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Development of photoacoustic flow cytometry by employing multi-channel high frequency ultrasonic probe

Research Project

Project/Area Number 16H06619
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionUniversity of Toyama (2017)
Tohoku University (2016)

Principal Investigator

Nagaoka Ryo  富山大学, 工学部, 特命助教 (60781648)

Research Collaborator SAIJO Yoshifumi  東北大学, 大学院医工学研究科, 教授 (00292277)
UMEMURA Shin-ichiro  東北大学, 大学院医工学研究科, 教授 (20402787)
YOSHIZAWA Shin  東北大学, 大学院医工学研究科, 准教授 (30455802)
ARAKAWA Mototaka  東北大学, 大学院医工学研究科, 准教授 (00333865)
ISHIKAWA Kazuo  東北大学, 工学部・電気系技術部
Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords超音波計測 / 光音響スペクトロスコピー計測 / 多チャンネル高周波数超音波プローブ / 計測工学 / 光音響計測 / 高周波数超音波プローブ / 光音響波イメージング
Outline of Final Research Achievements

In a traditional photoacoustic flow cytometry, cells in vessels are aligned in one line by laser manipulation, and the photoacoustic signals induced from the cells are measured to classify the characteristics. However, scattering and absorption in the living tissues has effects on the propagation of the radiated laser, and the alignment of the cell by the manipulation cannot be achieved owing to the effect. In this study, the effect of the scattering and absorption was minimized by acoustical focusing, and the method could visualize the living tissues at the deeper part was developed.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Basic Study on Improvement of Axial Resolution and Suppression of Time Side Lobe by Phase-Corrected Wiener filtering in Photoacoustic Tomography2018

    • Author(s)
      R. Nagaoka, S. Yoshizawa, S.-I. Umemura, Y. Saijo
    • Journal Title

      Jpn. J. Appl. Phys.

      Volume: 印刷中

    • NAID

      210000149310

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of murine lymph vessels using photoacoustic imaging with contrast agents2018

    • Author(s)
      Nagaoka Ryo、Tabata Takuya、Yoshizawa Shin、Umemura Shin-ichiro、Saijo Yoshifumi
    • Journal Title

      Photoacoustics

      Volume: 9 Pages: 39-48

    • DOI

      10.1016/j.pacs.2018.01.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Real-Time 3-D Photoacoustic Imaging System Employing Spherically Curved Array Transducer2017

    • Author(s)
      Nagaoka R., Tabata T., Takagi R., Yoshizawa S., Umemura S.-I., Saijo Y.
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 64 Issue: 8 Pages: 1223-1233

    • DOI

      10.1109/tuffc.2017.2718030

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of Photoacoustic Tomography System for Visualization of Micro-Circulation2018

    • Author(s)
      R. Nagaoka, S. Yoshizawa, S.-I. Umemura, Y. Saijo
    • Organizer
      International Young Researchers’ Workshop on Multimodal Medical Engineering 2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] パラボリックアレイトランスデューサを用いたリアルタイム光音響イメージング2017

    • Author(s)
      長岡 亮, 高木 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文
    • Organizer
      日本音響学会 2017年春季研究発表会
    • Place of Presentation
      明治大学生田キャンパス、神奈川県川崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 光音響波イメージングのための半球面アレイトランスデューサの設計とその応用2017

    • Author(s)
      長岡 亮, 高木 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文
    • Organizer
      圧電材料・デバイスシンポジウム2017
    • Place of Presentation
      東北大学カタールサイエンスキャンパスホール、宮城県仙台市
    • Year and Date
      2017-02-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visualization of the microcirculation in micro vasculatures by Photoacoustic Tomography with high frequency Spherical Array Transducer2017

    • Author(s)
      R. Nagaoka, T. Tabata, R. Takagi, S. Yoshizawa, S.-I. Umemura, Y. Saijo
    • Organizer
      2017 IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
  • [Presentation] Differentiation of Vein and Lymphatic Vessel by Photoacoustic Imaging System with Parabolic Array Transducer and Tunable Laser2017

    • Author(s)
      T. Tabata, R. Nagaoka, S. Yoshizawa, S.-I. Umemura, Y. Saijo
    • Organizer
      2017 IEEE International Ultrasonics Symposium
    • Related Report
      2017 Annual Research Report
  • [Presentation] 球面アレイトランスデューサを用いた血管網の光音響イメージング2017

    • Author(s)
      長岡 亮, 高木 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文
    • Organizer
      日本超音波医学会第90回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光音響波イメージングのための線音源及び点音源における光音響波音場に関する基礎検討2017

    • Author(s)
      長岡 亮, 吉澤 晋, 梅村 晋一郎, 西條 芳文
    • Organizer
      日本音響学会2017年秋季研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Skin vasculature imaging by acoustical resolution photoacoustic microscope with parabolic array transducer2016

    • Author(s)
      Yoshifumi Saijo, Ryo Nagaoka, Israr Ul Haq, Syahril Siregar, Ryo Takagi, Shin Yoshizawa, ShinIchiro Umemura
    • Organizer
      5th Joint Meeting of the Acoustical Society of America and Acoustical Society of Japan
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 光音響イメージングにおける信号処理2017

    • Inventor(s)
      長岡亮, 西條芳文, 梅村晋一郎, 吉澤晋
    • Industrial Property Rights Holder
      長岡亮, 西條芳文, 梅村晋一郎, 吉澤晋
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-084155
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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