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High-resolution impedance manometry and swallowing CT for dysphagia evaluation and therapy

Research Project

Project/Area Number 16K01477
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionFujita Health University

Principal Investigator

Aoyagi Yoichiro  藤田医科大学, 医学部, 准教授 (30286661)

Co-Investigator(Kenkyū-buntansha) 加賀谷 斉  藤田医科大学, 医学部, 教授 (40282181)
Research Collaborator Saitoh Eiichi  
Inamoto Yoko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords高解像度インピーダンスマノメトリー / 嚥下障害 / 評価 / 食道 / 嚥下CT / 高解像度マノメトリー / 嚥下造影検査 / 摂食嚥下障害 / 摂食嚥下リハビリテーション / マノメトリー
Outline of Final Research Achievements

We evaluated the usefulness of high-resolution impedance manometry for the evaluation of dysphagia. Pressure-flow variables derived from analysis of high-resolution impedance manometry measurements provided valuable physiological and diagnostic information including aspiration.
We also evaluated the effects of different kinds of stimulation via water and air injection of the esophagus on the initiation of the swallowing reflex. While the swallowing reflex is evoked by stimulation via fluid injection of the esophagus in humans, swallowing reflex was evoked in most cases. This methodology may be applied for dysphagia patients.

Academic Significance and Societal Importance of the Research Achievements

高解像度インピーダンスマノメトリーは嚥下病態評価に有用である。嚥下造影検査のように被爆の問題がないため、今後の臨床実用に向けてさらに検討したい。
食道内刺激により嚥下反射が誘発することが、今回はじめてヒトで明らかなとなった。この新しい方法論は、嚥下反射が阻害される嚥下障害患者のリハビリテーション治療として利用できる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (33 results)

All 2019 2018 2017 2016

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 13 results) Presentation (14 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Book (3 results)

  • [Journal Article] Dysphagia associated with acute-phase brainstem cerebrovascular disorder2018

    • Author(s)
      2)Akahori R, Kagaya H, Ozeki M, Shibata S, Aoyagi Y, Onogi K, Saitoh E
    • Journal Title

      Jpn J Compr Rehabil Sci

      Volume: 9 Pages: 43-51

    • NAID

      130007501450

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A health insurance system for maintaining or improving activities of daily living in acute wards in Japan2018

    • Author(s)
      Aoyagi Y, Saitoh E, Kono Y, Mori E
    • Journal Title

      Int J Neurorehab

      Volume: 5 Pages: 324-325

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of bolus volume and flow time on temporospatial coordination in oropharyngeal pressure production in healthy subjects2018

    • Author(s)
      Yano Jitsuro、Aoyagi Yoichiro、Ono Takahiro、Hori Kazuhiro、Yamaguchi Wakami、Fujiwara Shigehiro、Kumakura Isami
    • Journal Title

      Physiology & Behavior

      Volume: 189 Pages: 92-98

    • DOI

      10.1016/j.physbeh.2018.03.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an oesophageal stimulation method to elicit swallowing reflex in humans2018

    • Author(s)
      Taniguchi H.、Aoyagi Y.、Matsuo K.、Nakagawa K.、Saitoh E.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 45 Issue: 3 Pages: 211-215

    • DOI

      10.1111/joor.12599

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyoid Bone Movement at Rest by Peripheral Magnetic Stimulation of Suprahyoid Muscles in Normal Individuals2018

    • Author(s)
      Kagaya Hitoshi、Ogawa Mao、Mori Shino、Aoyagi Yoichiro、Shibata Seiko、Inamoto Yoko、Mori Hitoshi、Saitoh Eiichi
    • Journal Title

      Neuromodulation: Technology at the Neural Interface

      Volume: Epub ahead of print Issue: 5 Pages: 593-596

    • DOI

      10.1111/ner.12777

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] さまざまな高次脳機能障害の症状を理解しよう 失行(2) 口腔顔面失行とその関連症状2018

    • Author(s)
      青柳陽一郎
    • Journal Title

      リハビリナース

      Volume: 別冊 Pages: 129-133

    • Related Report
      2017 Research-status Report
  • [Journal Article] 摂食嚥下障害の評価2018

