurosci.1590-18.2018
  • Peer Reviewed / Open Access
• [Journal Article] New observations in neuroscience using superresolution microscopy (2018)
  • Author(s): *Igarashi M, Nozumi M, Wu LG, Cella Zanacchi F, Katona I, Barna L, Xu P, Zhang M, Xue F. Boyden E
  • Journal Title: J Neurosci Volume: 38 Pages: 9459-9467
  • DOI: 10.1523/jneurosci.1678-18.2018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. (2018)
  • Author(s): de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To. Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
  • Journal Title: EMBO Mol Med Volume: 2018 Issue: 10 Pages: 1-21
  • DOI: 10.15252/emmm.201809024
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of PTH in mouse skin tumorigenesis. (2018)
  • Author(s): Okumura K, Saito M, and Wakabayashi Y.
  • Journal Title: Integrative Cancer Science and Therapeutics Volume: 5 Pages: 1-1
  • DOI: 10.15761/icst.1000271
  • Peer Reviewed / Open Access
• [Journal Article] Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer (2018)
  • Author(s): Kurataka Otsuka, Yusuke Yamamoto, Takahiro Ochiya
  • Journal Title: Oncotarget Volume: 9 Issue: 37 Pages: 24718-24730
  • DOI: 10.18632/oncotarget.25339
  • Peer Reviewed / Open Access
• [Journal Article] Anti-claudin-4 extracellular domain antibody enhances the antitumoral effects of chemotherapeutic and antibody drugs in colorectal cancer (2018)
  • Author(s): Fujiwara-Tani R, Sasaki T, Luo Y, Ohmori H, Nishiguchi Y, Kishi S, Mori S, Goto K, Kondoh M, Kuniyasu H
  • Journal Title: Oncotarget Volume: 9 Issue: 100 Pages: 37367-37378
  • DOI: 10.18632/oncotarget.26427
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of brain monoamine content in three populations of Lymnaea that correlates with taste-aversive learning ability (2018)
  • Author(s): Aonuma H., Totani Y., Sakakibara M., Lukowiak K. and Ito E.
  • Journal Title: BIOPHYSICS Volume: 15 Issue: 0 Pages: 129-135
  • DOI: 10.2142/biophysico.15.0_129
  • NAID: 130006736414
  • ISSN: 2189-4779
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prednisolone-responsive Postpartum IgG4-related Hypophysitis. (2018)
  • Author(s): Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
  • Journal Title: Intern Med Volume: 57 Issue: 3 Pages: 367-375