コホート・生体試料支援プラットフォーム

• Project/Area Number: 16H06277
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: 村上 善則 (2019-2020) 東京大学, 医科学研究所, 教授; 今井 浩三 (2016-2018) 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha): 若井 建志 名古屋大学, 大学院医学系研究科, 教授 (50270989) ; 村上 善則 東京大学, 医科学研究所, 教授 (30182108) ; 松尾 恵太郎 愛知県がんセンター(研究所), がん予防研究分野, 分野長 (80393122) ; 三上 春夫 千葉県がんセンター(研究所), がん予防センター, 部長 (10332355) ; 鈴木 貞夫 名古屋市立大学, 大学院医学研究科, 教授 (20226509) ; 喜多 義邦 敦賀市立看護大学, 看護学部, 准教授 (30147524) ; 渡辺 能行 (渡邊 能行) 京都府立医科大学, 大学院医学研究科, 教授 (00191809) ; 田中 恵太郎 佐賀大学, 医学部, 教授 (50217022) ; 嶽崎 俊郎 鹿児島大学, 医歯学域医学系, 教授 (50227013) ; 栗木 清典 静岡県立大学, 食品栄養科学部, 教授 (20543705) ; 古庄 憲浩 九州大学, 大学院医学研究院, 准教授 (10346786) ; 有澤 孝吉 徳島大学, 大学院医歯薬学研究部, 教授 (30203384) ; 玉腰 暁子 北海道大学, 大学院医学研究院, 教授 (90236737) ; 今田 恒夫 山形大学, 大学院医学系研究科, 教授 (60333952) ; 武林 亨 慶應義塾大学, 医学部, 教授 (30265780) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452) ; 成松 宏人 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん予防・情報学部, 部長 (50524419) ; 鈴木 康司 藤田保健衛生大学, 保健学研究科, 教授 (60288470) ; 村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50183653) ; 高尾 昌樹 (高雄 昌樹) 公益財団法人脳血管研究所, 美原記念病院, 研究員 (50245487) ; 赤津 裕康 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, 研究員 (00399734) ; 齊藤 祐子 国立研究開発法人国立精神・神経医療研究センター, 病院臨床検査科, 医長 (60344066) ; 矢部 博興 福島県立医科大学, 医学部, 教授 (60210316) ; 中杤 昌弘 名古屋大学, 医学部附属病院, 病院講師 (10559983) ; 清水 厚志 岩手医科大学, いわて東北メディカル・メガバンク機構, 特命教授 (30327655) ; 醍醐 弥太郎 東京大学, 医科学研究所, 特任教授 (30345029) ; 高橋 隆 名古屋大学, 大学院医学系研究科, 教授 (50231395) ; 宮城 洋平 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん分子病態学部, 総括部長 (00254194) ; 渡邉 俊樹 東京大学, 名誉教授 (30182934) ; 安井 寛 東京大学, 医科学研究所, 特任准教授 (40448593) ; 田中 英夫 愛知県がんセンター研究所, 疫学・予防部, 部長 (60470168) ; 内藤 真理子 名古屋大学, 大学院医学系研究科, 准教授 (10378010) ; 大中 佳三 九州大学, 医学研究院, 講師 (30325518) ; 森 満 札幌医科大学, 医学部, 教授 (50175634) ; 川崎 良 山形大学, 大学院医学系研究科, 准教授 (70301067)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥2,276,040,000 (Direct Cost: ¥1,750,800,000、Indirect Cost: ¥525,240,000); Fiscal Year 2018: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2017: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2016: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000)
• Keywords: 生体試料支援 / 健常人コホート / ブレインバンク / 最先端解析技術支援 / 臨床検体 / コホート / 一般健常人 / 大規模ゲノム解析 / 大規模ゲノム解析・オミックス解析 / オミックス解析

Outline of Annual Research Achievements

①総括支援活動 : 若手支援研究成果発表会をオンラインで開催した(2021/2/9)。コホート・生体試料支援プラットフォーム(以下、CoBiA)の各支援機能の説明と教育講演に続き、31名の若手研究者がCoBiAの支援を受けて行った研究成果の発表と情報交換を行った。また、東北メディカル・メガバンク等国内4ゲノムコホート等と、日本多施設共同コーホート(J-MICC)研究の間で、共同研究の実施を合意するなど、わが国のゲノムコホート間の連携が進んだ。また日本疫学会のホームページでの告知、関連分野の科研費取得者へのダイレクトメールなど、研究支援の周知を図った。
②コホートによるバイオリソース支援活動 : 今年度は291件の研究支援を実施した。またコホート(J-MICC)研究の追跡調査データ(死亡及びがん罹患。遺伝情報利用も含む)を用いた研究の解析テーマ募集を開始した。J-MICC研究において、新たにがん罹患追跡データを基盤として整備し、研究支援に供した。
③ブレインリソースの整備と活用支援 : 大阪大学に本邦初のブレインバンク部門を創設し、大阪刀根山医療センター、宇多野病院、大阪府立母子医療センター、連合小児自閉症ゲノム・不死化細胞トリオ、法医学自殺レジストリを統合し、筋萎縮性側索硬化症エピゲノム研究等に貢献した。
④生体試料による支援活動 : 298課題に生体機能分子の高感度解析・技術支援と共同研究ネットワーク構築支援を実施した。142課題にがん関連試料・情報(組織、血液)を提供した。7,774試料(血清、リンパ球、凍結組織、パラフィン包埋組織、DNA等)を収集し、3,581試料を提供した。ヒト試料解析研究の申請支援と病理形態学的解析支援を実施した。解析支援・連携構築支援・試料収集及び提供支援体制を強化した。学会・研究会及び公開講座を通じたヒト生体試料の活用研究の普及・啓発講演を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 若手支援研究成果発表会における研究者の交流を通じて、CoBiA各班間の連携強化と被支援者との学際的連携を図り、新たな共同研究や支援機能の構築に向けた情報共有と学術交流を実施できた。
全国で、総研究参加者約36万名のゲノムコホート連携が進み、本プラットフォームを構成するコホート研究が一定の役割を果たしつつある。また広報活動により、これまでとは異なる研究グループからの支援に関する問い合わせが増え、支援申請に結びついた。
②コホートによるバイオリソース支援活動 : 200件以上の研究支援を実施し、支援を受けた研究成果が、一流国際雑誌も含め多くの掲載論文として公表された。またコホート研究の死亡およびがん罹患追跡データを整備し、研究支援内容の充実を図ることができた。さらに、がん早期診断マーカーの検証支援を再開した。
③ブレインリソースの整備と活用支援 : 大阪大学、京都大学、奈良県立医科大学、和歌山県立医科大学と連携し、日本ブレインバンクネットワーク関西拠点を創設した。阪大法医学教室、大阪監察事務局との連携、連合小児発達学研究科を核とし、自閉症バイオリソース、自殺者死後脳レジストリ構築を開始した。コロナ禍での剖検障壁に、患者、医師、研究者の連携の下、生前献脳同意を推進し、グループ全体で昨年と同レベルのリソース構築、提供を達成できた。
④生体試料による支援活動 : 日進月歩で多様化する生命科学研究の動向を踏まえ、新規の高精度分子解析技術による解析支援体制の強化、生体試料バンクのISO20387「バイオバンキングの一般要求事項」に準じた体制整備、健常者血清の提供体制の強化と支援内容・成果の広報・啓発を進めた。この結果、支援課題数は生体機能分子解析・技術・連携支援及び生体試料収集・提供支援ともに令和2年度の研究支援実施計画を上回り、国際的にインパクトのある学術論文発表に貢献した。

Strategy for Future Research Activity

①総括支援活動 : CoBiAと支援利用者との情報共有を促進し、広範で多彩なニーズに迅速かつ高品質の支援を提供するため、令和3年度も若手支援研究成果発表会を開催する。
ゲノムコホート連携については、共同研究契約の締結などを進め、共同研究を開始する。また学会での広報、関連分野の科研費取得者への案内などを通じて本支援活動の周知を継続する。
②コホートによるバイオリソース支援活動 : 支援件数の増加を図るため、関連分野の研究室および科研費代表研究者へのダイレクトメール、関係学会のメーリングリストなどで支援活動の広報を行う。支援の主要な基盤であるJ-MICC研究(参加者数10.3万人)について、第二次調査データ、および虚血性心疾患・脳卒中罹患データを整備する。また、がん罹患症例と対照のGWAS用タイピングを継続するとともに、データを順次、支援に使用する。
③ブレインリソースの整備と活用支援 : 本邦ブレインバンクの国際的優越性は、全身剖検を基盤としており、脳だけでなく脊髄、末梢組織リソースを持つ点、患者・医師協力の元臨床症状・放射線画像・バイオリソースとの統合化が可能である点、神経病理学会ブレインバンク委員会の指導の元国際的に一流の神経病理診断に基づく運用・管理が可能である点からなる。基礎神経科学者に対するヒト死後脳研究への勧誘を継続し、研究者数増加への努力を今後も継続する。
④生体試料による支援活動 : 多彩な生命科学領域のニーズと技術革新に迅速に対応して支援成果を研究者に還元するため、先進的な分子解析支援技術の導入・強化を進め、新倫理指針に対応し、国際水準の質を確保した多彩なヒト試料の収集・提供を進める。先進的研究拠点等との連携を強化し、次相を見据えた学際的共同研究の構築支援を行い、学会や教育の場で研究者や若手向けの普及・啓発活動を展開する。また、コロナ禍で支障をきたした研究への支援を強化する。

Research Products

• [Int'l Joint Research] George Mason University/University of Texas, MD Anderson Cancer Center/National Institute on Aging(アメリカ)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] リエージュ大学(ベルギー)
• [Int'l Joint Research] デューク大学/ユタ大学/南カリフォルニア大学（米国）
• [Int'l Joint Research] ケンブリッジ大学/エジンバラ大学（英国）
• [Int'l Joint Research] クイーンズランド大学（オーストラリア）
• [Int'l Joint Research] 国立がんセンター（韓国）
• [Int'l Joint Research] センメルヴェイス大学（ハンガリー）
• [Int'l Joint Research] ハーバード大学 ダナファーバーがん研究所/シカゴ大学/NIH(米国)
• [Int'l Joint Research] University of Chicago/NCI/Vanderbilt University(米国)
• [Int'l Joint Research] University of Hong Kong/Shandong Academy of Medical Sciences/Tianjin Medical University Cancer Institute and Hospital(中国)
• [Int'l Joint Research] NHRI, Taiwan/Academia Sinica/National Yang-Ming University(台湾)
• [Int'l Joint Research] Chonnam National University, Korea/Seoul National University College of Medicine/Korea University Anam Hospital(韓国)
• [Int'l Joint Research] Institute of Predictive and Personalized Medicine of Cancer(スペイン)
• [Int'l Joint Research] National University of Singapore/Genome Institute of Singapore(シンガポール)
• [Journal Article] Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study. (2022)
  • Author(s): Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, ...Kuriki K, et al.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 11 Pages: 483-488
  • DOI: 10.2188/jea.je20200540 10.2188/jea.JE20200540
  • NAID: 130007988449
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-11-05
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Association between nutrient patterns and fatty liver index : Baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushim, Japan (2022)
  • Author(s): Nguyen Van Tien, Kokichi Arisawa, Hirokazu Uemura, Nahomi Imaeda, Chiho Goto, Sakurako Katsuura-Kamano
  • Journal Title: Journal of Epidemiology Volume: 12 Issue: 8 Pages: 376-383
  • DOI: 10.2188/jea.je20200447 10.2188/jea.JE20200447
  • NAID: 130007986095
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2022-08-05
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Are Japanese women less physically active than men? Findings from the DOSANCO Health Study. (2021)
  • Author(s): Amagasa S, Inoue S, Ukawa S, Sasaki S, Nakamura K, Yoshimura A, Tanaka A, Kimura T, Nakagawa T, Imae A, Ding D, Kikuchi H, Tamakoshi A.