    • Author(s)
      青柳陽一郎
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 1315-1319

    • Related Report
      2017 Research-status Report
  • [Journal Article] Efforts and effects of additional medical coverage to maintain or improve activities of daily living in an acute cardiovascular internal medicine ward2017

    • Author(s)
      Kono Y, Aoyagi Y, Kayukawa T, Mori E, Ishika A, Yatsuya K, Mizokoshi E, Izawa H, Saitoh E
    • Journal Title

      Jpn J Compr Rehabil Sci

      Volume: 8 Pages: 104-108

    • NAID

      130006285447

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of bolus volume on laryngeal closure and UES opening in swallowing: Kinematic analysis using 320-row area detector CT study2017

    • Author(s)
      Shibata S.、Inamoto Y.、Saitoh E.、Kagaya H.、Aoyagi Y.、Ota K.、Akahori R.、Fujii N.、Palmer J. B.、Gonz?lez-Fern?ndez M.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 44 Issue: 12 Pages: 974-981

    • DOI

      10.1111/joor.12573

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mendelsohn Maneuver and its Effects on Swallowing: Kinematic Analysis in Three Dimensions Using Dynamic Area Detector CT2017

    • Author(s)
      Inamoto Yoko、Saitoh Eiichi、Ito Yuriko、Kagaya Hitoshi、Aoyagi Yoichiro、Shibata Seiko、Ota Kikuo、Fujii Naoko、Palmer Jeffrey B.
    • Journal Title

      Dysphagia

      Volume: Epub ahead of print Issue: 4 Pages: 419-430

    • DOI

      10.1007/s00455-017-9870-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] マノメトリーでわかること2017

    • Author(s)
      青柳陽一郎, 粟飯原けい子
    • Journal Title

      MEDICAL REHABILITATION

      Volume: 212 Pages: 107-112

    • Related Report
      2017 Research-status Report
  • [Journal Article] 摂食嚥下障害のCT評価2017

    • Author(s)
      青柳陽一郎, 稲本陽子, 才藤栄一
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 54 Pages: 661-665

    • NAID

      130006192293

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] 呼吸器疾患に対するリハビリテーションとエビデンス2017

    • Author(s)
      青柳陽一郎, 河野裕治
    • Journal Title

      JOURNAL OF CLINICAL REHABILITATION

      Volume: 26 Pages: 390-395

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 咀嚼を意識した摂食嚥下障害の評価と治療2017

    • Author(s)
      柴田斉子, 加賀谷斉, 小野木啓子, 松尾浩一郎, 稲本陽子, 青柳陽一郎, 戸田芙美, 赤堀遼子, 小川真央, 才藤栄一
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 54 Pages: 986-992

    • NAID

      130006307743

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] 摂食嚥下障害における神経生理学的評価 高解像度マノメトリーと筋電図検査2016

    • Author(s)
      青柳陽一郎
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 53 Pages: 479-483

    • NAID

      130005166256

    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] Progress in Rehabilitation Medicin2016

    • Author(s)
      Kagaya H, Saitoh E, Yokoyama M, Shibata S, Aoyagi Y, Kanamori D, Inamoto Y
    • Journal Title

      Initiation of pharyngeal response during discrete swallowing and chew-swallowing in healthy subjects

      Volume: 1 Pages: 1-4

    • Related Report
      2016 Research-status Report
    • Open Access
  • [Presentation] Effect of head turn on pharyngeal and upper esophageal sphincter pressures -a study using high-resolution manometry-2019

    • Author(s)
      Aoyagi Y, Inamoto Y, Aihara K, Hirumuta M, Shibata S, Kagaya H, Saitoh E
    • Organizer
      Dysphagia Research Society Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elicitation of swallowing reflex by esophageal stimulation in healthy subjects -evaluation using high resolution manometry-2018

    • Author(s)
      Aoyagi Y, Taniguchi H, Imaeda S, Hirumuta M, Saitoh E
    • Organizer
      International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 摂食嚥下障害における評価法の進歩 マノメトリーでわかること2018

