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The mechanism of TMJ-OA pathogenesis in HIF-1a gene deficient mice

Research Project

Project/Area Number 16H07019
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontics/Pediatric dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

MORI Hiroki  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (90779985)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsTMJ / 歯学 / 低酸素応答遺伝子 / 顎関節 / 病理学
Outline of Final Research Achievements

Mechanical stress was applied to the TMJ of C57BL/6NCr wild-type (WT) and HIF-1α+/- mice with a sliding plate for 10 days. Histological analysis was performed by HE staining, Safranin-O/Fast green staining, and immunostaining specific for articular cartilage homeostasis.HIF-1α+/- mice had thinner cartilage and smaller areas of proteoglycan than WT controls, without and with mechanical stress. Mechanical stress resulted in prominent degenerative changes with increased expression of HIF-1α, VEGF, and the apoptosis factor cleaved Caspase-3 in condylar cartilage. Our results indicate that HIF-1α may be important for articular cartilage homeostasis and protective against articular cartilage degradation in the TMJ under mechanical stress condition, therefore HIF-1α could be an important new therapeutic target in TMJ-OA.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Roles of hypoxia inducible factor-1α in the temporomandibular joint2017

    • Author(s)
      Mino-Oka A, Izawa T, Shinohara T, Mori H, Yasue A, Tomita S, Tanaka E
    • Journal Title

      Archives of Oral Biology

      Volume: 73(1) Pages: 274-281

    • DOI

      10.1016/j.archoralbio.2016.10.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2016-09-02   Modified: 2019-03-29  

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