  • Journal Title: Journal of Epidemiology Volume: in press Issue: 10 Pages: 530-536
  • DOI: 10.2188/jea.je20200185 10.2188/jea.JE20200185
  • NAID: 130008101394
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-10-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body Mass Index and Mortality From Aortic Aneurysm and Dissection (2021)
  • Author(s): Takada M, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: J Atheroscler Thromb Volume: 28 Issue: 4 Pages: 338-348
  • DOI: 10.5551/jat.57232
  • NAID: 130008014047
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-04-01
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Alcohol consumption and risk of gastric cancer : The Japan Collaborative Cohort study. (2021)
  • Author(s): Li Y, Eshak ES, Kokoro S, Liu K, Jy D, Iso H, Tamakoshi A
  • Journal Title: Journal of Epidemiology Volume: - Issue: 1 Pages: 30-36
  • DOI: 10.2188/jea.je20190304 10.2188/jea.JE20190304
  • NAID: 130007966029
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-01-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Genome-wide Association Study on Confection Consumption in a Japanese Population-The Japan Multi-Institutional Collaborative Cohort study. (2021)
  • Author(s): Suzuki T, Nakamura Y, Doi Y, Narita A, Shimizu A, Imaeda N, Goto C, Kuriki K, et al.
  • Journal Title: Br J Nutr. Volume: 126(12) Pages: 1843-1851
  • DOI: 10.1017/s0007114521000684
  • NAID: 120007000435
  • Description: In press
  • Peer Reviewed
• [Journal Article] Alteration of mucins in the submandibular gland during aging in mice. (2021)
  • Author(s): Kameyama, A., Thet Tin, WW., Nishijima, R., Yamakoshi, K.
  • Journal Title: Archives of Oral Biology Volume: 121 Pages: 104967-104967
  • DOI: 10.1016/j.archoralbio.2020.104967
  • Peer Reviewed
• [Journal Article] Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease. (2021)
  • Author(s): Hata K, Koyama T, Ozaki E, Kuriyama N, Mizuno S, Matsui D, Watanabe I, Uehara R, Watanabe Y.
  • Journal Title: Healthcare Volume: 9 Pages: 162-162
  • DOI: 10.3390/healthcare9020162
  • Peer Reviewed / Open Access
• [Journal Article] Association between circulating vascular-related microRNAs and an increase in blood pressure : a 5-year longitudinal population-based study (2021)
  • Author(s): Suzuki K, Yamada H, Fujii R, Munetsuna E, Ando Y, Ohashi K, Ishikawa H, Yamazaki M, Maeda K, Hashimoto S, Hamajima N.
  • Journal Title: J Hypertens. Volume: 39 Issue: 1 Pages: 84-89
  • DOI: 10.1097/hjh.0000000000002606
  • Peer Reviewed
• [Journal Article] Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice. (2021)
  • Author(s): Kameyama, A., Nishijima, R., Yamakoshi, K.
  • Journal Title: PLoS One Volume: 16 Issue: 1
  • DOI: 10.1371/journal.pone.0245607
  • Peer Reviewed / Open Access
• [Journal Article] Body mass index and colorectal cancer risk : A Mendelian randomization study. (2021)
  • Author(s): Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, et al.
  • Journal Title: Cancer Sci. Volume: 112 Pages: 1579-1588
  • DOI: 10.1111/cas.14824
  • NAID: 120007147665
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Dietary fish and ω-3 polyunsaturated fatty acids are associated with leukocyte ABCA1 DNA methylation levels (2021)
  • Author(s): Fujii R, Yamada H, Munetsuna E, Yamazaki M, Mizuno G, Ando Y, Maeda K, Tsuboi Y, Ohashi K, Ishikawa H, Hagiwara C, Wakai K, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: Nutrition Volume: 81 Pages: 110951-110951
  • DOI: 10.1016/j.nut.2020.110951
  • Peer Reviewed
• [Journal Article] Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor (2021)
  • Author(s): 93.Maeda J. Sahara N.（他１９名）
  • Journal Title: Brain Communications Volume: 3 Issue: 1 Pages: 1-19
  • DOI: 10.1093/braincomms/fcab011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of the window period of human T-cell leukemia virus type 1 and 2 tests by a lookback study of seroconverters among Japanese voluntary blood donors (2021)
  • Author(s): Yasuko Sagara, Hitomi Nakamura, Midori Yamamoto, Toshinobu Ezaki, Tomohide Koga, Masuhiro Shimamura, Masahiro Satake, Kazuo Irita
  • Journal Title: Transfusion
  • DOI: 10.1111/trf.16213
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Extracellular release of ILEI/FAM3C and amyloid-beta is associated with the activation of distinct synapse subpopulations. (2021)
  • Author(s): Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M.
  • Journal Title: Journal of Alzheimer's Disease Volume: 80 Pages: 159-174
  • DOI: 10.3233/jad-201174
  • NAID: 120007019774
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese : the Japan Multi-Institutional Collaborative Cohort Study (2021)
  • Author(s): Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, ... Kuriki K, et al.
  • Journal Title: Nagoya Journal of Medical Science Volume: 83 Issue: 1 Pages: 183-194
  • DOI: 10.18999/nagjms.83.1.183
  • NAID: 120007127303
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/2000215
  • Peer Reviewed / Open Access
• [Journal Article] Green tea and coffee consumption and all-cause mortality among persons with and without stroke or myocardial infarction (2021)
  • Author(s): Teramoto M, Muraki I, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: Stroke Volume: 52 Pages: 957-965
  • DOI: 10.1161/strokeaha.120.032273
  • NAID: 120007141669
  • Peer Reviewed / Open Access
• [Journal Article] High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies (2021)
  • Author(s): Tagai K, Ono M, Kubota M, Kitamura S, Takahata K, Seki C, Takado Y, Shinotoh H, Sano Y, Yamamoto Y, Matsuoka K, Takuwa H, Shimojo M, (24人省略), Shimada H.
  • Journal Title: Neuron Volume: 109 Pages: 42-58
  • DOI: 10.1016/j.neuron.2020.09.042
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histidine-rich glycoprotein stimulates human neutrophil phagocytosis and prolongs survival through CLEC1A. (2021)
  • Author(s): Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M.
  • Journal Title: J Immunol Volume: 206(4) Pages: 737-750
  • DOI: 10.4049/jimmunol.2000817
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Incorporating kidney disease measures into cardiovascular risk prediction : Development and validation in 9 million adults from 72 datasets (2021)
  • Author(s): Matsushita K, Jassal SK, Sang Y, Ballew SH, Grams ME, Yatsuya H, Zhang L, Schaeffner E, Coresh J, et al.
  • Journal Title: EClinicalMedicine Volume: 27 Pages: 100552-100552
  • DOI: 10.1016/j.eclinm.2020.100552
  • NAID: 120007132584
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inverse correlation between serum high-molecular-weight adiponectin and proinsulin level in a Japanese population : The Dynamics of Lifestyle and Neighborhood Community on Health Study (2021)
  • Author(s): Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T.
  • Journal Title: J Diabetes Investig Volume: 12 Issue: 1 Pages: 63-66
  • DOI: 10.1111/jdi.13323
  • Peer Reviewed / Open Access
• [Journal Article] Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort : the JACC study (2021)
  • Author(s): Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H
  • Journal Title: Sci Rep Volume: 11 Pages: 1531-1531
  • DOI: 10.1038/s41598-020-79860-4
  • NAID: 120007141676
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes (2021)
  • Author(s): Eshak ES, Muraki I, Imano H, Yamagishi K, Tamakoshi A, Iso H
  • Journal Title: Maturitas Volume: 143 Pages: 127-131
  • DOI: 10.1016/j.maturitas.2020.10.009
  • NAID: 120007132579
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease (2021)
  • Author(s): Sobue A, Kimine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido T. C., Sahara N, Higuchi M, Ogi T, Yamanaka K.