    • Author(s)
      青柳陽一郎
    • Organizer
      日本リハビリテーション医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of temperature in eliciting swallowing reflex by esophageal stimulation in humans2018

    • Author(s)
      Aoyagi Y, Taniguchi H, Imaeda S, Hirumuta M, Saitoh E
    • Organizer
      2018 Annual Dysphagia Research Society Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improvement of posture and thermal sensitivity for an esophageal stimulation method to elicit swallowing reflex in humans2018

    • Author(s)
      Taniguchi H, Aoyagi Y, Imaeda S, Hirumuta M, Matsuo K, Saitoh E
    • Organizer
      2018 Annual Dysphagia Research Society Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] .高齢呼吸器疾患患者における身体機能と栄養指標 -誤嚥性肺炎と非誤嚥性肺炎の比較-2018

    • Author(s)
      青柳陽一郎, 田矢理子,大橋美穂,河野裕治, 辻有佳子, 渥美雅子, 溝越恵里子, 蛭牟田誠 山本聖美, 加賀谷斉, 才藤栄一
    • Organizer
      第41回日本嚥下医学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Effects of head rotation on pharyngeal and upper esophageal sphincter pressures –a study using high resolution manometry2017

    • Author(s)
      Aoyagi Y, Ando S, Aihara K, Imaeda S, Inamoto Y, Shibata S, Kagaya H, Saitoh E
    • Organizer
      7th ESSD Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of an esophageal mechanical stimulation method for eliciting the swallowing reflex in healthy young humans2017

    • Author(s)
      Taniguchi H, Aoyagi Y, Imaeda S, Hirumuta M, Matsuo K, Saitoh E
    • Organizer
      7th ESSD Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of Mendelsohn maneuver and effortful swallow on esophageal motility2017

    • Author(s)
      Imaeda S, Aoyagi Y, H. Taniguchi H. Inamoto Y, Hirumuta M, Saitoh E
    • Organizer
      7th ESSD Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rehabilitation strategies for dysphagia2017

    • Author(s)
      Maggie-Lee Huckabee, Shaheen Hamdy, Yoko Inamoto, Yoichiro Aoyagi
    • Organizer
      7th ESSD Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 嚥下反射中の圧パラメータ変化に関する解剖学的基盤 -高解像度マノメトリーと嚥下CTを用いた検討-2017

    • Author(s)
      青柳陽一郎, 稲本陽子,粟飯原けい子,金森大輔, 石黒百合子, 柴田斉子, 加賀谷斉, 才藤栄一
    • Organizer
      第23回日本摂食嚥下 リハビリテーション学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Physiological evaluation and rehabilitative approach for swallowing and its disorder2016

    • Author(s)
      Yoichiro Aoyagi
    • Organizer
      Glenrose Rehabilitation Hospital GRAND ROUNDS
    • Place of Presentation
      Edmonton, Canada
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Diagnosis and Evaluation of Swallowing Disorders2016

    • Author(s)
      Yoichiro Aoyagi
    • Organizer
      The 10th International Society of Physical and Rehabilitation Medicine World Congress
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 嚥下生理学とマノメトリー2016

    • Author(s)
      青柳陽一郎
    • Organizer
      第22回日本摂食嚥下リハビリテーション学会学術集会ハンズオンセミナー
    • Place of Presentation
      朱鷺メッセ, 新潟
    • Related Report
      2016 Research-status Report
  • [Book] 神経・精神疾患による消化管障害ベッドサイドマニュアル2019

    • Author(s)
      青柳陽一郎
    • Total Pages
      379
    • Publisher
      中外医学社
    • ISBN
      9784498140486
    • Related Report
      2018 Annual Research Report
  • [Book] Dysphagia and treatment from the perspective of rehabilitation medicine2017

    • Author(s)
      Pongpipatpaiboon K, Inamoto Y, Matsuo K, Aoyagi Y, Shibata S, Kagaya H, Saitoh E
    • Total Pages
      194
    • Publisher
      Springer
    • Related Report
      2017 Research-status Report
  • [Book] Dysphagia and treatment from the perspective of rehabilitation medicine2017

    • Author(s)
      青柳陽一郎
    • Total Pages
      10
    • Publisher
      リハビリテーション総論
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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