Altered neural basis of vulnerability in recurrent depression
| Project/Area Number |
16H07011
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical psychology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Yamamoto Tetsuya 徳島大学, 大学院社会産業理工学研究部(社会総合科学域), 特任講師 (60779396)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMOTO Junichiro 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (10403346)
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| Research Collaborator |
Siegle Greg J.
TAKAMURA Masahiro
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 抑うつ / fMRI / 機械学習 / 再発 / 感情 / 扁桃体 / DLPFC / 気分誘導 / うつ病 / 脆弱性 / 再発予防 / 機能的磁気共鳴画像法（fMRI） / 認知神経科学 / バイオマーカー / 認知行動療法 |
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| Outline of Final Research Achievements |
To identify abnormal neural patterns related to the experience of a major depressive episode, we performed functional magnetic resonance imaging (fMRI) experiments using cognitive tasks in participants with depression and remission in depression. The patients with major depressive disorder showed specific brain activity during recall of happy/negative memories, compared to the healthy participants. Furthermore, the patients who had experienced multiple episodes showed distinctive functional connectivity patterns in (a) the cluster related to self/executive function and (b) the cluster related to the emotional system, compared to the patients who had experienced a single episode.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Increased amygdala reactivity following early life stress: a potential resilience enhancer role.2017
Author(s)
Yamamoto T, Toki S, Siegle GJ, Takamura M, Takaishi Y, Yoshimura S, Okada G, Matsumoto T, Nakao T, Muranaka H, Kaseda Y, Murakami T, Okamoto Y, Yamawaki S
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Journal Title
BMC psychiatry
Volume: 17
Issue: 1
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression.2017
Author(s)
Takamura M, Okamoto Y, Okada G, Toki S, Yamamoto T, Yamamoto O, Jitsuiki H, Yokota N, Tamura T, Kurata A, Kaichi Y, Akiyama Y, Awai K, Yamawaki S
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Journal Title
Neuropsychobiology
Volume: 74
Issue: 2
Pages: 69-77
DOI
Related Report
Peer Reviewed
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