| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Purpose: Long-term parenteral nutrition following massive bowel resection causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD).The aim of this study was to evaluate the effects of the administration of ghrelin in the liver in a parenterally fed rat model of short bowel syndrome (SBS).Methods: Rats underwent jugular vein catheterization, and were divided into 3 groups: 90% small bowel resection (90% SBR) and TPN (SBS/TPN group), 90% SBR and TPN plus ghrelin (SBS/TPN/ghrelin group), sham operation with normal chow (sham group). Ghrelin was administered continuously. Result: The AST and LDH levels significantly increased and the accumulation of lipids in the liver was observed in the TPN/SBS group. The accumulation of lipids in the liver of the rats in the SBS/TPN group was attenuated by the administration of ghrelin. Conclusion: The administration of ghrelin has a therapeutic potential for IFALD.
|