  • Journal Title: Acta Neuropathologica Communications Volume: 9 Pages: 1-1
  • DOI: 10.1186/s40478-020-01099-x
  • Peer Reviewed / Open Access
• [Journal Article] Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. (2021)
  • Author(s): Koyama T, et al.
  • Journal Title: Sci Rep. Volume: 11 Pages: 305-305
  • DOI: 10.1038/s41598-020-79525-2
  • Peer Reviewed / Open Access
• [Journal Article] Perceived stress, depressive symptoms, and cortisol-to-cortisone ratio in spot urine in 6878 older adults (2021)
  • Author(s): Shimanoe, C., Matsumoto A., Hara, M., Akao C., Nishida, Y., Horita, M., Nanri H., Higaki, Y., Tanaka, K
  • Journal Title: Psychoneuroendocrinology, Volume: 125 Pages: 105125-105125
  • DOI: 10.1016/j.psyneuen.2020.105125
  • Peer Reviewed / Open Access
• [Journal Article] Relationship of Hemoglobin Level and Plasma Coproporphyrin-I Concentrations as an Endogenous Probe for Phenotyping OATP1B (2021)
  • Author(s): Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Oda A, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K
  • Journal Title: Clin Transl Sci Volume: -
  • DOI: 10.1111/cts.12996
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Reproducibility and validity of food group intake in a short food frequency questionnaire for the middle-aged Japanese population. (2021)
  • Author(s): Imaeda N, Goto C, Sasakabe T, Mikami H, Oze I, Hosono A, Naito M, ... Kuriki K, et al.
  • Journal Title: Environ Health Prev Med Volume: 26 Issue: 1
  • DOI: 10.1186/s12199-021-00951-3
  • NAID: 120007153323
  • ISSN: 1342-078X, 1347-4715
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Substantially Increased Plasma Coproporphyr in-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population (2021)
  • Author(s): Suzuki Y, Sasamoto Y, Koyama T, Yoshijima C, Nakatochi M, Kubo M, Momozawa Y, Uehara R, Ohno K.
  • Journal Title: Clin Transl Sci Volume: 14 Issue: 1 Pages: 382-388
  • DOI: 10.1111/cts.12889
  • Peer Reviewed / Open Access
• [Journal Article] The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. (2021)
  • Author(s): Araki K, Kinoshita R, Tomonobu N, Yamamoto KI, Murata H, Suzawa K, Shien K, Yamamoto H, Okazaki M, Nishibori M, Miyahara N, Toyooka S, Sakaguchi M.
  • Journal Title: J Mol Med (Berl) Volume: 99 Pages: 131-145
  • DOI: 10.1007/s00109-020-02001-x
  • Peer Reviewed / Open Access
• [Journal Article] Genome wide association study of HTLV-1-associated myelopathy/tropical spastic paraparesis in the Japanese population. (2021)
  • Author(s): Penova M, Kawaguchi S, Yasunaga JI, Kawaguchi T, Watanabe T, Uchimaru K, Iwanaga M, Utsunomiya A, Tabara Y, Paul R, Yamano Y, Matsuoka M, Matsuda F.
  • Journal Title: PNAS Volume: 118
  • DOI: 10.1073/pnas.2004199118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K, Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL)cells. (2021)
  • Author(s): Nakano K, Chihara Y, Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T, Uchimaru K.
  • Journal Title: Sci Rep. Volume: 11 Pages: 4114-4114
  • DOI: 10.1038/s41598-021-83613-2
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern. (2021)
  • Author(s): Suzuki Harumitsu、Nakamura Yasuyuki、Matsuo Keitaro、Imaeda Nahomi、Goto Chiho、Wakai Kenji et al.
  • Journal Title: Eur J Clin Nutr Volume: - Pages: 937-945
  • DOI: 10.1038/s41430-020-00823-z
  • Description: in press
  • Peer Reviewed
• [Journal Article] Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study (2021)
  • Author(s): Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, …, Kuriki K, et al.
  • Journal Title: Nutrients Volume: 12 Pages: 1605-1605
  • DOI: 10.3390/nu12061605
  • NAID: 120007146105
  • Peer Reviewed / Open Access
• [Journal Article] Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts : EPOCH-JAPAN. (2021)
  • Author(s): Li Y, Yatsuya H, Tanaka S, Iso H, Okayama A, Tsuji I, Sakata K, Miyamoto Y, Ueshima H, Miura K, Murakami Y, Okamura T
  • Journal Title: J Atheroscler Thromb Volume: . Issue: 8 Pages: 816-825
  • DOI: 10.5551/jat.58958
  • NAID: 130008070351
  • ISSN: 1340-3478, 1880-3873
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats. (2021)
  • Author(s): Nakamura K, Akagi S, Ejiri K, Yoshida M, Miyoshi T, Sakaguchi M, Higashimoto Y, Fukami K, Matsubara H, Ito H.
  • Journal Title: J Cardiol Volume: - Pages: 12-16
  • DOI: 10.1016/j.jjcc.2020.12.009
  • NAID: 120007182876
  • Peer Reviewed / Open Access
• [Journal Article] Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. (2021)
  • Author(s): Takeuchi K, Momozawa Y, Tanaka K, Matsuo K, Oze I, Mikami H, Takezaki T, Suzuki S, Watanabe I, Kita Y, Arisawa K, Hamajima N, Tanaka H, Wakai K.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 12 Pages: 660-668
  • DOI: 10.2188/jea.je20200147 10.2188/jea.JE20200147
  • NAID: 130008125571
  • ISSN: 0917-5040, 1349-9092
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells (2021)
  • Author(s): Rie Kajino-Sakamoto, Teruaki Fujishita, Makoto Mark Taketo, Masahiro Aoki.
  • Journal Title: Oncogene Volume: 40 Pages: 408-420
  • DOI: 10.1038/s41388-020-01541-3
  • Peer Reviewed
• [Journal Article] Validity Assessment of Self-reported Medication Use for Hypertension, Diabetes, and Dyslipidemia in a Pharmacoepidemiologic Study by Comparison With Health Insurance Claims (2021)
  • Author(s): Minako Matsumoto, Sei Harada, Miho Iida, Tomonori Okamura, Toru Takebayashi
  • Journal Title: Journal of Epidemiology Volume: Online ahead of print. Issue: 9 Pages: 495-502
  • DOI: 10.2188/jea.je20200089 10.2188/jea.JE20200089
  • NAID: 130008084668
  • ISSN: 0917-5040, 1349-9092
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Differential effect of polymorphisms on body mass index across the life course of Japanese : the Japan Multi-Institutional Collaborative Cohort Study (2021)
  • Author(s): Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Kuriki K, wakai K, et al.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 3 Pages: 0-0
  • DOI: 10.2188/jea.je20190296 10.2188/jea.JE20190296
  • NAID: 130007995132
  • ISSN: 0917-5040, 1349-9092
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Impact of PSCA polymorphisms on the risk of duodenal ulcer (2021)
  • Author(s): Usui Y, Matsuo K, Oze I, Ugai T, Koyanagi Y, Maeda Y, Ito H, Hishida A, Takeuchi K, Tamura T, Tsukamoto M, Kadomatsu Y, Hara M, Wakai K, et al
  • Journal Title: Journal of Epidemiology Volume: 31 Pages: 12-20
  • DOI: 10.2188/jea.je20190184
  • NAID: 130007965897
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Relationships between reproductive history and mortality from cardiovascular diseases among Japanese women : the Japan Collaborative Cohort (JACC) Study (2020)
  • Author(s): Tanigawa K, Ikehara S, Kimura T, Imano H, Muraki I, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 11 Pages: 509-515
  • DOI: 10.2188/jea.je20190020 10.2188/jea.JE20190020
  • NAID: 130007936916
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-11-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diabetes and mortality from respiratory diseases : the Japan Collaborative Cohort Study. (2020)
  • Author(s): Wang M, Muraki I, Liu K, Shirai K, Tamakoshi A, Hu Y, Iso H.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 10 Pages: 457-463
  • DOI: 10.2188/jea.je20190091 10.2188/jea.JE20190091
  • NAID: 130007922496
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-10-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney di-sease in a Japanese population (2020)
  • Author(s): Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Keisuke Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 4 Pages: 177-182
  • DOI: 10.2188/jea.je20180233 10.2188/jea.JE20180233
  • NAID: 130007828834
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-04-05
  • Peer Reviewed
• [Journal Article] Disclosure of secondary findings in exome sequencing of 2480 Japanese cancer patients. (2020)
  • Author(s): Horiuchi Y, Matsubayashi H, Kiyozumi Y, Nishimura S, Higashigawa S, Kado N, Nagashima T, Mizuguchi M, Ohnami S, Arai M, Urakami K, Kusuhara M, Yamaguchi K.
  • Journal Title: Hum Genet
  • DOI: 10.1007/s00439-020-02207-6
  • Description: in press
  • Peer Reviewed
• [Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo (2020)
  • Author(s): Masumichi Saito, Hiroo Hasegawa, Shunsuke Yamauchi, et al.
  • Journal Title: Int J Hematol Volume: 112 Issue: 3 Pages: 300-306
  • DOI: 10.1007/s12185-020-02935-5
  • Peer Reviewed / Open Access
• [Journal Article] A nobel multivariate index for cancer risk detection based on the serum trace elements : Metallo-Balance Method. (2020)
  • Author(s): Okamoto N, Mikami H, Nakamura Y, Kusakabe M, Fujimoto S, Ueda M, Inagaki S, Miyagi Y, Nagase H, et al
  • Journal Title: Journal of Cancer Epidemiology and Prevention Volume: 5 Pages: 1-9
  • Peer Reviewed / Open Access
• [Journal Article] ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G×E interaction analysis. (2020)
  • Author(s): Yoichi Sutoh, Tsuyoshi Hachiya, Yuji Suzuki, Shohei Komaki, Hideki Ohmomo, Keisuke Kakisaka, Ting Wang, Yasuhiro Takikawa & Atsushi Shimizu
  • Journal Title: Scientific Reports Volume: 10 Pages: 16227-16227
  • DOI: 10.1038/s41598-020-73263-1
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense. (2020)
  • Author(s): Sakaguchi, Y., Uchiyama, J., Take, A., Gotoh, K., Sakaguchi, M., Suzuki, T., Yamamoto, Y., Hosomi, K., Kohda, T., Mukamoto, M., Kozaki, S., Hayashi, S., Oguma, K.
