The moleculer mechanisms of epithelial to mesenchymeal transition of primary gastrointestinal tumor from the point of view of endodermal embryology
| Project/Area Number |
16H07015
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 上皮間葉転換 / 原発性肝癌 / microRNA / 内胚葉 / EMT |
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| Outline of Final Research Achievements |
The significance of endoderm-related microRNA was investigated in gastrointestinal tumors. Using the the surgically resected specimens (Cholangiocellular carcinoma: n=32, Colorectal cancer: n=72), expressions of miR-1263 and miR-449a were analyzed and correlation to clinicopathological factors was examined. miR-1263 was barely detected and there was no significant difference in the samples. miR-449a was expressed lower in the more malignant colorectal cancer. The patients with lower expression of miR-449a had worse prognosis after surgery. Furthermore, HDAC1 was inversely correlated with miR-449a exression and could be the important target gene of miR-449a. miR-449a might be tumor-suppressor gene for the tumor generated from endodermal organ, especially for colorectal cancer.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy2018
Author(s)
Yoshimoto T, Imura S, Morine Y, Ikemoto Y, Arakawa Y, Iwahashi S, Saito YU, Takasu C, Ishikawa D, Teraoku H, Bando Y, Shimada M
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Journal Title
Anticancer Research
Volume: 38
Issue: 1
Pages: 501-507
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevated Preoperative Serum CEA Level Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition.2017
Author(s)
Yoshikawa M, Morine Y, Ikemoto T, Imura S, Higashijima J, Iwahashi S, Saito YU, Takasu C, Yamada S, Ishikawa D, Teraoku H, Takata A, Yoshimoto T, Shimada M
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Journal Title
Anticancer Res.
Volume: 37
Issue: 3
Pages: 1169-1175
DOI
Related Report
Peer Reviewed
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[Presentation] Signigficance of CD4+CD49b+regulatory T cells and Foxp3+regulatory T cells in the peripheral blood of cancer patients2016
Author(s)
Ishikawa D, Ikemoto T, Yoshimoto T, Takata A, Yoshikawa M,Takasu C, Saito Y, Iwahashi S, Morine Y, Imura S, Shimada M
Organizer
40th World Congress of the International College of Surgeons
Place of Presentation
京都国際会館(京都府京都市)
Year and Date
2016-10-25
Related Report
Int'l Joint Research
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[Presentation] 転移性肝癌における腫瘍悪性度制御因子としてのTHBS-1の役割2016
Author(s)
石川大地, 寺奥大貴, 髙田厚史, 吉川雅登, 高須千絵, 齋藤裕, 岩橋衆一, 池本哲也, 居村暁, 森根裕二, 島田光生
Organizer
第27回日本消化器癌発生学会総会
Place of Presentation
城山観光ホテル(鹿児島県鹿児島市)
Year and Date
2016-09-16
Related Report
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[Presentation] FBXW7発現は転移性肝癌における切除後再発予測因子となる2016
Author(s)
石川大地, 川下陽一郎, 良元俊昭, 髙田厚史, 吉川雅登, 齋藤裕, 岩橋衆一, 池本哲也, 森根裕二, 居村暁, 島田光生
Organizer
第54回日本癌治療学会学術集会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2016-09-16
Related Report
