association between activity of daily living and tau deposition in alzheimers disease
Project/Area Number |
16H06621
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Basic / Social brain science
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Research Institution | Tohoku University |
Principal Investigator |
Harada Aiko 東北大学, 大学病院, 助教 (30778634)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | アルツハイマー病 / 日常生活動作 / タウ / PET / 認知症 / 脳・神経 / 老年医学 / 診断 |
Outline of Final Research Achievements |
Tau accumulation in the brain correlates with the cognitive function in Alzheimer’s disease (AD). The activity of daily living (ADL) which determines the stage of dementia is also seemed to correlate with tau deposition. On order to verify the hypothesis, we performed longitudinal [18F]THK-5351 PET scan which have been developed as tau PET tracer and ADL score in AD and mild cognitive impairment patients. At baseline study, [18F]THK-5351 retention significantly correlated with the ADL score. However, the facts that [18F]THK-5351 bound to monoamine oxidase-B (MAO-B) and might have limited utility as a biomarker of tau protein were revealed in other post-mortem study . In consequence, prearranged follow up study was cancelled.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] [18F]-THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy.2018
Author(s)
Brendel M, Schoneckerr S, Hoglinger G, Lindner S, Havla J, Blautzik J, Sauerbeck J, Rohrer G, Zach C, Vettermann F, Lang AE, Golbe L, Nubling G, Bartenstein P, Furukawa K, Ishiki A, Botzel K, Danek A, Okamura N, Levin J, Rominger A.
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Journal Title
Front Aging Neurosci.
Volume: 9
Pages: 440-440
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy.2017
Author(s)
Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
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Journal Title
Eur J Neurol.
Volume: 24
Issue: 1
Pages: 130-136
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Erratum to: Characterization of the radiolabeled metabolite of tau PET tracer 18F-THK5351.2017
Author(s)
Harada R, Furumoto S, Tago T, Furukawa K, Ishiki A, Tomita N, Iwata R, Tashiro M, Arai H, Yanai K, Kudo Y, Okamura N.
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 44
Pages: 177-177
Related Report
Peer Reviewed
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