  • Journal Title: Anaerobe Volume: 66 Pages: 102281-102281
  • DOI: 10.1016/j.anaerobe.2020.102281
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation. (2020)
  • Author(s): Miyauchi S, Shien K, Takeda T, Araki K, Nakata K, Miura A, Tomida S, Yamane M, Sakaguchi M, Toyooka S.
  • Journal Title: Anticancer Res Volume: 40 Pages: 2667-2673
  • DOI: 10.21873/anticanres.14237
  • Peer Reviewed / Open Access
• [Journal Article] ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. (2020)
  • Author(s): Sekiguchi M, Sobue A, Kushima I, et al.
  • Journal Title: Transl Psychiatry. Volume: 10 Pages: 1-15
  • DOI: 10.1038/s41398-020-00917-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association among chronic kidney disease, airflow limitation, and mortality in a community-based population : The Yamagata (Takahata)study. (2020)
  • Author(s): Suzuki N, Matsuki E, Araumi A, Ashitomi S, Watanabe S, Kudo K, Ichikawa K, Inoue S, Watanabe M, Ueno Y, Ishizawa K, Kayama T, Konta T.
  • Journal Title: Sci Rep. Volume: 10 Pages: 5570-5570
  • DOI: 10.1038/s41598-020-62540-8
  • Peer Reviewed / Open Access
• [Journal Article] Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study. (2020)
  • Author(s): Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, H?bert JR, Tamakoshi A.
  • Journal Title: Nagoya Journal of Medical Science Volume: 82 Issue: 2 Pages: 237-249
  • DOI: 10.18999/nagjms.82.2.237
  • NAID: 120006847435
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/30088
  • Peer Reviewed / Open Access
• [Journal Article] Association between plasma levels of homocysteine, folate, and vitamin B(12), and dietary folate intake and hypertension in a cross-sectional study. (2020)
  • Author(s): Tamura Takashi、Kuriyama Nagato、Koyama Teruhide、Suzuki Sadao、Nakagawa-Senda Hiroko、Takezaki Toshiro、Shimoshikiryo Ippei、Ikezaki Hiroaki、Murata Masayuki、Oze Isao、Ito Hidemi、Mikami Haruo、Nakamura Yohko、Kuriki Kiyonori、Arisawa Kokichi、Uemura Hirokazu、Takeuchi Kenji、Wakai Kenji, et al.
  • Journal Title: Sci. Rep. Volume: 10 Issue: 1 Pages: 18499-18499
  • DOI: 10.1038/s41598-020-75267-3
  • NAID: 120007146089
  • Peer Reviewed / Open Access
• [Journal Article] Association between Socioeconomic Status and Digestive Tract Cancers : A Case-Control Study. (2020)
  • Author(s): Kawakatsu Y, Koyanagi YN, Oze I, Kasugai Y, Morioka H, Yamaguchi R, Ito H, Matsuo K.
  • Journal Title: Cancers (Basel). Volume: 12 Pages: 3258-3258
  • DOI: 10.3390/cancers12113258
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Association of smoking habits with TXNIP DNA methylation levels in leukocytes among general Japanese population. (2020)
  • Author(s): Maeda K, Yamada H, Munetsuna E, Fujii R, Yamazaki M, Ando Y, Mizuno G, Ishikawa H, Ohashi K, Tsuboi Y, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: PLOS ONE Volume: 15 Issue: 7
  • DOI: 10.1371/journal.pone.0235486
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects : The Yakumo Study. (2020)
  • Author(s): Nakashima H, Ando K, Kobayashi K, Seki T, Ishizuka S, Fujii R, Takegami Y, Yamada H, Ando Y, Suzuki K, Hasegawa Y, Imagama S.
  • Journal Title: Biomed Res Int. Pages: 5047243-5047243
  • DOI: 10.1155/2020/5047243
  • Peer Reviewed / Open Access
• [Journal Article] Brain Transcriptome Analysis Links Deficiencies of Stress-Responsive Proteins to the Pathomechanism of Kii ALS/PDC (2020)
  • Author(s): Morimoto S, Ishikawa M, Watanabe H, Isoda M, Takao M, Nakamura S, Ozawa F, Hirokawa Y, Kuzuhara S, Okano H, Kokubo Y.
  • Journal Title: Antioxidants (Basel) Volume: 9 Issue: 5 Pages: 1-16
  • DOI: 10.3390/antiox9050423
  • Peer Reviewed / Open Access
• [Journal Article] Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells. (2020)
  • Author(s): 1, Nanumi Han, Delnur Anwar, Naoki Hama, Takuto Kobayashi Hidefumi Suzuki, Hidehisa Takahashi, Haruka Wada, Ryo Otsuka, Muhammad Baghdadi, Ken-ichiro Seino.
  • Journal Title: Inflammation and Regeneration Volume: 40 Pages: 25-25
  • DOI: 10.1186/s41232-020-00129-4
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer. (2020)
  • Author(s): Nakamura M, Takano A, Thang PM, Tsevegjav B, Zhu M, Yokose T, Yamashita T, Miyagi Y, Daigo Y
  • Journal Title: International Journal of Oncology Volume: 57 Issue: 1 Pages: 277-288
  • DOI: 10.3892/ijo.2020.5060
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Glioma-associated Oncogene 1 Expression in Patients With Locally Advanced Gastric Cancer Administered Adjuvant Chemotherapy With S-1 After Curative Surgery. (2020)
  • Author(s): Hashimoto I, Oue N, Kimura Y, Hiroshima Y, Yamada T, Tamagawa H, Yamamoto N, Ogata T, Shiozawa M, Morinaga S, Rino Y, Yasui W, Masuda M, Miyagi Y, Oshima T.
  • Journal Title: Anticancer Res. Volume: 40 Pages: 5815-5821
  • DOI: 10.21873/anticanres.14599
  • Peer Reviewed
• [Journal Article] Comparison of common and disease-specific post-translational modifications of pathological tauassociated with a wide range of tauopathies (2020)
  • Author(s): Kametani F, Yoshida M, Matsubara T, Murayama S, Saito Y, Kawakami I, Onaya M, Tanaka H, Kakita A, Robinson A, Mann M, Hasegawa M.
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 581936-581936
  • DOI: 10.3389/fnins.2020.581936
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive Serum Glycopeptide Spectra Analysis Combined with Artificial Intelligence (CSGSA-AI) to Diagnose Early-Stage Ovarian Cancer. (2020)
  • Author(s): Tanabe K, Ikeda M, Hayashi M, Matsuo K, Yasaka M, Machida H, Shida M, Katahira T, Imanishi T, Hirasawa T, Sato K, Yoshida H, Mikami M.
  • Journal Title: Cancers (Basel) Volume: 12（9） Issue: 9
  • DOI: 10.3390/cancers12092373
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation between serum proinsulin levels and fatty liver : The Dynamics of Lifestyle and Neighborhood Community on Health Study (2020)
  • Author(s): Miya A, Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T
  • Journal Title: J Diabetes Investig Volume: 11 Issue: 4 Pages: 964-970
  • DOI: 10.1111/jdi.13221
  • Peer Reviewed / Open Access
• [Journal Article] Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells. (2020)
  • Author(s): Yamamoto KI, Kagawa H, Arimoto S, Tan XW, Yasui K, Oshiki T, Sakaguchi M.
  • Journal Title: Acta Medica Okayama Volume: 74 Issue: 4 Pages: 327-334
  • DOI: 10.18926/AMO/60371
  • NAID: 120006880210
  • URL: http://ousar.lib.okayama-u.ac.jp/60371
  • Peer Reviewed / Open Access
• [Journal Article] Daily Consumption of Coffee and Eating Bread at Breakfast Time Is Associated with Lower Visceral Adipose Tissue and with Lower Prevalence of Both Visceral Obesity and Metabolic Syndrome in Japanese Populations : A Cross-Sectional Study. (2020)
  • Author(s): Koyama T, Maekawa M, Ozaki E, Kuriyama N, Uehara R.
  • Journal Title: Nutrients. Volume: 12 Issue: 10 Pages: 3090-3090
  • DOI: 10.3390/nu12103090
  • Peer Reviewed / Open Access
• [Journal Article] Depressive tendency and the risk of death from pneumonia : The JACC study (2020)
  • Author(s): Tanabe N, Seki N, Horikawa C, Yatsuya H, Yamagishi K, Iso H, Ukawa S, Tamakoshi A
  • Journal Title: Intern. Med. Volume: 59 Issue: 24 Pages: 3123-3130
  • DOI: 10.2169/internalmedicine.5052-20
  • NAID: 130007956117
  • ISSN: 0918-2918, 1349-7235
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Enhancement of intestinal epithelial barrier function by Weissella confusa F213 and Lactobacillus rhamnosus FBB81 probiotic candidates in an in vitro model of hydrogen peroxide-induced inflammatory bowel disease. (2020)
  • Author(s): Fatmawati NND, Gotoh K, Mayura IPB, Nocianitri KA, Suwardana GNR, Komalasari NLGY, Ramona Y, Sakaguchi M, Matsushita O, Sujaya IN.
