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Neural circuit mechanisms for regulation of social conflicts

Research Project

Project/Area Number 16H06317
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Basic / Social brain science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Okamoto Hitoshi  国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (40183769)

Project Period (FY) 2016-05-31 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥185,770,000 (Direct Cost: ¥142,900,000、Indirect Cost: ¥42,870,000)
Fiscal Year 2020: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2019: ¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
Fiscal Year 2018: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2017: ¥31,330,000 (Direct Cost: ¥24,100,000、Indirect Cost: ¥7,230,000)
Fiscal Year 2016: ¥56,160,000 (Direct Cost: ¥43,200,000、Indirect Cost: ¥12,960,000)
Keywords手綱核 / 脚間核 / 社会的闘争 / ゼブラフィッシュ / マウス / オレキシン / AMPA型グルタミン酸受容体 / スプライシング / セロトニン / 勝者と敗者 / 縫線核 / アセチルコリン / サブスタンス P / 勝敗 / 遺伝子操作
Outline of Final Research Achievements

The habenula is among the evolutionarily most conserved parts of the brain and has been known for its role in the control of behavior to cope with aversive stimuli. Recent studies in zebrafish have revealed the novel roles of the two parallel neural pathways from the dorsal habenula to its target, the interpeduncular nucleus, in the control of behavioral choice whether to behave dominantly or submissively in the social conflict. They are modifiable depending on the internal state of the fish such as hunger and play another important role in orientation of attention whether to direct it internally to oneself or externally to others. These studies, therefore, are revealing a novel role for the habenula as the integrated switchboard for concertedly controlling behavior either as a winner with self-centered (idiothetic) attention or a loser with others-oriented (allothetic) attention.

Academic Significance and Societal Importance of the Research Achievements

闘争による社会的上下関係の決定は、動物だけで無く、人間でも見られる過程である。また、敗者が、敗北の記憶によって敗者となり続けるという現象は、人間の社会的振る舞いでも共通してみられる。この様な行動の脳科学的解明は、極めて社会的意義が大きい。また、社会的引きこもり等の治療などにも、研究の成果が利用される可能背が高い。また、いわゆるハングリー精神と言われる、闘争をあきらめない心の仕組みの一端を明らかにしたことは、社会的にも大きな関心を呼んだ。さらに、手綱核から脚間核への2本の神経経路が、動物が注意を外界と内面のどちらに向けるかのスイッチとして働く可能性は、今後の注意研究への重要な足がかりとなる。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2021 Research Progress Assessment (Verification Result) ( PDF )
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (54 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (13 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 7 results) Presentation (30 results) (of which Int'l Joint Research: 21 results,  Invited: 29 results) Remarks (9 results)

  • [Int'l Joint Research] Bar-Ilan University(イスラエル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] National Taiwan University(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Habenula as the experience-dependent controlling switchboard of behavior and attention in social conflict and learning.2021

    • Author(s)
      Okamoto H, Cherng BW, Nakajo H, Chou MY, Kinoshita M.
    • Journal Title

      Curr Opin Neurobiol.

      Volume: 68 Pages: 36-43

    • DOI

      10.1016/j.conb.2020.12.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Dorsal Lateral Habenula-Interpeduncular Nucleus Pathway Is Essential for Left-Right-Dependent Decision Making in Zebrafish.2020

    • Author(s)
      Cherng BW, Islam T, Torigoe M, Tsuboi T, Okamoto H.
    • Journal Title

      Cell Rep.

      Volume: 32 Issue: 11 Pages: 108143-108143

    • DOI

      10.1016/j.celrep.2020.108143

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene2020

    • Author(s)
      Nakajo Haruna、Chou Ming-Yi、Kinoshita Masae、Appelbaum Lior、Shimazaki Hideaki、Tsuboi Takashi、Okamoto Hitoshi
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 12 Pages: 107790-107790

    • DOI

      10.1016/j.celrep.2020.107790

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wide and Deep Imaging of Neuronal Activities by a Wearable NeuroImager Reveals Premotor Activity in the Whole Motor Cortex2019

    • Author(s)
      Takuma Kobayashi, Tanvir Islam, Masaaki Sato, Masamichi Ohkura, Junichi Nakai, Yasunori Hayashi & Hitoshi Okamoto
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8366-8366

    • DOI

      10.1038/s41598-019-44146-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Behavioral Paradigm to Induce Repeated Social Defeats in Zebrafish2019

    • Author(s)
      Nakajo H, Tsuboi T, Okamoto H.
    • Journal Title

      Neuroscience Research

      Volume: S0168-0102(19)30590-5. Pages: 24-32

    • DOI

      10.1016/j.neures.2019.11.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature.2018

    • Author(s)
      Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del'Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 3804-3804

    • DOI

      10.1038/s41467-018-06225-x

    • NAID

      120006780674

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optical measurement of neuronal activity in the developing cerebellum of zebrafish using voltage-sensitive dye imaging2018

    • Author(s)
      Okumura Kanoko、Kakinuma Hisaya、Amo Ryunosuke、Okamoto Hitoshi、Yamasu Kyo、Tsuda Sachiko
    • Journal Title