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• [Journal Article] Blood Metabolite Signatures of Metabolic Syndrome in Two Cross-Cultural Older Adult Cohorts. (2019)
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• [Journal Article] Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) (2019)
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• [Journal Article] Calmodulin mutations and life-threatening cardiac arrhythmias : insights from the International Calmodulinopathy Registry. (2019)
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  • Journal Title: Lab Invest. Volume: - Issue: 9 Pages: 1349-1362
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• [Journal Article] CD4+ CADM1+ cell percentage predicts disease progression in HTLV-1 carriers and indolent adult T-cell leukemia/lymphoma. (2019)
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  • Journal Title: Cancer Science Volume: 110(12) Pages: 3746-3753
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• [Journal Article] Change in Brain Plasmalogen Composition by Exposure to Prenatal Undernutrition Leads to Behavioral Impairment of Rats (2019)
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  • Journal Title: Thrombosis and Haemostasis Volume: 印刷中 Pages: 1058-1071
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  • Journal Title: Cancers (Basel) Volume: 11 Pages: 1492-1492
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• [Journal Article] Clinical significance of PD-L1-positive cancer-associated fibroblasts in pNOMO non-small cell lung cancer (2019)
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  • Journal Title: Lung Cancer Volume: 137 Pages: 56-63
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• [Journal Article] Comparing different definitions of prediabetes with subsequent risk of diabetes : an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. (2019)
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  • Journal Title: Biochem Biophys Rep Volume: - Pages: 100619-100619
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  • Journal Title: Neoplasia Volume: 21(7) Pages: 627-640
  • DOI: 10.1016/j.neo.2019.04.006
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  • Journal Title: Microbiology and Immunology Volume: 63(11) Issue: 11 Pages: 458-464
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• [Journal Article] Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder (2019)
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• [Journal Article] Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain. (2019)
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• [Journal Article] Efficiency score from data envclopment analysis can predict the future onset of hypertension and dyslipidemia : A cohort study. (2019)
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  • Journal Title: EMBO Mol Med Volume: 11(12) Issue: 12
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• [Journal Article] Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases. (2019)
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• [Journal Article] Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers. (2019)
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• [Journal Article] Fiber intake and the risk of head and neck cancer in the prostate, lung, colorectal and ovarian (PLCO) cohort. (2019)
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• [Journal Article] Flotillin is a novel diagnostic blood marker of Alzheimer's disease (2019)
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• [Journal Article] Functional Analysis of Aberrantly Spliced Caspase 8 Variants in Adult T-cell Leukemia Cells. (2019)
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• [Journal Article] Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. (2019)
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• [Journal Article] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals (2019)
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  • Journal Title: Carcinogenesis Volume: - Pages: 661-668
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  • Journal Title: Int. J. Sports Med. Volume: 40 Pages: 670-677
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• [Journal Article] Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma : a case-control study in Japan (2019)
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  • Journal Title: Annals of Hematology Volume: 98(8) Pages: 1981-1987
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• [Journal Article] Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations (2019)
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  • Journal Title: Cancers Volume: 11 Pages: 266-266
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• [Journal Article] Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians (2019)
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  • Journal Title: Cancer Epidemiol Biomarkers Prev Volume: 29 Pages: 477-486
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  • Journal Title: Sci Rep Volume: 9 Pages: 17332-17332
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• [Journal Article] Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population (2019)
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  • Journal Title: Endocrine Volume: 印刷中 Issue: 3 Pages: 552-563
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• [Journal Article] Intraoperative Capsule Rupture, Postoperative Chemotherapy, and Survival of Women With Stage I Epithelial Ovarian Cancer. (2019)
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  • Journal Title: Obstet Gynecol Volume: 134(5) Issue: 5 Pages: 1017-1026
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• [Journal Article] Investigation of betaine as a novel psychotherapeutic for schizophrenia (2019)
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  • Journal Title: EBioMedicine Volume: 45 Pages: 432-446
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  • Journal Title: Biochemistry and biophysics reports Volume: 20 Pages: 100704-100704
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• [Journal Article] Malignant rhabdoid tumour in an adult kidney : A case report. (2019)
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  • Journal Title: Mol Clin Oncol Volume: 11 Pages: 55-58
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• [Journal Article] Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion. (2019)
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  • Journal Title: Metabolites Volume: 19
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• [Journal Article] Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease. (2019)
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  • Journal Title: IRDR Volume: 8 Issue: 2 Pages: 120-128
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  • Journal Title: Intractable & Rare Diseases Research Volume: 8 Pages: 260-265
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• [Journal Article] Neoadjuvant chemotherapy for epithelial ovarian cancer in Japan : a JSGO-JSOG joint study. (2019)
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  • Journal Title: Mol Carcinog Volume: - Pages: 980-995
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• [Journal Article] Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. (2019)
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• [Journal Article] Predictors for pathological parametrial invasion in clinical stage IIB cervical cancer. (2019)
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• [Journal Article] Prognostic value of IL-34 in colorectal cancer patients. (2019)
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• [Journal Article] RBM10-TFE3 Renal Cell Carcinoma Characterized by Paracentric Inversion with Consistent Closely Split Signals in Break-apart Fluorescence in situ Hybridization : Study of Ten Cases and a Literature Review (2019)
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• [Journal Article] Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer. (2019)
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• [Journal Article] Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. (2019)
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  • Journal Title: Brain Volume: 142 Pages: 1077-1092
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• [Journal Article] Significance of Malignant Peritoneal Cytology on the Survival of Women with Early-Stage Cervical Cancer : A Japanese Gynecologic Oncology Group Study. (2019)
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• [Journal Article] Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas (2019)
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• [Journal Article] Tau isoform expression and phosphorylation in marmoset brains. (2019)
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  • Journal Title: Cancer Res Treat. Volume: 51 Pages: 1509-1517
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• [Journal Article] TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease. (2019)
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• [Journal Article] The basis of clinicopathological heterogeneity in TDP-43 proteinopathy. (2019)
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• [Journal Article] The Consortium of Metabolomics Studies (COMETS) : Metabolomics in 47 Prospective Cohort Studies. (2019)
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  • Journal Title: American Journal of Epidemiology Volume: - Pages: 991-1012
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• [Journal Article] Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015 : A JSGO-JSOG joint study. (2019)
  • Author(s): Machida H, Mastuo K, Yamagami W, Ebina Y, Kobayashi Y, Tabata T, Kanauchi M, Nagase T, Enomoto T, Mikami M.
  • Journal Title: Gynecol Oncol Volume: 153 Issue: 3 Pages: 589-596
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• [Journal Article] Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma: A Review (2019)
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• [Journal Article] 一般住民における降圧薬治療の有無別に見た血圧と循環器疾患死亡との関連 (2019)
  • Author(s): 山岸良匡, 磯博康
  • Journal Title: 血圧 Volume: 26 Pages: 726-727
• [Journal Article] 沖縄型神経原性筋萎縮症の自然史-2019年における臨床研究の現状 (2019)
  • Author(s): 諏訪園秀吾
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• [Journal Article] 魚摂取と大動脈疾患死亡リスク (2019)
  • Author(s): 山岸良匡
  • Journal Title: 医学のあゆみ Volume: 270 Pages: 1214-1215
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  • Journal Title: Prev Med Volume: 118 Pages: 220-225
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  • Peer Reviewed
• [Journal Article] No substantial effect of polymorphisms in CPT1B and CPT2 on plasma carnitine levels in Japanese. (CPT遺伝子多型と血漿カルニチン濃度に関する研究) (2019)
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  • Journal Title: Nagoya J Med Sci
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] MAO-B binding of 18F-THK5351 to visualize glioblastoma and associated gliosis : an autopsy-confirmed case. (2019)
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  • Journal Title: Clin Nucl Med Volume: 44 Issue: 6 Pages: 507-509
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• [Journal Article] Intensity-specific and modified effects of physical activity on serum adiponectin in a middle-aged population (2019)
  • Author(s): Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
  • Journal Title: Journal of the Endocrine Society Volume: 3 Issue: 1 Pages: 13-26
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• [Journal Article] Identification of 28 novel susceptibility loci for type 2 diabetes in the Japanese population (2019)
  • Author(s): Suzuki K, Akiyama M, Horikoshi M, Kamatani Y, Hosoe J, Shojima N, Ishigaki K, Kanai M, Atsushi H, Kadota A, Kuriki K, Naito M, Tannno K, Ishigaki Y, Hirata M, Matsuda K, Iwata N, Ikeda M, Sawada N, Yamaji T, Iwasaki M, Ikegawa S, Okada Y, Maeda S, Murakam
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• [Journal Article] Sleep duration and risk of breast cancer : The JACC Study. (2019)
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• [Journal Article] Fat-soluble vitamins from diet in relation to risk of type 2 diabetes mellitus in Japanese population. (2019)
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• [Journal Article] Estimating genome-wide off-target effects for pyrrole-imoidazole polyamide binding by a pathway-based expression profiling approach (2019)
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  • Journal Title: 自律神経
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• [Journal Article] Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases. (2019)
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  • Journal Title: Proceedings of the Japan Academy, Series B
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• [Journal Article] Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. (2019)
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• [Journal Article] Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection. (2019)
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  • Journal Title: Hum Mol Genet Volume: 28 Pages: 341-348
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• [Journal Article] Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population : A reconfirmation by the J-MICC Daiko Study (2019)
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  • NAID: 120006716075
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• [Journal Article] Fish intake and risk of mortality due to aortic dissection and aneurysm : A pooled analysis of the Japan cohort consortium (2019)
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  • Journal Title: Clinical and Experimental Nephrology Volume: 23 Pages: 380-386
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• [Journal Article] Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection (2019)
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  • Journal Title: Clinical Cancer Research Volume: 25(2) Pages: 619-628
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• [Journal Article] Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. (2019)
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• [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. (2019)
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  • NAID: 120006988174
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• [Journal Article] Identification of specific microRNAs in neutrophils of type 2 diabetic mice : overexpression of microRNA-129-2-3p accelerates diabetic wound healing. (2019)
  • Author(s): Umehara T, Mori R, Mace K, Murase T, Abe Y, Yamamoto T, Ikematsu K
  • Journal Title: Diabetes Volume: 68 Issue: 3 Pages: 617-630
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• [Journal Article] Handling has an anxiolytic effect that is not affected by the inhibition of the protein kinase C pathway in adult prenatal undernourished male rat offspring. (2019)
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  • NAID: 210000155421
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  • Peer Reviewed
• [Journal Article] Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens (2019)
  • Author(s): Takahira Shirahase, Yoshihisa Watanabe, Atsushi Tsujimura, Shin Kwak, Toshiro Yamamoto, Narisato Kanamura and Masaki Tanaka
  • Journal Title: Front. Behav. Neurosci Volume: 12 Pages: 1-12
  • DOI: 10.3389/fnbeh.2018.00331
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• [Journal Article] Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma (2019)
  • Author(s): H. Yoda, T. Inoue, Y. Shinozaki, J. Lin, T. Watanabe, N. Koshikawa, A. Takatori, H. Nagase
  • Journal Title: Cancer Research Volume: 79 Issue: 4 Pages: 830-840
  • DOI: 10.1158/0008-5472.can-18-1198
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• [Journal Article] Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth. (2019)
  • Author(s): Ishikawa M, Osaki M, Yamagishi M, Onuma K, Ito H, Okada F, Endo H
  • Journal Title: Oncogene Volume: in press Pages: 4715-4728
  • DOI: 10.1038/s41388-019-0748-z
  • Description: in press
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• [Journal Article] Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS. (2019)
  • Author(s): Yamashita T, Kwak S
  • Journal Title: Neurosci Res Volume: 印刷中
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• [Journal Article] Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population : the Yakumo Study (2019)
  • Author(s): Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 82 Pages: 155-160
  • DOI: 10.1016/j.archger.2019.01.007
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• [Journal Article] Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor. (2019)
  • Author(s): Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
  • Journal Title: Int J Cancer. Volume: 144 Issue: 5 Pages: 1170-1179
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• [Journal Article] APOE4-mediated amyloid-βpathology depends on its neuronal receptor LRP1 (2019)
  • Author(s): Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T.
  • Journal Title: J Clin Invest Volume: 129 Issue: 3 Pages: 1272-1277
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• [Journal Article] Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations : Analysis of the First Large-Scale Nationwide Survey. (2019)
  • Author(s): Kamoi K, Okayama A, Izumo S, Hamaguchi I, Uchimaru K, Tojo A, Ohno-Matsui K.
  • Journal Title: Frontiers in Microbiology Volume: 9 Pages: 3240-3240
  • DOI: 10.3389/fmicb.2018.03240
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• [Journal Article] ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs (2019)
  • Author(s): Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
  • Journal Title: Neurosci Res Volume: 印刷中
  • DOI: 10.1016/j.neures.2018.11.005
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• [Journal Article] 5-HT3 Antagonist Ondansetron Increases ApoE Secretion by Modulating the LXR-ABCA1 Pathway (2019)
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  • Journal Title: Int. J. Mol. Sci Volume: 20 Issue: 6 Pages: 1488-1488
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• [Journal Article] Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype : A case-control study. (2018)
  • Author(s): Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y, Murakami S, Matsuo K.
  • Journal Title: Cancer Volume: 124 Issue: 1 Pages: 118-124
  • DOI: 10.1002/cncr.30957
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• [Journal Article] Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. (2018)
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  • Journal Title: Nat Commun Volume: 9 Pages: 16193-16193
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• [Journal Article] Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. (2018)
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  • Journal Title: PLoS ONE Volume: 13 Issue: 7
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• [Journal Article] Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer : a replication and mediation analysis. (2018)
  • Author(s): Ishioka K, Masaoka H, Ito H, Oze I, Ito S, Tajika M, Shimizu Y, Niwa Y, Nakamura S, Matsuo K.
  • Journal Title: Gastric Cancer Volume: 印刷中 Issue: 6 Pages: 936-945
  • DOI: 10.1007/s10120-018-0823-0
  • NAID: 40021694566
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• [Journal Article] Value assignment of the reference material for human T-cell leukemia virus type l quantitative PCR in Japan (2018)
  • Author(s): Madoka Kuramitsu, Kaoru Uchimaru, Yasuko Sagara, Toshiki Watanabe, Isao Hamaguchi, et al.
  • Journal Title: Microbiol Immunol Volume: 62 Issue: 10 Pages: 673-676
  • DOI: 10.1111/1348-0421.12644
  • NAID: 40021702629
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• [Journal Article] The association between self-rated health and high-sensitivity C-reactive protein level : a cross-sectional and 5-year longitudinal study. (2018)
  • Author(s): Tamura T, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Okada R, Kawai S, Hishida A, Wakai K.
  • Journal Title: BMC Public Health Volume: 18 Issue: 1 Pages: 1380-1380
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• [Journal Article] TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD. (2018)
  • Author(s): Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K. K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M.
  • Journal Title: Biol. Psychiatry Volume: 84(7) Pages: 509-521
  • DOI: 10.1016/j.biopsych.2018.03.008
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• [Journal Article] Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma (2018)
  • Author(s): Yoshihiro Komohara, Osamu Noyori, Yoichi Saito, Hiroto Takeya, Muhammad Baghdadi, Fumihito Kitagawa, Naoki Hama, Kozo Ishikawa, Yutaka Okuno, Kisato Nosaka, Ken-ichiro Seino, Masao Matsuoka, Shinya Suzu
  • Journal Title: J Clin Exp Hematopathol Volume: Vol. 58 No.4 Issue: 4 Pages: 152-160
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  • NAID: 130007529824
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• [Journal Article] Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons (2018)
  • Author(s): Takeyuki Tsuchida, Tatsuo Mano, Kagari-Koshi-Mano, Taro Bannai, Satoshi Yamashita, Toshikazu Ushijima, Kenichi Nagata, Shigeo Murayama, Tatsushi Toda, Shoji Tsuji, Atsushi Iwata
  • Journal Title: Brain Research Volume: 1697 Pages: 59-66
  • DOI: 10.1016/j.brainres.2018.06.017
  • Peer Reviewed
• [Journal Article] Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men (2018)
  • Author(s): Hirokazu Uemura, Sakurako Katsuura-Kamano, Mariko Nakamoto, Miwa Yamaguchi, Miho Fujioka, Yuki Iwasaki, Kokichi Arisawa
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 9667-9667
  • DOI: 10.1038/s41598-018-28038-0
  • NAID: 120006535059
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-34, a comprehensive review (2018)
  • Author(s): Muhammad Baghdadi, Yui Umeyama, Naoki Bama, Takuto Kobayashi, Nanumi Han, Haruka Wada, Ken-ichiro Seino
  • Journal Title: Journal of leukocyte biology Volume: 104 Issue: 5 Pages: 931-951
  • DOI: 10.1002/jlb.mr1117-457r
  • Peer Reviewed / Open Access
• [Journal Article] High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers (2018)
  • Author(s): Baghdadi M, Endo H, Takano A, Ishikawa K, Kameda Y, Wada H, Miyagi Y, Yokose T, Ito H, Nakayama H, Daigo Y, Suzuki N, Seino K
  • Journal Title: Sci Rep. Volume: 11;8(1) Issue: 1 Pages: 418-418
  • DOI: 10.1038/s41598-017-18796-8
  • NAID: 120006414003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population. (2018)
  • Author(s): MikiA, SakuradaY, TanakaK, SembaK, MitamuraY, YuzawaM, TajimaA, NakatochiM, YamamotoK, MatsuoK, ImotoI, HondaS.
  • Journal Title: Invest Ophtalmol Vis Sci Volume: 59(13) Issue: 13 Pages: 5542-5542
  • DOI: 10.1167/iovs.18-25497
  • NAID: 120006959762
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• [Journal Article] Genome-Wide Association Study of Renal Function Traits : Results from the Japan Multi-Institutional Collaborative Cohort Study. (2018)
  • Author(s): Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Turin TC, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura
  • Journal Title: American Journal of Nephrol Volume: 47 Issue: 5 Pages: 304-316
  • DOI: 10.1159/000488946
  • NAID: 120006504382
  • Peer Reviewed
• [Journal Article] Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults. (2018)
  • Author(s): Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H.
  • Journal Title: Med Sci Sports Exerc Volume: 50 Issue: 12 Pages: 2433-2441
  • DOI: 10.1249/mss.0000000000001712
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population (2018)
  • Author(s): Fujii R, Hishida A, Wu M. C, Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, Kuriki K, Wakai K.
  • Journal Title: Nagoya Journal of Medical Science Volume: 80 Issue: 1 Pages: 109-120
  • DOI: 10.18999/nagjms.80.1.109
  • NAID: 120006410517
  • ISSN: 0027-7622
  • URL: https://nagoya.repo.nii.ac.jp/records/25283
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced IL-34 expression in Nivolumab-resistant metastatic melanoma (2018)
  • Author(s): Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata, Ken-ichiro Seino
  • Journal Title: Inflammation and Regeneration Volume: 5 Pages: 3-3
  • DOI: 10.1186/s41232-018-0060-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced expression of IL-34 in an inflammatory cyst of the submandibular gland : a case report (2018)
  • Author(s): Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima, Ken-ichiro Seino
  • Journal Title: Inflammation and Regeneration Volume: 38 Issue: 12
  • DOI: 10.1186/s41232-018-0069-6
  • Peer Reviewed / Open Access
• [Journal Article] Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia (2018)
  • Author(s): Matsumoto J, Nagaoka A, Kunii Y, Miura I, Hino M, Niwa SI, Nawa H, Takahashi H, Kakita A, Yabe H
  • Journal Title: Psychiatry Res Volume: 264 Pages: 116-118
  • DOI: 10.1016/j.psychres.2018.03.029
  • Peer Reviewed
• [Journal Article] Dietary Antioxidant Micronutrients and All-Cause Mortality : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk. (2018)
  • Author(s): Ma E, Iso H, Yamagishi K, Ando M, Wakai K, Tamakoshi A.