      NeuroReport

      Volume: 29 Issue: 16 Pages: 1349-1354

    • DOI

      10.1097/wnr.0000000000001113

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord.2018

    • Author(s)
      Ohata S, Uga H, Okamoto H, Katada T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 501 Pages: 786-790

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optical interrogation of neuronal circuitry in zebrafish using genetically encoded voltage indicators2018

    • Author(s)
      Miyazawa Hiroaki、Okumura Kanoko、Hiyoshi Kanae、Maruyama Kazuhiro、Kakinuma Hisaya、Amo Ryunosuke、Okamoto Hitoshi、Yamasu Kyo、Tsuda Sachiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 6048-6048

    • DOI

      10.1038/s41598-018-23906-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 同種間の社会的闘争を制御する神経回路2018

    • Author(s)
      岡本仁
    • Journal Title

      生体の科学

      Volume: 69 Pages: 10-13

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Social conflict resolution regulated by two dorsal habenular subregions in zebrafish.2016

    • Author(s)
      Chou, M-Y., Amo, R., Kinoshita, M., Cherng, B-W., Shimazaki, H., Agetsuma, M., Shiraki, T., Aoki, T., Yamazaki, M., Higashijima, S., and Okamoto, H.
    • Journal Title

      Science

      Volume: 352 Issue: 6281 Pages: 87-90

    • DOI

      10.1126/science.aac9508

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] For Motor Adjustments, Serotonin Steps In.2016

    • Author(s)
      Okamoto H.
    • Journal Title

      Cell

      Volume: 167 Issue: 4 Pages: 886-887

    • DOI

      10.1016/j.cell.2016.10.037

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manipulating the Cellular Circadian Period of Arginine Vasopressin Neurons Alters the Behavioral Circadian Period.2016

    • Author(s)
      Mieda M, Okamoto H, Sakurai T.
    • Journal Title

      Curr Biol.

      Volume: S0960-9822(16) Issue: 18 Pages: 30773-4

    • DOI

      10.1016/j.cub.2016.07.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The dorsal lateral habenula-interpeduncular nucleus pathway is essential for left-right dependent decision making in zebrafish2020

    • Author(s)
      Cherng Bor-Wei Bruce
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Goal directed behavior based on future prediction by adult zebrafish.2019

    • Author(s)
      Hitoshi Okamoto
    • Organizer
      Francis Crick Symposium - Transforming Neurosciences: Questions & Experiments
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of social conflict by the synaptic plasticity in the habenuro-interpeduncular pathway.2019

    • Author(s)
      Hitoshi Okamoto
    • Organizer
      Neurobiology of behavior and Neuropsychiatric disorders
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of social conflict by the synaptic plasticity in the habenulo-interpeduncular pathway.2019

    • Author(s)
      Hitoshi Okamoto
    • Organizer
      6th Congress of AsCNP
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] in-vivo imaging of the telencephalic activities in the closed-loop virtual reality environment revealed active inference in decision making.2019

    • Author(s)
      Hitoshi Okamoto
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissecting our mind based on evolutionaly conservation2019

    • Author(s)
      岡本仁
    • Organizer
      Biohub Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment revealed active inference in decision making2019

    • Author(s)
      岡本仁
    • Organizer
      8th strategic conference of zebrafish investigators
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] How does social conflict affect the synapticplasticity in habenulo-interpeduncular pathway?2019

    • Author(s)
      岡本仁
    • Organizer
      9th FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The evolutionary conserved mechanisms for the regulation of social conflict by the habenula2018

    • Author(s)
      岡本仁
    • Organizer
      22nd Biennial Meeting of the International Society for Developmental Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The active inference in decision making by adult zebrafish revealed by in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment2018

    • Author(s)
      岡本仁
    • Organizer
      2018 Zebrafish Neuroethology Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] None-fishly tale of fish decision making: What can we learn from fish about our mind?2018

    • Author(s)
      岡本仁
    • Organizer
      Developmental Neurobiology Course 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The active inference in decision making by adult zebrafish revealed by in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment2018

    • Author(s)
      岡本仁
    • Organizer
      平成 30 年度生理学研究所研究会「認知神経科学の先端 知覚学習と運動学習」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Dissecting our mind based on evolutionary conservation2018

    • Author(s)
      岡本仁
    • Organizer
      Symposium on Systems Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dissecting our mind based on evolutionary conservation2018

    • Author(s)
      岡本仁
    • Organizer
      ICOB Seminar
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The active inference in decision making by adult zebrafish revealed by in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment2018

    • Author(s)
      岡本仁
    • Organizer
      2018 Imaging Structure and Function in the Zebrafish Brain Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The active inference in decision making by adult zebrafish revealed by in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment2018

    • Author(s)
      岡本仁
    • Organizer
      Neuroscience Interest Group External Seminar Series 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 体の痛み、心の痛み、共感2017