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 9 Pages: 388-396
  • DOI: 10.2188/jea.je20170023 10.2188/jea.JE20170023
  • NAID: 130007481554
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  • Peer Reviewed / Open Access
• [Journal Article] Common variant of BCAS3 is associated with gout risk in Japanese population : the first replication study after gout GWAS in Han Chinese. (2018)
  • Author(s): Sakiyama M, Matsuo H, Nakaoka H, Kawamura Y, Kawaguchi M, Higashino T, Nakayama A, Akashi A, Ueyama J, Kondo T, Wakai K, Sakurai Y, Yamamoto K, Ooyama H, Shinomiya N.
  • Journal Title: BMC Med Genet Volume: 19 Issue: 1 Pages: 96-96
  • DOI: 10.1186/s12881-018-0583-z
  • Peer Reviewed / Open Access
• [Journal Article] Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan : Does school-based sport club participation matter? (2018)
  • Author(s): Gero K, Iso H, Kitamura A, Yamagishi K, Yatsuya H, Tamakoshi A.
  • Journal Title: Prev Med Volume: 113 Pages: 102-108
  • DOI: 10.1016/j.ypmed.2018.05.012
  • NAID: 120007134030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan : a cross-sectional study. (2018)
  • Author(s): Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanag
  • Journal Title: Medicine (Baltimore) Volume: 97 Issue: 48
  • DOI: 10.1097/md.0000000000013241
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study in the Japanese population identifies the 12q24 locus for habftual coffee consumption : The J-MICC Study (2018)
  • Author(s): Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Watanabe M, Ito H, Hara M, Nishida Y, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Wakai K, et al.
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  • NAID: 120006535054
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• [Journal Article] Water intake from foods and beverages and risk of mortality from CVD : the Japan Collaborative Cohort (JACC) Study. (2018)
  • Author(s): Cui R, Iso H, Eshak ES, Maruyama K, Tamakoshi A
  • Journal Title: Public Health Nutr Volume: 21 Issue: 16 Pages: 3011-3017
  • DOI: 10.1017/s1368980018001386
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• [Journal Article] Multiancestry genome-wide association study of 520.000 subjects identifies 32 loci associated with stroke and stroke subtypes. (2018)
  • Author(s): Malik R, Chauhan G, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worral
  • Journal Title: Nature Genetics Volume: 50 Issue: 4 Pages: 524-537
  • DOI: 10.1038/s41588-018-0058-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ikigai, Subjective Wellbeing, as a Modifier of the Parity-Cardiovascular Mortality Association- The Japan Collaborative Cohort Study. (2018)
  • Author(s): Yasukawa S, Eguchi E, Ogino K, Tamakoshi A, Iso H.
  • Journal Title: Circ J Volume: 82 Issue: 5 Pages: 1302-1308
  • DOI: 10.1253/circj.cj-17-1201 10.1253/circj.CJ-17-1201
  • NAID: 130006725979
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  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24. 11-12 and 20q11. 21 (2018)
  • Author(s): Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, In
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4015-4024
  • DOI: 10.1111/cas.13815
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13. 1. (2018)
  • Author(s): Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K.
  • Journal Title: PLOS ONE Volume: 13 Issue: 12
  • DOI: 10.1371/journal.pone.0209096
  • Peer Reviewed / Open Access
• [Journal Article] Fish Intake and Death From Pulmonary Embolisms Among Japanese Men and Women- The Japan Collaborative Cohort (JACC) Study. (2018)
  • Author(s): Ohira T, Iso H, Yamagishi K, Tamakoshi A
  • Journal Title: Circ J Volume: 82 Issue: 8 Pages: 2063-2070
  • DOI: 10.1253/circj.cj-18-0040 10.1253/circj.CJ-18-0040
  • NAID: 130007419808
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  • Peer Reviewed / Open Access
• [Journal Article] 脳脊髄液減少症(特発性低髄液圧症候群)と脳型トランスフェリン (2018)
  • Author(s): 村上友太、高橋浩一、星 京香、伊藤浩美、齋藤 清、宮嶋雅一、新井 一、美馬達夫、橋本康弘
  • Journal Title: 日本頭痛学会誌 Volume: 45 Issue: 1 Pages: 25-33
  • Peer Reviewed
• [Journal Article] Novel Common Genetic Susceptibility Loci for Colorectal Cancer. (2018)
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  • Journal Title: J Natl Cancer Inst Volume: 111 Issue: 2 Pages: 146-157
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• [Journal Article] Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid (2018)
  • Author(s): Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Masakazu Miyajima, Hajime Arai, Yasuhiro Hashimoto, Tatsuo Mima
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1862 Pages: 1835-1842
  • DOI: 10.1016/j.bbagen.2018.03.027
  • Peer Reviewed
• [Journal Article] Rapid increase of "brain-type" transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus : a prognosis marker for cognitive recovery (2018)
  • Author(s): Yuta Murakami, Yuka Matsumoto, Kyoka Hoshi, Hiromi Ito, Takashi J, Fuwa, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Kenneth Nollet, Naho Kato, Rie Nishikata, Naohito Kuroda, Takashi Honda, Jun Sakuma, Kiyoshi Saito, Yasuhiro Hashi
  • Journal Title: The Journal of Biochemistry Volume: 164 Issue: 3 Pages: 205-213
  • DOI: 10.1093/jb/mvy043
  • NAID: 40021678439
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Analysis of Surface Electromyography for Pediatric Neuromuscular Disorders (2018)
  • Author(s): Higashihara M, Somoo M, Ishiyama A, Nagashima Y, Matsumoto K, Uesugi H, et al.
  • Journal Title: Muscle Nerve Volume: 58 Issue: 6 Pages: 824-827
  • DOI: 10.1002/mus.26299
  • Peer Reviewed
• [Journal Article] Prediction model for pancreatic cancer risk in the general Japanese population. (2018)
  • Author(s): Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo
  • Journal Title: PloS ONE Volume: 13(9)
  • DOI: 10.1371/journal.pone.0203386
  • NAID: 120006822483
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• [Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia (2018)
  • Author(s): Yukawa t, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R. Takahashi H, Kakita A, Someya T, *Nawa H
  • Journal Title: Psychiatry Res Volume: 270 Pages: 940-946
  • DOI: 10.1016/j.psychres.2018.10.062
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• [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adpocytes and cancer cells. (2018)
  • Author(s): Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 33 Pages: 8370-8375
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutational intratumor heterogeneity is a complex and early event in the development of adult T-cell leukemia/lymphoma. (2018)
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  • Journal Title: Neoplasia Volume: 9 Issue: 9 Pages: 883-893
  • DOI: 10.1016/j.neo.2018.07.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lectin-based assay for glycoform-specific detection of ・2, 6sialylated transferrin and carcinoembryonic antigen in tissue and body fluid (2018)
  • Author(s): Hiromi Ito, Kyoka Hoshi, Takashi Honda, Yasuhiro Hashimoto
  • Journal Title: Molecule Volume: 23 Pages: 1314-1314
  • DOI: 10.3390/molecules23061314
  • Peer Reviewed
• [Journal Article] Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (2018)
  • Author(s): Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, et al.
  • Journal Title: Nature Communications Volume: 9 Pages: 5052-5052
  • DOI: 10.1038/s41467-018-07345-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of somatic mutations in postmortem human brains by whole gonome scquencing and their implications for psychiatric disorders. (2018)
  • Author(s): Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 72 Issue: 4 Pages: 280-294
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  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia-Lymphoma. (2018)
  • Author(s): Yamagishi M, Fujikawa D, Watanabe T, Uchimaru K.
  • Journal Title: Front Microbiol Volume: 9 Pages: 1686-1686
  • DOI: 10.3389/fmicb.2018.01686
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• [Journal Article] Genome-wide analysis of polymorphism?×?sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus (2018)
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  • Author(s): Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T,
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Pages: 13045-13050
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• [Journal Article] Cigarette smoking and cervical cancer risk : an evaluation based on a systematic review and meta-analysis among Japanese women (2018)
  • Author(s): Sugawara Y, Tsuji I, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tanaka K, Tamakoshi A, Tsugane S, Shimazu T ; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
  • Journal Title: Jpn J Clin Oncol
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  • Author(s): Nakashima M, Yamochi T, Watanabe M, Uchimaru K, Utsunomiya A, Higashihara M, Watanabe T, Horie R,
  • Journal Title: Clin Cancer Res. Volume: 24 Issue: 21 Pages: 5445-5457
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• [Journal Article] Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. (2018)
  • Author(s): Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N.
  • Journal Title: Cell Volume: 174(3) Issue: 3 Pages: 636-648
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• [Journal Article] Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling. (2018)
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  • Journal Title: Biol Cell Volume: 110 Issue: 5 Pages: 109-124
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• [Journal Article] Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. (2018)
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  • Journal Title: Cancer Sci Volume: 109 Pages: 15-23
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• [Journal Article] Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population. (2018)
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  • Journal Title: J Atheroscler Thromb Volume: 25 Issue: 12 Pages: 1231-1239
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• [Journal Article] Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease : The Japan Collaborative Cohort Study. (2018)
  • Author(s): Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A
  • Journal Title: Stroke Volume: 49 Issue: 2 Pages: 454-457
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• [Journal Article] Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease (2018)
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• [Journal Article] Prednisolone-responsive Postpartum IgG4-related Hypophysitis. (2018)
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• [Journal Article] Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma (2018)
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  • Journal Title: Acta Neuropathol Commun. Volume: 6 Pages: 53-53
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• [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. (2018)
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• [Journal Article] Maternal undernutrition during early pregnancy inhibits postnatal growth of the tibia in the female offspring of rats by alteration of chondrogenesis. (2018)
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  • Journal Title: Gen Comp Endocrinol. Volume: 260 Issue: 1 Pages: 58-60
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• [Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells (2018)
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  • Journal Title: Methods in Molecular Biology Volume: 1731 Pages: 29-37
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• [Journal Article] Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer. (2018)
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  • Journal Title: Oncotarget Volume: 9 Issue: 59 Pages: 31448-31458
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• [Journal Article] Identification and functional analysis of inflammation-related miRNAs in skin wound repair. (2018)
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  • Journal Title: Dev Growth Differ Volume: 60 Issue: 6 Pages: 306-315
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• [Journal Article] HIV LTR-driven antisense RNA by itself has regulatory function and may curtail virus reactivation from latency. (2018)
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  • Journal Title: Front. Microbiol. Volume: 9 Pages: 1066-1066
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• [Journal Article] Glucagonoma With Necrolytic Migratory Erythema : Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene. (2018)
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  • Journal Title: J Clin Endocrinol Metab Volume: 23 Issue: 7 Pages: 2417-2423
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• [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women : Chiba bone survey. (2018)
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  • Journal Title: Endocr J Volume: 65 Issue: 2 Pages: 193-202
  • DOI: 10.1507/endocrj.ej17-0331 10.1507/endocrj.EJ17-0331
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• [Journal Article] Epigenetic changes around the pX region and spontaneous HTLV-1 transcription are CTCF-independent. (2018)
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  • Journal Title: Wellcome Open Res. Volume: 3
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• [Journal Article] Enhanced expression of PD-L1 in non-muscle-invasive bladder cancer after treatment with Bacillus Calmette-Guerin. (2018)
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• [Journal Article] Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Yamagishi K, Cui R, Tamakoshi A.