    • Author(s)
      岡本仁
    • Organizer
      国際高等研究所 研究プロジェクト「精神発達障害から考察するdecision makingの分子的基盤」2016年度第1回研究会
    • Place of Presentation
      国際高等研究所(京都、木津川)
    • Year and Date
      2017-02-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] In-vivo imaging of telencephalic neural activity in adult zebrafish in the closed-loop virtual reality envirnment2017

    • Author(s)
      岡本仁
    • Organizer
      The 7th Strategic conference of Zebrafish Investigators
    • Place of Presentation
      Pacific Grove, USA
    • Year and Date
      2017-01-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光遺伝学による情動行動の制御機構の解析2017

    • Author(s)
      岡本仁
    • Organizer
      第64回日本実験動物学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The sedative effect of the cholinergic transmission in the habenulo-interpeduncular pathway in social conflict2017

    • Author(s)
      岡本仁
    • Organizer
      International Workshop on Zebrafish Neural Circuits and Behavior
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The sedative effect of the cholinergic transmission in the habenulo-interpedunclar pathway in social conflict2017

    • Author(s)
      岡本仁
    • Organizer
      Molecular and Cellular Mechanisms Underlying Mood: From Well Being to Disorders
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 進化的比較から解き明かされる意思決定の仕組み2017

    • Author(s)
      岡本仁
    • Organizer
      東京理科大学研究推進機構総合研究院脳学際研究部門 第1回公開シンポジウム 脳の理科~脳の謎に挑む
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] In-vivo imaging of telencephalic neural activities in adult zebrafish in the closed-loop virtual reality environment2017

    • Author(s)
      岡本仁
    • Organizer
      第44回内藤コンファレンス Decision Making in the Brain―Motivation, Prediction, and Learning 意思決定の脳科学―動機、予測と学習
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] he sedative effect of the cholinergic transmission in the habenulo- interpeduncular pathway in social conflict2017

    • Author(s)
      岡本仁
    • Organizer
      MyNEURO 2017 “Reconnecting the Synapses”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The sedative effect of the cholinergic transmission in the habenulo-interpeduncular pathway in social conflict2017

    • Author(s)
      岡本仁
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Evolutionarily conserved role of the habenula in resolution of social conflict2016

    • Author(s)
      岡本仁
    • Organizer
      5th IIIS Symposium 32nd Wako Workshop Joint Meeting -Solving the mystery of sleep-
    • Place of Presentation
      東京コンファレンスセンター(東京、品川)
    • Year and Date
      2016-12-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evolutionarily conserved role of the habenula in resolution of social conflict2016

    • Author(s)
      岡本仁
    • Organizer
      国立遺伝学研究所 The 1903rd Biological Symposium
    • Place of Presentation
      国立遺伝学研究所(静岡、三島)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Live imaging of the whole-brain neural activities in adult zebrafish under the closed- loop virtual reality environment2016

    • Author(s)
      岡本仁
    • Organizer
      第3回名古屋大学神経回路国際シンポジウム
    • Place of Presentation
      名古屋大学(愛知、名古屋)
    • Year and Date
      2016-07-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 社会的闘争の解決における進化的に保存された手綱核の役割2016

    • Author(s)
      岡本仁
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      韓国、ソウル
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of social conflict by the habenula2016

    • Author(s)
      岡本仁
    • Organizer
      Laterarl Habenula under the spotlight
    • Place of Presentation
      Paris, France
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 研究室ホームページ

    • URL

      https://cbs.riken.jp/jp/faculty/h.okamoto/

    • Related Report
      2020 Annual Research Report
  • [Remarks] Keynote Lecture in Neuromatch Conference

    • URL

      https://www.youtube.com/watch?v=YoSZZQ1BSkM

    • Related Report
      2020 Annual Research Report
  • [Remarks] テレ朝ニュース“ハングリー精神”魚で証明「空腹で粘り強くなる」[2020/06/25 12:37]

    • URL

      https://news.tv-asahi.co.jp/news_society/articles/000186978.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] ANN News Channel、「腹ペコ」のほうが勝率高い!「ハングリー精神」の解明へ

    • URL

      https://www.youtube.com/watch?v=BGZ9nwhmLyU

    • Related Report
      2020 Annual Research Report
  • [Remarks] 動物の争いでいつ降参するかを決める神経回路

    • URL

      http://www.riken.jp/pr/press/2016/20160401_1/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 脳神経科学研究センター 意思決定回路動態研究チーム 岡本 仁

    • URL

      http://www.riken.jp/research/labs/cbs/neur_circ_dyn_decision_making/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 意思決定回路動態研究チームオリジナルホームページ

    • URL

      http://dgr.brain.riken.jp

    • Related Report
      2017 Annual Research Report
  • [Remarks] 理化学研究所、脳科学総合研究センター、研究室案内

    • URL

      http://www.brain.riken.jp/jp/faculty/details/37

    • Related Report
      2016 Annual Research Report
  • [Remarks] 理化学研究所、脳科学総合研究センター、発生遺伝子制御研究チーム、ホームページ

    • URL

      http://dgr.brain.riken.jp

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-06-01   Modified: 2023-10-16  

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