  • Journal Title: Nutrition Volume: 47 Pages: 50-55
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• [Journal Article] Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation. (2018)
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  • Journal Title: Bone Marrow Transplant Volume: 53 Issue: 11 Pages: 1470-1473
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• [Journal Article] Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Maruyama K, Muraki I, Tamakoshi A.
  • Journal Title: Clin Nutr Volume: 印刷中 Issue: 2 Pages: 667-674
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  • NAID: 120006600946
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• [Journal Article] Associations between copper and zinc intakes from diet and mortality from cardiovascular disease in a large population-based prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Yamagishi K, Maruyama K, Umesawa M, Tamakoshi A.
  • Journal Title: J Nutr Biochem Volume: 56 Pages: 126-132
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• [Journal Article] Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population. (2018)
  • Author(s): Munetsuna E, Yamada H, Ando Y, Yamazaki M, Tsuboi Y, Kondo M, Mizuno G, Ishikawa H, Sugimoto K, Osakabe K, Ichino N, Ohashi K, Hamajima N, Suzuki K.
  • Journal Title: Annals of Clinical Biochemistry Volume: 55 Issue: 4 Pages: 437-445
  • DOI: 10.1177/0004563217735124
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• [Journal Article] Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus. (2018)
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  • Journal Title: Sci Rep. Volume: 17 Pages: 10767-10767
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• [Journal Article] Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo (2018)
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  • Journal Title: Anticancer Res. Volume: 38 Pages: 4257-4266
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• [Journal Article] A Potential New Risk Factor for Stroke : Streptococcus Mutans With Collagen-Binding Protein. (2018)
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  • Journal Title: World Neurosurg Volume: 113 Pages: 77-81
  • DOI: 10.1016/j.wneu.2018.01.158
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• [Journal Article] Complete Sequences of the HTLV-1 Proviral Genomes from Newly Established ATL cell-lines in Oita Prefecture, Japan (2018)
  • Author(s): Takuro Fukumoto, Emi Ikebe, Masao Ogata, Kazuhiro Kohno, Madoka Kuramitsu, Yusuke Sato, Nichole Fife, Takashi Matsumoto, Takaaki Yahiro, Masanori Ikeda, Shuichi Kusano, Akihiko Okayama, Mitsuo Hori, Naoki Hijiya, Yoshiyuki Tsukamoto, Yuka Hirashita, Masatsugu Moriyama, Kamruddin Ahmed, Hiroo Hasegawa, Akira Nishizono, Masumichi Saito*, and Hidekatsu Iha*
  • Journal Title: Genome Announcements Volume: 6 Issue: 25
  • DOI: 10.1128/genomea.00090-18
  • Peer Reviewed / Open Access
• [Journal Article] 成人T細胞白血病・リンパ腫のエピゲノム異常と新規EZH1/2阻害剤の開発 (2018)
  • Author(s): 山岸誠
  • Journal Title: 臨床血液 Volume: 59 Pages: 432-438
• [Journal Article] HTLV-1感染細胞におけるゲノム・エピゲノム異常 (2018)
  • Author(s): 山岸誠
  • Journal Title: 医学の歩み Volume: 267 Pages: 771-775
• [Journal Article] 悪性リンパ腫におけるEZH1/EZH2依存性エピゲノム異常と創薬 (2018)
  • Author(s): 山岸誠
  • Journal Title: 血液内科 Volume: 78 Pages: 87-92
• [Journal Article] Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADHIB polymorphisms in Japanese men (2018)
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  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 4 Pages: 185-193
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  • Description: in press
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• [Journal Article] Association of genetic polymorphisms with erythrocyte traits : Verification of SNPs reported in a previous GWAS in a Japanese population (2018)
  • Author(s): Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K.
  • Journal Title: Gene Volume: 642 Pages: 172-177
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• [Journal Article] Genome-wide association study identifies seven novel susceptibility loei for primary open-angle glaucoma (2018)
  • Author(s): Shiga Y, Akiyama M, Nishiguchi K M, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yanaka T, et al.
  • Journal Title: Human Molecular Genetics Volume: 27 Issue: 8 Pages: 1486-1496
  • DOI: 10.1093/hmg/ddy053
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• [Journal Article] GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. (2018)
  • Author(s): Tanikawa C, Kamatani Y, Takahashi A, Nagayama S, Mimori K, Mori M, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Matsuda K, et al.
  • Journal Title: Carcinogenesis Volume: Epub Pages: 652-660
  • DOI: 10.1093/carcin/bgy026
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• [Journal Article] Correlation between thyroid stimulating hormone and the renal function of cuthyroid residents of Japan : Results from the Kyushu and Okinawa Population Study(KOPS) (2018)
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  • Journal Title: J Atheroscler Thromb Volume: 25 Issue: 4 Pages: 335-343
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• [Journal Article] A Common variant of MAF/c-MAF, transcriptional factor genc in the kidney, is associated with gout susceptjbility. (2018)
  • Author(s): Toshihide Higashino, Hirotaka Matsuo, Yukinori Okada, Hiroshi Nakashima, Seiko Shimizu, Masayuki Sakiyama, Shin Tadokoro, Akiyoshi Nakayama, Makoto Kawaguchi, Mako Komatsu, Asahi Hishida, Masahiro Nakatochi, Hiroshi Ooyama, Junko Imaki, Nariyoshi Shinomiy
  • Journal Title: Hum Cell. Volume: 31 Pages: 10-13
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• [Journal Article] Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Hcart Disease : The Japan Collaborative Cohort Study (2018)
  • Author(s): Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A.
  • Journal Title: Stroke Volume: 49 Issue: 2 Pages: 454-457
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• [Journal Article] The prospective association between plasma concentrations of cellular growth factors and risk of heart failure mortality in Japanese population. (2018)
  • Author(s): Ehab S Eshak, Koutatsu Maruyama, Hiroyasu Iso, Akiko Tamakoshi.
  • Journal Title: J of Epidemiology
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• [Journal Article] Physical activity earlier in life is inversely associated with insulin resistance among adults in Japan (2018)
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  • Journal Title: Journal of Epidemiology
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  • Description: in press
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• [Journal Article] 地域住民の身体活動量と運動に対する自己評価 (2018)
  • Author(s): 藤田ひとみ、鈴木貞夫
  • Journal Title: 日本福祉大学健康科学論集 Volume: 21 Pages: 37-43
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• [Journal Article] Association of birth weight with diabetes and insulin resistance among community residents (2018)
  • Author(s): Kamiya M. Hosono A. Tamai Y. Watanabe M. Shibata K. Tsujimura S. Oka K. Fujita H. Okamoto X. Kondo F. Wakabayashi R, Yamada T. Suzuki S.
  • Journal Title: Nagoya Medical Journal
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• [Journal Article] Does waist circumference give us any significant information rcgarding obcsity? (2018)
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  • Journal Title: Nagoya Medical Journal
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• [Journal Article] Unusual tau pathology of the cerebellum in patients with amyotrophic latoral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. (2018)
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  • Journal Title: Brain Pathol Volume: - Issue: 2 Pages: 287-291
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• [Journal Article] Prion-Like seeding of misfolded alpha-synuclein in the brains of dementia with lewy body patients in RT-QUIC. (2018)
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  • Journal Title: Mol Neurobiol Volume: - Issue: 5 Pages: 3916-3930
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• [Journal Article] Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients. (2018)
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  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: 2 Pages: 211-215
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• [Journal Article] Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration. (2018)
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  • Journal Title: Neuropathology Volume: 38 Issue: 2 Pages: 171-178
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• [Journal Article] Optineurin pathology in the spinal cord of amyotrophic latoral sclerosis/parkinsonism-dementia complex patients in kii peninsula, Japan. (2018)
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  • Journal Title: Brain Pathol. Volume: 28 Pages: 422-426
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• [Journal Article] Intractable epilepsy due to a rosette-forming glioneuronal tumor with a dysembryoplastic neuroepithelial background. (2018)
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  • Journal Title: Neuropathology Volume: 12 Pages: 300-304
  • DOI: 10.1111/neup.12450
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Marked accumulation of oligodendroglia-like cells in temporal lobe epilcpsy with amygdala enlargement and hippocampal sclerosis. (2018)
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  • Journal Title: Neuropathology Volume: 38 Issue: 2 Pages: 154-158
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• [Journal Article] Complement activation in capillary cerebral amyloid angiopathy. (2018)
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• [Journal Article] Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma (2018)
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• [Journal Article] Different clonal dynamics of chronic myeloid leukaemia betwecn bone marrow and the central nervous system (2018)
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